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Steps to understanding diabetes kidney disease: a focus on metabolomics
Hyo Jin Kim, Sang Heon Song
Korean J Intern Med. 2024;39(6):898-905. Published online October 22, 2024
Diabetic nephropathy (DN), a leading cause of chronic kidney disease and end-stage kidney disease (ESKD), poses global health challenges given its increasing prevalence. DN increases the risk of mortality and cardiovascular events. Early identification and appropriate DN management are crucial. Howe..
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Omics-based biomarkers for diagnosis and prediction of kidney allograft rejection
Jeong-Hoon Lim, Byung Ha Chung, Sang-Ho Lee, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Chan-Duck Kim
Korean J Intern Med. 2022;37(3):520-533. Published online April 15, 2022
Kidney transplantation is the preferred treatment for patients with end-stage kidney disease, because it prolongs survival and improves quality of life. Allograft biopsy is the gold standard for diagnosing allograft rejection. However, it is invasive and reactive, and continuous monitoring is unreal..
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Pulmonology
Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model
Soo-Taek Uh, So-My Koo, An Soo Jang, Sung Woo Park, Jae Sung Choi, Yong-Hoon Kim, Choon Sik Park
Korean J Intern Med. 2015;30(1):62-72. Published online December 30, 2014
Background/Aims: Acute exacerbations in chronic obstructive pulmonary disease may be related to air pollution, of which ozone is an important constituent. In this study, we investigated the protein profiles associated with ozone-induced exacerbations in a smoking-induced emphysema model.
Methods: M..
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Allergy
A polymorphism in the histone deacetylase 1 gene is associated with the response to corticosteroids in asthmatics
Min-Hye Kim, Sae-Hoon Kim, Yook-Keun Kim, Soo-Jong Hong, Kyung-Up Min, Sang-Heon Cho, Heung-Woo Park
Korean J Intern Med. 2013;28(6):708-714. Published online October 29, 2013
Background/AimsRecent investigations suggest that histone deacetylase 1 (HDAC1) and HDAC2 may be target molecules to predict therapeutic responses to corticosteroids. We evaluated the effects of variation in HDAC1 and ..
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