|
Metformin and its therapeutic applications in autoimmune inflammatory rheumatic disease
Ji-Won Kim, Jung-Yoon Choe, Sung-Hwan Park
Korean J Intern Med. 2022;37(1):13-26. Published online December 10, 2021
Metformin is a first-line therapeutic agent for type 2 diabetes. Apart from its glucose- lowering effect, metformin is attracting interest regarding possible therapeutic benefits in various other conditions. As metformin regulates cell metabolism, proliferation, growth, and autophagy, it may also mo..
|
|
|
Hemato-oncology
Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer
Guk Jin Lee, Yun Hwa Jung, Tae-Jung Kim, Yosep Chong, Seo-Won Jeong, In Kyu Lee, In Sook Woo
Korean J Intern Med. 2021;36(Suppl 1):S235-S244. Published online July 2, 2020
Background/Aims: Colorectal cancer (CRC) rate increases with aging. Aging-related proteins, such as sirtuins (SIRTs) may be a potential therapeutic target in the elderly patients with CRC. The clinical implications of SIRT1 and SIRT2 have not been reported for elderly patients with cancer. The aim of..
|
|
|
Induction chemotherapy followed by concurrent chemoradiotherapy versus CCRT for locally
advanced hypopharynx and base of tongue cancer
Sung Hee Lim, Jong-Mu Sun, Joohyun Hong, Dongryul Oh, Yong Chan Ahn, Man Ki Chung, Han-Sin Jeong, Young-Ik Son, Myung-Ju Ahn, Chung-Hwan Baek, Keunchil Park
Korean J Intern Med. 2021;36(Suppl 1):S217-S224. Published online April 3, 2020
Background/Aims: Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over c..
|
|
|
Nephrology
L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
Hai Yan Zhao, Hui Ying Li, Jian Jin, Ji Zhe Jin, Long Ye Zhang, Mei Ying Xuan, Xue Mei Jin, Yu Ji Jiang, Hai Lan Zheng, Ying Shun Jin, Yong Jie Jin, Bum Soon Choi, Chul Woo Yang, Shang Guo Piao, Can Li
Korean J Intern Med. 2021;36(Suppl 1):S180-S195. Published online September 18, 2020
Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on renal fibrosis. This study examined whether LC treatment would..
|
|
|
Pulmonology
Characteristics and risk factors associated with missed diagnosis in patients with smear-negative pulmonary tuberculosis
Se Hyun Kwak, Ji Soo Choi, Eun Hye Lee, Su Hwan Lee, Ah Young Leem, Sang Hoon Lee, Song Yee Kim, Kyung Soo Chung, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Joon Chang, Young Ae Kang
Korean J Intern Med. 2021;36(Suppl 1):S151-S159. Published online August 20, 2020
Background/Aims: Delayed diagnosis and treatment of smear-negative pulmonary tuberculosis (TB) are major concerns for TB control. We evaluated characteristics of patients with smear-negative pulmonary TB who received a delayed diagnosis and identified risk factors that may have contributed to this d..
|
|
|
A genome wide association study for lung function in the Korean population using an exome array
Kyu-Sun Lee, Kun Hee Kim, Yeon-Mok Oh, Buhm Han, Woo Jin Kim
Korean J Intern Med. 2021;36(Suppl 1):S142-S150. Published online April 29, 2020
Background/Aims: Lung function is an objective indicator of diagnosis and prognosis of respiratory diseases. Many common genetic variants have been associated with lung function in multiple ethnic populations. We looked for coding variants associated with forced expiratory volume in 1 second (FEV
|
|
|
Cardiology
Effects of renin-angiotensin system blockers on the risk and outcomes of severe acute respiratory syndrome coronavirus 2 infection in patients with hypertension
Jinwoo Lee, Seong Jin Jo, Youngjin Cho, Ji Hyun Lee, Il-Young Oh, Jin Joo Park, Young-Seok Cho, Dong-Ju Choi
Korean J Intern Med. 2021;36(Suppl 1):S123-S131. Published online February 10, 2021
Background/Aims: There are concerns that the use of renin-angiotensin system (RAS) blockers may increase the risk of being infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or progressing to a severe clinical course after infection. This this study aimed to investigate the i..
