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Gastroenterology / Original Article
The role of PD-1/PD-L1 pathway in ulcerative colitis and changes following tonsil-derived mesenchymal stem cells treatment
Eun Mi Song, Yang Hee Joo, Sung-Ae Jung, Ju-Ran Byeon, A-Reum Choe, Yehyun Park, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim
Korean J Intern Med. 2024;39(6):917-930. Published online November 1, 2024
Background/Aims: The programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway has not been fully evaluated in inflammatory bowel disease. We evaluated PD-1/PD-L1 levels in patients with ulcerative colitis (UC) and their significance in tonsil-derived mesenchymal stem cells (TMSCs) treatme..
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Geriatrics / Original Article
Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model
Heayon Lee, In Kyoung Kim, Jeonghyeon Im, Bae Suk Jin, Hwan Hee Kim, Sei Won Kim, Chang Dong Yeo, Sang Haak Lee
Korean J Intern Med. 2023;38(6):934-944. Published online October 5, 2023
Background/Aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we evaluated the effects of IH in an older mouse model of..
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Cardiology / Original Article
Clinical efficacy of angiotensin receptor-neprilysin inhibitor in de novo heart failure with reduced ejection fraction
Su Yeong Park, Min Gyu Kong, Inki Moon, Hyun Woo Park, Hyung-Oh Choi, Hye Sun Seo, Yoon Haeng Cho, Nae-Hee Lee, Kwan Yong Lee, Ho-Jun Jang, Je Sang Kim, Ik Jun Choi, Jon Suh
Korean J Intern Med. 2023;38(5):692-703. Published online August 31, 2023
Background/Aims: We aimed to analyze the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) by the disease course of heart failure (HF).
Methods: We evaluated 227 patients with HF in a multi-center retrospective cohort that included those with left ventricular ejection fraction (LVEF) ≤..
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Allergy / Original Article
MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β–Smad7 pathway
Jung Hur, Chin Kook Rhee, Sook Young Lee, Young Kyoon Kim, Ji Young Kang
Korean J Intern Med. 2021;36(3):706-720. Published online February 18, 2021
Background/Aims: Current asthma therapies remain unsatisfactory for controlling airway remodelling in asthma. MicroRNA-21 is a key player in asthma pathogenesis, but the molecular mechanisms underlying its effects on airway remodelling are not completely understood. We investigated the effects of in..
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Cardiology / Original Article
Left ventricular response after cardiac resynchronization therapy is related to early left atrial volume reduction
In-Jeong Cho, Jae-Sun Uhm, Jaewon Oh, Jong-Ho Nam, Hee Tae Yu, Taehoon Kim, Boyoung Joung, Seok-Min Kang
Korean J Intern Med. 2020;35(5):1125-1135. Published online February 6, 2020
Background/Aims: The current study aimed to elucidate a time-course change in left atrial volume after cardiac resynchronization therapy (CRT) and to verify factors associated with left atrial volume reduction (LAVR) and its prognostic implications.
Methods: The records of 97 patients were retrospe..
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Hemato-oncology / Original Article
Comparison of three risk stratification models for non-clear cell renal cell carcinoma patients treated with temsirolimus as first-line therapy
In Hee Lee, Byung Woog Kang, Jong Gwang Kim, Woo Kyun Bae, Myung Seo Ki, Inkeun Park, Jae-Cheol Jo, Jin Young Kim, Sung Ae Koh, Kyung Hee Lee, Yoon Young Cho, Hun Mo Ryoo, Sang Gyu Kwak, Jung Lim Lee, Sun Ah Lee
Korean J Intern Med. 2020;35(1):185-193. Published online October 12, 2018
Background/Aims: For metastatic renal cell carcinoma (RCC), various prognostic scoring systems have been developed. However, owing to the low prevalence of nonclear cell RCC, the three most commonly used tools were mainly developed based on patients with clear cell histology. Accordingly, this study..
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Hemato-oncology / Original Article
Clinical factors affecting progression-free survival with crizotinib in ALK-positive non-small cell lung cancer
Chan-Young Ock, Shin-Hye Yoo, Bhumsuk Keam, Miso Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Dae Seog Heo
Korean J Intern Med. 2019;34(5):1116-1124. Published online June 29, 2018
Background/Aims: Although crizotinib is standard chemotherapy for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), clinical factors affecting progression-free survival (PFS) have not been reported. The purpose of this study was to identify clinical factor..
