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Hemato-oncology
Prognostic Significance Of Sequential 18f-fdg Pet/Ct During Frontline Treatment Of Peripheral T Cell Lymphomas
Ga-Young Song, Sung-Hoon Jung, Seo-Yeon Ahn, Mihee Kim, Jae-Sook Ahn, Je-Jung Lee, Hyeoung-Joon Kim, Jang Bae Moon, Su Woong Yoo, Seong Young Kwon, Jung-Joon Min, Hee-Seung Bom, Sae-Ryung Kang, Deok-Hwan Yang
Korean J Intern Med. 2024;39(2):327-337. Published online January 25, 2024
Background/Aims: The prognostic significance of 18F-fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET/CT) in peripheral T-cell lymphomas (PTCLs) are controversial. We explored the prognostic impact of sequential 18F-FDG PET/CT during frontline chemo..
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Rituximab plus multiagent chemotherapy for newly diagnosed CD20-positive acute lymphoblastic leukemia: a prospective phase II study
Dong Won Baek, Han-Seung Park, Sang Kyun Sohn, Dae Young Kim, Inho Kim, Jae-Sook Ahn, Young Rok Do, Se Ryeon Lee, Hyeon-Seok Eom, Won-Sik Lee, Sung-Hyun Kim, Ho Sup Lee, Yoo Jin Lee, Joon Ho Moon, Je-Hwan Lee; Adult Acute Lymphoblastic Leukemia Working Party, the Korean Society of Hematology
Korean J Intern Med. 2023;38(5):734-746. Published online June 20, 2023
Background/Aims: We performed a prospective study to determine the efficacy and safety of rituximab including chemotherapy in CD20-positive acute lymphoblastic leukemia (ALL).
Methods: Patients with newly diagnosed ALL, aged ≥ 15 years, were eligible for the study if their leukemic blast cells in ..
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Predictive role of absolute lymphocyte count in daratumumab-treated patients with relapsed/ refractory multiple myeloma
[corrected-article]
Hee Jeong Cho, Jae-Cheol Jo, Yoo Jin Lee, Myung Won Lee, Do Young Kim, Ho Jin Shin, Sung Nam Im, Ji Hyun Lee, Sung Hwa Bae, Young Rok Do, Won Sik Lee, Min Kyung Kim, Jina Jung, Jung Min Lee, Ju-Hyung Kim, Dong Won Baek, Sang-Kyun Sohn, Joon Ho Moon
Korean J Intern Med. 2023;38(2):238-247. Published online January 26, 2023
Background/Aims: Daratumumab has shown an encouraging antitumor effect in patients with multiple myeloma (MM), and was known to alter the immune properties by off-targeting immunosuppressive cells. Here, we aimed to evaluate the change in absolute lymphocyte count (ALC) as a surrogate marker for pre..
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Pulmonology
Granulocyte colony-stimulating factor in bronchoalveolar lavage fluid is a potential biomarker for prognostic prediction of idiopathic pulmonary fibrosis
Jong-Uk Lee, Jae Sung Choi, Min Kyung Kim, Sun A Min, Jong-Sook Park, Choon-Sik Park
Korean J Intern Med. 2022;37(5):979-988. Published online June 22, 2022
Background/Aims: Neutrophilia is frequently observed in bronchoalveolar lavage fluid (BALF) of idiopathic pulmonary fibrosis (IPF) patients. Granulocyte colony-stimulating factor (G-CSF) is a potent neutrophil-activating glycoprotein. However, the clinical implications of G-CSF remain poorly underst..
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Hemato-oncology
Influence of creatinine levels on survival in patients with veno-occlusive disease treated with defibrotide
Seom Gim Kong, Je-Hwan Lee, Young Tak Lim, Ji Hyun Lee, Hyeon-Seok Eom, Hyewon Lee, Do Young Kim, Sung-Nam Lim, Sung-Soo Yoon, Sung-Yong Kim, Ho Sup Lee
Korean J Intern Med. 2022;37(1):179-189. Published online December 14, 2021
Background/Aims: Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is one of the most fatal complications of hematopoietic cell transplantation (HCT), and defibrotide is the only curative drug. We conducted this study to confirm the survival rate of VOD/SOS patients diagnosed in Korea..
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Pulmonology
Pleuroparenchymal fibroelastosis in Korean patients: clinico-radiologic-pathologic features and 2-year follow-up
Jae Ha Lee, Eun Jin Chae, Joon Seon Song, Miae Kim, Jin Woo Song
Korean J Intern Med. 2021;36(Suppl 1):S132-S141. Published online February 24, 2020
Background/Aims: Pleuroparenchymal fibroelastosis (PPFE) is a type of rare idiopathic interstitial pneumonia that is characterized by predominantly upper lobe involvement with pleural fibrosis and subjacent parenchymal fibrosis. This study aimed to determine the clinico-radiologic-pathologic feature..