|
|
|
Sex differences in long-term clinical outcomes of acute myocardial infarction according to the presence of diabetes mellitus
Yu Ri Kim, Myung Ho Jeong, Youngkeun Ahn, Ju Han Kim, Young Joon Hong, Min Chul Kim, Kyung Hoon Cho, Xiong Yi Han; other KAMIR-NIH Registry Investigators
Korean J Intern Med. 2021;36(Suppl 1):S99-S113. Published online January 12, 2021
Background/Aims: This study compared long-term clinical outcomes between male and female acute myocardial infarction (AMI) patients with and without diabetes mellitus (DM).
Methods: From November 2011 to December 2015, 13,104 patients with AMI were enrolled in the Korea Acute Myocardial Infarction ..
|
|
|
Clinical significance of high on-treatment platelet reactivity in patients with prolonged clopidogrel therapy
Sehun Kim, Donghoon Han, Jae Hyuk Choi, Eun-Joo Park, Dong Geum Shin, Min-Kyung Kang, Seonghoon Choi, Namho Lee, Jung Rae Cho
Korean J Intern Med. 2021;36(Suppl 1):S80-S89. Published online February 25, 2021
Background/Aims: Prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel beyond 1 year has been shown to reduce ischemic events at the expense of increased bleeding. However, limited data are available on the clinical significance of platelet reactivity (PR) at 1 year.
Methods: We r..
|
|
|
Clinical outcomes of endovascular treatment for ruptured thoracic aortic disease
Jong Hyun Choi, Sang-Pil Kim, Han Cheol Lee, Tae Sik Park, Jong Ha Park, Bo Won Kim, Jinhee Ahn, Jin Sup Park, Hye Won Lee, Jun-Hyok Oh, Jung Hyun Choi, Kwang Soo Cha, Taek Jong Hong
Korean J Intern Med. 2021;36(Suppl 1):S72-S79. Published online April 10, 2020
Background/Aims: Untreated rupture of the thoracic aorta is associated with a high mortality rate. We aimed to review the clinical results of endovascular treatment for ruptured thoracic aortic disease.
Methods: We retrospectively reviewed data on 37 patients (mean age, 67.0 ± 15.18 years) treate..
|
|
|
Long-term efficacy of vasodilating β-blocker in patients with acute myocardial infarction: nationwide multicenter prospective registry
Jaehoon Chung, Jung-Kyu Han, Han-Mo Yang, Kyung-Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Myung Ho Jeong, Hyo-Soo Kim; on behalf of investigators for Korea Acute Myocardial Infarction Registry (KAMIR)
Korean J Intern Med. 2021;36(Suppl 1):S62-S71. Published online July 3, 2020
Background/Aims: Long-term benefit of vasodilating β-blockers is unknown. This study aimed to investigate the long-term benefit of vasodilating β-blockers over conventional β-blockers in patients with acute myocardial infarction (AMI).
Methods: Using nationwide prospective multicenter Korean Acute ..
|
|
|
Feasibility of primary percutaneous coronary intervention via the distal radial approach in patients with ST-elevation myocardial infarction
Yongcheol Kim, Jun-Won Lee, Sang Yeub Lee, Jang-Whan Bae, Sang Jun Lee, Myung Ho Jeong, Seung-Hwan Lee, Youngkeun Ahn
Korean J Intern Med. 2021;36(Suppl 1):S53-S61. Published online March 3, 2020
Background/Aims: Recently, distal radial approach (DRA), called as snuffbox approach, has gained the interest of interventional cardiologists, but there is a lack of data about the feasibility of DRA as an alternative route for primary percutaneous coronary intervention (PCI).
