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Nephrology
Hepatitis C virus infection in chronic kidney disease: paradigm shift in management
So Mi Kim, Il Han Song
Korean J Intern Med. 2018;33(4):670-678. Published online June 28, 2018
Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated inte..
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Applications of kidney organoids derived from human pluripotent stem cells
Yong Kyun Kim, Sun Ah Nam, Chul Woo Yang
Korean J Intern Med. 2018;33(4):649-659. Published online June 28, 2018
The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing of compounds, and regenerative therapy are attractive ap..
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Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys
Sejoong Kim, Eun Sook Jung, Jeonghwan Lee, Nam Ju Heo, Ki Young Na, Jin Suk Han
Korean J Intern Med. 2018;33(3):568-576. Published online March 18, 2017
Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral urete..
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Outcomes of living donor kidney transplantation in diabetic patients: age and sex matched comparison with non-diabetic patients
Chung Hee Baek, Hyosang Kim, Seung Don Baek, Mun Jang, Wonhak Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
Korean J Intern Med. 2018;33(2):356-366. Published online August 21, 2017
Background/Aims: Kidney transplantation (KT) reportedly provides a significant survival advantage over dialysis in diabetic patients. However, KT outcome in diabetic patients compared with that in non-diabetic patients remains controversial. In addition, owing to recent improvements in the outcomes ..
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Clinical significance of the presence of anti-human leukocyte antigen-donor specific antibody
in kidney transplant recipients with allograft dysfunction
Byung Ha Chung, Jeong Ho Kim, Bum Soon Choi, Cheol Whee Park, Ji-Il Kim, In Sung Moon, Yong-Soo Kim, Yeong Jin Choi, Eun-Jee Oh, Chul Woo Yang
Korean J Intern Med. 2018;33(1):157-167. Published online October 20, 2016
Background/Aims: This study investigated the clinical significance of detecting anti-human leukocyte antigen-donor specific antibody (HLA-DSA) in kidney transplant recipients (KTRs) requiring indication biopsy owing to allograft dysfunction.
Methods: We analyzed the presence of HLA-DSA in 210 KTRs ..
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Long-term prognosis of end-stage renal disease patients with normal myocardial perfusion as determined by single photon emission computed tomography
Gun Ha Park, Jae Won Song, Chang Min Lee, Young Rim Song, Sung Gyun Kim, Hyung Jik Kim, Jwa Kyung Kim
Korean J Intern Med. 2018;33(1):148-156. Published online November 22, 2016
Background/Aims: Normal myocardial perfusion is closely associated with very low rates of cardiac events and better long-term outcomes; however, little is known about its prognostic value in patients with end-stage renal disease (ESRD).
Methods: A total of 286 incident patients underwent baseline c..
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Xp11.2 translocation renal cell carcinoma in the autosomal dominant polycystic kidney disease patient with preserved renal function
Hyuk Huh, Hyung Ah Jo, YongJin Yi, Seung Hyup Kim, Kyung Chul Moon, Curie Ahn, Hayne Cho Park
Korean J Intern Med. 2017;32(6):1108-1111. Published online October 17, 2017
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Nephrology
Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury
Sun Chul Kim, Yoon Sook Ko, Hee Young Lee, Myung-Gyu Kim, Sang-Kyung Jo, Won-Yong Cho
Korean J Intern Med. 2017;32(6):1053-1061. Published online February 15, 2017
Background/Aims: Recent findings have demonstrated the occurrence of neutrophil transendothelial migration in the reverse direction (reverse TEM) and that endothelial junctional adhesion molecule C (JAM-C) is a negative regulator of reverse TEM. In this study, we tested the effects of a JAM-C blocki..
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Development of Kaposi sarcoma and hemophagocytic lymphohistiocytosis associated with human herpesvirus 8 in a renal transplant recipient
Young Jae Park, Hyun Jin Bae, Ji-Yeun Chang, Chul Woo Yang, Byung Ha Chung
Korean J Intern Med. 2017;32(4):750-752. Published online February 4, 2016
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Endocrinology-metabolism
Treatment of diabetic kidney disease: current and future targets
Mi-Kyung Kim
Korean J Intern Med. 2017;32(4):622-630. Published online June 30, 2017
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease in Korea and worldwide, and is a risk factor for the development of cardiovascular complications. The conventional treatments for DKD are control of blood glucose and blood pressure levels by inhibiting the renin-angiotensin..
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Nephrology
Vitamin D deficiency is associated with increased risk of bacterial infections after kidney transplantation
Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Jong-Hak Lee, Eugene Kwon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Chan-Duck Kim
Korean J Intern Med. 2017;32(3):505-513. Published online March 25, 2016
Background/Aims: There may be an association between vitamin D levels and allograft outcomes in kidney transplant recipients (KTRs). However, few studies have been conducted to determine the association between vitamin D levels and post-transplant infections. This study investigated the impact of vi..
