|
Hemato-oncology / Original Article
Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells
Yoo Jin Na, Eun Sang Yu, Dae Sik Kim, Dae-Hee Lee, Sang Cheul Oh, Chul Won Choi
Korean J Intern Med. 2021;36(Suppl 1):S196-S206. Published online April 3, 2020
Background/Aims: Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years. In addition, a considerable number of patients receiving nilotinib developed diabetes. Metformin is a ..
|
|
|
Nephrology / Original Article
L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
Hai Yan Zhao, Hui Ying Li, Jian Jin, Ji Zhe Jin, Long Ye Zhang, Mei Ying Xuan, Xue Mei Jin, Yu Ji Jiang, Hai Lan Zheng, Ying Shun Jin, Yong Jie Jin, Bum Soon Choi, Chul Woo Yang, Shang Guo Piao, Can Li
Korean J Intern Med. 2021;36(Suppl 1):S180-S195. Published online September 18, 2020
Background/Aims: Accumulating evidence indicates that L-carnitine (LC) protects against multiorgan damage through its antioxidant properties and preservation of the mitochondria. Little information is available about the effects of LC on renal fibrosis. This study examined whether LC treatment would..
|
|
|
Endocrinology-metabolism / Original Article
Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey
Jeonghoon Ha, Jeongmin Lee, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Min-Hee Kim
Korean J Intern Med. 2021;36(Suppl 1):S170-S179. Published online June 9, 2020
Background/Aims: Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle changes in thyroid hormones within normal ranges can induce alterations in glucose h..
|
|
|
Pulmonology / Original Article
In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin
Xiaoyuan Sun, Yu Kang, Shan Xue, Jing Zou, Jiabo Xu, Daoqiang Tang, Hui Qin
Korean J Intern Med. 2021;36(Suppl 1):S160-S169. Published online June 9, 2020
Background/Aims: MicroRNAs (miRNAs) play critical regulatory roles in the pathogenesis of pulmonary fibrosis. The aim of this study was to explore whether miRNA antagomirs could serve as potential therapeutic agents in interstitial lung diseases.
Methods: A mouse model of pulmonary fibrosis was est..
|
|
|
Pulmonology / Original Article
Characteristics and risk factors associated with missed diagnosis in patients with smear-negative pulmonary tuberculosis
Se Hyun Kwak, Ji Soo Choi, Eun Hye Lee, Su Hwan Lee, Ah Young Leem, Sang Hoon Lee, Song Yee Kim, Kyung Soo Chung, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Joon Chang, Young Ae Kang
Korean J Intern Med. 2021;36(Suppl 1):S151-S159. Published online August 20, 2020
Background/Aims: Delayed diagnosis and treatment of smear-negative pulmonary tuberculosis (TB) are major concerns for TB control. We evaluated characteristics of patients with smear-negative pulmonary TB who received a delayed diagnosis and identified risk factors that may have contributed to this d..
|
|
|
Pulmonology / Original Article
A genome wide association study for lung function in the Korean population using an exome array
Kyu-Sun Lee, Kun Hee Kim, Yeon-Mok Oh, Buhm Han, Woo Jin Kim
Korean J Intern Med. 2021;36(Suppl 1):S142-S150. Published online April 29, 2020
Background/Aims: Lung function is an objective indicator of diagnosis and prognosis of respiratory diseases. Many common genetic variants have been associated with lung function in multiple ethnic populations. We looked for coding variants associated with forced expiratory volume in 1 second (FEV
|
|
|
Pulmonology / Original Article
Pleuroparenchymal fibroelastosis in Korean patients: clinico-radiologic-pathologic features and 2-year follow-up
Jae Ha Lee, Eun Jin Chae, Joon Seon Song, Miae Kim, Jin Woo Song
Korean J Intern Med. 2021;36(Suppl 1):S132-S141. Published online February 24, 2020
Background/Aims: Pleuroparenchymal fibroelastosis (PPFE) is a type of rare idiopathic interstitial pneumonia that is characterized by predominantly upper lobe involvement with pleural fibrosis and subjacent parenchymal fibrosis. This study aimed to determine the clinico-radiologic-pathologic feature..
