Infectious diseases
Diagnostic yield of computed tomography-guided bone biopsy and clinical outcomes of tuberculous and pyogenic spondylitis
Eun-Jeong Joo, Joon-Sup Yeom, Young Eun Ha, So Yeon Park, Chong-Suh Lee, Eun-Sang Kim, Cheol-In Kang, Doo-Ryeon Chung, Jae-Hoon Song, Kyong Ran Peck
Korean J Intern Med. 2016;31(4):762-771. Published online April 15, 2016
Background/Aims: This study aimed to evaluate the efficacy of computed tomography (CT)-guided bone biopsy for the diagnosis of spinal infection and compared the clinical outcomes between tuberculous and pyogenic spinal infections.
Methods: The retrospective cohort study included patients who receiv..
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Pulmonology
Neuron-specific enolase as a novel biomarker reflecting tuberculosis activity and treatment
response
Sung-Jin Nam, Jee-Yeong Jeong, Tae-Won Jang, Mann-Hong Jung, Bong-Kwon Chun, Hee-Jae Cha, Chul-Ho Oak
Korean J Intern Med. 2016;31(4):694-702. Published online June 3, 2016
Background/Aims: It is not clear which tests are indicative of the activity and severity of tuberculosis (TB). This study aimed to investigate the predictive value of neuron-specific enolase (NSE) and to determine the origin of NSE in TB patients.
Methods: A single-center retrospective analysis was..
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A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea
Sun Hyo Park, Seung Jun Lee, Yu Ji Cho, Yi Yeong Jeong, Ho Cheol Kim, Jong Deog Lee, Hee Jin Kim, Dick Menzies
Korean J Intern Med. 2016;31(3):517-524. Published online April 7, 2016
Background/Aims: The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in Korea.
Methods: Adult close contacts of active pulmonary TB patients were recruited ..
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Gastroenterology
Early monitoring for detection of antituberculous drug-induced hepatotoxicity
Chang Min Lee, Sang Soo Lee, Jeong Mi Lee, Hyun Chin Cho, Wan Soo Kim, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee
Korean J Intern Med. 2016;31(1):65-72. Published online December 28, 2015
Background/Aims: We investigated the time of onset of antituberculous drug-induced hepatotoxicity (ADIH) and related characteristics.
Methods: Adult patients (n = 1,031) treated with first-line antituberculous drugs between February 2009 and January 2013 were enrolled.
Results: Of the 1,031 pati..
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Infectious diseases
Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?
Wing Wai Yew, Won-Jung Koh
Korean J Intern Med. 2016;31(1):15-29. Published online December 28, 2015
A worsening scenario of drug-resistant tuberculosis has increased the need for new treatment strategies to tackle this worldwide emergency. There is a pressing need to simplify and shorten the current 6-month treatment regimen for drug-susceptible tuberculosis. Rifamycins and fluoroquinolones, as we..
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Pulmonology
Drug-resistance pattern of Mycobacterium tuberculosis strains from patients with pulmonary and extrapulmonary tuberculosis during 2006 to 2013 in a Korean tertiary medical center
Ho Young Lee, Jin Lee, Young Seok Lee, Mi-Yeong Kim, Hyun-Kyung Lee, Young-Min Lee, Jeong Hwan Shin, Yousang Ko
Korean J Intern Med. 2015;30(3):325-334. Published online April 29, 2015
Background/Aims: We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) at a private referral center in South Korea.
Methods: All patients..
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Pleural fluid characteristics of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis
Ki-Eun Hwang, Hyo-Yeop Song, Jae-Wan Jung, Su-Jin Oh, Kwon-Ha Yoon, Do-Sim Park, Eun-Taik Jeong, Hak-Ryul Kim
Korean J Intern Med. 2015;30(1):56-61. Published online December 30, 2014
Background/Aims: Pleuropulmonary paragonimiasis produces no specific symptoms or radiologic findings, allowing for the possibility of misdiagnosis. We evaluated the specific clinical and pleural fluid features of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis.
Methods: We retro..