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Sleep duration and chronic kidney disease: The Korean Genome and Epidemiology Study (KoGES)-Kangwha study
Hansol Choi, Hyeon Chang Kim, Joo Young Lee, Ju-Mi Lee, Dong Phil Choi, Il Suh
Korean J Intern Med. 2017;32(2):323-334. Published online February 15, 2017
Background/Aims: Sleep duration affects health in various ways. The objective of this study was to investigate the associations of sleep duration with chronic kidney disease (CKD) in a Korean adult population.
Methods: This cross-sectional analysis was conducted for total of 1,360 participants who ..
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Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population
Eunhee Ji, Yon Su Kim
Korean J Intern Med. 2016;31(6):1120-1130. Published online March 25, 2016
Background/Aims: An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was..
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Infectious diseases
Differences of cytomegalovirus diseases between kidney and hematopoietic stem cell transplant recipients during preemptive therapy
Tark Kim, Yu-Mi Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Heungsup Sung, Joo Hee Jung, Sung Shin, Young Hoon Kim, Young-Ah Kang, Young-Shin Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Su-Kil Park, Duck Jong Han, Sung-Han Kim
Korean J Intern Med. 2016;31(5):961-970. Published online April 8, 2016
Background/Aims: Cytomegalovirus (CMV) surveillance and preemptive therapy is a widely-used strategy for preventing CMV disease in transplant recipients. However, there are limited data on the incidence and patterns of CMV disease during the preemptive period. Thus, we investigated the incidence and..
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Nephrology
Urine synaptopodin excretion is an important marker of glomerular disease progression
Soon Kil Kwon, Seung Jung Kim, Hye-Young Kim
Korean J Intern Med. 2016;31(5):938-943. Published online September 1, 2016
Background/Aims: Podocytes play an important role in maintaining the glomerular filtration barrier and in formation of the slit diaphragm. Podocyte loss is associated with chronic kidney disease progression, but it is not clear whether urinary podocyte proteins in urine reflect the clinical extent o..
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Duration of anuria predicts recovery of renal function after acute kidney injury requiring continuous renal replacement therapy
Hee-Yeon Jung, Jong-Hak Lee, Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
Korean J Intern Med. 2016;31(5):930-937. Published online February 12, 2016
Background/Aims: Little is known regarding the incidence rate of and factors associated with developing chronic kidney disease after continuous renal replacement therapy (CRRT) in acute kidney injury (AKI) patients. We investigated renal outcomes and the factors associated with incomplete renal reco..
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Determinants and burden of chronic kidney disease in a high-risk population in Korea: results from a cross-sectional study
Yong Un Kang, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Korean J Intern Med. 2016;31(5):920-929. Published online January 13, 2016
Background/Aims: This study aimed to investigate the prevalence of chronic kidney disease (CKD) and associated risk factors in a high-risk population in Korea.
Methods: A total of 6,045 participants aged ≥ 65 years (mean age, 73.0 ± 5.5) with diabetes or hypertension were enrolled. Participants w..
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Clinical value of pathologic examination of non-neoplastic kidney in patients with upper urinary tract malignancies
Jee Wan Wee, Hye Ran Kang, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, So-Young Jin, Won Jae Yang, Hyunjin Noh
Korean J Intern Med. 2016;31(4):739-749. Published online May 30, 2016
Background/Aims: While surgical resection remains the standard of care in the treatment of upper urinary tract malignancies, nephrectomy is a risk factor for the development of chronic kidney disease (CKD). The aim of this study was to determine whether histologic evaluation of non-neoplastic kidney..
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Safety and immunologic benefits of conversion to sirolimus in kidney transplant recipients with long-term exposure to calcineurin inhibitors
Ji Hyun Yu, Kyoung Woon Kim, Bo-Mi Kim, Byung Ha Chung, Mi-La Cho, Bum Soon Choi, Cheol Whee Park, Yong-Soo Kim, Chul Woo Yang
Korean J Intern Med. 2016;31(3):552-559. Published online March 11, 2016
Background/Aims: Sirolimus (SRL) is a promising immunosuppressant replacingcalcineurin inhibitors (CNIs). This study was performed to evaluate the safetyand immunologic benefits of conversion to SRL in stable kidney transplant (KT)recipients exposed to CNIs for long periods.
Methods: Fourteen CNI-t..
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Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
Hyung Wook Kim, Young Ok Kim, Sun Ae Yoon, Jeong-Sun Han, Hyun-Bae Chun, Young Soo Kim
Korean J Intern Med. 2016;31(1):116-124. Published online December 28, 2015
Background/Aims: We investigated whether angiotensin III (Ang III) is involved in monocyte recruitment through regulation of the chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured human proximal tubular epithelial cells (HK-2 cells).
Methods: We measured MCP-1 levels in HK-2 cells tha..
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