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Hemato-oncology / Original Article
BCR-ABL1 transcripts (MR4.5) at post-transplant 3 months as an early predictor for long-term outcomes in chronic myeloid leukemia
Sung-Eun Lee, Soo Young Choi, Soo-Hyun Kim, Hye-Young Song, Hea-Lyun Yoo, Mi-Young Lee, Ki-Hoon Kang, Hee-Jeong Hwang, Eun-Jung Jang, Dong-Wook Kim
Korean J Intern Med. 2017;32(1):125-136. Published online June 22, 2016
Background/Aims: The aim of this study was to identify the role of BCR-ABL1 transcript level as a predictor for post-transplant relapse and outcome in patients who underwent allogeneic stem cell transplantation (SCT) for chronic phase (CP) chronic myeloid leukemia (CML). Methods: Of 101 patients rec..
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Gastroenterology / Original Article
Comparing the clinical outcomes of young-onset and adult-onset ulcerative colitis: a multi-center Korean Association for the Study for Intestinal Diseases study
Ji Yeon Kim, Dong Il Park, Dong Soo Han, Kyu-Chan Huh, Chang Kyun Lee, Jeong Eun Shin, Jae Hak Kim, You Sun Kim, Yunho Jung, Sung-Ae Jung, Hyun Joo Song, Hyun Joo Jang, Young-Ho Kim, Sung No Hong
Korean J Intern Med. 2017;32(1):69-78. Published online June 25, 2016
Background/Aims: The aim of this study was to compare the clinical features and outcomes of ulcerative colitis (UC) according to the age of onset in Korea. Methods: A total of 1,141 patients who were diagnosed with UC between July 1987 and November 2013 at 11 tertiary hospitals were enrolled. The ba..
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Endocrinology-metabolism / Review
Is islet transplantation a realistic approach to curing diabetes?
Sang-Man Jin, Kwang-Won Kim
Korean J Intern Med. 2017;32(1):62-66. Published online January 1, 2017
Since the report of type 1 diabetes reversal in seven consecutive patients by the Edmonton protocol in 2000, pancreatic islet transplantation has been reappraised based on accumulated clinical evidence. Although initially expected to therapeutically target long-term insulin independence, islet trans..
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Rheumatology / Review
CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells
Eun Ji Kim, Ki Ho Kang, Ji Hyeon Ju
Korean J Intern Med. 2017;32(1):42-61. Published online January 1, 2017
Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology—and particularly clustered regularly interspaced short palindromic repeats (CRISPR)—will allow us to impro..
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Nephrology / Review
New therapeutic agents in diabetic nephropathy
Yaeni Kim, Cheol Whee Park
Korean J Intern Med. 2017;32(1):11-25. Published online January 1, 2017
Studies investigating diabetic nephropathy (DN) have mostly focused on interpreting the pathologic molecular mechanisms of DN, which may provide valuable tools for early diagnosis and prevention of disease onset and progression. Currently, there are few therapeutic drugs for DN, which mainly consist..
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Endocrinology-metabolism / Review
Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
Han Hee Lee, Myung-Gyu Choi, Tayyaba Hasan
Korean J Intern Med. 2017;32(1):1-10. Published online January 1, 2017
Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient complian..
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Letter to the editor
Pulmonary graft-versus-host disease after autologous hematopoietic stem cell transplantation
Sue In Choi, Eun Joo Lee, Dong Oh Kang, Sang Yeub Lee, Kwang Ho In, Han-Kyeom Kim, Sanghoon Park
Korean J Intern Med. 2016;31(6):1181-1183. Published online December 23, 2015
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Nephrology / Original Article
The impact of blood flow rate during hemodialysis on all-cause mortality
Kyung Yoon Chang, Su-Hyun Kim, Young Ok Kim, Dong Chan Jin, Ho Chul Song, Euy Jin Choi, Yong-Lim Kim, Yon-Su Kim, Shin-Wook Kang, Nam-Ho Kim, Chul Woo Yang, Yong Kyun Kim
Korean J Intern Med. 2016;31(6):1131-1139. Published online February 22, 2016
Background/Aims: Inadequacy of dialysis is associated with morbidity and mortality in chronic hemodialysis (HD) patients. Blood flow rate (BFR) during HD is one of the important determinants of increasing dialysis dose. However, the optimal BFR is unclear. In this study, we investigated the impact o..
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Nephrology / Original Article
Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population
Eunhee Ji, Yon Su Kim
Korean J Intern Med. 2016;31(6):1120-1130. Published online March 25, 2016
Background/Aims: An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was..
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Pulmonology / Original Article
Glomerular filtration rate affects interpretation of pulmonary function test in a Korean general population: results from the Korea National Health and Nutrition Examination Survey 2010 to 2012
Young Soo Kim, Hee Yeon Kim, Hyo-Suk Ahn, Tae Seo Sohn, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Seong Cheol Jeong, Mihee Hong, Hiun Suk Chae, Kyungdo Han, Chang Dong Yeo
Korean J Intern Med. 2016;31(6):1101-1109. Published online March 21, 2016
Background/Aims: The pulmonary abnormalities (principally restrictive abnormalities) are characteristic of renal transplant recipients or those with end-stage renal disease. Our aim was to explore whether the prevalence of spirometric abnormalities was influenced by the estimated glomerular filtrati..