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Infectious diseases
Kinetics of T-cell-based assays on cerebrospinal fluid and peripheral blood mononuclear cells in patients with tuberculous meningitis
Ki-Ho Park, Mi Suk Lee, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Joong Koo Kang, Sang-Ahm Lee, Sung-Han Kim
Korean J Intern Med. 2014;29(6):793-799. Published online October 31, 2014
Background/Aims: The goal of this study was to monitor tuberculosis (TB)-specific T-cell responses in cerebrospinal f luid-mononuclear cells (CSF-MCs) and peripheral blood mononuclear cells (PBMCs) in patients with tuberculous meningitis (TBM) over the course of anti-TB therapy.
Methods: Adult pati..
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Pulmonology
Impact of outdoor air pollution on the incidence of tuberculosis in the Seoul metropolitan area, South Korea
Seung-sik Hwang, Sungchan Kang, Ji-Young Lee, Ji Sun Lee, Hee Jin Kim, Sung Koo Han, Jae-Joon Yim
Korean J Intern Med. 2014;29(2):183-190. Published online February 27, 2014
Background/Aims: Although indoor air pollution is a well-known risk factor for tuberculosis (TB), the possible link between outdoor air pollution and TB development has not been examined fully. We assessed the impact of outdoor air pollution on TB development in the Seoul metropolitan area, South Ko..
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Rheumatology
Poor agreement between QuantiFERON-TB
Gold test and tuberculin skin test results for the
diagnosis of latent tuberculosis infection in
rheumatoid arthritis patients and healthy controls
Joo-Hyun Lee, Hae Sook Sohn, Jin Ho Chun, Hyoun-Ah Kim, Chang Hee Suh, Yun Woo Lee, Bo Young Yoon
Korean J Intern Med. 2014;29(1):76-84. Published online January 2, 2014
Background/Aims: We investigated the agreement between the QuantiFERON-
TB Gold (QFT‑Gold) test and the tuberculin skin test (TST) in the diagnosis
of latent tuberculosis infection in patients with rheumatoid arthritis (RA), compared
with healthy controls, in Korea.
Methods: We recruited 64 pa..
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Pulmonology
Relationship between bronchial anthracofibrosis and endobronchial tuberculosis
Hyun Ji Kim, Sang Dong Kim, Dong Woo Shin, Soo Hyun Bae, Ah Lim Kim, Ji Na Kim, Seung Wook Jung, Byung Ki Lee, Yeon Jae Kim
Korean J Intern Med. 2013;28(3):330-338. Published online May 1, 2013
Background/AimsVarious pulmonary diseases may be associated with bronchial anthracofibrosis (BAF). Our aim was to identify a relationship between BAF and endobronchial tuberculosis (EBTB). MethodsIn total, 156 patients, diagnosed with EBTB using..
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Gastroenterology
Clinical characteristics and the usefulness of the QuantiFERON-TB Gold In-Tube test in hematologic patients with hepatic or splenic lesions
Jae-Cheol Kwon, Si-Hyun Kim, Sun Hee Park, Su-Mi Choi, Dong-Gun Lee, Jung-Hyun Choi, Jin-Hong Yoo, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Seok-Goo Cho, Jong-Wook Lee, Woo-Sung Min
Korean J Intern Med. 2013;28(2):187-196. Published online February 27, 2013
Background/AimsHepatic or splenic lesions in hematologic patients are not defined well because they are not easy to evaluate due to limitations of invasive procedures. Management typically depends on the clinical diagnosis with few microbiological data. Me..
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Pulmonology
Clinical characteristics and treatment responses of patients who developed tuberculosis following use of a tumor necrosis factor-α inhibitor
Keun Bum Chung, Eun Young Lee, Jong Pil Im, Sung Koo Han, Jae-Joon Yim
Korean J Intern Med. 2013;28(2):174-179. Published online February 27, 2013
Background/AimsIndividuals being treated with tumor necrosis factor (TNF)-α inhibitors are at increased risk of developing tuberculosis (TB). We determined the clinical characteristics and treatment response of patients who developed TB after using TNF-α inhibitors. ..
