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Gastroenterology / Original Article
Comparison of the efficacy and safety of direct-acting antiviral therapy with or without hepatitis C-related hepatocellular carcinoma
Byung Soo Kwan, Jeong Han Kim, Seong Jun Park, Won Hyeok Choe, So Young Kwon, Byung-Chul Yoo
Korean J Intern Med. 2021;36(2):292-304. Published online April 3, 2020
Background/Aims: Chronic hepatitis C (CHC) treatment has dramatically improved since direct-acting antiviral (DAA) therapy was introduced. However, the use of DAA therapy in CHC patients with hepatocellular carcinoma (HCC) remains controversial. We investigated the DAA treatment response in CHC pati..
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Hemato-oncology / Original Article
Treatment outcome and prognostic factors of Korean patients with chronic lymphocytic leukemia: a multicenter retrospective study
Yunsuk Choi, Jung-Hee Lee, Chul Won Jung, Jae-Cheol Jo, Jin Seok Kim, Inho Kim, Silvia Park, June-won Cheong, Sang-Hyuk Park, Sung-Yong Kim, Hong-Ghi Lee
Korean J Intern Med. 2021;36(1):194-204. Published online April 14, 2020
Background/Aims: Compared with Western countries, chronic lymphocytic leukemia (CLL) rarely occurs in Asia and has different clinical characteristics. Thus, we aimed to evaluate the clinical characteristics, treatment outcomes, and prognostic significance of Korean patients with CLL.
Methods: We re..
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Allergy / Original Article
Anxiety, depression, and stress in Korean patients with chronic urticaria
Gil-Soon Choi, Young-Hee Nam, Chan-Sun Park, Mi-Yeong Kim, Eun-Jung Jo, Hye-Kyung Park, Hee-Kyoo Kim
Korean J Intern Med. 2020;35(6):1507-1516. Published online May 27, 2020
Background/Aims: Emotional distress is thought to cause or maintain chronic urticaria (CU). We aimed to investigate the presence of anxiety, depression, and stress in Korean adult CU patients and to explore their potential impact on treatment.
Methods: We enrolled 79 CU patients and a disease contr..
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Review
The clinical impact of gut microbiota in chronic kidney disease
So Mi Kim, Il han Song
Korean J Intern Med. 2020;35(6):1305-1316. Published online September 29, 2020
Gut microorganisms play critical roles in both maintaining host homeostasis and the development of diverse diseases. Gut dysbiosis, an alteration of the composition and function of gut microorganisms, is commonly seen in patients with chronic kidney disease (CKD). CKD itself contributes to a disrupt..
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Review
Nutritional management in patients with chronic kidney disease
Sun Moon Kim, Ji Yong Jung
Korean J Intern Med. 2020;35(6):1279-1290. Published online September 23, 2020
The global prevalence of chronic kidney disease (CKD) is increasing with the aging of populations worldwide. As kidney function declines, the accumulation of metabolic waste products and excessive electrolytes can significantly impair the health of patients with CKD. As nutritional management of pat..
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Hemato-oncology / Original Article
Cancer incidence according to the National Health Information Database in Korean patients with end-stage renal disease receiving hemodialysis
Jisun Myung, Jung Hye Choi, Joo Hark Yi, Inah Kim
Korean J Intern Med. 2020;35(5):1210-1219. Published online February 20, 2020
Background/Aims: The aim of this study was to investigate incidence, survival, and risk factors of cancer in end-stage renal disease (ESRD) patients with hemodialysis using information from the National Health Information Database (NHID).
Methods: Using the NHID, we identified ESRD patients who sta..
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Pulmonology / Original Article
Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study
Jaeyoung Cho, Chang-Hoon Lee, Deog Kyeom Kim, Hun-Gyu Hwang, Yu-Il Kim, Hye Sook Choi, Jeong-Woong Park, Kwang Ha Yoo, Ki-Suck Jung, Sang-Do Lee; the KOLD and KOCOSS Investigators
Korean J Intern Med. 2020;35(5):1154-1163. Published online February 27, 2020
Background/Aims: Despite increasing awareness of the burden of chronic obstructive pulmonary disease (COPD) in women, knowledge regarding gender differences in COPD outcomes is limited. Therefore, we aimed to evaluate whether COPD outcomes, including exacerbations, lung function, and symptoms differ..
