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Allergy / Review
New targets for type 2-low asthma
Quang Luu Quoc, Youngwoo Choi, Gyu-Young Hur, Hae-Sim Park
Korean J Intern Med. 2024;39(2):215-227. Published online February 6, 2024
Asthma is characterized by airway obstruction and inflammation, and presents significant diagnostic and treatment challenges. The concept of endotypes has improved understanding of the mechanisms of asthma and has stimulated the development of effective treatment strategies. Sputum profiles may be u..
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Cardiology / Original Article
The role of discharge checklist in guideline-directed medical therapy for heart failure patients
Helsi Rismiati, Kyu-Sun Lee, Jeehoon Kang, Hyun-Jai Cho, Hae-Young Lee
Korean J Intern Med. 2023;38(2):195-206. Published online February 21, 2023
Background/Aims: Initiation of guideline-directed medical therapy (GDMT) during hospitalization is recommended for patients with heart failure (HF). However, GDMT is underutilized in real-world practice. This study evaluated the role of a discharge checklist on GDMT.
Methods: This was a single-cent..
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Review
Current state and prospects of gout treatment in Korea
Eun Hye Park, Sang Tae Choi, Jung Soo Song
Korean J Intern Med. 2022;37(4):719-731. Published online June 3, 2022
Effective management of gout includes the following: appropriate control of gout flares; lifestyle modifications; management of comorbidities; and long-term urate-lowering therapy (ULT) to prevent subsequent gout flares, structural joint damage, and shortening of life expectancy. In addition to trad..
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Hemato-oncology / Original Article
Characteristics and treatment patterns in older patients with locally advanced head and neck cancer (KCSG HN13-01)
Eun Joo Kang, Yun-Gyoo Lee, Bhumsuk Keam, Jin-Hyuk Choi, Jin-Soo Kim, Keon Uk Park, Kyoung Eun Lee, Hyo Jung Kim, Keun-Wook Lee, Min Kyoung Kim, Hee Kyung Ahn, Seong Hoon Shin, Jii Bum Lee, Jung Hye Kwon, Hye Ryun Kim, Sung-Bae Kim, Hwan Jung Yun
Korean J Intern Med. 2022;37(1):190-200. Published online December 21, 2021
Background/Aims: Treatment decisions for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) are complicated, and multi-modal treatments are usually indicated. However, it is challenging for older patients to complete treatments. Thus, we investigated disease characteristics, real-world..
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Pulmonology / Original Article
Efficacy and safety of mepolizumab in Korean patients with severe eosinophilic asthma from the DREAM and MENSA studies
Mi-Kyeong Kim, Hae-Sim Park, Choon-Sik Park, Soung-Jun Min, Frank C. Albers, Steven W. Yancey, Bhabita Mayer, Namhee Kwon
Korean J Intern Med. 2021;36(2):362-370. Published online May 26, 2020
Background/Aims: The efficacy and safety of mepolizumab in patients with severe eosinophilic asthma has been evaluated in a global clinical trial programme. This post hoc analysis assesses the efficacy and safety of mepolizumab in Korean patients.
Methods: Data from Korean patients in the Ph..
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Review
Systemic treatment for advanced urothelial cancer: an update on recent clinical trials and current treatment options
Inkeun Park, Jae Lyun Lee
Korean J Intern Med. 2020;35(4):834-853. Published online July 1, 2020
After cisplatin-based chemotherapy became the standard treatment for metastatic urothelial cancer (mUC), very little progress has been made in the treatment landscape of this condition until recently. With increased knowledge about the molecular biology of mUC and advances in the field of cancer imm..
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Review
Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications
Youngwoo Choi, Soyoon Sim, Hae-Sim Park
Korean J Intern Med. 2020;35(4):823-833. Published online May 29, 2020
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncon..
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Rheumatology / Original Article
Treatment patterns of knee osteoarthritis patients in Korea
Ha-Rim Park, Soo-Kyung Cho, Seul Gi Im, Sun-Young Jung, Dalho Kim, Eun Jin Jang, Yoon-Kyoung Sung
Korean J Intern Med. 2019;34(5):1145-1153. Published online March 21, 2018
Background/Aims: To evaluate the treatment patterns of knee osteoarthritis (OA) patients in South Korea.
Methods: Using the Korean nationwide claims database, all knee OA patients in Korea during 2014 were identified by the knee OA diagnostic code (M17) or any OA diagnostic code (M15 to M19) in com..
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Hemato-oncology / Original Article
Long-term rivaroxaban for the treatment of acute venous thromboembolism in patients with active cancer in a prospective multicenter trial
Ho-Young Yhim, Won-Il Choi, Sung-Hyun Kim, Seung-Hyun Nam, Kyoung Ha Kim, Yeung-Chul Mun, Doyeun Oh, Hun-Gyu Hwang, Keun-Wook Lee, Eun-Kee Song, Yong Shik Kwon, Soo-Mee Bang
Korean J Intern Med. 2019;34(5):1125-1135. Published online May 23, 2018
Background/Aims: Limited data are available regarding the efficacy of rivaroxaban for the treatment of cancer-associated venous thromboembolism (VTE). The aim of this study was to evaluate the effectiveness and safety of rivaroxaban for the treatment of VTE in active cancer patients.
Methods: In th..
