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Primary systematic AL amyloidosis with upper gastrointestinal involvement: endoscopic findings of a protein deposition disorder
Andrey P. Kiryukhin, Pavel V. Pavlov, Alexander S. Tertychnyy, Alexandr A. Derinov, Irina E. Rudenko
Korean J Intern Med. 2021;36(3):744-745. Published online July 31, 2020
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Atypical cutaneous features in a patient with adult-onset Still’s disease
Woo Seong Jeong, Jinseok Kim, Sang Taek Heo, Jae Wang Kim, Jeong Rae Yoo
Korean J Intern Med. 2021;36(3):742-743. Published online April 3, 2020
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Rheumatology
Clinical features of Korean elderly patients with antineutrophil cytoplasmic antibody-associated vasculitis
Byung-Woo Yoo, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2021;36(3):731-741. Published online August 20, 2020
Background/Aims: We compared the clinical and laboratory data between elderly and non-elderly patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) at diagnosis; further, we investigated the predictors at diagnosis for all-cause mortality and end-stage renal disease (E..
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Pregnancy outcomes in Korean women with ankylosing spondylitis
Eun Hye Park, Jung Sun Lee, Ye-Jee Kim, Seung Mi Lee, Jong Kwan Jun, Eun Bong Lee, Yong-Gil Kim
Korean J Intern Med. 2021;36(3):721-730. Published online September 26, 2019
Background/Aims: Because ankylosing spondylitis (AS) mainly affects sacroiliac joints, special attention should be given to normal labour and pregnancy outcomes. Here, we investigate pregnancy outcomes in Korean women with AS.
Methods: Based on data from the Korean Health Insurance Review and Asses..
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Allergy
MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β–Smad7 pathway
Jung Hur, Chin Kook Rhee, Sook Young Lee, Young Kyoon Kim, Ji Young Kang
Korean J Intern Med. 2021;36(3):706-720. Published online February 18, 2021
Background/Aims: Current asthma therapies remain unsatisfactory for controlling airway remodelling in asthma. MicroRNA-21 is a key player in asthma pathogenesis, but the molecular mechanisms underlying its effects on airway remodelling are not completely understood. We investigated the effects of in..
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Infectious diseases
Evaluation of the early fluconazole treatment of candidemia protocol with automated short message service alerts: a before-and-after study
Jeong Rae Yoo, Bo Ra Shin, Sujin Jo, Sang Taek Heo
Korean J Intern Med. 2021;36(3):699-705. Published online July 9, 2020
Background/Aims: We introduced the Early Fluconazole Treatment in Candidemia (EFTC) protocol in August 2015 to improve the outcomes of patients with candidemia. This study evaluated the effectiveness of the EFTC protocol.
Methods: We conducted a retrospective before-and-after study among patients i..
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Hemato-oncology
Pulmonary toxicities of molecular targeted antineoplastic agents: a single-center 10-year experience
Min-Young Lee, Seug Yun Yoon, Kyoung Ha Kim, Namsu Lee, Ha Youn Kim, Jung Hwa Hwang, Jong-Ho Won
Korean J Intern Med. 2021;36(3):689-698. Published online January 8, 2021
Background/Aims: A better understanding of cancer cell biology has led to the discovery and development of several new targeted agents for cancer. These drugs are widely used in cancer treatment and have good toxicity profiles. However, some patients are extremely sensitive to these drugs and can de..
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Association between absolute lymphocyte count and overall mortality in patients with surgically resected gastric cancer
Se Jun Park, Jinsoo Lee, Hyunho Kim, Kabsoo Shin, MyungAh Lee, Jae Myung Park, Myung-Gyu Choi, Cho Hyun Park, Kyo Young Song, Han Hong Lee, In-Ho Kim
Korean J Intern Med. 2021;36(3):679-688. Published online February 19, 2021
Background/Aims: Lymphocytes are an important component of the cell-mediated immune system. As lymphopenia is reportedly associated with poor prognoses in patients with various cancers, we investigated this notion in patients who underwent curative gastrectomy.
Methods: We retrospectively analyzed ..
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Real-world data on the survival outcome of patients with newly diagnosed Waldenström macroglobulinemia
Jang Ho Cho, Joon-Ho Shim, Sang Eun Yoon, Hee-Jin Kim, Sun-Hee Kim, Young Hyeh Ko, Seung-Tae Lee, Kihyun Kim, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2021;36(3):668-678. Published online August 14, 2020
Background/Aims: Waldenström macroglobulinemia (WM) is a rare lymphoproliferative disorder that usually follows an indolent clinical course. However, some patients show an aggressive clinical course leading to death. We explored the risk factors predicting poor prognosis in WM patients.
Methods: ..
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Nephrology
Effect of urinary angiotensinogen and high-salt diet on blood pressure in patients with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD)
Ha Yeon Kim, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Su-Ah Sung, Seung Hyeok Han, Kook-Hwan Oh, Curie Ahn, Soo Wan Kim
Korean J Intern Med. 2021;36(3):659-667. Published online October 8, 2020
Background/Aims: This study aimed to investigate whether urinary angiotensinogen (UAGT) excretion was associated with elevated blood pressure in patients with chronic kidney disease (CKD) and to evaluate the relationship among blood pressure, intra-renal renin-angiotensin system (RAS) activity, and ..
