| Reviews |
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Cardiology
Current status of acute myocardial infarction in Korea
Yongcheol Kim, Youngkeun Ahn, Myeong Chan Cho, Chong Jin Kim, Young Jo Kim, Myung Ho Jeong
Korean J Intern Med. 2019;34(1):1-10. Published online December 28, 2018
Coronary artery disease, especially acute myocardial infarction (AMI), is a leading cause of death in the Asia-Pacific region. The Korea Acute Myocardial Infarction Registry (KAMIR) is the first nationwide, prospective, multicenter registry of Korean patients with AMI. Since the KAMIR first began in..
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Update on heart failure management and future directions
[corrected-article]
Hong-Mi Choi, Myung-Soo Park, Jong-Chan Youn
Korean J Intern Med. 2019;34(1):11-43. Published online December 28, 2018
Heart failure (HF) is an important cardiovascular disease because of its increasing prevalence, significant morbidity, high mortality, and rapidly expanding health care cost. The number of HF patients is increasing worldwide, and Korea is no exception. There have been marked advances in definition, ..
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Management plans for populations with normal-to-hypertensive blood pressures:
risks and benefits of antihypertensive drug treatment in populations previously defined as
having high-normal blood pressure
Sungha Park
Korean J Intern Med. 2019;34(1):44-49. Published online December 28, 2018
Recent changes in American and European guidelines on the management of arterial hypertension have caused a considerable shift in the landscape of hypertension management. The 2017 American College of Cardiology/American Heart Association/American Society of Hypertension guideline recommends an offi..
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Hemato-oncology
Current status of immune checkpoint inhibitors in treatment of non-small cell lung cancer
Sung Won Lim, Myung-Ju Ahn
Korean J Intern Med. 2019;34(1):50-59. Published online September 3, 2018
Lung cancer remains a leading cause of cancer mortality worldwide, including in Korea. Systemic therapy including platinum-based chemotherapy and targeted therapy should be provided to patients with stage IV non-small cell lung cancer (NSCLC). Applications of targeted therapy, such as an epidermal g..
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| Editorials |
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| Original Articles |
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Gastroenterology
Clinicopathological features of colorectal polyps in 2002 and 2012
Yoon Jeong Nam, Kyeong Ok Kim, Chan Seo Park, Si Hyung Lee, Byung Ik Jang
Korean J Intern Med. 2019;34(1):65-71. Published online November 8, 2017
Background/Aims: There are few comparative studies on the historical changes in the clinicopathologic characteristics of colorectal polyps in Korea. This retrospective study compared the clinicopathologic characteristics of colorectal polyps treated at our institution in 2002 and 2012.
Methods: The..
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The usefulness of fecal calprotectin in assessing inflammatory bowel disease activity
Yang Woon Lee, Kang-Moon Lee, Ji Min Lee, Yoon Yung Chung, Dae Bum Kim, Yeon Ji Kim, Woo Chul Chung, Chang-Nyol Paik
Korean J Intern Med. 2019;34(1):72-80. Published online January 20, 2018
Background/Aims: Fecal calprotectin (FC) is known to correlate with disease activity and can be used as a predictor for relapse or treatment response in inflammatory bowel disease (IBD). We evaluated the usefulness of FC as a biomarker for disease activity in patients with IBD using both enzyme-link..
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Development, validation, and application of a novel tool to measure disease-related knowledge in patients with inflammatory bowel disease
Hyuk Yoon, Suk-Kyun Yang, Hoonsub So, Ko Eun Lee, Sang Hyoung Park, Sung-Ae Jung, Joong Haeng Choh, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
Korean J Intern Med. 2019;34(1):81-89. Published online November 29, 2017
Background/Aims: The Crohn’s and Colitis Knowledge (CCKNOW) score does not reflect updated knowledge relating to inflammatory bowel disease (IBD). The aim of this study was to develop, validate, and apply a novel tool to measure disease-related knowledge in IBD patients.
Methods: A questionnaire ..
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Cardiology
Olmesartan is not associated with the risk of enteropathy: a Korean nationwide observational
cohort study
Seng Chan You, Hojun Park, Dukyong Yoon, Sooyoung Park, Boyoung Joung, Rae Woong Park
Korean J Intern Med. 2019;34(1):90-98. Published online November 27, 2017
Background/Aims: Olmesartan, a widely used angiotensin II receptor blocker (ARB), has been linked to sprue-like enteropathy. No cases of olmesartan-associated enteropathy have been reported in Northeast Asia. We investigated the associations between olmesartan and other ARBs and the incidence of ent..