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Gastroenterology
Longstanding postoperative fluid collection influences recurrence of pancreatic malignancy
Young Jung Kim, Young Koog Cheon, Tae Yoon Lee, Seong-Hwan Chang, Mi-Hye Yu
Korean J Intern Med. 2021;36(6):1338-1346. Published online June 21, 2021
Background/Aims: Postoperative abdominal fluid collection (PAFC) is a frequent complication of pancreatobiliary cancer surgery. The effects of the existence and duration of PAFC are not well known. This study aimed to assess the effects of PAFC on patient prognosis after surgery for pancreatobiliary..
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Hemato-oncology
Clinical characteristics and survival of colorectal cancer patients in Korea stratified by age
Sun Kyung Baek, Ji Sung Lee, In Gyu Hwang, Jong Gwang Kim, Tae Won Kim, Seung Kook Sohn, Mi Yeon Kang, Sang-Cheol Lee
Korean J Intern Med. 2021;36(4):985-991. Published online April 6, 2021
Background/Aims: This nationwide study was undertaken to determine differences in clinicopathologic characteristics and survival of patients with colorectal cancer (CRC) according to age using big data from the Korean National Health Insurance Service (NHIS).
Methods: The NHIS data including qualit..
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Real-world data on the survival outcome of patients with newly diagnosed Waldenström macroglobulinemia
Jang Ho Cho, Joon-Ho Shim, Sang Eun Yoon, Hee-Jin Kim, Sun-Hee Kim, Young Hyeh Ko, Seung-Tae Lee, Kihyun Kim, Won Seog Kim, Seok Jin Kim
Korean J Intern Med. 2021;36(3):668-678. Published online August 14, 2020
Background/Aims: Waldenström macroglobulinemia (WM) is a rare lymphoproliferative disorder that usually follows an indolent clinical course. However, some patients show an aggressive clinical course leading to death. We explored the risk factors predicting poor prognosis in WM patients.
Methods: ..
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Impact of subsequent chemotherapy on the survival of elderly patients with extensive stage small cell lung cancer
Eun Joo Kang, Yoon Ji Choi, Se Ryeon Lee, Hwa Jung Sung, Jung Sun Kim
Korean J Intern Med. 2020;35(6):1468-1476. Published online April 29, 2020
Background/Aims: The prognosis of small cell lung cancer (SCLC) is still poor because of rapid recurrence, despite good response to initial chemotherapy. Additionally, patients’ old ages and comorbidities are often obstacles that make it difficult to apply subsequent treatment after initial treatm..
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Nephrology
Characteristics of kidney transplantation recipients over time in South Korea
Sehoon Park, Myoungsuk Kim, Ji Eun Kim, Kwangsoo Kim, Minsu Park, Yong Chul Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Korean J Intern Med. 2020;35(6):1457-1467. Published online March 30, 2020
Background/Aims: Detailed nationwide information regarding the recent status and time trends of kidney transplantation (KT) in South Korea is limited.
Methods: We performed a nationwide, population-based cohort study using the national claims database of Korea. We included KT recipients from 2008 t..
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Cardiology
Clinical significance of postoperative atrial arrhythmias in patients who underwent lung transplantation
Byung Gyu Kim, Jae-Sun Uhm, Pil-Sung Yang, Hee Tae Yu, Tae-Hoon Kim, Boyoung Joung, Hui-Nam Pak, Song Yee Kim, Moo Suk Park, Jin Gu Lee, Hyo Chae Paik, Moon-Hyoung Lee
Korean J Intern Med. 2020;35(4):897-905. Published online November 25, 2019
Background/Aims: Atrial arrhythmia (AA) occasionally occurs after lung transplantation (LT); however, risk factors for AA and their impact on clinical outcomes are inconsistent. We aimed to investigate the incidence, predisposing factors, and clinical outcomes of AA after LT.
Methods: We retrospect..
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Gastroenterology
Prognostic impact of hepatitis B or C on intrahepatic cholangiocarcinoma
Jung Woong Seo, Byung Soo Kwan, Young Koog Cheon, Tae Yoon Lee, Chan Sup Shim, So Young Kwon, Won Hyeok Choe, Byung Chul Yoo, Jeong Min Yoon, Jung Hoon Lee
Korean J Intern Med. 2020;35(3):566-573. Published online January 10, 2020
Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy, arising from the peripheral intrahepatic bile duct epithelium. Hepatitis B virus (HBV) or hepatitis C virus (HCV) may be involved in the development of ICC. We explored the prognostic value of ..
