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Hemato-oncology
Clinicopathologic significance of tumor microenvironment CD11c, and FOXP3 expression in diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, anthracycline, vincristine, and prednisone (R-CHOP) combination chemotherapy
Seul Lee, Dong Hyun Kim, Sung Yong Oh, So Yeon Kim, Myeong Seok Koh, Ji Hyun Lee, Suee Lee, Sung-Hyun Kim, Jong-Young Kwak, Min Gyoung Pak, Mi Ha Ju, Hyo-Jin Kim, Jin Sook Jeong
Korean J Intern Med. 2017;32(2):335-344. Published online March 11, 2016
Background/Aims: CD11c is a dendritic cell marker in humans, which potentially induces a cytotoxic effect on lymphoma cells. Forkhead boxP3 (FOXP3) is a regulator of T lymphocyte in the microenvironment of the lymphoma. The principal objective of this study was to determine whether the tumors’ mic..
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Assessment of bone marrow involvement in patients with lymphoma: report on a consensus meeting of the Korean Society of Hematology Lymphoma Working Party
Yong Park, Byung Bae Park, Ji Yun Jeong, Wook Youn Kim, Seongsoo Jang, Bong Kyung Shin, Dong Soon Lee, Jae Ho Han, Chan-Jeoung Park, Cheolwon Suh, Insun Kim, Hyun-Sook Chi
Korean J Intern Med. 2016;31(6):1030-1041. Published online November 1, 2016
In September 2011, the Korean Society of Hematology Lymphoma Working Party held a nationwide conference to establish a consensus for assessing bone marrow (BM) involvement in patients with lymphoma. At this conference, many clinicians, hematopathologists, and diagnostic hematologists discussed vario..
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Nephrology
Duration of anuria predicts recovery of renal function after acute kidney injury requiring continuous renal replacement therapy
Hee-Yeon Jung, Jong-Hak Lee, Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
Korean J Intern Med. 2016;31(5):930-937. Published online February 12, 2016
Background/Aims: Little is known regarding the incidence rate of and factors associated with developing chronic kidney disease after continuous renal replacement therapy (CRRT) in acute kidney injury (AKI) patients. We investigated renal outcomes and the factors associated with incomplete renal reco..
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Gastroenterology
Investigation of pulmonary involvement in inflammatory bowel disease in an experimental
model of colitis
Bunyamin Aydin, Yıldıran Songur, Necla Songur, Oğuzhan Aksu, Altug Senol, I. Metin Ciris, Recep Sutcu
Korean J Intern Med. 2016;31(5):853-859. Published online August 19, 2016
Background/Aims: Inflammatory bowel disease (IBD) may also involve various extra-intestinal organs. Clinical studies have found asymptomatic/symptomatic pulmonary involvement in 1% to 6% of patients with IBD. The present study histopathologically investigated pulmonary involvement in an experimental..
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Endocrinology-metabolism
Current status of managing diabetes mellitus in Korea
Kyoung Hwa Ha, Dae Jung Kim
Korean J Intern Med. 2016;31(5):845-850. Published online September 1, 2016
Diabetes mellitus is an increasing global health problem. Guidelines for diabetic care recommend management of lifestyle and risk factors (glucose, blood pressure, and cholesterol), as well as regular screening for complications associated with treatment of the conditions related to diabetes. The pr..
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Intermittent, subtle change of ST segment in narrow QRS regular tachycardia
Hyeong Won Seo, Hyung Wook Park, Ki Hong Lee, Joon-Ho Ahn, Ji Eun Yu, Nam Sik Yoon, Jeong Gwan Cho
Korean J Intern Med. 2016;31(4):791-793. Published online June 17, 2016
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Endocrinology-metabolism
Association between household size, residential area, and osteoporosis: analysis of 2008 to 2011 Korea National Health and Nutrition Examination Survey
Sung-Woo Kim, Kwi-Hyun Bae, Jung-Beom Seo, Jae-Han Jeon, Won-Kee Lee, In-Kyu Lee, Jung-Guk Kim, Keun-Gyu Park
Korean J Intern Med. 2016;31(4):712-721. Published online April 15, 2016
Background/Aims: The prevalence of single-person households has rapidly increased in Korea. Individuals living alone and in rural areas may have a higher risk of various metabolic diseases due to differences in lifestyle. However, few studies have investigated the association of household size and r..