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Experiences of magnetic resonance imaging scanning in patients with pacemakers or implantable cardioverter-defibrillators
Donghoon Han, Si-Hyuck Kang, Youngjin Cho, Il-Young Oh
Korean J Intern Med. 2019;34(1):99-107. Published online April 4, 2018
Background/Aims: Despite the U.S. Food and Drug Adminstration approving a magnetic resonance imaging (MRI)-conditional pacemaker system in 2011, many physicians remain reluctant to perform MRI scanning in patients with cardiac implantable electronic devices. Herein, we aimed to evaluate the real-wor..
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Pulmonology
Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease
Sulhattin Arslan, Gürsel Yildiz, Levent Özdemir, Erdal Kaysoydu, Bülent Özdemir
Korean J Intern Med. 2019;34(1):108-115. Published online November 16, 2018
Background/Aims: Many systems including the cardiovascular system (ischemic heart diseases, heart failure, and hypertension) may act as comorbidities that can be seen during the course of chronic obstructive pulmonary disease (COPD). Comorbidities affect the severity and prognosis of COPD negatively..
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Nonpulmonary risk factors of acute respiratory distress syndrome in patients with septic bacteraemia
Hyunseung Nam, Seung Hun Jang, Yong Il Hwang, Joo-Hee Kim, Ji Young Park, Sunghoon Park
Korean J Intern Med. 2019;34(1):116-124. Published online June 14, 2018
Background/Aims: The relationship between nonpulmonary organ failure and the development of acute respiratory distress syndrome (ARDS) in patients with sepsis has not been well studied.
Methods: We retrospectively reviewed the medical records of patients with septic bacteremia admitted to the medic..
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Endocrinology-metabolism
Analysis of diabetes quality assessment findings and future directions for the appropriate management of diabetes in Korea
Yu Jin Kim, Suk Chon, Seungjoon Oh, Jeong-taek Woo, Sung Woon Kim, Sang Youl Rhee
Korean J Intern Med. 2019;34(1):125-136. Published online March 15, 2017
Background/Aims: Due to recent increases in the disease burden of diabetes mellitus, the Health Insurance Review and Assessment Service (HIRA) of Korea implemented a quality assessment of the treatment of diabetes to improve patient care. The present study was conducted to identify any changes after..
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Nephrology
Value of Doppler evaluation of physically abnormal fistula: hemodynamic guidelines and access outcomes
Seong Cho, Yu-Ji Lee, Sung-Rok Kim
Korean J Intern Med. 2019;34(1):137-145. Published online April 18, 2017
Background/Aims: The strategy of access care at out center involves the use of ultrasound (USG) in case of physical examination (PE) abnormality. USG determines the need of angiography. This study investigated the possible association between the need for percutaneous transluminal angioplasty (PTA) ..
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Paricalcitol attenuates indoxyl sulfate-induced apoptosis through the inhibition of MAPK, Akt, and NF-kB activation in HK-2 cells
Jung Sun Park, Hoon In Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Korean J Intern Med. 2019;34(1):146-155. Published online October 10, 2017
Background/Aims: Indoxyl sulfate (IS) is a uremic toxin and an important causative factor in the progression of chronic kidney disease. Recently, paricalcitol (19-nor-1,25-dihydroxyvitamin D2) was shown to exhibit protective effects in kidney injury. Here, we investigated the effects of paricalcitol..
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Hemato-oncology
Factors associated with treatment interruption in elderly patients with cancer
Hye Sung Won, Der Sheng Sun, Ji Young Choi, Ho Jung An, Yoon Ho Ko
Korean J Intern Med. 2019;34(1):156-164. Published online February 23, 2018
Background/Aims: This study was conducted to identify risk factors that predict vulnerability to cancer therapy on the basis of the clinical, geriatric, and quality of life assessment before starting treatment in elderly patients.
Methods: Seventy-five patients aged 65 years and over with newly dia..
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The impact of primary tumor location in patients with metastatic colorectal cancer: a Korean Cancer Study Group CO12-04 study
Jae Ho Byun, Joong Bae Ahn, Sun Young Kim, Jung Hun Kang, Dae Young Zang, Seok Yun Kang, Myoung Joo Kang, Byoung Yong Shim, Sun Kyung Baek, Bong-Seog Kim, Kyung Hee Lee, Soon Il Lee, Sang-Hee Cho, Byeong Seok Sohn, Samyong Kim, In Gyu Hwang, Eun Mi Nam, Bong-Gun Seo, Sang Cheul Oh, Myung-Ah Lee, Sang-Cheol Lee, Ji Hyung Hong, Young Suk Park
Korean J Intern Med. 2019;34(1):165-177. Published online November 28, 2017
Background/Aims: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC).
