|
Diagnostic and therapeutic advances in adults with acute lymphoblastic leukemia in the era of gene analysis and targeted immunotherapy
Jae-Ho Yoon, Seok Lee
Korean J Intern Med. 2024;39(1):34-56. Published online January 1, 2024
Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological malignancies with advanced understanding of the genetic landscape, detection methods of minimal residual disease (MRD), and the development of immunotherapeutic agents with good clinical outcomes. The annual inciden..
|
|
|
Hemato-oncology
Pediatric-inspired regimen with late intensification and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study
Dong Won Baek, Dae Young Kim, Sang Kyun Sohn, Youngil Koh, Sung-Hoon Jung, Ho-Young Yhim, Yunsuk Choi, Joon Ho Moon
Korean J Intern Med. 2021;36(6):1471-1485. Published online September 24, 2021
Background/Aims: The objective of this study was to evaluate the efficacy and feasibility of the pediatric-inspired regimen of the adult acute lymphoblastic leukemia (ALL) Working Party, the Korean Society of Hematology.
Methods: Data of 99 patients with newly diagnosed ALL, who were treated with t..
|
|
|
|
|
Feasibility of Non-TBI Conditioning with Busulfan and Fludarabine for Allogeneic Stem Cell Transplantation in Lymphoid Malignancy
Ho Cheol Shin, Yoo Jin Lee, Joon Ho Joon Ho, Soo Jung Lee, Byung Woog Kang, Yee Soo Chae, Jong Gwang Kim, Jun Young Choi, Jong Won Seo, Yu Kyung Kim, Jang Soo Suh, Sang Kyun Sohn
Korean J Intern Med. 2012;27(1):72-83. Published online February 28, 2012
Background/AimsThis retrospective study evaluated the transplantation outcomes of patients with adult lymphoid malignancies who received chemotherapy-based conditioning with busulfan and fludarabine (BuFlu) and busulfan and cyclophosphamide (BuCy2). Method.. </div>
</td>
</tr>
</table>
</td>
</tr> </table>
</td>
</tr>
</form>
</table>
<div style="width: 100%; margin: 0 auto; float:left;">
<ul class="pager">
<li><a class="on" href="">1</a></li>
</ul>
</div>
</div>
<div class="aside">
<div class="journal" style='padding-top:0px;padding-bottom:60px;'>
<dl style='height:100px;'>
<dd style='float:left;'><img src='/upload/thumbnails/kjim-39-6-cover.jpg' border='0' width='118px' title='Volume 39, No. 6'></dd>
<dd style='float:left;padding:10px 0px 0px 20px;'>
<p style='font-size:1.3em;font-weight:bold;color:#C62F37;padding-bottom:10px;'>Korean Journal of<br/>Internal Medicine</p>
<p style='font-size:1.0em;line-height:178%;'>
Print ISSN: 1226-3303<br/>
Online ISSN: 2005-6648<br/>
</p>
</dd>
</dl>
</div>
<ul class="moreInfo">
<li>
<a href="https://submit.kjim.org/" target="_blank">
<img src="/image2/main/e_submission.gif" title="E-Submission">
</a>
</li>
<li>
<a href="https://mjl.clarivate.com/cgi-bin/jrnlst/jlresults.cgi?PC=MASTER&ISSN=1226-3303" target="_blank">
<div style="position: relative;background-size:cover;background-image:url('/image/300v2_impact_factor_2022.jpg');width:300px;height:47px;font-family: 'Roboto', 'Noto Sans KR', sans-serif">
<div style='position:absolute;left:225px;top:7px;color:#6817FF;font-weight:bold;font-size:15pt;'>
2.2
</div>
</div>
</a>
</li>
<li>
<a href="/articles/covid19.php"><img src="/image/covid19.jpg" alt="Impact factor" /></a>
</li>
<li style='padding-top:25px;'>
<style>
div.aside li section {
display: none;
padding: 0px 0 0;
border-top: 1px solid #ddd;}
div.aside li input {
display: none !important;}
div.aside li label {
display: inline-block;
margin: 0 0 -1px;
padding: 10px 0px;
font-weight: 600;
text-align: center;
color: #999;
width:147px;
font-size:1.1em;}
div.aside li label:hover {
color: #C62F37;
cursor: pointer;}
/*input 클릭시, label 스타일*/
div.aside li input:checked + label {
color: #555;
border: 1px solid #ddd;
border-top: 4px solid #C62F37;
border-bottom: 1px solid #ffffff;}
div.aside li #tab1:checked ~ #content1,
div.aside li #tab2:checked ~ #content2 {
display: block;}
</style>
<input id="tab2" type="radio" name="tabs" checked> <!--디폴트 메뉴-->
<label for="tab2">MOST VIEWED</label>
<input id="tab1" type="radio" name="tabs"> <!--디폴트 메뉴-->
<label for="tab1">MOST CITED</label>
<!-- <input id="tab2" type="radio" name="tabs">
<label for="tab2">AHEAD-OF PRINT</label> -->
<section id="content2">
<dl><dd><table style='border-left:1px solid #eee;border-right:1px solid #eee;'> <tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='middel'>5,886</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170635' style='font-weight:bold;'>Metformin and its therapeutic applications in autoimmune inflammatory rheumatic disease</a>