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Hemato-oncology
Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation
Taeyun Kim, Yunsuk Choi, Je-Hwan Lee, Silvia Park, Jae-Sook Ahn, Joon-Ho Moon, Ho-Jin Shin, Won Sik Lee, Dajung Kim, Ho Sup Lee
Korean J Intern Med. 2020;35(2):429-437. Published online January 10, 2019
Background/Aims: Rabbit anti-thymocyte globulin (ATG) is usually incorporated in hematopoietic stem cell transplantation (HSCT) to reduce the incidence of graft-versus-host disease (GVHD). This study aimed to find optimal ATG doses in patients undergoing human leukocyte antigen (HLA)-mismatched allo..
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Comparison of three risk stratification models for non-clear cell renal cell carcinoma patients treated with temsirolimus as first-line therapy
In Hee Lee, Byung Woog Kang, Jong Gwang Kim, Woo Kyun Bae, Myung Seo Ki, Inkeun Park, Jae-Cheol Jo, Jin Young Kim, Sung Ae Koh, Kyung Hee Lee, Yoon Young Cho, Hun Mo Ryoo, Sang Gyu Kwak, Jung Lim Lee, Sun Ah Lee
Korean J Intern Med. 2020;35(1):185-193. Published online October 12, 2018
Background/Aims: For metastatic renal cell carcinoma (RCC), various prognostic scoring systems have been developed. However, owing to the low prevalence of nonclear cell RCC, the three most commonly used tools were mainly developed based on patients with clear cell histology. Accordingly, this study..
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Poor prognostic factors in human papillomavirus-positive head and neck cancer: who might not be candidates for de-escalation treatment?
Shin Hye Yoo, Chan-Young Ock, Bhumsuk Keam, Sung Joon Park, Tae Min Kim, Jin Ho Kim, Yoon Kyung Jeon, Eun-Jae Chung, Seong Keun Kwon, J. Hun Hah, Tack-Kyun Kwon, Kyeong Chun Jung, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo
Korean J Intern Med. 2019;34(6):1313-1323. Published online November 16, 2018
Background/Aims: Since patients with human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have favorable outcomes after treatment, treatment de-escalation for these patients is being actively investigated. However, not all HPV-positive HNSCCs are curable, and some pati..
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Gastroenterology
Clinical outcomes of patients with a single hepatocellular carcinoma less than 5 cm treated with transarterial chemoembolization
Min Young Baek, Jeong-Ju Yoo, Soung Won Jeong, Jae Young Jang, Yong Kwon Kim, Shin Ok Jeong, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Su Yeon Park
Korean J Intern Med. 2019;34(6):1223-1232. Published online October 26, 2018
Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC ≤ 5 cm treated with TACE.
Methods: This study analyzed 175 conse..
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Evaluating the recent developments in palliative chemotherapy for metastatic colorectal cancer
Sun Kyung Baek, Kyu Taek Lee, Sang Byung Bae, Sang-Cheol Lee
Korean J Intern Med. 2019;34(6):1188-1196. Published online July 29, 2019
The incidence of colorectal cancer (CRC) has increased. CRC is the third most common cancer and the fourth most common cause of cancer-related deaths in Korea. Palliative chemotherapy can be used to shrink tumors and ease symptoms caused by the cancer when cure is not possible. It is important to id..
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Hemato-oncology
Clinical factors affecting progression-free survival with crizotinib in ALK-positive non-small cell lung cancer
Chan-Young Ock, Shin-Hye Yoo, Bhumsuk Keam, Miso Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Dae Seog Heo
Korean J Intern Med. 2019;34(5):1116-1124. Published online June 29, 2018
Background/Aims: Although crizotinib is standard chemotherapy for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), clinical factors affecting progression-free survival (PFS) have not been reported. The purpose of this study was to identify clinical factor..
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Costs and clinical outcomes of patients with diffuse large B-cell lymphoma in first remission: role of PET/CT surveillance
Koung Jin Suh, Ki Hwan Kim, Ryul Kim, Ja Min Byun, Miso Kim, Jin Hyun Park, Bhumsuk Keam, Tae Min Kim, Jin-Soo Kim, In Sil Choi, Dae Seog Heo
Korean J Intern Med. 2019;34(4):894-901. Published online February 23, 2018
Background/Aims: The role of [18F]-f luorodeoxyglucose positron emission tomography-computed tomography (PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL) in first remission is unclear.
Methods: Medical costs within the first 3 years of treatment completion and clinical outcomes of 118..
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