|
Pulmonology
Prolonged low-dose cyclophosphamide treatment after pulse therapy attenuates lung injury in rats with paraquat intoxication
Jie Gao, Shunyi Feng, Yong Li
Korean J Intern Med. 2018;33(6):1137-1142. Published online May 31, 2018
Background/Aims: This study tested the hypothesis that prolonged low-dose cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)-induced lung injury in rats.
Methods: PQ (25 mg/kg) was administered intraperitoneally to induce PQ-intoxicated rat model. The rats were randomly di..
|
|
|
Nephrology
The dose of cyclophosphamide for treating paraquat-induced rat lung injury
Jae-Sung Choi, Sung-Shick Jou, Mee-Hye Oh, Young-Hee Kim, Min-Ju Park, Hyo-Wook Gil, Ho-Yeon Song, Sae-Yong Hong
Korean J Intern Med. 2013;28(4):420-427. Published online July 1, 2013
Background/AimsCyclophosphamide (CP) is a promising treatment for severe cases of paraquat (PQ) poisoning. We investigated the effective dose of CP for mitigating PQ-induced lung injury. MethodsAdult male Sprague-Dawley rats were allocated into ..
|
|
|
Association of the Superoxide Dismutase (V16A) and Catalase (C262T) Genetic Polymorphisms with the Clinical Outcome of Patients with Acute Paraquat Intoxication
Joong-Rock Hong, Su-Jin Seok, Du-Shin Jeong, Sang-Gon Lee, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2010;25(4):422-428. Published online November 27, 2010
Background/AimsMany patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover. Therefore, it is possible that individual differences in antioxidant capacity are responsible for the variable clinical out..
|
|
|
Effect of Glutathione Administration on Serum Levels of Reactive Oxygen Metabolites in Patients with Paraquat Intoxication: A Pilot Study
Jung-Hoon Kim, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2010;25(3):282-287. Published online August 31, 2010
Background/AimsBased on preliminary in vitro data from a previous study, we proposed that 50 mg/kg glutathione (GSH) would be adequate for suppressing reactive oxygen species in patients with acute paraquat (PQ) intoxication. Methods</titl.. </div>
</td>
</tr>
</table>
</td>
</tr> <tr>
<td colspan="3">
<table cellpadding="0" cellspacing="0" border="0" id="article_tbl_162347" style="border:1px solid #ffffff; border-bottom:1px solid #E2E2E2;">
<tr>
<td style="padding-left:10px;padding-right:27px; padding-top:10px;padding-bottom:10px;width:733px;" valign="top" >
<div style="color:#0D52AD;"></div>
<a class="artiletitle" href="/journal/view.php?number=162347" onmouseover="showAbstract('162347' );" onmouseout="hideAbstract('162347' );"><b><font><font style='background-color:#CCE4CB'>Paraquat</font> Intoxication in Subjects Who Attempt Suicide: Why They Chose <font style='background-color:#CCE4CB'>Paraquat</font></font></b></a>
<div style="padding-top:2px;padding-left:0px" class="article_authors">Su-Jin Seok, Hyo-Wook Gil, Du-Shin Jeong, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong</div>
<div style="padding-top:2px;padding-left:0px" class="article_issue">
<em>Korean J Intern Med.</em> 2009;24(3):247-251. Published online August 26, 2009 </div>
<div class="doi">DOI: <a href="https://doi.org/10.3904/kjim.2009.24.3.247"><font class="doi">https://doi.org/10.3904/kjim.2009.24.3.247</font></a>
<a href="/journal/CitedByRenew.php?number=162347" onclick="window.open(this.href, 'CrossRef Citedby', 'width=800,height=800,scrollbars=yes');return false;" style="color:#DD434F;font-size:10pt;"> Crossref 58</a>
</div>
<div class="etc" style="padding-top:5px;text-align: right;">
<a href='/journal/view.php?number=162347' style='text-decoration:underline;color:#2046f8'><img src='/image/button/fulltext.gif' alt='Full Text' /></a> <a href='/journal/view.php?viewtype=pubreader&number=162347' style='text-decoration:underline;color:#2046f8'><img src='/image/button/pubreader.gif' alt='PubReader' /></a> <a style='cursor: pointer;' onclick='journal_download("epub", "162347", "path=L2hvbWUvdmlydHVhbC9rYWltL2pvdXJuYWwvdXBsb2FkL2VwdWIva2ppbS0yNC0yNDcuZXB1Yg==&filename=a2ppbS0yNC0yNDcuZXB1Yg==")'><img src='/image/button/epub.gif' alt='ePub' /></a> <a style='cursor: pointer;' onclick='journal_download("pdf", "162347", "kjim-24-247.pdf")'><img src='/image/button/pdf.gif' alt='PDF' /></a> </div>
<div id="162347" style="display:none;padding-top:10px;padding-left:0px; color:#7b7b7b">
<sec><title>Background/AimsParaquat (PQ) has been used in suicide attempts; an estimated 2,000 toxic ingestions occur annually, with 60-70% mortality. We sought to determine why PQ is such a common agent for suicide attempts in Korea. MethodsWe analyzed 250..
|
|
|
Marked Recovery From Paraquat-Induced Lung Injury During Long-Term Follow-up
Kwon-Hyun Lee, Hyo-Wook GIL, Young-Tong Kim, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong
Korean J Intern Med. 2009;24(2):95-100. Published online June 8, 2009
Background/AimsParaquat-induced lung injury has been considered a progressive and irreversible disease. The purpose of this study was to report the long-term evolution of lung lesions in eight survivors with significant paraquat-induced lung injuries who could be followed-up f..
|
|
|
Relationship between Pulmonary Surfactant Protein and Lipid Peroxidation in Lung Injury due to Paraquat Intoxication in Rats
Hyo-Wook Gil, Mi-Hae Oh, Kee-Min Woo, Eun-Young Lee, Myung-Ho Oh, Sae-Yong Hong
Korean J Intern Med. 2007;22(2):67-72. Published online June 30, 2007
BackgroundPulmonary damage resulting from lipid peroxidation is a principal effect of paraquat intoxication. The host-defense functions of surfactant are known to be mediated by the surfactant proteins A and D (SP-A and SP-D, respectively). The primary objective of this study ..
|
|
|
