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Hemato-oncology / Review
Recent advances in the diagnosis and management of primary myelofibrosis
Katsuto Takenaka, Kazuya Shimoda, Koichi Akashi
Korean J Intern Med. 2018;33(4):679-690. Published online April 20, 2018
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) in which dysregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathways is the major pathogenic mechanism. Most patients with PMF carry a driver mutation in the JAK2, MPL (my..
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Nephrology / Review
Hepatitis C virus infection in chronic kidney disease: paradigm shift in management
So Mi Kim, Il Han Song
Korean J Intern Med. 2018;33(4):670-678. Published online June 28, 2018
Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated inte..
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Nephrology / Review
Clinical usefulness of bioimpedance analysis for assessing volume status in patients receiving maintenance dialysis
Jung Hwan Park, Young-Il Jo, Jong-Ho Lee
Korean J Intern Med. 2018;33(4):660-669. Published online June 28, 2018
Chronic volume overload is associated with left ventricular hypertrophy and high cardiovascular mortality in patients undergoing dialysis. Therefore, estimating body fluid status is important in these patients. However, most dry-weight assessments are still performed clinically, while attempts have ..
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Nephrology / Review
Applications of kidney organoids derived from human pluripotent stem cells
Yong Kyun Kim, Sun Ah Nam, Chul Woo Yang
Korean J Intern Med. 2018;33(4):649-659. Published online June 28, 2018
The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing of compounds, and regenerative therapy are attractive ap..
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Image of interest
Paget disease in a radius
Ruiguo Zhang, Guizhi Zhang, Renfei Wang, Qiang Jia, Jian Tan
Korean J Intern Med. 2018;33(3):647-648. Published online March 19, 2018
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Image of interest
A growing hepatic mass in a cryptogenic cirrhosis patient
Ji Soo Song, Hee Chul Yu, Woo Sung Moon
Korean J Intern Med. 2018;33(3):645-646. Published online October 19, 2017
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Letter to the editor
Loeffler endocarditis in chronic eosinophilic leukemia with FIP1L1/PDGFRA rearrangement: full recovery with low dose imatinib
Dae Sik Kim, Sunki Lee, Chul Won Choi
Korean J Intern Med. 2018;33(3):642-644. Published online June 28, 2017
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Letter to the editor
Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene
Jae Won Song, Hyo-Jeong Hwang, Chang Min Lee, Gun Ha Park, Chul Sik Kim, Seong Jin Lee, Sung-Hee Ihm
Korean J Intern Med. 2018;33(3):638-641. Published online January 16, 2017
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Letter to the editor
Multiple metastasis of follicular variant of papillary thyroid carcinoma coexistent with malignant melanoma
Yu Ji Kim, Kyung Ae Lee, Tae Sun Park, Hong Sun Baek, Heung Yong Jin
Korean J Intern Med. 2018;33(3):634-637. Published online January 16, 2017
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Letter to the editor
Histologically confirmed nonbacterial thrombotic endocarditis in a febrile leukemic patient
Eun Gyo Jeong, Mi-Hyang Jung, Ho-Joong Youn
Korean J Intern Med. 2018;33(3):632-633. Published online June 26, 2017
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Letter to the editor
Multivessel spontaneous coronary artery dissection presenting as acute myocardial infarction
Seung Ki Moon, Seung Uk Lee, Dong Hoon Yang, Cheol Min Bak, Shin Hyoung Jo, Sung Soo Kim, Dong Goo Kang, Sang Ki Cho
Korean J Intern Med. 2018;33(3):629-631. Published online April 20, 2016
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Rheumatology / Original Article
Baseline extent of damage predicts spinal radiographic progression in Korean patients with ankylosing spondylitis treated with golimumab
Jeong Seok Lee, Yeong Wook Song, Tae Hwan Kim, Won Tae Chung, Seung Geun Lee, Sung Hwan Park, Gwan Gyu Song, Dae Young Yu, Stephen Xu, Eun Young Lee
Korean J Intern Med. 2018;33(3):622-628. Published online January 20, 2017
Background/Aims: For patients with ankylosing spondylitis (AS), golimumab has consistent efficacy in controlling disease activity over 5 years but its benefit in preventing radiographic progression was less clear at 4 years. To predict radiographic progression, we analyzed the baseline characteristi..