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Cardiology
Five-year clinical outcomes of drug-eluting stents according to on-label and off-label use
Kyu-Hwan Park, Ung Kim, Chan-Hee Lee, Jang-Won Son, Jong-Seon Park, Dong-Gu Shin, Young-Jo Kim, Jeong-Hwan Cho
Korean J Intern Med. 2016;31(4):678-684. Published online March 25, 2016
Background/Aims: To compare the clinical outcomes of ‘on-label’ and ‘off-label’ drug-eluting stents (DESs) over a 5-year follow-up period.
Methods: A total of 929 patients that underwent percutaneous coronary intervention with DESs were enrolled. Patients were divided into two groups according..
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Etc.
The Korean version of the FRAIL scale: clinical feasibility and validity of assessing the frailty status of Korean elderly
Hee-Won Jung, Hyun-Jung Yoo, Si-Young Park, Sun-Wook Kim, Jung-Yeon Choi, Sol-Ji Yoon, Cheol-Ho Kim, Kwang-il Kim
Korean J Intern Med. 2016;31(3):594-600. Published online December 23, 2015
Background/Aims: The fatigue, resistance, ambulation, illnesses, and loss of weight (FRAIL) scale is a screening tool for frailty status using a simple 5-item questionnaire. The aim of this study was to evaluate the clinical feasibility and validity of the Korean version of the FRAIL (K-FRAIL) scale..
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Nephrology
Effect of low-dose valsartan on proteinuria in normotensive immunoglobulin A nephropathy with minimal proteinuria: a randomized trial
Young-Il Jo, Ha-Young Na, Ju-Young Moon, Sang-Woong Han, Dong-Ho Yang, Sang-Ho Lee, Hyeong-Cheon Park, Hoon-Young Choi, So-Dug Lim, Jeong-Hae Kie, Yong-Kyu Lee, Sug-Kyun Shin
Korean J Intern Med. 2016;31(2):335-343. Published online February 15, 2016
Background/Aims: Immunoglobulin A nephropathy (IgAN) is a generally progressive disease, even in patients with favorable prognostic features. In this study, we aimed to investigate the antiproteinuric effect and tolerability of low-dose valsartan (an angiotensin II receptor blocker) therapy in normo..
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Endocrinology-metabolism
Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas
Yang Seon Yi, Sang Soo Kim, Won Jin Kim, Min Jung Bae, Ji Hyun Kang, Bo Gwang Choi, Yun Kyung Jeon, Bo Hyun Kim, Byung Joo Lee, Soo Geun Wang, In Joo Kim, Yong Ki Kim
Korean J Intern Med. 2016;31(2):313-322. Published online December 23, 2015
Background/Aims: The purpose of this study was to compare the diagnostic validity of two-dimensional (2D) and three-dimensional (3D) ultrasonography (US) when predicting the extrathyroidal extension of papillary thyroid cancer.
Methods: All 2D data were interpreted in real time and 3D data were sto..
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Rheumatology
The specialist physician’s approach to rheumatoid arthritis in South Africa
Frederik C. J. Bester, Fredricka J. Bosch, Barend J. Jansen van Rensburg
Korean J Intern Med. 2016;31(2):219-236. Published online February 26, 2016
Rheumatoid arthritis (RA) is expected to increase in Africa and South Africa. Due to the low numbers of rheumatologists in South Africa, specialist physicians also have to care for patients with RA. Furthermore several new developments have taken place in recent years which improved the management a..
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Nephrology
Time points for obtaining representative values of 24-hour blood pressure in chronic kidney disease
Jiwon Ryu, Ran-hui Cha, Dong Ki Kim, Ju Hyun Lee, Sun Ae Yoon, Dong Ryeol Ryu, Jieun Oh, Sejoong Kim, Sang-Youb Han, Eun Young Lee, Yon Su Kim
Korean J Intern Med. 2015;30(5):665-674. Published online August 27, 2015
Background/Aims: Ambulatory blood pressure (BP) monitoring has been widely recommended for evaluating the status of BP, but is lacking in practicality. Determination of the specific time points for BP measurement that are representative of 24-hour mean BP could be useful and convenient in hypertensi..