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Allergy / Original Article
Different anti-remodeling effect of nilotinib and fluticasone in a chronic asthma model
Hye Seon Kang, Chin Kook Rhee, Hea Yon Lee, Hyoung Kyu Yoon, Soon Seok Kwon, Sook Young Lee
Korean J Intern Med. 2016;31(6):1150-1158. Published online October 20, 2016
Background/Aims: Inhaled corticosteroids are the most effective treatment currently available for asthma, but their beneficial effect against airway remodeling is limited. The tyrosine kinase inhibitor nilotinib has inhibitory activity against c-kit and the platelet-derived growth factor receptor. W..
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Pulmonology / Original Article
Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
Hwa Young Lee, Chin Kook Rhee, Ji Young Kang, Chan Kwon Park, Sook Young Lee, Soon Suk Kwon, Young Kyoon Kim, Hyoung Kyu Yoon
Korean J Intern Med. 2016;31(1):89-97. Published online December 28, 2015
Background/Aims: Asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Peroxisome proliferator-activated receptors have been reported to regulate inflammatory responses in many cells. In this study, we examined the effects of intranasal rosiglitazone on airway remodeli..
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Cardiology / Original Article
Interatrial septal thickness as a marker of structural and functional remodeling of the left atrium in patients with atrial fibrillation
Hong Euy Lim, Jin Oh Na, Sung Il Im, Cheol Ung Choi, Seong Hwan Kim, Jin Won Kim, Eung Ju Kim, Seong Woo Han, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Chun Hwang
Korean J Intern Med. 2015;30(6):808-820. Published online October 30, 2015
Background/Aims: There have been reports that interatrial septal (IAS) thickness is increased in patients with atrial fibrillation (AF). This study was performed to investigate whether IAS thickness determined by transthoracic echocardiography (TTE) represents the amount of left atrium (LA) structur..
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Rheumatology / Original Article
Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use
Mie Jin Lim, Seong Ryul Kwon, Kowoon Joo, Min Jung Son, Shin-Goo Park, Won Park
Korean J Intern Med. 2014;29(6):807-813. Published online October 31, 2014
Background/Aims: Our aim was to assess whether short-term treatment with soluble tumor necrosis factor (TNF) receptor affects circulating markers of bone metabolism in rheumatoid arthritis (RA) patients.
Methods: Thirty-three active RA patients, treated with oral disease-modifying antirheumatic dru..
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Cardiology / Review
Recent technological updates and clinical applications of induced pluripotent stem cells
Sebastian Diecke, Seung Min Jung, Jaecheol Lee, Ji Hyeon Ju
Korean J Intern Med. 2014;29(5):547-557. Published online August 28, 2014
Induced pluripotent stem cells (iPSCs) were first described in 2006 and have since emerged as a promising cell source for clinical applications. The rapid progression in iPSC technology is still ongoing and directed toward increasing the efficacy of iPSC production and reducing the immunogenic and t..
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Cardiology / Original Article
Effect of anemia correction on left ventricular structure and filling pressure in anemic patients without overt heart disease
In-Jeong Cho, Yeung Chul Mun, Ki Hwan Kwon, Gil Ja Shin
Korean J Intern Med. 2014;29(4):445-453. Published online June 27, 2014
Background/Aims: There are few data on the effects of low hemoglobin levels on the left ventricle (LV) in patients without heart disease. The objective of this study was to document changes in the echocardiographic variables of LV structure and function after the correction of anemia without signif..
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Original Article
Effects of D-003 (10 mg/day) on Bone Mineral Density of the Lumbar Spine and Femoral Neck in Postmenopausal Women: A Randomized, Double-Blinded Study
Alfredo Ceballos, Gladys Castaño, Sarahí Mendoza, Juan González, Rosa Mas, Lilia Fernández, José Illnait, Meilis Mesa, Rafael Gámez, Julio César Fernández, Ricardo Telles, Duany Marrero, Mainel Gómez Eng, Dalmer Ruiz, Yunaisi Jardines
Korean J Intern Med. 2011;26(2):168-178. Published online June 1, 2011
Background/AimsIncreased osteoclast activity is a pivotal finding in osteoporosis. This increase is mediated via the mevalonate-to-cholesterol pathway, which is involved in producing the intermediates required for osteoclast activity. D-003, a mixture of high molecular weight ..
