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Rheumatology
Nailfold capillaroscopy findings of interstitial pneumonia with autoimmune features
Sang-Heon Lee, Hong Ki Min, Se-Hee Kim, Young Whan Kim, Kwang Ha Yoo, Hee Joung Kim, In Ae Kim, Hae-Rim Kim
Korean J Intern Med. 2023;38(6):903-911. Published online July 25, 2023
Background/Aims: We evaluated nailfold capillaroscopy (NFC) of interstitial pneumonia with autoimmune features (IPAF) and compared it with that of patients with connective tissue disease-interstitial lung disease (CTD-ILD) and idiopathic interstitial pneumonia (IIP).
Methods: Patients with newly di..
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Hemato-oncology
Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing
Min Ji Jeon, Eun Sang Yu, Chul Won Choi, Dae Sik Kim
Korean J Intern Med. 2023;38(6):893-902. Published online August 21, 2023
Background/Aims: Although rituximab, an antiCD20 monoclonal antibody, has dramatically improved the clinical outcomes of diffuse large B-cell lymphoma, rituximab resistance remains a challenge.
Methods: We developed a rituximab-resistant cell line (RRCL) by sequential exposure to gradually increasi..
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Pulmonology
Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
Ji Yeon Choi, Bora Shim, Youngmok Park, Young Ae Kang
Korean J Intern Med. 2023;38(6):879-892. Published online October 23, 2023
Background/Aims: Although the incidence of nontuberculous mycobacteria pulmonary disease (NTM-PD), a chronic infectious disease, is increasing, lung and gut microbiota dysbiosis in NTM patients has rarely been studied and was therefore the focus of this study.
Methods: We analyzed the microbiota di..
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Cardiology
Exercise capacity and risk of incident atrial fibrillation in healthy adults
Ju Youn Kim, Soo Jin Cho, Juwon Kim, Tae-Wan Chung, Seung-Jung Park, Kyoung-Min Park, June Soo Kim, Young Keun On
Korean J Intern Med. 2023;38(6):872-878. Published online November 1, 2023
Background/Aims: Atrial fibrillation (AF) is a common arrhythmia and is associated with cardiovascular morbidity and mortality. It is important to identify and control the modifiable risk factors of AF. We aimed to examine the association of exercise capacity with the risk of incident AF within 3 ye..
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Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing
Ki-Woon Kang, Kyung-Won Hong, Seong-Kyu Lee
Korean J Intern Med. 2023;38(6):865-871. Published online November 1, 2023
Background/Aims: Scrub typhus infection has been known to complicate cardiovascular diseases mainly attributing to high mortality. Genetic susceptibility loci for complicating cardiac diseases such as atrial fibrillation, heart failure, and ischemic heart disease identified by genomic study have bee..
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Gastroenterology
Genetic susceptibility to post-endoscopic retrograde cholangiopancreatography pancreatitis identified in propensity score-matched analysis
Young Hoon Choi, Younggyun Lim, Dong Kee Jang, Dong-Won Ahn, Ji Kon Ryu, Woo Hyun Paik, Yong-Tae Kim, Ju Han Kim, Sang Hyub Lee
Korean J Intern Med. 2023;38(6):854-864. Published online October 23, 2023
Background/Aims: A previous history of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a risk factor for PEP, suggesting that there may be a genetic predisposition to PEP. However, nothing is known about this yet. The aim of this study was to identify genetic variati..
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Impact of hepatitis B virus infection on the risk of gallbladder polyps: a cohort study
Nam Hee Kim, Hong Joo Kim, Ji Hun Kang
Korean J Intern Med. 2023;38(6):844-853. Published online October 18, 2023
Background/Aims: We aimed to determine whether hepatitis B virus (HBV) or hepatitis C virus (HCV) infection remains an important risk factor for gallbladder polyps (GBPs) in the current context of reduced prevalence of these infections.
Methods: The cohort included 392,913 asymptomatic adults who unde..
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Factors influencing occurrence of metachronous gastric cancer after endoscopic resection: a systematic review and meta-analysis
Younghee Choe, Jae Myung Park, Joon Sung Kim, Yu Kyung Cho, Byung-Wook Kim, Myung-Gyu Choi
Korean J Intern Med. 2023;38(6):831-843. Published online November 1, 2023
Background/Aims: Metachronous gastric cancer (MGC) can occur after endoscopic resection for gastric cancer. Further studies on factors other than Helicobacter pylori infection are needed. This systematic review and meta-analysis aimed to evaluate risk factors for metachronous recurrence of en..