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Pulmonology / Original Article
The health-related quality-of-life of chronic obstructive pulmonary disease patients and disease-related indirect burdens
Hye Sook Choi, Dong-Wook Yang, Chin Kook Rhee, Hyoung Kyu Yoon, Jin Hwa Lee, Seong Yong Lim, Yu-Il Kim, Kwang Ha Yoo, Yong-Il Hwang, Sang Haak Lee, Yong Bum Park
Korean J Intern Med. 2020;35(5):1136-1144. Published online February 20, 2020
Background/Aims: Many chronic obstructive pulmonary disease (COPD) patients have physical limitations. We investigated EuroQol five-dimensions five-level (EQ-5D-5L) of COPD patients to assess quality of life, and assessed indirect burden including time expenditure to visit doctor, home care rate, an..
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Gastroenterology / Original Article
Effects of vitamin D supplements in patients with chronic hepatitis C: a randomized, multi-center, open label study
Jae Yoon Jeong, Dae Won Jun, Sol Ji Park, Joo Hyun Sohn, Sang Gyune Kim, Se Whan Lee, Soung Won Jeong, Moon Young Kim, Won Kim, Jae-Jun Shim, Hyoung Su Kim, Ki Tae Suk, Sang Bong Ahn
Korean J Intern Med. 2020;35(5):1074-1083. Published online November 12, 2019
Background/Aims: We aimed to assess the role of vitamin D supplementation in the response to pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV) treatment in patients with chronic hepatitis C (CHC).
Methods: Our study was a multi-center, randomized controlled trial in 11 hospitals. CHC patient..
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Rheumatology / Original Article
Renal safety and urate-lowering efficacy of febuxostat in gout patients with stage 4–5 chronic kidney disease not yet on dialysis
Sang-Hyon Kim, So-Yeon Lee, Ji-Min Kim, Chang-Nam Son
Korean J Intern Med. 2020;35(4):998-1003. Published online April 8, 2019
Background/Aims: The safety and efficacy of febuxostat in patients with stage 4–5 chronic kidney disease (CKD) are still unclear owing to a lack of studies in these patients. Therefore, we aimed to evaluate the effect of febuxostat on renal function, general safety, and efficacy in gout patients wi..
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Gastroenterology / Original Article
Immunological measurement of aspartate/alanine aminotransferase in predicting liver fibrosis and inflammation
Hyun Jeong Kim, Sang Yeol Kim, Suk Pyo Shin, Young Joo Yang, Chang Seok Bang, Gwang Ho Baik, Dong Joon Kim, Young Lim Ham, Eui Yul Choi, Ki Tae Suk
Korean J Intern Med. 2020;35(2):320-330. Published online January 23, 2019
Background/Aims: Enzymatic analysis of aspartate/alanine aminotransferase (AST/ALT) does not exactly represent the progression of liver fibrosis or inflammation. Immunoassay for AST (cytoplasmic [c] AST/mitochondrial [m] AST) and ALT (ALT1/ALT2) has been suggested as one alternatives for enzymatic a..
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Pulmonology / Review
Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease
Chin Kook Rhee, Deog Kyeom Kim
Korean J Intern Med. 2020;35(2):276-283. Published online February 28, 2020
Phosphodiesterase-4 inhibitors (PDE4Is) are potent anti-inf lammatory agents and roflumilast has been used to prevent acute exacerbation of chronic obstructive pulmonary disease (COPD). Roflumilast decreases neutrophil migration, restores cystic fibrosis transmembrane conductance regulator activity,..
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Pulmonology / Original Article
Mortality of patients with chronic obstructive pulmonary disease: a nationwide populationbased cohort study
Seon Cheol Park, Dong Wook Kim, Eun Cheol Park, Cheung Soo Shin, Chin Kook Rhee, Young Ae Kang, Young Sam Kim
Korean J Intern Med. 2019;34(6):1272-1278. Published online October 16, 2019
Background/Aims: Chronic obstructive pulmonary disease (COPD) is a major cause of mortality in the world. There are no population-based studies on longterm mortality in COPD patients in Korea.
Methods: Using the large, population-based, National Health Insurance Service- National Sample Cohort (NHI..