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Pulmonology
Chronic obstructive pulmonary disease (COPD) assessment test scores corresponding to modified Medical Research Council grades among COPD patients
Chang-Hoon Lee, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Jae-Joon Yim, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo
Korean J Intern Med. 2015;30(5):629-637. Published online August 27, 2015
Background/Aims: In assigning patients with chronic obstructive pulmonary disease (COPD) to subgroups according to the updated guidelines of the Global Initiative for Chronic Obstructive Lung Disease, discrepancies have been noted between the COPD assessment test (CAT) criteria and modified Medical ..
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Cardiology
Discordance between ambulatory versus clinic blood pressure according to global cardiovascular risk group
Jinho Shin, Sung Ha Park, Ju Han Kim, Sang Hyun Ihm, Kwang-il Kim, Woo Shik Kim, Wook Bum Pyun, Yu-Mi Kim, Sung-il Choi, Soon Kil Kim
Korean J Intern Med. 2015;30(5):610-619. Published online August 27, 2015
Background/Aims: The detection of white coat hypertension (WCH), treated normalized hypertension, and masked hypertension (MH) is important to improve the effectiveness of hypertension management. However, whether global cardiovascular risk (GCR) profile has any effect on the discordance between amb..
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Gastroenterology
Can proton pump inhibitors reduce rebleeding following Histoacryl sclerotherapy for gastric variceal hemorrhage?
Ka Rham Kim, Chung Hwan Jun, Kyu Man Cho, Jin Woo Wi, Seon Young Park, Sung Bum Cho, Wan Sik Lee, Chang Hwan Park, Young Eun Joo, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew
Korean J Intern Med. 2015;30(5):593-601. Published online August 27, 2015
Background/Aims: To evaluate the efficacy of proton pump inhibitors (PPIs) in reducing rebleeding and bleeding-related death rates after endoscopic gastric variceal obliteration (GVO) using N-butyl-2-cyanoacrylate (NBC).
Methods: This study enrolled 341 patients who were consecutively diagnosed wi..
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Rheumatology
Quantitative analysis of nailfold capillary morphology in patients with fibromyalgia
Dug-Hyun Choi, Hyun-Sook Kim
Korean J Intern Med. 2015;30(4):531-537. Published online June 29, 2015
Background/Aims: Nailfold capillaroscopy (NFC) has been used to examine morphological and functional microcirculation changes in connective tissue diseases. It has been demonstrated that NFC patterns reflect abnormal microvascular dynamics, which may play a role in fibromyalgia (FM) syndrome. The ai..
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Gastroenterology
Long-term efficacy of tenofovir disoproxil fumarate therapy after multiple nucleos(t)ide analogue failure in chronic hepatitis B patients
Hyo Jin Kim, Ju-Yeon Cho, Yu Jin Kim, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Kwang Cheol Koh, Seung Woon Paik, Byung Chul Yoo, Joon Hyeok Lee
Korean J Intern Med. 2015;30(1):32-41. Published online December 30, 2014
Background/Aims: The efficacy of tenofovir disoproxil fumarate (TDF) for the treatment of chronic hepatitis B (CHB) patients following prior treatment failure with multiple nucleos(t)ide analogues (NAs) is not well defined, especially in Asian populations. In this study we investigated the efficacy ..
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Infectious diseases
Kinetics of T-cell-based assays on cerebrospinal fluid and peripheral blood mononuclear cells in patients with tuberculous meningitis
Ki-Ho Park, Mi Suk Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Joong Koo Kang, Sang-Ahm Lee, Sung-Han Kim
Korean J Intern Med. 2014;29(6):793-799. Published online October 31, 2014
Background/Aims: The goal of this study was to monitor tuberculosis (TB)-specific T-cell responses in cerebrospinal f luid-mononuclear cells (CSF-MCs) and peripheral blood mononuclear cells (PBMCs) in patients with tuberculous meningitis (TBM) over the course of anti-TB therapy.
Methods: Adult pati..
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Hemato-oncology
Recent advances in treatment of aplastic anemia
Seung Hwan Shin, Sung Eun Lee, Jong Wook Lee
Korean J Intern Med. 2014;29(6):713-726. Published online October 31, 2014
Recent advances in the treatment of aplastic anemia (AA) made most of patients to expect to achieve a long-term survival. Allogeneic stem cell transplantation (SCT) from HLA-matched sibling donor (MSD-SCT) is a preferred first-line treatment option for younger patients with severe or very severe AA,..
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