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Hepatic hemangioma: proportion and predictor of surgical treatment with emphasis on its growth rate
Young Cheol Shin, Eun Ju Cho, Hee Young Na, Jai Young Cho, Ho-Seong Han, Yoon Jin Lee, Haeryoung Kim, Sangmi Jang, Gwang Hyeon Choi, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong
Korean J Intern Med. 2023;38(6):818-830. Published online November 1, 2023
Background/Aims: There are limited studies on the management of hepatic hemangiomas (HHs). We investigated the proportion and predictors of surgical resection and analyzed HH growth rates in addition to associated factors.
Methods: A retrospective case-control study of patients treated in 2 centers..
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Long-acting interferon: pioneering disease modification of myeloproliferative neoplasms
Seug Yun Yoon, Sung-Yong Kim
Korean J Intern Med. 2023;38(6):810-817. Published online November 1, 2023
Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells. The malignant clones produce cytokines that drive self-perpetuating inflammatory responses and tend to transform into more aggressive clones, leading to disease progression. The progression of MPNs follows a biolog..
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Expanding the therapeutic landscape: ezetimibe as non-statin therapy for dyslipidemia
Jeongmin Lee, Seung-Hwan Lee
Korean J Intern Med. 2023;38(6):797-809. Published online October 20, 2023
Dyslipidemia is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), and statins are the primary therapeutic options for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, it can be challenging to achieve optimal LDL-C goals with statin monotherapy. Ezetim..
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Perioperative immunotherapy in stage IB-III non-small cell lung cancer: a critical review of its rationale and considerations
Jae Kyeom Sim, Juwhan Choi, Sung Yong Lee
Korean J Intern Med. 2023;38(6):787-796. Published online November 1, 2023
Lung cancer is a dismal disease as a leading cause of overall cancer death, but the development of immune checkpoint inhibitors (ICIs) in driver gene mutation negative metastatic non-small cell lung cancer (NSCLC) is changing the paradigm of lung cancer treatment. Recently, ICIs are expanding their ..
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An unusual cause of pneumonia: Strongyloides stercoralis infection
Chun-Jing Lu, Jin-Yan Zhang, Wei-Feng Huang
Korean J Intern Med. 2023;38(5):781-782. Published online June 20, 2023
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Uncovering the unforeseen: pericarditis and mycotic coronary aneurysm at previous stent site
Sook-Jung Kim, Osung Kwon, Jeong-Eun Yi, Joon-Kyu Kang, Yun-Seok Choi
Korean J Intern Med. 2023;38(5):779-780. Published online June 9, 2023
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Rheumatology
Long-term renal outcomes of patients with non-proliferative lupus nephritis
Eun-Song Kang, Soo Min Ahn, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
Korean J Intern Med. 2023;38(5):769-776. Published online August 7, 2023
Background/Aims: Although non-proliferative lupus nephritis (LN) (class I, II or V) has been considered as a less severe type of LN, data on long-term renal prognosis are limited. We investigated the long-term outcomes and prognostic factors in non-proliferative LN.
Methods: We retrospectively revi..
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Infectious diseases
Antibiotics use patterns in end-of-life cancer patients and medical staff’s perception of antimicrobial stewardship programs
Min Kwan Kwon, Kyung Hwa Jung, Sungim Choi, Hyeonjeong Kim, Chang-Yun Woo, Mingee Lee, Jeong Geun Ji, Hyo-Ju Son
Korean J Intern Med. 2023;38(5):758-768. Published online August 17, 2023
Background/Aims: While most cancer patients with end-of-life (EOL) care receive antibiotic treatments, antibiotic use should be decided appropriately considering the benefits, side effects, resistance, and cost effects. Antimicrobial stewardship programs (ASP) are important for patients with EOL car..
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Hemato-oncology
Treatment pattern of chronic lymphocytic leukemia/small lymphocytic lymphoma in Korea: a multicenter retrospective study (KCSG LY20-06)
Jung Sun Kim, Tae Min Kim, Myoung Joo Kang, Sung Ae Koh, Hyunkyung Park, Seung-Hyun Nam, Jae Joon Han, Gyeong-Won Lee, Young Jin Yuh, Hee Jeong Lee, Jung Hye Choi
Korean J Intern Med. 2023;38(5):747-757. Published online June 26, 2023
Background/Aims: Little attention is paid to chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Korea due to the rarity of the disease. With its rising incidence, we aimed to evaluate recent changes in treatment patterns and survival outcomes of patients with CLL/SLL.
Methods: A t..
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