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Rheumatology / Original Article
Grape seed proanthocyanidin extract ameliorates murine autoimmune arthritis through regulation of TLR4/MyD88/NF-κB signaling pathway
Sang-Hyon Kim, Jihye Bang, Chang-Nam Son, Won-Ki Baek, Ji-Min Kim
Korean J Intern Med. 2018;33(3):612-621. Published online June 3, 2016
Background/Aims: Grape seed proanthocyanidin extract (GSPE) has been reported to have a beneficial effect on regulating inf lammation. However, the anti-inflammatory mechanism of GSPE remains unclear. The aim of this study was to verify the influence of GSPE on the Toll-like receptor 4 (TLR4)-mediat..
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Allergy / Original Article
The virtual asthma guideline e-learning program: learning effectiveness and user satisfaction
Sung-Yoon Kang, Sae-Hoon Kim, Yong-Eun Kwon, Tae-Bum Kim, Hye-Kyung Park, Heung-Woo Park, Yoon-Seok Chang, Young-Koo Jee, Hee-Bom Moon, Kyung-Up Min, Sang-Heon Cho
Korean J Intern Med. 2018;33(3):604-611. Published online July 21, 2017
Background/Aims: Effective educational tools are important for increasing adherence to asthma guidelines and clinical improvement of asthma patients. We developed a computer-based interactive education program for asthma guideline named the Virtual Learning Center for Asthma Management (VLCAM). We e..
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Infectious diseases / Original Article
Changing trends in clinical characteristics and antibiotic susceptibility of Klebsiella pneumoniae bacteremia
Miri Hyun, Chang In Noh, Seong Yeol Ryu, Hyun Ah Kim
Korean J Intern Med. 2018;33(3):595-603. Published online November 10, 2017
Background/Aims: Klebsiella pneumoniae is second most common organism of gram-negative bacteremia in Korea and one of the most common cause of urinary tract infection, and intra-abdominal infection.
Methods: We compared clinical and microbiological characteristics about K. pneumoniae ..
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Hemato-oncology / Original Article
Prevalence of and factors associated with anxiety and depression in Korean patients with newly diagnosed advanced gastrointestinal cancer
Junghwa Chung, Gawon Ju, Jiyoul Yang, Jiwon Jeong, Yusook Jeong, Moon Ki Choi, Jihyun Kwon, Ki Hyeong Lee, Seung Taik Kim, Hye Sook Han
Korean J Intern Med. 2018;33(3):585-594. Published online February 14, 2017
Background/Aims: The purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer.
Methods: One hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer ..
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Hemato-oncology / Original Article
Initial titration with 200 μg fentanyl buccal tablets: a retrospective safety analysis in Korean cancer patients
Mi-Young Kwon, Ha-Na Cho, Dong-Hoe Koo, Yun-Gyoo Lee, Sukjoong Oh, Seung-Sei Lee
Korean J Intern Med. 2018;33(3):577-584. Published online January 24, 2017
Background/Aims: Managing breakthrough pain (BTP) is important for many cancer patients because of the rapid onset and unpredictable nature of the pain episodes. Fentanyl buccal tablets (FBTs) are a rapid-onset opioid indicated for BTP management. However, FBT titration is needed to optimize BTP ma..
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Nephrology / Original Article
Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys
Sejoong Kim, Eun Sook Jung, Jeonghwan Lee, Nam Ju Heo, Ki Young Na, Jin Suk Han
Korean J Intern Med. 2018;33(3):568-576. Published online March 18, 2017
Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral urete..
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Nephrology / Original Article
Comparison of tolvaptan treatment between patients with the SIADH and congestive heart failure: a single-center experience
Gun Ha Park, Chang Min Lee, Jae Won Song, Moon Chan Jung, Jwa Kyung Kim, Young Rim Song, Hyung Jik Kim, Sung Gyun Kim
Korean J Intern Med. 2018;33(3):561-567. Published online March 13, 2017
Background/Aims: Tolvaptan is a very effective treatment for hypervolemic or euvolemic hyponatremia. We compared the clinical efficacy of and response to tolvaptan in patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and congestive heart failure (CHF).
Methods: We r..
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