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Gastroenterology / Original Article
Platelet count is associated with sustained virological response rates in treatments for chronic hepatitis C
Baek Gyu Jun, Eui Ju Park, Woong Cheul Lee, Jae Young Jang, Soung Won Jeong, Young Don Kim, Gab Jin Cheon, Young Sin Cho, Sae Hwan Lee, Hong Soo Kim, Yun Nah Lee, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim
Korean J Intern Med. 2019;34(5):989-997. Published online March 14, 2018
Background/Aims: This study was conducted to clarify the sustained virological response (SVR) prediction ability of baseline and treatment-related factors in patients with chronic hepatitis C virus (HCV) infection.
Methods: This retrospective study collected data at four tertiary referral hospitals..
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Review
Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis
Mikala C. Osani, Raveendhara R. Bannuru
Korean J Intern Med. 2019;34(5):966-973. Published online March 15, 2019
About 21% of adults with osteoarthritis (OA) are diagnosed with concomitant depression in addition to chronic pain. Duloxetine, an anti-depressant medication, has been recently approved for managing Knee OA. We performed a systematic review to ascertain the efficacy and safety of duloxetine for OA. ..
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Review
The epidemiology of hepatitis B virus infection in Korea
Sun Young Yim, Ji Hoon Kim
Korean J Intern Med. 2019;34(5):945-953. Published online March 29, 2019
The global burden of hepatitis B virus (HBV) infection is profound, and represents a public health threat as chronic infection can lead to liver cirrhosis, hepatocellular carcinoma, and death. The risk factors for chronic hepatitis B-related liver disease differ according to HBV endemicity, hepatiti..
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Nephrology / Original Article
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease
Seon Ha Baek, Ran-hui Cha, Shin Wook Kang, Cheol Whee Park, Dae Ryong Cha, Sung Gyun Kim, Sun Ae Yoon, Sejoong Kim, Sang-Youb Han, Jung Hwan Park, Jae Hyun Chang, Chun Soo Lim, Yon Su Kim, Ki Young Na
Korean J Intern Med. 2019;34(4):858-866. Published online November 29, 2017
Background/Aims: Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical ou..
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Gastroenterology / Original Article
Efficacy of long-term tenofovir disoproxil fumarate therapy in chronic hepatitis B patients with partial virologic response in real practice
Jeong Eun Song, Chang Hyeong Lee, Byung Seok Kim
Korean J Intern Med. 2019;34(4):802-810. Published online April 8, 2019
Background/Aims: The optimal management of chronic hepatitis B (CHB) patients with partial virologic response (PVR) to tenofovir disoproxil fumarate (TDF) remains unclear. We aimed to evaluate the long-term efficacy of prolonged TDF therapy in treatment-naïve CHB patients with PVR to TDF therapy in..
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Gastroenterology / Original Article
Daclatasvir and asunaprevir combination therapy for patients with chronic hepatitis C virus genotype 1b infection in real world
Jae Young Oh, Byung Seok Kim, Chang Hyeong Lee, Jeong Eun Song, Heon Ju Lee, Jung Gil Park, Jae Seok Hwang, Woo Jin Chung, Byoung Kuk Jang, Young Oh Kweon, Won Young Tak, Soo Young Park, Se Young Jang, Jeong Ill Suh, Sang Gyu Kwak
Korean J Intern Med. 2019;34(4):794-801. Published online May 25, 2018
Background/Aims: Previous studies have reported a high rate of sustained virologic response (SVR) and a low rate of serious adverse events with the use of daclatasvir (DCV) and asunaprevir (ASV) combination therapy. We evaluated the efficacy and safety of DCV and ASV combination therapy for patient..
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Nephrology / Original Article
Impact of sarcopenia on long-term mortality and cardiovascular events in patients undergoing hemodialysis
Jwa-Kyung Kim, Sung Gyun Kim, Ji-Eun Oh, Young-Ki Lee, Jung-Woo Noh, Hyung Jik Kim, Young Rim Song
Korean J Intern Med. 2019;34(3):599-607. Published online November 23, 2017
Background/Aims: A high body mass index (BMI) is known to correlate with better survival in patients on hemodialysis (HD). However, the impacts of body composition and sarcopenia on survival have not been well studied in this population.
Methods: One hundred and forty-two prevalent HD patients were..
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