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Pulmonology / Original Article
Clinical impact of pleural fluid carcinoembryonic antigen on therapeutic strategy and efficacy in lung adenocarcinoma patients with malignant pleural effusion
Jaehee Lee, Deok Heon Lee, Ji Eun Park, Yong Hoon Lee, Sun Ha Choi, Hyewon Seo, Seung Soo Yoo, Shin Yup Lee, Seung-Ick Cha, Jae Yong Park, Chang Ho Kim
Korean J Intern Med. 2024;39(2):318-326. Published online February 14, 2024
Background/Aims: Epidermal growth factor receptor (EGFR) mutation is important in determining the treatment strategy for advanced lung cancer patients with malignant pleural effusion (MPE). Contrary to serum carcinoembryonic antigen (S-CEA) levels, the associations between pleural fluid CEA (PF-CEA)..
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Hemato-oncology / Review
Long-acting interferon: pioneering disease modification of myeloproliferative neoplasms
Seug Yun Yoon, Sung-Yong Kim
Korean J Intern Med. 2023;38(6):810-817. Published online November 1, 2023
Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells. The malignant clones produce cytokines that drive self-perpetuating inflammatory responses and tend to transform into more aggressive clones, leading to disease progression. The progression of MPNs follows a biolog..
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Rheumatology / Original Article
Mutation of ten-eleven translocation-2 is associated with increased risk of autoimmune disease in patients with myelodysplastic syndrome
Yoon-Jeong Oh, Dong-Yeop Shin, Sang Mee Hwang, Sung-Min Kim, Kyongok Im, Hee Sue Park, Jung-Ah Kim, Yeong Wook Song, Ana Márquez, Javier Martín, Dong-Soon Lee, Jin Kyun Park
Korean J Intern Med. 2020;35(2):457-464. Published online October 25, 2019
Background/Aims: Myelodysplastic syndrome (MDS) is caused by genetic and epigenetic alteration of hematopoietic precursors and immune dysregulation. Approximately 20% of patients with MDS develop an autoimmune disease (AID). Here, we investigated whether particular genetic mutations are associated w..
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Review
Recent insights regarding the molecular basis of myeloproliferative neoplasms
Mi-Ae Jang, Chul Won Choi
Korean J Intern Med. 2020;35(1):1-11. Published online November 29, 2019
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders characterized by the overproduction of mature blood cells that have an increased risk of thrombosis and progression to acute myeloid leukemia. Next-generation sequencing studies have provided key insights regarding the..
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Letter to the editor
Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene
Jae Won Song, Hyo-Jeong Hwang, Chang Min Lee, Gun Ha Park, Chul Sik Kim, Seong Jin Lee, Sung-Hee Ihm
Korean J Intern Med. 2018;33(3):638-641. Published online January 16, 2017
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Letter to the editor
Two different KIT mutations may lead to different responses to imatinib in metastatic gastrointestinal stromal tumor
Eunjung Yim, Ho Jung An, Uiju Cho, Youngwoo Kim, Seung Hoon Kim, Yeon-Geun Choi, Byoung Yong Shim
Korean J Intern Med. 2018;33(2):432-434. Published online July 7, 2016
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Letter to the editor
A novel neurofibromatosis type 1 (NF1) mutation in a patient with NF1 and pheochromocytoma
Yoorim Seo, Yeonjeong Jeong, Dong Yoon Kim, Kyueun Choi, Eun Sook Kim, Sung Dae Moon, Je Ho Han
Korean J Intern Med. 2018;33(1):214-217. Published online November 29, 2017
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Letter to the editor
First Korean case of Emberger syndrome (primary lymphedema with myelodysplasia) with a novel GATA2 gene mutation
Sang Kyung Seo, Kyu Yeun Kim, Seo Ae Han, Joon Seok Yoon, Sang-Yong Shin, Sang Kyun Sohn, Joon Ho Moon
Korean J Intern Med. 2016;31(1):188-190. Published online December 28, 2015
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Letter to the editor
A novel PRKAR1A mutation resulting in a splicing variant in a case of Carney complex
Yi Sun Jang, Sung Dae Moon, Ju Hee Kim, Ihn Suk Lee, Jong Min Lee, Hye Soo Kim
Korean J Intern Med. 2015;30(5):730-734. Published online August 27, 2015
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Rheumatology / Original Article
The presence of MEFV gene mutations in patients with primary osteoarthritis who require surgery
Sedat Yilmaz, Hakan Erdem, Servet Tunay, Deniz Torun, Halil Genc, Yusuf Tunca, Omer Karadag, Ismail Simsek, Muhterem Bahce, Salih Pay, Ayhan Dinc
Korean J Intern Med. 2013;28(5):594-598. Published online August 14, 2013
Background/AimsChronic arthritis of familial Mediterranean fever (FMF) involves weight-bearing joints and can occur in patients without a history of acute attack. Our aim was to investigate a possible causal relationship between FMF and osteoarthritis in a population in which ..
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Original Article
Microarray Analysis of Papillary Thyroid Cancers in Korean
Hyun Sook Kim, Do Hyung Kim, Ji Yeon Kim, Nam Ho Jeoung, In Kyu Lee, Jin Gu Bong, Eui Dal Jung
Korean J Intern Med. 2010;25(4):399-407. Published online November 27, 2010
Background/AimsPapillary thyroid cancer (PTC) is the most common malignancy of the thyroid gland. It involves several molecular mechanisms. The BRAF V600E mutation has been identified as the most common genetic abnormality in PTC. Moreover, it is known to be m..
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Original Article
EGFR and KRAS Mutations in Patients With Adenocarcinoma of the Lung
Tae Won Jang, Chul Ho Oak, Hee Kyung Chang, Soon Jung Suo, Mann Hong Jung
Korean J Intern Med. 2009;24(1):48-54. Published online March 6, 2009
Background/AimsMutations of the epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) are important in the pathogenesis of lung cancer, and recent reports have revealed racial and geographical differences in mutation expression.
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Case Report
Resistance to Thyroid Hormone with Missense Mutation (V349M) in the Thyroid Hormone Receptor Beta Gene
Ji Yon Kim, Eun Suk Choi, Jong Chan Lee, Kyung Uk Lee, Yeo Joo Kim, Sang Jin Kim, Yong Wha Lee
Korean J Intern Med. 2008;23(1):45-48. Published online March 20, 2008
Resistance to thyroid hormone (RTH) is a syndrome characterized by reduced sensitivity to the thyroid hormone. It is generally caused by mutations in the thyroid hormone receptor β (TRβ) gene. On the basis of its clinical features, two different forms of this syndrome have been described: genera..
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Original Article
Diagnostic Usefulness of the Janus Kinase 2 Mutation in non BCR/ABL Myeloproliferative Disorders
Soo-Mee Bang, Jeong Yeal Ahn, Jiyoon Park, Soo Jin Yoo, Se Hoon Park, Eun Mi Nam, Pil Whan Park, Yiel Hea Seo, Eun Kyung Cho, Dong Bok Shin, Jae Hoon Lee
Korean J Intern Med. 2006;21(4):219-224. Published online December 31, 2006
BackgroundWe investigated the Janus kinase 2 (JAK2) mutation and its diagnostic value in patients suffering with non BCR/ABL myeloproliferative diseases (nMPD) or other reactive conditions. Methods..
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