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Tuberculosis of the urachal cyst
Tarun Jindal, Mir Reza Kamal, Jayesh Kumar Jha
Korean J Intern Med. 2013;28(1):103-105. Published online December 28, 2012
Urachal cysts are uncommon. Rarely, these cysts can become infected. Tuberculosis of the urachal cyst is exceedingly rare, with only one case reported previously in the English language literature. Here we report the case of a 23-year-old male who presented with an infra-umbilical mass that turne..
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Spontaneous Cerebrospinal Fluid Rhinorrhea with Pneumocephalus: An Unusual Manifestation of Nasal Tuberculosis
Waqas Wahid Baig, Mudugundur Vishwares Nagaraja, Muralidhar Varma
Korean J Intern Med. 2012;27(3):350-352. Published online September 1, 2012
An unusual case of spontaneous cerebrospinal fluid (CSF) rhinorrhea with a pneumocephalus is described in a middle-aged woman who presented with a watery nasal discharge for 1 week and headache, vomiting, and fever for 1 day. The neurological examination revealed meningeal signs and bilateral pap..
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Central Venous Stenosis Caused by Traction of the Innominate Vein due to a Tuberculosis-Destroyed Lung
Eun Ju Song, Dae Hyun Baek, Young-Hwan Hwang, So-Young Lee, Young-Kwon Cho, Su-Ah Sung
Korean J Intern Med. 2011;26(4):460-462. Published online November 28, 2011
We report a case of central venous stenosis due to a structural deformity caused by a tuberculosis-destroyed lung in a 65-year-old woman. The patient presented with left facial edema. She had a history of pulmonary tuberculosis, and the chest X-ray revealed a collapsed left lung. Angiography show..
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Retrospective Comparison of Levofloxacin and Moxifloxacin on Multidrug-Resistant Tuberculosis Treatment Outcomes
Jinwoo Lee, Chang-Hoon Lee, Deog Kyeom Kim, Ho Il Yoon, Jae Yeol Kim, Sang-Min Lee, Seok-Chul Yang, Jae Ho Lee, Chul-Gyu Yoo, Choon-Taek Lee, Hee Soon Chung, Young Whan Kim, Sung Koo Han, Jae-Joon Yim
Korean J Intern Med. 2011;26(2):153-159. Published online June 1, 2011
Background/AimsTo compare the effect of levofloxacin and moxifloxacin on treatment outcomes among patients with multidrug-resistant tuberculosis (MDR-TB). MethodsA retrospective analysis of 171 patients with MDR-TB receiving either levofloxacin ..
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A Case of Tuberculous Arthritis Following the Use of Etanercept
Seung Won Choi, Jong Joon Ahn, Young Tae Hwang, Sang Hoon Koh, Sung Do Cho
Korean J Intern Med. 2009;24(4):397-401. Published online November 27, 2009
Etanercept is a tumor necrosis factor (TNF) inhibitor that has been used for the treatment of chronic inflammatory diseases including rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Because of its immunosuppressive activity, opportunistic infections have been noted in treate..
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Role of C-Reactive Protein and Procalcitonin in Differentiation of Tuberculosis from Bacterial Community Acquired Pneumonia
Young Ae Kang, Sung-Youn Kwon, Ho IL Yoon, Jae Ho Lee, Choon-Taek Lee
Korean J Intern Med. 2009;24(4):337-342. Published online November 27, 2009
Background/AimsWe investigated the utility of serum C-reactive protein (CRP) and procalcitonin (PCT) for differentiating pulmonary tuberculosis (TB) from bacterial community-acquired pneumonia (CAP) in South Korea, a country with an intermediate TB burden.
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Clinical findings of the patients with legal pulmonary disability - Short-term follow-up at a tertiary university hospital in Korea
Sun Young Kyung, Yu Jin Kim, Chang Hyeok An, Sang Pyo Lee, Jeong Woong Park, Sung Hwan Jeong
Korean J Intern Med. 2008;23(2):72-77. Published online June 20, 2008
Background/AimsLegal pulmonary disability in Korea is decided for chronic respiratory patients who have been diagnosed for a year or more, and the patients haven't gotten better after more than 2 months of sufficient treatment and they have shown no change in their pulmonary f..
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