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Cardiology
Sex differences in clinical characteristics and long-term outcome in patients with heart failure: data from the KorAHF registry
Hyue Mee Kim, Hack-Lyoung Kim, Myung-A Kim, Hae-Young Lee, Jin Joo Park, Dong-Ju Choi; on the behalf of the KorAHF Investigators
Korean J Intern Med. 2024;39(1):95-109. Published online December 14, 2023
Background/Aims: Sex differences in the prognosis of heart failure (HF) have yielded inconsistent results, and data from Asian populations are even rare. This study aimed to investigate sex differences in clinical characteristics and long-term prognosis among Korean patients with HF.
Methods: A tot..
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Clinical efficacy of angiotensin receptor-neprilysin inhibitor in de novo heart failure with reduced ejection fraction
Su Yeong Park, Min Gyu Kong, Inki Moon, Hyun Woo Park, Hyung-Oh Choi, Hye Sun Seo, Yoon Haeng Cho, Nae-Hee Lee, Kwan Yong Lee, Ho-Jun Jang, Je Sang Kim, Ik Jun Choi, Jon Suh
Korean J Intern Med. 2023;38(5):692-703. Published online August 31, 2023
Background/Aims: We aimed to analyze the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) by the disease course of heart failure (HF).
Methods: We evaluated 227 patients with HF in a multi-center retrospective cohort that included those with left ventricular ejection fraction (LVEF) ≤..
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Role of cardiac imaging in management of heart failure
So Ree Kim, Seong-Mi Park
Korean J Intern Med. 2023;38(5):607-619. Published online August 29, 2023
The significant advancement in cardiac imaging in recent years led to improved diagnostic accuracy in identifying the specific causes of heart failure and also provided physicians with guidelines for appropriately managing patients with heart failure. Diseases that were once considered rare are now ..
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Optimization of guideline-directed medical treatment for heart failure patients with reduced ejection fraction
Minjung Bak, Jin-Oh Choi
Korean J Intern Med. 2023;38(5):595-606. Published online September 1, 2023
With the increasing number of medications demonstrating mortality benefits in heart failure with reduced ejection fraction (HFrEF), the pharmacological treatment of HFrEF is entering a new phase. To enhance outcomes in heart failure patients through medical treatment, the choice of appropriate medic..
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Cardiology
Development and validation of equation for cardiorespiratory fitness in patients with heart failure with preserved ejection fraction
Byambakhand Battumur, Ji Eun Lee, Soo Hyung Park, You-Jung Choi, Dong Oh Kang, Eun Jin Park, Ji Bak Kim, Jah Yeon Choi, Seung Young Roh, Jin Oh Na, Cheol Ung Choi, Jin Won Kim, Seung Woon Rha, Chang Gyu Park, Eung Ju Kim
Korean J Intern Med. 2023;38(4):514-525. Published online June 20, 2023
Background/Aims: Cardiorespiratory fitness (CRF), as measured by maximal oxygen consumption (VO2max), is an important independent predictive factor of cardiovascular outcomes in patients with heart failure (HF). However, it is unclear whether conventional equations for estimating CRF are applicable ..
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Advanced heart failure: a contemporary approach
Kyeong-Hyeon Chun, Seok-Min Kang
Korean J Intern Med. 2023;38(4):471-483. Published online June 28, 2023
Advanced heart failure (HF) is defined as the persistence of severe symptoms despite the use of optimized medical, surgical, and device therapies. These patients require timely advanced treatments, such as heart transplantation or long-term mechanical circulatory support (MCS). Inotropic agents are ..
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Cardiology
The role of discharge checklist in guideline-directed medical therapy for heart failure patients
Helsi Rismiati, Kyu-Sun Lee, Jeehoon Kang, Hyun-Jai Cho, Hae-Young Lee
Korean J Intern Med. 2023;38(2):195-206. Published online February 21, 2023
Background/Aims: Initiation of guideline-directed medical therapy (GDMT) during hospitalization is recommended for patients with heart failure (HF). However, GDMT is underutilized in real-world practice. This study evaluated the role of a discharge checklist on GDMT.
Methods: This was a single-cent..
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Obesity-related heart failure with preserved ejection fraction: diagnostic and therapeutic challenges
Mi-Hyang Jung, Mi-Seung Shin
Korean J Intern Med. 2023;38(2):157-166. Published online February 6, 2023
The prevalence of heart failure with preserved ejection fraction (HFpEF) has increased in recent decades. In particular, obesity-related HFpEF is a distinct and frequently encountered phenotype; however, its diagnosis is complex. Furthermore, the management of obesity-related HFpEF has not been esta..