|
|
|
Cardiology / Original Article
Effects of renin-angiotensin system blockers on the risk and outcomes of severe acute respiratory syndrome coronavirus 2 infection in patients with hypertension
Jinwoo Lee, Seong Jin Jo, Youngjin Cho, Ji Hyun Lee, Il-Young Oh, Jin Joo Park, Young-Seok Cho, Dong-Ju Choi
Korean J Intern Med. 2021;36(Suppl 1):S123-S131. Published online February 10, 2021
Background/Aims: There are concerns that the use of renin-angiotensin system (RAS) blockers may increase the risk of being infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or progressing to a severe clinical course after infection. This this study aimed to investigate the i..
|
|
|
Cardiology / Original Article
Update on association between exposure to renin-angiotensin-aldosterone system inhibitors and coronavirus disease 2019 in South Korea
Jeongkuk Seo, Minkook Son
Korean J Intern Med. 2021;36(Suppl 1):S114-S122. Published online February 25, 2021
Background/Aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angiotensin-aldosterone system (RAAS) inhibitors and the risk and severity of COVID-19.
Methods: We performed a case-control study that util..
|
|
|
Cardiology / Original Article
Sex differences in long-term clinical outcomes of acute myocardial infarction according to the presence of diabetes mellitus
Yu Ri Kim, Myung Ho Jeong, Youngkeun Ahn, Ju Han Kim, Young Joon Hong, Min Chul Kim, Kyung Hoon Cho, Xiong Yi Han; other KAMIR-NIH Registry Investigators
Korean J Intern Med. 2021;36(Suppl 1):S99-S113. Published online January 12, 2021
Background/Aims: This study compared long-term clinical outcomes between male and female acute myocardial infarction (AMI) patients with and without diabetes mellitus (DM).
Methods: From November 2011 to December 2015, 13,104 patients with AMI were enrolled in the Korea Acute Myocardial Infarction ..
|
|
|
Cardiology / Original Article
Effect of body mass index and abdominal obesity on mortality after percutaneous coronary intervention: a nationwide, population-based study
Woo-Hyuk Song, Eun Hui Bae, Jeong Cheon Ahn, Tae Ryom Oh, Yong-Hyun Kim, Jin Seok Kim, Sun-Won Kim, Soo Wan Kim, Kyung-Do Han, Sang-Yup Lim
Korean J Intern Med. 2021;36(Suppl 1):S90-S98. Published online February 25, 2021
Background/Aims: We investigated the impact of obesity on the clinical outcomes following percutaneous coronary intervention (PCI).
Methods: We included South Koreans aged > 20 years who underwent the Korean National Health Screening assessment between 2009 and 2012. Obesity was defined using the b..
|
|
|
Cardiology / Original Article
Clinical significance of high on-treatment platelet reactivity in patients with prolonged clopidogrel therapy
Sehun Kim, Donghoon Han, Jae Hyuk Choi, Eun-Joo Park, Dong Geum Shin, Min-Kyung Kang, Seonghoon Choi, Namho Lee, Jung Rae Cho
Korean J Intern Med. 2021;36(Suppl 1):S80-S89. Published online February 25, 2021
Background/Aims: Prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel beyond 1 year has been shown to reduce ischemic events at the expense of increased bleeding. However, limited data are available on the clinical significance of platelet reactivity (PR) at 1 year.
Methods: We r..
|
|
|
Cardiology / Original Article
Clinical outcomes of endovascular treatment for ruptured thoracic aortic disease
Jong Hyun Choi, Sang-Pil Kim, Han Cheol Lee, Tae Sik Park, Jong Ha Park, Bo Won Kim, Jinhee Ahn, Jin Sup Park, Hye Won Lee, Jun-Hyok Oh, Jung Hyun Choi, Kwang Soo Cha, Taek Jong Hong
Korean J Intern Med. 2021;36(Suppl 1):S72-S79. Published online April 10, 2020
Background/Aims: Untreated rupture of the thoracic aorta is associated with a high mortality rate. We aimed to review the clinical results of endovascular treatment for ruptured thoracic aortic disease.
Methods: We retrospectively reviewed data on 37 patients (mean age, 67.0 ± 15.18 years) treate..
|
|
|
Cardiology / Original Article
Long-term efficacy of vasodilating β-blocker in patients with acute myocardial infarction: nationwide multicenter prospective registry
Jaehoon Chung, Jung-Kyu Han, Han-Mo Yang, Kyung-Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Myung Ho Jeong, Hyo-Soo Kim; on behalf of investigators for Korea Acute Myocardial Infarction Registry (KAMIR)
Korean J Intern Med. 2021;36(Suppl 1):S62-S71. Published online July 3, 2020
Background/Aims: Long-term benefit of vasodilating β-blockers is unknown. This study aimed to investigate the long-term benefit of vasodilating β-blockers over conventional β-blockers in patients with acute myocardial infarction (AMI).