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Infectious diseases / Original Article
Application of therapeutic plasma exchange in patients having severe fever with thrombocytopenia syndrome
Jeong Rae Yoo, Sun Hyung Kim, Young Ree Kim, Keun Hwa Lee, Won Sup Oh, Sang Taek Heo
Korean J Intern Med. 2019;34(4):902-909. Published online November 10, 2017
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever with a high fatality rate. However, effective treatments for SFTS cases not responded to supportive therapy have not been established. Herein, we introduced the therapeutic plasma exchange (TPE) in SFTS ..
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Cardiology / Review
Chronic venous insufficiency and varicose veins of the lower extremities
Young Jin Youn, Juyong Lee
Korean J Intern Med. 2019;34(2):269-283. Published online October 26, 2018
Chronic venous insufficiency (CVI) of the lower extremities manifests itself in various clinical spectrums, ranging from asymptomatic but cosmetic problems to severe symptoms, such as venous ulcer. CVI is a relatively common medical problem but is often overlooked by healthcare providers because of ..
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Gastroenterology / Review
Recent advances in the diagnosis and management of chronic pancreatitis
Chang-Il Kwon, Jae Hee Cho, Sung Hoon Choi, Kwang Hyun Ko, Temel Tirkes, Mark A. Gromski, Glen A. Lehman
Korean J Intern Med. 2019;34(2):242-260. Published online February 25, 2019
Chronic pancreatitis is a chronic condition characterized by pancreatic inflammation that causes fibrosis and the destruction of exocrine and endocrine tissues. Chronic pancreatitis is a progressive disease, and no physiological treatment is available to reverse its course. However, with advances in..
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Infectious diseases / Review
Vibrio vulnificus infection: a persistent threat to public health
Na Ra Yun, Dong-Min Kim
Korean J Intern Med. 2018;33(6):1070-1078. Published online June 15, 2018
Vibrio vulnificus is a gram-negative bacterium that can cause serious, potentially fatal infections. V. vulnificus causes three distinct syndromes: an overwhelming primary septicemia caused by consuming contaminated seafood, wound infections acquired when an open wound is exposed to contaminated war..
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Infectious diseases / Review
Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea
Young Ah Kim, Yoon Soo Park
Korean J Intern Med. 2018;33(2):247-255. Published online February 27, 2018
Antimicrobial resistance is becoming one of the greatest challenges to public health worldwide. Infections by antimicrobial-resistant organisms could result in the failure of treatment, increased medical costs, prolonged hospital stays, and an increased socioeconomic burden. Antimicrobial usage in K..
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Hemato-oncology / Original Article
Clinical features and treatment outcomes of blastic plasmacytoid dendritic cell neoplasm: a single-center experience in Korea
Hae Su Kim, Hee-Jin Kim, Sun-Hee Kim, Joon Young Choi, Young Hyeh Ko, Won Seog Kim, Chul Won Jung, Seok Jin Kim
Korean J Intern Med. 2017;32(5):890-899. Published online August 18, 2017
Background/Aims: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that typically presents in the form of skin manifestations with or without lymph node and bone marrow involvement. Given its rarity and recent recognition as a distinct pathological entity, no stan..
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Endocrinology-metabolism / Review
Treatment of diabetic kidney disease: current and future targets
Mi-Kyung Kim
Korean J Intern Med. 2017;32(4):622-630. Published online June 30, 2017
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease in Korea and worldwide, and is a risk factor for the development of cardiovascular complications. The conventional treatments for DKD are control of blood glucose and blood pressure levels by inhibiting the renin-angiotensin..
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Pulmonology / Original Article
Qualitative and quantitative results of interferon-γ release assays for monitoring the response to anti-tuberculosis treatment
I-Nae Park, Tae Sun Shim
Korean J Intern Med. 2017;32(2):302-308. Published online December 13, 2016
Background/Aims: The usefulness of interferon-γ release assays (IGRAs) in monitoring to responses to anti-tuberculosis (TB) treatment is controversial. We compared the results of two IGRAs before and after anti-TB treatment in same patients with active TB.
Methods: From a retrospective review, we..
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Infectious diseases / Review
Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?
Wing Wai Yew, Won-Jung Koh
Korean J Intern Med. 2016;31(1):15-29. Published online December 28, 2015
A worsening scenario of drug-resistant tuberculosis has increased the need for new treatment strategies to tackle this worldwide emergency. There is a pressing need to simplify and shorten the current 6-month treatment regimen for drug-susceptible tuberculosis. Rifamycins and fluoroquinolones, as we..
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Cardiology / Review
The scientific achievements of the decades in Korean Acute Myocardial Infarction Registry
Hyun Kuk Kim, Myung Ho Jeong, Seung Hun Lee, Doo Sun Sim, Young Joon Hong, Youngkeun Ahn, Chong Jin Kim, Myeong Chan Cho, Young Jo Kim
Korean J Intern Med. 2014;29(6):703-712. Published online October 31, 2014
The Korea Acute Myocardial Infarction Registry (KAMIR) was the first nationwide registry data collection designed to track outcomes of patients with acute myocardial infarction (AMI). These studies ref lect the current therapeutic approaches and management for AMI in Korea. The results of KAMIR coul..
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Review
Recent Paradigm Shifts in the Diagnosis and Treatment of Rheumatoid Arthritis
Young Ok Jung, Hyun Ah Kim
Korean J Intern Med. 2012;27(4):378-387. Published online November 27, 2012
Rheumatoid arthritis (RA) is a progressive inflammatory disease with severe symptoms of pain and stiffness. Chronic persistent inflammation of RA often leads to joint destruction, deformity and limitation of function, which ultimately results in significant deterioration of quality of life (QoL)...
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