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Pulmonology / Original Article
Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer
Hea Yon Lee, In Kyoung Kim, Hye In Lee, Hwa Young Lee, Hye Seon Kang, Chang Dong Yeo, Hyun Hui Kang, Hwa Sik Moon, Sang Haak Lee
Korean J Intern Med. 2018;33(3):541-551. Published online December 15, 2017
Background/Aims: We explored the effects of intermittent normobaric hyperoxia alone or combined with chemotherapy on the growth, general morphology, oxidative stress, and apoptosis of benzo[a]pyrene (B[a]P)-induced lung tumors in mice.
Methods: Female A/J mice were given a single dose of B[a]P and ..
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Pulmonology / Original Article
Histopathologic heterogeneity of acute respiratory distress syndrome revealed by surgical lung biopsy and its clinical implications
Jimyung Park, Yeon Joo Lee, Jinwoo Lee, Sung Soo Park, Young-Jae Cho, Sang-Min Lee, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo
Korean J Intern Med. 2018;33(3):532-540. Published online November 1, 2017
Background/Aims: Diffuse alveolar damage (DAD) is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). However, there are several non-DAD conditions mimicking ARDS. The purpose of this study was to investigate the histopathologic heterogeneity of ARDS revealed by surgical lung..
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Letter to the editor
Invasive pulmonary aspergillosis in a patient with metastatic non-small cell lung cancer after
treatment with gefitinib
Sejeong Park, Soyoung Park, Hana Choi, Ji Young Park, Hyo Seok Lim, Myung Jae Park, Si-Young Kim
Korean J Intern Med. 2018;33(1):211-213. Published online November 25, 2016
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Hemato-oncology / Original Article
Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer
Min Young Baek, Hee Kyung Ahn, Kyu Ree Park, Hwa-Sun Park, Shin Myung Kang, Inkeun Park, Young Saing Kim, Junshik Hong, Sun Jin Sym, Jinny Park, Jae Hoon Lee, Dong Bok Shin, Eun Kyung Cho
Korean J Intern Med. 2018;33(1):168-175. Published online April 20, 2016
Background/Aims: We investigated the time taken for patients with metastatic non-small cell lung cancer (NSCLC) to develop brain metastases (BM), as well as their subsequent overall median survival following diagnosis, considering the epidermal growth factor receptor (EGFR) mutational status...
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Letter to the editor
Epiphora following chemotherapy with pemetrexed in patients with advanced non-small cell lung cancer
Yun Duk Jung, Sang Bin Lee, Yun Wha Jung, Jung Sub Song, In Sook Woo
Korean J Intern Med. 2017;32(5):923-925. Published online March 18, 2017
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Pulmonology / Review
Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist’s point of view
So-My Koo, Soo-Taek Uh
Korean J Intern Med. 2017;32(4):600-610. Published online June 30, 2017
Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular disease (CVD), referred to as connective tissue disease (CTD). Despite advances in management strategies, ILD continues to be a significant cause of mortality in patients with CVD-associated ILD (CTD-ILD). There is a la..
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Hemato-oncology / Original Article
KRAS G12C mutation as a poor prognostic marker of pemetrexed treatment in non-small cell lung cancer
Sehhoon Park, Ji-Yeon Kim, Se-Hoon Lee, Beomseok Suh, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo
Korean J Intern Med. 2017;32(3):514-522. Published online April 14, 2017
Background/Aims: The predictive and prognostic value of KRAS mutation and its type of mutations in non-small cell lung cancer (NSCLC) are controversial. This clinical study was designed to investigate the predictive value of KRAS mutations and its mutation types to pemetrexed and gemcitabine based t..
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Hemato-oncology / Review
Does the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor differ according to the type of EGFR mutation in non-small cell lung cancer?
Yong Won Choi, Jin-Hyuk Choi
Korean J Intern Med. 2017;32(3):422-428. Published online March 30, 2017
An exon 19 deletion and a L858R mutation in exon 21 of the epidermal growth factor receptor (EGFR) are the two most common mutations that predict favorable efficacy of EGFR tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). Many retrospective and prospective studi..
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Pulmonology / Original Article
Clinical significance of serum vascular endothelial growth factor in young male asthma patients
Hea Yon Lee, Kyung Hoon Min, Sang Min Lee, Ji Eun Lee, Chin Kook Rhee
Korean J Intern Med. 2017;32(2):295-301. Published online March 21, 2016
Background/Aims: Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and t..
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Pulmonology / Review
Diagnosis and treatment of cystic lung disease
Sanghoon Park, Eun Joo Lee
Korean J Intern Med. 2017;32(2):229-238. Published online February 28, 2017
Cystic lung disease (CLD) is a group of lung disorders characterized by the presence of multiple cysts, defined as air-filled lucencies or low-attenuating areas, bordered by a thin wall (usually < 2 mm). The recognition of CLDs has increased with the widespread use of computed tomography. This artic..
