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Nephrology
Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats
Jian Jin, Sun Woo Lim, Long Jin, Ji Hyun Yu, Hyun Seon Kim, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2017;32(2):314-322. Published online September 30, 2016
Background/Aims: Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset diabetes after transplantation caused by immunosuppressant therapy is unclear. We compared the effects of MET on DM caused by tacrolimus (TAC) or sirolimus (SRL).
Methods: DM was induced..
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Endocrinology-metabolism
Linking resistin, inflammation, and cardiometabolic diseases
Hyeong Kyu Park, Mi Kyung Kwak, Hye Jeong Kim, Rexford S. Ahima
Korean J Intern Med. 2017;32(2):239-247. Published online February 16, 2017
Adipose tissue secretes a variety of bioactive substances that are associated with chronic inflammation, insulin resistance, and an increased risk of type 2 diabetes mellitus. While resistin was first known as an adipocyte-secreted hormone (adipokine) linked to obesity and insulin resistance in rode..
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Is islet transplantation a realistic approach to curing diabetes?
Sang-Man Jin, Kwang-Won Kim
Korean J Intern Med. 2017;32(1):62-66. Published online January 1, 2017
Since the report of type 1 diabetes reversal in seven consecutive patients by the Edmonton protocol in 2000, pancreatic islet transplantation has been reappraised based on accumulated clinical evidence. Although initially expected to therapeutically target long-term insulin independence, islet trans..
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Gastroenterology
Prevention of type 2 diabetes mellitus in women with previous gestational diabetes mellitus
Joon Ho Moon, Soo Heon Kwak, Hak C. Jang
Korean J Intern Med. 2017;32(1):26-41. Published online January 1, 2017
Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset or first recognition during pregnancy, is characterized by underlying maternal defects in the β-cell response to insulin during pregnancy. Women with a previous history of GDM have a greater than 7-fold hi..
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Expressive aphasia as the manifestation of hyperglycemic crisis in type 2 diabetes
Ji Hyun Lee, Ye An Kim, Joon Ho Moon, Se Hee Min, Young Shin Song, Sung Hee Choi
Korean J Intern Med. 2016;31(6):1187-1190. Published online March 12, 2016
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Endocrinology-metabolism
Elevated lipoprotein(a) levels predict cardiovascular disease in type 2 diabetes mellitus: a 10-year prospective cohort study
Tae-Seok Lim, Jae-Seung Yun, Seon-Ah Cha, Ki-Ho Song, Ki-Dong Yoo, Yu-Bae Ahn, Yong-Moon Park, Seung-Hyun Ko
Korean J Intern Med. 2016;31(6):1110-1119. Published online October 18, 2016
Background/Aims: Elevated lipoprotein(a) (Lp[a]) level is known to be a risk factor for cardiovascular disease (CVD). However, the data that has been reported on the association between the Lp(a) level and CVD in type 2 diabetes has been limited and incoherent. The aim of this study was to investiga..
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Prevalence and risk factors of periodontitis among adults with or without diabetes mellitus
Mihee Hong, Hee Yeon Kim, Hannah Seok, Chang Dong Yeo, Young Soo Kim, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Hyo-Suk Ahn, Yoon Ho Ko, Seong Cheol Jeong, Hiun Suk Chae, Tae Seo Sohn
Korean J Intern Med. 2016;31(5):910-919. Published online September 1, 2016
Background/Aims: This study examined prevalence and risk factors of periodontitis in representative samples of Korean adults, with and without diabetes mellitus (DM). Methods: Data from the 2012 Korean National Health and Nutritional Examination Survey were analyzed. A total of 4,477 adults (≥ 30 y..
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Current status of managing diabetes mellitus in Korea
Kyoung Hwa Ha, Dae Jung Kim
Korean J Intern Med. 2016;31(5):845-850. Published online September 1, 2016
Diabetes mellitus is an increasing global health problem. Guidelines for diabetic care recommend management of lifestyle and risk factors (glucose, blood pressure, and cholesterol), as well as regular screening for complications associated with treatment of the conditions related to diabetes. The pr..
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Urachal abscess precipitated as acute pyelonephritis in an adult patient with diabetes
Yoo A Choi, Se Young Kim, Kyung Yoon Chang, Hyeon Seok Hwang, Suk Young Kim, Yoon Kyung Chang
Korean J Intern Med. 2016;31(4):798-801. Published online January 28, 2016
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Endocrinology-metabolism
Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus
Jae Ho Cho, Ho Jin Kim, Jun Ho Lee, Il Rae Park, Jun Sung Moon, Ji Sung Yoon, In-Kyu Lee, Kyu Chang Won, Hyoung Woo Lee
Korean J Intern Med. 2016;31(4):703-711. Published online June 8, 2016
Background/Aims: Overt hypothyroidism is frequently found in patients with type 2 diabetes mellitus (T2DM), but it remains unknown the relationship between subclinical hypothyroidism (SCH) and T2DM. We attempt to evaluate the difference in prevalence of SCH between patients with T2DM and general pop..
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Association between blood glucose level derived using the oral glucose tolerance test and glycated hemoglobin level
Hyoung Joo Kim, Young Geon Kim, Jin Soo Park, Young Hwan Ahn, Kyoung Hwa Ha, Dae Jung Kim
Korean J Intern Med. 2016;31(3):535-542. Published online February 22, 2016
Background/Aims: Glycated hemoglobin (HbA1c) is widely used as a marker of glycemic control. Translation of the HbA1c level to an average blood glucose level is useful because the latter figure is easily understood by patients. We studied the association between blood glucose levels revealed by the ..