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Endocrinology-metabolism
Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study
Yi-Suk Kim, Yong-Moon Park, Kyung-Do Han, Jae-Seung Yun, Yu-Bae Ahn, Seung-Hyun Ko
Korean J Intern Med. 2021;36(3):647-658. Published online July 7, 2020
Background/Aims: Although people with diabetes have been shown to have higher mortality than people without diabetes, there is a lack of data on the association between fasting plasma glucose (FPG) levels and cause-specific mortality rates in the general population.
Methods: A total of 326,547 Kore..
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Pulmonology
Clinical impact of long-term change in air trapping on pulmonary function and computed tomography parameters in chronic obstructive pulmonary disease
Jeong Uk Lim, Jae Seung Lee, Ji-Hyun Lee, Sang-Do Lee, Yeon-Mok Oh, Chin Kook Rhee; for the Korean Obstructive Lung Disease (KOLD) Study Group
Korean J Intern Med. 2021;36(3):636-646. Published online November 25, 2020
Background/Aims: Air trapping is associated with unfavorable outcomes in chronic obstructive pulmonary disease (COPD). The present study evaluated the association between longitudinal changes in air trapping with pulmonary function, computed tomography (CT) parameters and exacerbation.
Methods: Pat..
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Cut-off value of FEV1/FEV6 to determine airflow limitation using handheld spirometry in subjects with risk of chronic obstructive pulmonary disease
Yong Il Hwang, Youlim Kim, Chin Kook Rhee, Deog Kyeom Kim, Yong Bum Park, Kwang Ha Yoo, Ki-Suck Jung, Chang Youl Lee
Korean J Intern Med. 2021;36(3):629-635. Published online June 24, 2020
Background/Aims: Postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) less than 0.7 using spirometry is the golden standard to diagnose airf low limitation of chronic obstructive pulmonary disease (COPD). Recently, measuring FEV6 has been s..
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Cardiology
Different therapeutic associations of renin-angiotensin system inhibitors with coronavirus disease 2019 compared with usual pneumonia
Hae-Young Lee, Juhee Ahn, Juhong Park, Chang Kyung Kang, Sung-Ho Won, Dong Wook Kim, Jong-Heon Park, Ki-Hyun Chung, Joon-Sung Joh, JI Hwan Bang, Cheong Hee Kang, Myoung-don Oh, Wook Bum Pyun; The Korean Society of Hypertension; The National Committee for Clinical Management of Emerging Infectious Diseases
Korean J Intern Med. 2021;36(3):617-628. Published online April 16, 2021
Background/Aims: Although it is near concluded that renin-angiotensin system inhibitors do not have a harmful effect on coronavirus disease 2019 (COVID-19), there is no report about whether angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) offer any protective..
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The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome
Min Chul Kim, Seok Oh, Youngkeun Ahn, Keumyi Moon, Joon Ho Ahn, Dae Young Hyun, Kyung Hoon Cho, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Korean J Intern Med. 2021;36(3):608-616. Published online January 4, 2021
Background/Aims: High-sensitivity cardiac troponin (hs-TnT) assays detect very low levels of cardiac troponin. This study examined the interval change between initial and subsequent hs-TnT levels and evaluated its ability to predict significant coronary stenosis.
Methods: The study analyzed 163 pat..
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The relationship between miRNA-26b and connective tissue growth factor in rat models of aortic banding and debanding
Jung Sun Cho, Jongho Lee, Ki Cheol Park, Keum-Jin Yang, Eun Joo Cho
Korean J Intern Med. 2021;36(3):596-607. Published online December 30, 2019
Background/Aims: Connective tissue growth factor (CTGF) is a profibrotic factor implicated in pressure overload-mediated myocardial fibrosis. In this study, we determined the role of predicted CTGF-targeting microRNAs (miRNAs) in rat models of aortic stenosis and reverse cardiac remodeling.
Methods..
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Gastroenterology
Effect of Helicobacter pylori treatment on the long-term mortality in patients with type 2 diabetes
Young-Il Kim, Young Ae Kim, Hak Jin Kim, Su-Hyun Kim, Yul Hwangbo, Jae Gyu Kim, Jae J. Kim, Il Ju Choi
Korean J Intern Med. 2021;36(3):584-595. Published online November 25, 2020
Background/Aims: Meta-analyses of randomized trials reported a non-significant increase in overall mortality risk after Helicobacter pylori eradication. In this study, we investigated whether H. pylori treatment is associated with increased risk of overall mortality in patients with ty..
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Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals
Weitao Shen, Jiayu Sun, Zhiyang Li, Fen Yao, Kaihuang Lin, Xiaoyang Jiao
Korean J Intern Med. 2021;36(3):568-583. Published online November 10, 2020
Background/Aim: It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types of intestinal flora remains to be clarified. We aimed to analyze the associations between food intake and intestinal flora ..
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Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Korean J Intern Med. 2021;36(3):557-567. Published online July 7, 2020
Background/Aims: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rar..
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The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2
Sung Yong Han, Hyun Young Woo, Jeong Heo, Sang Gyu Park, Sung Ik Pyeon, Young Joo Park, Dong Uk Kim, Gwang Ha Kim, Hyung Hoi Kim, Geun Am Song, Mong Cho
Korean J Intern Med. 2021;36(3):544-556. Published online March 19, 2019
Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical ..
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