</td>
</tr>
<tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='middel'>4,457</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170519' style='font-weight:bold;'>Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells</a>
</td>
</tr>
<tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='middel'>790</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170938' style='font-weight:bold;'>Efficacy of single-dose evolocumab injection in early-phase acute myocardial infarction: a retrospective single-center study</a>
</td>
</tr>
<tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='middel'>4,625</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170427' style='font-weight:bold;'>Cancer risk in Korean patients with gout</a>
</td>
</tr>
<tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='middel'>5,867</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170471' style='font-weight:bold;'>MicroCLOTS pathophysiology in coronavirus disease 2019</a>
</td>
</tr>
</table></dd></dl> <p align='right' style='font-size:1.2em;padding-right:5px;'><a href='/articles/mostread.php'>+more</a></p>
</section>
<section id="content1">
<dl><dd><table style='border-left:1px solid #eee;border-right:1px solid #eee;'> <tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='top'>Cited By<br/>25</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170635' style='font-weight:bold;'>Metformin and its therapeutic applications in autoimmune inflammatory rheumatic disease</a>
</td>
</tr>
<tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='top'>Cited By<br/>18</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170427' style='font-weight:bold;'>Cancer risk in Korean patients with gout</a>
</td>
</tr>
<tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='top'>Cited By<br/>18</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170519' style='font-weight:bold;'>Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells</a>
</td>
</tr>
<tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='top'>Cited By<br/>18</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170642' style='font-weight:bold;'>Reference diameter and characteristics of the distal radial artery based on ultrasonographic assessment</a>
</td>
</tr>
<tr>
<td style='width:65px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;' align='center' valign='top'>Cited By<br/>17</td>
<td style="width:233px;padding-left:10px;margin-bottom:10px;border-bottom:1px solid #ddd;padding-bottom:10px;padding-top:10px;padding-right:5px;" valign="top">
<a href='/journal/view.php?number=170660' style='font-weight:bold;'>Emotional and cognitive changes in chronic kidney disease</a>
</td>
</tr>
</table></dd></dl> <p align='right' style='font-size:1.2em;padding-right:5px;'><a href='/articles/mostcited.php'>+more</a></p>
</section>
<li>
<a href="/metrics/metrics_total_down_ref.php" onclick="window.open(this.href, 'Metrics_Total_View', 'width=720, height=845,scrollbars=yes');return false;" style="cursor:pointer;">
<img src="/image2/b_Metrics.jpg" title="More information">
</a>
</li>
<li>
<img src="/image2/b_fast.jpg" title="Please note that KJIM offers fast track process for articles reporting results of multi-center prospective studies, epidemiologic studies using big data and Randomized Controlled Trials. Relevant articles will undergo an expedited peer-review and editing process to ensure fast electronic publication.">
</li>
<li style="margin-top:15px;background-color:#E5E5E5;padding-top:15px;padding-bottom:15px;text-align:center;">
<a href="http://www.scimagojr.com/journalsearch.php?q=26663&tip=sid&exact=no" title="SCImago Journal & Country Rank" target="_blank"><img border="0" src="https://www.scimagojr.com/journal_img.php?id=26663&title=true" alt="SCImago Journal & Country Rank" /></a>
</li>
<li>
<div id="vis"></div>
<script>var tags =[{"key": "", "value": 9067},{"key": "CT", "value": 44},{"key": "Arthritis, rheumatoid", "value": 31},{"key": "Neoplasms", "value": 28},{"key": "NO", "value": 20},{"key": "chronic", "value": 19},{"key": "Risk factors", "value": 18},{"key": "tuberculosis", "value": 17},{"key": "Diabetes", "value": 14},{"key": "Diabetes mellitus", "value": 13},{"key": "Hepatocellular", "value": 13},{"key": "Epidemiology", "value": 13},{"key": "rheumatoid", "value": 13},{"key": "kidney", "value": 12},{"key": "Transplantation", "value": 11},{"key": "Myocardial infarction", "value": 11},{"key": "Coronary artery disease", "value": 11},{"key": "Therapy", "value": 11},{"key": "Percutaneous coronary intervention", "value": 10},{"key": "endoscopic", "value": 10},{"key": "Prognosis", "value": 10},{"key": "Men", "value": 10},{"key": "Leukemia", "value": 10},{"key": "pneumonia", "value": 10},{"key": "Renal Insufficiency", "value": 9},{"key": "Treatment outcome", "value": 9},{"key": "chronic obstructive", "value": 9},{"key": "Lymphoma", "value": 9},{"key": "Colonoscopy", "value": 9},{"key": "Survival", "value": 9}];</script> <script src="https://d3js.org/d3.v3.min.js" charset="utf-8"></script>