Methods: A total of 1..
|
|
|
Gastroenterology
Effect of stent placement on stone recurrence and post-procedural cholangitis after endoscopic removal of common bile duct stones
Jung-Hye Choi, Tae-Yoon Lee, Young-Koog Cheon
Korean J Intern Med. 2021;36(Suppl 1):S27-S34. Published online August 24, 2020
Background/Aims: After endoscopic treatment of common bile duct (CBD) stones, recurrence of choledocholithiasis due to small stone fragments and post-endoscopic retrograde cholangiopancreatography (post-ERCP) cholangitis can occur. We determined the effect of biliary stenting after removal of CBD st..
|
|
|
Rheumatology
Predictors of joint damage in patients with rheumatoid arthritis: focus on short- and long-term effects of intra-articular glucocorticoid injections
Jung Hee Koh, Hanna Lee, Seung-Geun Lee
Korean J Intern Med. 2021;36(6):1515-1526. Published online February 15, 2021
Background/Aims: To investigate the short- and long-term efficacy of intra-articular glucocorticoid injections (IAGI) in patients with rheumatoid arthritis (RA).
Methods: This was a retrospective study of RA patients who had active arthritis in the hand or wrist joints and who received IAGI (or not..
|
|
|
Reliability and validity of the Korean version of the University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract instrument in patients with systemic sclerosis
Tae Hee Lee, Joon Seong Lee, Suyeon Park, Kyung-Ann Lee, Hyun-Sook Kim
Korean J Intern Med. 2021;36(6):1504-1514. Published online February 10, 2021
Background/Aims: Systemic sclerosis (SSc) is associated with a wide range of gastrointestinal (GI) changes. The University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract (UCLA SCTC GIT 2.0) instrument is a self-administered GI assessment instrument for patie..
|
|
|
Infectious diseases
Can reactogenicity predict immunogenicity after COVID-19 vaccination?
Young Hoon Hwang, Kyoung-Ho Song, Yunsang Choi, Suryeong Go, Su-Jin Choi, Jongtak Jung, Chang Kyung Kang, Pyoeng Gyun Choe, Nam-Joong Kim, Wan Beom Park, Myoung-don Oh
Korean J Intern Med. 2021;36(6):1486-1491. Published online May 28, 2021
Background/Aims: This study aimed to assess the association between local and systemic reactogenicity and humoral immunogenicity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
Methods: Adverse events were prospectively evaluated using an electronic diary in 135 heal..
|
|
|
Pulmonology
Chest computed tomography scan as an initial diagnostic method for tuberculosis infection detected by mass screening
Dong-Hyun Joo, Hyun Woo Lee, Seo-Young Yoon, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung, Jung-Kyu Lee
Korean J Intern Med. 2021;36(6):1410-1419. Published online July 15, 2021
Background/Aims: We assessed the diagnostic yield of chest computed tomography (CT) as an initial diagnostic method for patients with a tuberculosis (TB) infection detected by mass screening in a country with an intermediate TB burden.
Methods: A retrospective study was conducted on patients with T..
|
|
|
Survey of the management of patients with bronchiectasis: a pilot investigation in Asian populations
Ho Cheol Kim, Masaru Suzuki, Hui Fang Lim, Le Thi Tuyet Lan, Ho Lam Nguyen, Jeng-Shing Wang, Kang-Yun Lee, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee, Hayoung Choi, Hyun Lee, Sei Won Lee
Korean J Intern Med. 2021;36(6):1402-1409. Published online June 16, 2021
Background/Aims: Although international guidelines for bronchiectasis management have been published in Western countries, there is a lack of data about their application in Asian populations including patients with different phenotypes. We aimed to investigate the current status of bronchiectasis m..
|
|
|
Gastroenterology
Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
Young Jung Kim, Young Koog Cheon, Tae Yoon Lee, Seong-Hwan Chang, Mi-Hye Yu
Korean J Intern Med. 2021;36(6):1338-1346. Published online June 21, 2021
Background/Aims: Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary..
|
|
|
Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma
Andrew Li, Hiang Ping Chan, Phyllis X.L. Gan, Mei Fong Liew, W.S. Fred Wong, Hui-Fang Lim
Korean J Intern Med. 2021;36(6):1305-1319. Published online October 12, 2021
Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group accurately because they are more symptomatic and are at increased risk for exacerbations and accelerated decline in forced expiratory volume i..
|
|
|