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Original Article
Remodeling of Ion Channel Expression in Patients with Chronic Atrial Fibrillation and Mitral Valvular Heart Disease
Seil Oh, Ki-Bong Kim, Hyuk Ahn, Hyun-Ju Cho, Yun-Shik Choi
Korean J Intern Med. 2010;25(4):377-385. Published online November 27, 2010
Background/AimsUnderlying cardiac pathology and atrial fibrillation (AF) affect the molecular remodeling of ion channels in the atria. Changes in the expression of these molecules have not been demonstrated in Korean patients with mitral valvular heart disease. Thus, the purp..
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Original Article
Effect of the Combined Use of Tramadol and Milnacipran on Pain Threshold in an Animal Model of Fibromyalgia
Seong-Ho Kim, Junhwa Song, Hyunil Mun, Keon Uk Park
Korean J Intern Med. 2009;24(2):139-142. Published online June 8, 2009
Background/AimsAcidic saline injections produce mechanical hyperresponsiveness in male Sprague-Dawley rats. We investigated the effect of milnacipran in conjunction with tramadol on the pain threshold in an acidic saline animal model of pain. Methods</tit.. </div>
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<div style="color:#C62F37;font-family:'Noto Sans KR', 'Nanum Gothic', sans-serif;">Original Article </div>
<a class="artiletitle" href="/journal/view.php?number=15622" onmouseover="showAbstract('15622' );" onmouseout="hideAbstract('15622' );"><b><font>Comparison of Asthma Phenotypes Using Different Sensitizing Protocols in Mice</font></b></a>
<div style="padding-top:2px;padding-left:0px" class="article_authors">Yoon-Seok Chang, Yoon-Keun Kim, Joon-Woo Bahn, Sang-Heon Kim, Heung-Woo Park, Tae-Bum Kim, Sang-Heon Cho, Kyung-Up Min, You-Young Kim</div>
<div style="padding-top:2px;padding-left:0px" class="article_issue">
<em>Korean J Intern Med.</em> 2005;20(2):152-158. Published online June 30, 2005 </div>
<div class="doi">DOI: <a href="https://doi.org/10.3904/kjim.2005.20.2.152"><font class="doi">https://doi.org/10.3904/kjim.2005.20.2.152</font></a>
<a href="/journal/CitedByRenew.php?number=15622" onclick="window.open(this.href, 'CrossRef Citedby', 'width=800,height=800,scrollbars=yes');return false;" style="color:#DD434F;font-size:10pt;"> Crossref 14</a>
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<a href='/journal/view.php?number=15622' style='text-decoration:underline;color:#2046f8'><img src='/image/button/fulltext.gif' alt='Full Text' /></a> <a href='/journal/view.php?viewtype=pubreader&number=15622' style='text-decoration:underline;color:#2046f8'><img src='/image/button/pubreader.gif' alt='PubReader' /></a> <a style='cursor: pointer;' onclick='journal_download("epub", "15622", "path=L2hvbWUvdmlydHVhbC9rYWltL2pvdXJuYWwvdXBsb2FkL2VwdWIva2ppbS0yMC0xNTIuZXB1Yg==&filename=a2ppbS0yMC0xNTIuZXB1Yg==")'><img src='/image/button/epub.gif' alt='ePub' /></a> <a style='cursor: pointer;' onclick='journal_download("pdf", "15622", "kjim-20-152.pdf")'><img src='/image/button/pdf.gif' alt='PDF' /></a> </div>
<div id="15622" style="display:none;padding-top:10px;padding-left:0px; color:#7b7b7b">
<sec><title>BackgroundSeveral methods have been reported to induce asthmatic reactions in mice but few studies have compared their efficiency. We evaluated the efficiency of the protocols frequently used in the literature. MethodsBALB/c mice were sensitized..
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