<script src="https://publishing.m2comm.kr/script/d3.layout.cloud.js"></script>
<script type="text/javascript" src="/script/word-cloud.js"></script>
</li>
<style>
.dep__div{display:inline-block; zoom:1;*display:inline; font-size:14px;margin-bottom:5px;vertical-align:middle;text-align:center;margin-right:5px;}
.dep__div:nth-child(5n){margin-right:0;}
/*.dep__div:nth-child(odd){margin-right:5px;}*/
.dep__div a{width:144px;background-color:#3F3F3F;color:#ffffff;height:40px; display:table;}
.dep__div a span{display:table-cell; vertical-align:middle;text-align:center;line-height:120%;}
.dep__div .dep__a{width:144px;background-color:#3F3F3F;color:#ffffff;height:40px; display:table;}
</style>
<li>
<ul class="moreInfo">
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="http://www.ncbi.nlm.nih.gov/pmc/journals/904/" target="_blank"><img src="/image2/banner/pmc.gif" alt="PMC" title="PMC" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&term=%22Korean%20J%20Intern%20Med%22%5BJournal%5D" target="_blank"><img src="/image2/banner/pubmed.gif" alt="PubMed" title="PubMed" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="http://www.e-sciencecentral.org/journals/163/" target="_blank"><img src="/image2/banner/ScienceCentral_174_45.gif" alt="ScienceCentral" title="ScienceCentral" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.scopus.com/sourceid/26663" target="_blank"><img src="/image2/banner/scopus.gif" alt="scopus" title="scopus" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="http://scholar.google.com/scholar?as_publication=The Korean Journal of Internal Medicine&as_q=" target="_blank"><img src="/image2/banner/GoogleScholar.gif" alt="GoogleScholar" title="GoogleScholar" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://koreamed.org/volumes/64" target="_blank"><img src="/image2/banner/koreamed.gif" alt="KoreaMed" title="KoreaMed" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.komci.org/JournalVolume.php?id=64" target="_blank"><img src="/image2/banner/komci.gif" alt="KoMCI" title="KoMCI" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://doaj.org/toc/2005-6648" target="_blank"><img src="/image2/banner/DOAJ_174_45.gif" alt="DOAJ" title="DOAJ" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.crossref.org/services/similarity-check/" target="_blank"><img src="/image2/banner/CrossRef_Similarity_Check_174_45.gif" alt="Similarity Check" title="Similarity Check" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.crossref.org/services/cited-by/" target="_blank"><img src="/image2/banner/CrossRef_Cited_by_174_45.gif" alt="Crossref Cited-by Linking" title="Crossref Cited-by Linking" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.crossref.org/services/crossmark/" target="_blank"><img src="/image2/banner/Crossmark_174_45.gif" alt="CrossMark" title="CrossMark" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.crossref.org/services/funder-registry/" target="_blank"><img src="/image2/banner/Funder_Registry_174_45.gif" alt="Funder Registry" title="Funder Registry" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.crossref.org/members/prep/2270" target="_blank"><img src="/image2/banner/metadata.gif" alt="Metadata" title="Metadata" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="http://publicationethics.org/" target="_blank"><img src="/image2/banner/COPE.gif" alt="COPE" title="COPE" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.kofst.or.kr/main.bit?sys_type=0000" target="_blank"><img src="/image2/banner/KOFST_174_45.gif" alt="KOFST" title="KOFST" style="width:141px;height:38px;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.hanmi.co.kr" target="_blank"><img src="/image2/banner/ban_hanmi.gif" alt="hanmi" title="hanmi" style="width:137px;height:36px;border:1px solid #DBDBDB;" /></a></li>
<li style="float: left;margin:3px 3px 1px 3px;padding:3px 3px 3px 0px;"><a href="https://www.janssen.com/korea" target="_blank"><img src="/image2/banner/janssen_174_45.gif" alt="janssen" title="janssen" style="width:137px;height:36px;border:1px solid #DBDBDB;" /></a></li>