Methods: Demographic data and clinical information were collected from 1..
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Small RNA sequencing profiles of mir-181 and mir-221, the most relevant microRNAs in acute myeloid leukemia
Yun-Gyoo Lee, Inho Kim, Somi Oh, Dong-Yeop Shin, Youngil Koh, Keun-Wook Lee
Korean J Intern Med. 2019;34(1):178-183. Published online November 27, 2017
Background/Aims: To evaluate and select microRNAs relevant to acute myeloid leukemia (AML) pathogenesis, we analyzed differential microRNA expression by quantitative small RNA next-generation sequencing using duplicate marrow samples from individual AML patients.
Methods: For this study, we obtaine..
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Infectious diseases
Clinical and microbiological factors associated with early patient mortality from methicillin-resistant Staphylococcus aureus bacteremia
Tark Kim, Yong Pil Chong, Ki-Ho Park, Kyung Mi Bang, Su-Jin Park, Sung-Han Kim, Jin-Yong Jeong, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim
Korean J Intern Med. 2019;34(1):184-194. Published online July 6, 2017
Background/Aims: Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) is a major bloodstream infection with a high mortality rate. Identification of factors associated with early mortality in MRSAB patients would be useful for predicting prognosis and developing new therapeutic opti..
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Allergy
Direct costs of severe cutaneous adverse reactions in a tertiary hospital in Korea
Min-Suk Yang, Ju-Young Kim, Min-Gyu Kang, Suh-Young Lee, Jae-Woo Jung, Sang-Heon Cho, Kyung-Up Min, Hye-Ryun Kang
Korean J Intern Med. 2019;34(1):195-201. Published online February 23, 2018
Background/Aims: There are only a few reports on the direct costs of severe cutaneous adverse reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), despite the tremendous negative impact these..
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Rheumatology
Insulin resistance is an independent predictor of erectile dysfunction in patients with gout
Ji Hun Kim, Min Kyung Chung, Jin Young Kang, Jung Hee Koh, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Sung-Hwan Park
Korean J Intern Med. 2019;34(1):202-209. Published online October 12, 2017
Background/Aims: Gout is associated with metabolic disorders that are important risk factors for cardiovascular disease and erectile dysfunction (ED). We aimed to identify independent predictors of ED in patients with gout.
Methods: From August 2014 to August 2015, male outpatients who were being t..
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N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL in rheumatoid arthritis
[corrected-article]
Hae-Rim Kim, Kyoung-Woon Kim, Bo-Mi Kim, Kyung-Ann Lee, Sang-Heon Lee
Korean J Intern Med. 2019;34(1):210-219. Published online March 13, 2017
Background/Aims: This study aimed to determine the regulatory role of N-acetyl-l-cysteine (NAC), an antioxidant, in interleukin 17 (IL-17)-induced osteoclast differentiation in rheumatoid arthritis (RA).
Methods: After RA synovial fibroblasts were stimulated by IL-17, the expression and pro..
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Clinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor
Hong Ki Min, Youn Soo Lee, Suk-Woo Yang, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2019;34(1):220-226. Published online October 19, 2017
Background/Aims: This study investigated the clinical and pathological features of immunoglobulin G4 (IgG4)-related ophthalmic disease. To clarify the features, we compared IgG4-related ophthalmic disease and orbital inflammatory pseudotumor.
Methods: We retrospectively reviewed the medical records..
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| Letter to the editor |
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Atypical presentation of amniotic fluid embolism in liver and colon
Maurizio Zizzo, Maria Cecilia Mengoli, Magda Zanelli, Loredana De Marco, Filippo Lococo, Lara Ugoletti, Claudio Pedrazzoli
Korean J Intern Med. 2019;34(1):227-230. Published online June 25, 2018
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| Images of interest |
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Acute gastric dilatation and ischemia associated with portal vein gas caused by binge eating
Kwangwoo Nam, Hyun Deok Shin, Jeong Eun Shin
Korean J Intern Med. 2019;34(1):231-232. Published online November 15, 2017
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Cardiac computed tomography reveals aortic valve perforation in a patient with severe aortic regurgitation
Namkyun Kim, Sung Mok Kim, Sung-Ji Park, Yeon Hyeon Choe
Korean J Intern Med. 2019;34(1):233-234. Published online August 13, 2018
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Ciliary metaplasia in a patient with antineutrophil cytoplasmic autoantibody-associated pauci-immune glomerulonephritis
Chang-Hoon Lee, Jin Han Lim, Kyoung Min Kim, Moon Hyang Park, Kyung Pyo Kang
Korean J Intern Med. 2019;34(1):235-236. Published online January 8, 2018
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