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Nephrology
Impact of dialysis modality on technique survival in end-stage renal disease patients
Jong-Hak Lee, Sun-Hee Park, Jeong-Hoon Lim, Young-Jae Park, Sang Un Kim, Kyung-Hee Lee, Kyung-Hoon Kim, Seung Chan Park, Hee-Yeon Jung, Owen Kwon, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim
Korean J Intern Med. 2016;31(1):106-115. Published online December 28, 2015
Background/Aims: This study analyzed the risk factors for technique survival in dialysis patients and compared technique survival rates between hemodialysis (HD) and peritoneal dialysis (PD) in a prospective cohort of Korean patients.
Methods: A total of 1,042 patients undergoing dialysis from Sept..
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Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation
Sun Woo Lim, Ji Zhe Jin, Long Jin, Jian Jin, Can Li
Korean J Intern Med. 2015;30(6):759-770. Published online October 30, 2015
Despite strict pre- and post-transplantation screening, the incidence of new-onset diabetes after transplantation (NODAT) remains as high as 60%. This complication affects the risk of cardiovascular events and patient and graft survival rates. Thus, reducing the impact of NODAT could improve overall..
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Endocrinology-metabolism
Blood electrolyte disturbances during severe hypoglycemia in Korean patients with type 2 diabetes
Mi Yeon Kang
Korean J Intern Med. 2015;30(5):648-656. Published online August 27, 2015
Background/Aims: To investigate abnormalities in blood electrolyte levels during severe hypoglycemia in Korean patients with type 2 diabetes mellitus (T2DM) in a clinical setting.
Methods: Blood electrolyte levels in adult T2DM patients during severe hypoglycemia were collected from January 1, 200..
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Cardiology
The relationship between serum asymmetric dimethylarginine levels and subjective sleep quality in normotensive patients with type 2 diabetes mellitus
Alpay Aribas, Mehmet Kayrak, Mehmet Tekinalp, Hakan Akilli, Hayrudin Alibasic, Serkan Yildirim, Mehmet Gunduz, Alpaslan Taner, Ali Unlu
Korean J Intern Med. 2015;30(3):316-324. Published online April 29, 2015
Background/Aims: Poor sleep quality (SQ) is associated with increased cardiovascular mortality and morbidity. Additionally, asymmetric dimethylarginine (ADMA) is an independent predictor of cardiovascular mortality and morbidity. However, no sufficient data regarding the relationship between ADMA le..
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Nephrology
The association between an abnormal post-voiding urine volume and a lower estimated glomerular filtration rate in patients with type 2 diabetes with no voiding symptoms
A Jin Cho, Sung Tae Cho, Young-Ki Lee, Jieun Oh, Sung Gyun Kim, Jang Won Seo, Jong-Woo Yoon, Ja-Ryong Koo, Hyung Jik Kim, Yong Seong Lee, Young-Goo Lee, Jung Woo Noh
Korean J Intern Med. 2015;30(1):82-87. Published online December 30, 2014
Background/Aims: Diabetic cystopathy is a frequent complication of diabetes mellitus. This study assessed the association between the post-voiding residual (PVR) urine volume and diabetic nephropathy in type 2 diabetics with no voiding symptoms.
Methods: This study investigated 42 patients with typ..
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Endocrinology-metabolism
Avoiding or coping with severe hypoglycemia in patients with type 2 diabetes
Jae-Seung Yun, Seung-Hyun Ko
Korean J Intern Med. 2015;30(1):6-16. Published online December 30, 2014
Hypoglycemia is a major barrier to achieving the glycemic goal in patients with type 2 diabetes. In particular, severe hypoglycemia, which is defined as an event that requires the assistance of another person to actively administer carbohydrates, glucagon, or take other corrective actions, is a seri..
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The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes
Ohk-Hyun Ryu, Wankyo Chung, Sungwha Lee, Kyung-Soon Hong, Moon-Gi Choi, Hyung Joon Yoo
Korean J Intern Med. 2014;29(5):620-629. Published online August 28, 2014
Background/Aims: Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease. However, few interventional studies have evaluated the effect of vitamin D supplementation on cardiovascular ris..
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Ifosfamide-induced Fanconi syndrome with diabetes insipidus
Ah Young Leem, Han Sang Kim, Byung Woo Yoo, Beo Deul Kang, Min Hwan Kim, Sun Young Rha, Hyo Song Kim
Korean J Intern Med. 2014;29(2):246-249. Published online February 27, 2014
Ifosfamide-induced Fanconi syndrome is a rare complication that typically occurs in young patients due to a cumulative dose of ifosfamide > 40–60 g/m2, a reduction in kidney mass, or concurrent cisplatin treatment. It is usually characterized by severe and fatal progression accompanied by type II ..
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Neuropathic truncal pain in patients with type 2
diabetes mellitus relieved by topical cream and
nerve block
Sun Hee Kim, Cho-Ok Baek, Kyung Ae Lee, Heung Yong Jin, Hong Sun Baek, Tae Sun Park
Korean J Intern Med. 2014;29(1):120-122. Published online January 2, 2014
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