</ul>
</li>
<li>
<ul class="moreInfo" style='display:inline-block;'>
</ul>
</li>
<li style='padding-top:0px;'>
<a href="https://www.youtube.com/channel/UC1VxbnuIbMI9JdmhLQnFzdw/featured" target="_blank"><img src="/image2/ban_youtube_240920.jpg" style='border:1px solid #d6d6d6;margin-left:3px;padding:5px 8px;' title="youtube"></a>
</li>
</ul>
</div>
<!-- //aside -->
</div>
<hr />
<div class="footerWrap">
<div>
<dl>
<dt>Editorial Office</dt>
<dd>
101-2501, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea<br/>
Tel: +82-2-2271-6792 Fax: +82-2-790-0993 E-mail: <a href="mailto:kaim@kams.or.kr" class="link">kaim@kams.or.kr</a>
<script>
document.addEventListener('DOMContentLoaded', function() {
document.getElementById('view_mobile_site').addEventListener('click', function(event) {
event.preventDefault();
var url = '/articles/search_result.php?key=Lymphoblastic+leukemia&term=4';
document.cookie = "mobileView=; expires=Thu, 01 Jan 1970 00:00:00 UTC; path=/;";
window.location.href = url;
});
});
</script>
</dd>
</dl>
<p>Copyright © <a href="https://eng.kaim.or.kr/" target='_blank'>2024 by Korean Association of Internal Medicine.</a></p>
</div>
</div>
<!-- //footerWrap -->
</div>
<!-- //wrapper -->
<style>
#overlay { display: none; position: absolute; top: 0px; left: 0px; width: 100%; height: 100%; z-index: 999; }
#overlay #overlay_close { margin:25px auto 0px auto; height: 20px; text-align: right; }
#overlay #main_image_wrap { margin:25px auto 25px auto; height: 448px; text-align: center; }
</style>
<div id="overlay">
<div style="width:900px; background-color: rgba(208,208,208,0.85); border: 1px solid #a0a0a0; padding-bottom: 25px; margin: auto;">
<div id="overlay_close"><img src="/image/b_close.png" alt="Close layer" onclick="closePhotoView(); return false;" style="cursor:pointer;margin-right:25px;" /></div>
<div id="main_image_wrap"><table style="margin: auto;"><tr>
<td onclick="mImage_sliding('prev')" valign="middle" style="cursor: pointer;"><img src="/image/b_prev.png" alt="prev" border="0" /></td>
<td valign="middle" style="width: 800px;height:448px;"><img id="main_image" src="" width="800" height="448" /></td>
<td onclick="mImage_sliding('next')" valign="middle" style="cursor: pointer;"><img src="/image/b_next.png" alt="next" border="0" /></td>
</tr></table></div>
</div>
</div>
<script>
/* Image Slide */
var thumb_array = new Array();
var thumb_index = 0;
// $(window).scroll(function () {
// var y = $(this).scrollTop();
// $("#overlay").css("margin-top", y+100);
// });
function mImage_sliding(dir) {
if(dir == 'next') {
thumb_index++;
if(thumb_index >= thumb_array.length) {
thumb_index--;
return false;
}
} else {
thumb_index--;
if(thumb_index < 0) {
thumb_index++;
return false;
}
}
changeMainImage(thumb_array[thumb_index]);
}
function openPhotoView(obj) {
var y = $(this).scrollTop();
$("#overlay").css("margin-top", y+100);
$("#overlay").show();
thumb_array = new Array();
$(obj).parent().parent().find('img.thumb').each(function (index) {
thumb_array.push($(this).attr("src"));
if($(obj).attr("src") == $(this).attr("src")) {
thumb_index = index;
changeMainImage($(this).attr("src"));
}
});
}
function openPhotoView2() {
var y = $(this).scrollTop();
$("#overlay").css("margin-top", y+100);
$("#overlay").show();
thumb_array = new Array();
var src_data = $("#ss_516").html();
console.log(src_data);
}
/*
function openPhotoView2() {
var y = $(this).scrollTop();
$("#overlay").css("margin-top", y+100);
$("#overlay").show();
thumb_array = new Array();
$("#ss_516").find('img.thumb').each(function (index) {
if(index != 0) {
thumb_array.push($("#ss_516").attr("src"));
if($("#ss_516").attr("src") == $(this).attr("src")) {
thumb_index = index;
changeMainImage($(this).attr("src"));
}
}
});
console.log(thumb_array);
}
*/
function closePhotoView() {
$('#overlay').hide();
thumb_array = new Array();
}
function changeMainImage(src) {
$("<img />").attr("src", src).load(function() {
var ratio = 800 / this.width;
var width = this.width * ratio;
var height = this.height * ratio;
if(height > 448) {
ratio = 448 / this.height;
width = this.width * ratio;
height = this.height * ratio;
}
$("#overlay #main_image_wrap #main_image").attr('src', this.src);
$("#overlay #main_image_wrap #main_image").attr('width', width);
$("#overlay #main_image_wrap #main_image").attr('height', height);
});
}
/* Image Slide End */
</script>
</body>
</html> | | |