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Cardiology / Original Article
Blood count parameters can predict the severity of coronary artery disease
Hilal Bektas Uysal, Bekir Dağlı, Cağdaş Akgüllü, Mücahit Avcil, Cemil Zencir, Mediha Ayhan, Hulki Meltem Sönmez
Korean J Intern Med. 2016;31(6):1093-1100. Published online April 7, 2016
Background/Aims: Because of the inflammatory nature of coronary artery disease (CAD), both platelets and white blood cells have been investigated for years. The aim of this study was to investigate the relationships between some prominently hematologic blood count parameters (mean platelet volume [M..
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Gastroenterology / Original Article
Diagnostic accuracy of 22/25-gauge core needle in endoscopic ultrasound-guided sampling: systematic review and meta-analysis
Hyoung-Chul Oh, Hyun Kang, Jae Young Lee, Geun Joo Choi, Jung Sik Choi
Korean J Intern Med. 2016;31(6):1073-1083. Published online September 2, 2016
Background/Aims: To compare the diagnostic accuracy of endoscopic ultrasound-guided core needle aspiration with that of standard fine-needle aspiration by systematic review and meta-analysis.
Methods: Studies using 22/25-gauge core needles, irrespective of comparison with standard fine needles, wer..
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Letter to the editor
Relapsing polychondritis presenting with inflammatory pseudotumor
Yeong Hee Eun, Hyeri Seok, In Seub Shin, Seung-Eun Lee, You-Bin Lee, Jaejoon Lee
Korean J Intern Med. 2016;31(5):1003-1005. Published online March 11, 2016
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Letter to the editor
A confusing case of multiple sclerosis and central nervous system graft versus host disease
Byung-Nam Yoon, Choong Kun Ha, Kwang-Woo Lee, Sung-Hye Park, Jung-Joon Sung
Korean J Intern Med. 2016;31(5):995-998. Published online February 3, 2016
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Letter to the editor
Solitary bone and brain metastasis in a patient with papillary thyroid carcinoma mimicking cavernous angioma
Eugene Han, Ye Yeon Lee, El Kim, Sun Young Kwon, Sang Pyo Kim, Hye Soon Kim, Mi Kyung Kim
Korean J Intern Med. 2016;31(5):991-994. Published online January 27, 2016
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Letter to the editor
Angiographic spontaneous pseudo-resolution of a coronary artery aneurysm after implantation of a sirolimus-eluting stent
Yong-Woo Choi, Hong-Seok Lim, Seung-Jea Tahk, Myeong-Ho Yoon, Hyoung-Mo Yang, Xiong-Jie Jin
Korean J Intern Med. 2016;31(5):987-990. Published online January 28, 2016
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Infectious diseases / Original Article
Differences of cytomegalovirus diseases between kidney and hematopoietic stem cell transplant recipients during preemptive therapy
Tark Kim, Yu-Mi Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Heungsup Sung, Joo Hee Jung, Sung Shin, Young Hoon Kim, Young-Ah Kang, Young-Shin Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Su-Kil Park, Duck Jong Han, Sung-Han Kim
Korean J Intern Med. 2016;31(5):961-970. Published online April 8, 2016
Background/Aims: Cytomegalovirus (CMV) surveillance and preemptive therapy is a widely-used strategy for preventing CMV disease in transplant recipients. However, there are limited data on the incidence and patterns of CMV disease during the preemptive period. Thus, we investigated the incidence and..
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Hemato-oncology / Original Article
Clinical manifestations of autoimmune disease-related non-Hodgkin lymphoma: a Korean single-center, retrospective clinical study
Young-Woo Jeon, Jae-Ho Yoon, Sung-Eun Lee, Ki-Seong Eom, Yoo-Jin Kim, Hee-Je Kim, Seok Lee, Chang-Ki Min, Jong Wook Lee, Woo-Sung Min, Seok-Goo Cho
Korean J Intern Med. 2015;31(5):944-952. Published online July 7, 2016
Background/Aims: Recently, large cohort studies regarding associations between autoimmune disease and lymphomas have been reported in a few Western countries. However, Asian data concerning autoimmune-related lymphomas are limited. Therefore, we evaluated the clinical characteristics and prognostic ..
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Nephrology / Original Article
Duration of anuria predicts recovery of renal function after acute kidney injury requiring continuous renal replacement therapy
Hee-Yeon Jung, Jong-Hak Lee, Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
Korean J Intern Med. 2016;31(5):930-937. Published online February 12, 2016
Background/Aims: Little is known regarding the incidence rate of and factors associated with developing chronic kidney disease after continuous renal replacement therapy (CRRT) in acute kidney injury (AKI) patients. We investigated renal outcomes and the factors associated with incomplete renal reco..
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Pulmonology / Original Article
Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey
In Seon Lee, Ah Young Leem, Sang Hoon Lee, Yumie Rhee, Yoon Ha, Young Sam Kim
Korean J Intern Med. 2016;31(5):899-909. Published online September 1, 2016
Background/Aims: Osteoporosis is common in chronic obstructive pulmonary disease (COPD) patients. The relationship between osteoporosis and COPD has been primarily reported in patients with moderate to severe COPD, but there is no report in the general population. The aim of this study is to investi..
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