Methods: Using nationwide prospective multicenter Korean Acute ..
|
|
|
Cardiology / Original Article
Feasibility of primary percutaneous coronary intervention via the distal radial approach in patients with ST-elevation myocardial infarction
Yongcheol Kim, Jun-Won Lee, Sang Yeub Lee, Jang-Whan Bae, Sang Jun Lee, Myung Ho Jeong, Seung-Hwan Lee, Youngkeun Ahn
Korean J Intern Med. 2021;36(Suppl 1):S53-S61. Published online March 3, 2020
Background/Aims: Recently, distal radial approach (DRA), called as snuffbox approach, has gained the interest of interventional cardiologists, but there is a lack of data about the feasibility of DRA as an alternative route for primary percutaneous coronary intervention (PCI).
Methods: A total of 1..
|
|
|
Gastroenterology / Original Article
The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats
Ali Durmus, Ilgim Durmus, Omer Bender, Oguzhan Karatepe
Korean J Intern Med. 2021;36(Suppl 1):S44-S52. Published online June 19, 2020
Background/Aims: The aim of this study is to investigate the effects of the Hericium erinaceum on an experimental colitis model.
Methods: Twenty-four Wistar albino were included in this study. Rats were divided into three groups. Group 1 (n = 8) was sham group. Group 2 is the group of chemic..
|
|
|
Gastroenterology / Original Article
Colonoscopy quality in community hospitals and nonhospital facilities in Korea
Jae Gon Lee, Dong Soo Han, Young-Eun Joo, Dae-Seong Myung, Dong Il Park, Seul Ki Kim, Yunho Jung, Won Hyun Lee, Eun Soo Kim, Joon Seok Yoon, Chang Soo Eun
Korean J Intern Med. 2021;36(Suppl 1):S35-S43. Published online May 12, 2020
Background/Aims: High-quality colonoscopy is essential to reduce colorectal cancer-related deaths. Little is known about colonoscopy quality in non-academic practice settings. We aimed to evaluate the quality of colonoscopies performed in community hospitals and nonhospital facilities.
Methods: Col..
|
|
|
Gastroenterology / Original Article
Effect of stent placement on stone recurrence and post-procedural cholangitis after endoscopic removal of common bile duct stones
Jung-Hye Choi, Tae-Yoon Lee, Young-Koog Cheon
Korean J Intern Med. 2021;36(Suppl 1):S27-S34. Published online August 24, 2020
Background/Aims: After endoscopic treatment of common bile duct (CBD) stones, recurrence of choledocholithiasis due to small stone fragments and post-endoscopic retrograde cholangiopancreatography (post-ERCP) cholangitis can occur. We determined the effect of biliary stenting after removal of CBD st..
|
|
|
Gastroenterology / Original Article
Increased risk of gastric cancer in workers with occupational dust exposure
Mo-Yeol Kang, Jiyoun Jung, Jung-Wan Koo, Inah Kim, Hyoung-Ryoul Kim, Jun-Pyo Myong
Korean J Intern Med. 2021;36(Suppl 1):S18-S26. Published online May 7, 2020
Background/Aims: Workers who are exposed to dust in the workplace tend to show a higher incidence of gastric cancer. Nevertheless, scientific evidence to support an association between dust exposure and the risk of gastric cancer is inadequate. This study aimed to investigate whether or not occupati..
|
|
|
Gastroenterology / Original Article
Comparison of loss of response between anti-tumor necrosis factor alone and combined use with immunomodulators in patients with inflammatory bowel disease
Seung Wook Hong, Jaewoo Park, Hyuk Yoon, Hye Ran Yang, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Korean J Intern Med. 2021;36(Suppl 1):S9-S17. Published online June 25, 2020
Background/Aims: Combination therapy with immunomodulators (IMMs) was proposed as a strategy to prevent the development of loss of response (LOR) to anti-tumor necrosis factor (TNF) for patients with inflammatory bowel disease (IBD). However, the effect is unclear in patients already exposed to IMMs..
|
|
|