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Letter to the editor
Pulmonary graft-versus-host disease after autologous hematopoietic stem cell transplantation
Sue In Choi, Eun Joo Lee, Dong Oh Kang, Sang Yeub Lee, Kwang Ho In, Han-Kyeom Kim, Sanghoon Park
Korean J Intern Med. 2016;31(6):1181-1183. Published online December 23, 2015
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Hemato-oncology / Original Article
Nutritional status in the era of target therapy: poor nutrition is a prognostic factor in non-small
cell lung cancer with activating epidermal growth factor receptor mutations
Sehhoon Park, Seongyeol Park, Se-Hoon Lee, Beomseok Suh, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Young Whan Kim, Dae Seog Heo
Korean J Intern Med. 2016;31(6):1140-1149. Published online March 28, 2016
Background/Aims: Pretreatment nutritional status is an important prognostic factor in patients treated with conventional cytotoxic chemotherapy. In the era of target therapies, its value is overlooked and has not been investigated. The aim of our study is to evaluate the value of nutritional status ..
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Letter to the editor
Bone metastasis in pulmonary sclerosing hemangioma
Min Kyoung Kim, Se-Jin Jang, Yong Hee Kim, Sang-We Kim
Korean J Intern Med. 2015;30(6):928-930. Published online October 30, 2015
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Hemato-oncology / Original Article
Clinical efficacy of erlotinib, a salvage treatment for non-small cell lung cancer patients following gefitinib failure
Kyoung Min Cho, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae Seog Heo
Korean J Intern Med. 2015;30(6):891-898. Published online October 30, 2015
Background/Aims: The purpose of this study was to identify predictive factors for erlotinib treatment in non-small cell lung cancer (NSCLC) patients following gefitinib failure.
Methods: Forty-five patients with NSCLC who were treated with erlotinib following gefitinib failure at Seoul National Uni..
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Infectious diseases / Original Article
Infections after lung transplantation: time of occurrence, sites, and microbiologic etiologies
Ji Hyun Yun, Sang-Oh Lee, Kyung-Wook Jo, Se Hoon Choi, Jina Lee, Eun Jin Chae, Kyung-Hyun Do, Dae-Kee Choi, In-Cheol Choi, Sang-Bum Hong, Tae Sun Shim, Hyeong Ryul Kim, Dong Kwan Kim, Seung-Il Park
Korean J Intern Med. 2015;30(4):506-514. Published online June 29, 2015
Background/Aims: Infections are major causes of both early and late death after lung transplantation (LT). The development of prophylaxis strategies has altered the epidemiology of post-LT infections; however, recent epidemiological data are limited. We evaluated infections after LT at our instituti..
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Rheumatology / Original Article
Mortality in patients with rheumatoid arthritis-associated interstitial lung disease treated with an anti-tumor necrosis factor agent
Bon San Koo, Seokchan Hong, You Jae Kim, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
Korean J Intern Med. 2015;30(1):104-109. Published online December 30, 2014
Background/Aims: To evaluate the impact on mortality of anti-tumor necrosis factor (anti-TNF) treatment of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).
Methods: We retrospectively reviewed the medical records of 100 RA-ILD patients who visited our tertiary care medical center..
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Letter to the editor
Parvimonas micra chest wall abscess following transthoracic lung needle biopsy
Luis Gorospe, Isabel Bermudez-Coronel-Prats, Carol F. Gomez-Barbosa, Maria E. Olmedo-Garcia, Angel Ruedas-Lopez, Vicente Gomez del Olmo
Korean J Intern Med. 2014;29(6):834-837. Published online October 31, 2014
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Pulmonology / Original Article
The start of chemotherapy until the end of radiotherapy in patients with limited-stage small cell lung cancer
Kyoung Ju Lee, Eun Joo Lee, Gyu Young Hur, Sang Yeub Lee, Je Hyeong Kim, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo, Sung Yong Lee
Korean J Intern Med. 2013;28(4):449-455. Published online July 1, 2013
Background/AimsChemotherapy combined with radiation therapy is the standard treatment for limited stage small cell lung cancer (LS-SCLC). Although numerous studies indicate that the overall duration of chemoradiotherapy is the most relevant predictor of outcome, the optimal ch..
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Pulmonology / Review
Carbon monoxide: present and future indications for a medical gas
Stefan W. Ryter, Augustine M. K. Choi
Korean J Intern Med. 2013;28(2):123-140. Published online February 27, 2013
Gaseous molecules continue to hold new promise in molecular medicine as experimental and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar gaseous molecules (e.g., H2S, nitric oxide) have been implicated as potential inhalation therapies in inflammat..
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Case Report
Type B insulin-resistance syndrome presenting as autoimmune hypoglycemia, associated with systemic lupus erythematosus and interstitial lung disease
Seon Mee Kang, Heung Yong Jin, Kyung Ae Lee, Ji Hyun Park, Hong Sun Baek, Tae Sun Park
Korean J Intern Med. 2013;28(1):98-102. Published online December 28, 2012
We describe an unusual case of systemic lupus erythematosus with pulmonary manifestations presenting as hypoglycemia due to anti-insulin receptor antibodies. A 38-year-old female suffered an episode of unconsciousness and was admitted to hospital where her blood glucose was found to be 18 mg/dL. ..
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