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Cardiology
Clinical outcome in patients with end-stage heart failure who underwent continuous-flow left ventricular assist devices in a single center
Yoonjee Park, Darae Kim, Jeong Hoon Yang, Yang Hyun Cho, Jin-Oh Choi, Eun-Seok Jeon
Korean J Intern Med. 2022;37(2):340-349. Published online December 7, 2021
Background/Aims: The continuous flow left ventricular assist device (cf-LVAD) has improved the survival of chronic end-stage heart failure (HF) patients. Here we describe our clinical experience of the initial 50 LVAD patients from a single center.
Methods: A total of 50 patients underwent LVAD imp..
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HFA-PEFF scores: prognostic value in heart failure with preserved left ventricular ejection fraction
Koichi Egashira, Daisuke Sueta, Takashi Komorita, Eiichiro Yamamoto, Hiroki Usuku, Takanori Tokitsu, Koichiro Fujisue, Taiki Nishihara, Fumi Oike, Masafumi Takae, Shinsuke Hanatani, Seiji Takashio, Miwa Ito, Kenshi Yamanaga, Satoshi Araki, Hirofumi Soejima, Koichi Kaikita, Kenichi Matsushita, Kenichi Tsujita
Korean J Intern Med. 2022;37(1):96-108. Published online December 21, 2021
Background/Aims: The Heart Failure Association (HFA)-PEFF score is recognized as a simple method to diagnose heart failure (HF) with preserved ejection fraction (HFpEF). This study aimed to evaluate the relationship between HFA-PEFF scores and cardiovascular outcomes in HFpEF patients.
Methods: A to..
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Is there sufficient evidence to justify changes in dietary habits in heart failure patients? A systematic review
Alejandra García-García, Luis A. Alvarez-Sala-Walther, Hae-Young Lee, Cristina Sierra, Domingo Pascual-Figal, Miguel Camafort
Korean J Intern Med. 2022;37(1):37-47. Published online September 6, 2021
The incidence and prevalence of heart failure (HF) is increasing worldwide, leading to high morbidity and mortality. The global management of HF involves lifestyle changes in addition to pharmacological treatments. Changes include exercise and dietary recommendations, mainly salt and fluid restricti..
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Cardiology
Update on association between exposure to renin-angiotensin-aldosterone system inhibitors and coronavirus disease 2019 in South Korea
Jeongkuk Seo, Minkook Son
Korean J Intern Med. 2021;36(Suppl 1):S114-S122. Published online February 25, 2021
Background/Aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angiotensin-aldosterone system (RAAS) inhibitors and the risk and severity of COVID-19.
Methods: We performed a case-control study that util..
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The effect of beta-blockers in acute heart failure according to heart rate
Hyun-Jin Kim, Sang-Ho Jo, Min-Ho Lee, Won-Woo Seo, Jin-Oh Choi, Kyu-Hyung Ryu
Korean J Intern Med. 2021;36(4):898-905. Published online September 21, 2020
Background/Aims: Beta-blockers (BBs) have been shown to improve clinical outcomes in heart failure (HF) patients. We evaluated the prescribing status of BBs in patients with HF with reduced ejection fraction (HFrEF) at discharge according to the presence or not of bradycardia, and its effect on prog..
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Fimasartan, an angiotensin II receptor antagonist, ameliorates an in vivo zebrafish model of heart failure
Hailian Quan, Gyu Chul Oh, Seung Hyeok Seok, Hae-Young Lee
Korean J Intern Med. 2020;35(6):1400-1410. Published online March 13, 2020
Background/Aims: Angiotensin II in the failing heart initially helps to maintain cardiac output and blood pressure, but ultimately accelerates its deterioration. In this study, we established a model of arrhythmia-induced heart failure (HF) in zebrafish and investigated the role of renin-angiotensi..
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J-curve relationship between corrected QT interval and mortality in acute heart failure patients
Chan Soon Park, Hyun-Jai Cho, Eue-Keun Choi, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Jin-Oh Choi, Eun-Seok Jeon, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Byungsu Yoo, Dong-Ju Choi, Youngkeun Ahn, Kye-Hoon Kim, Myeong-Chan Cho, Byung-Hee Oh, Hae-Young Lee
Korean J Intern Med. 2020;35(6):1371-1384. Published online May 8, 2020
Background/Aims: This study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex.
Methods: We analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4..
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Heart failure with preserved ejection fraction: insights from recent clinical researches
[corrected-article]
Mi-Na Kim, Seong-Mi Park
Korean J Intern Med. 2020;35(3):514-534. Published online April 29, 2020
Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for nearly half of the cases of HF and its incidence might be increasing with the aging society. Patients with HFpEF present with significant symptoms, including exercise intolerance, impaired quality of life, and have a poor progn..
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Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence
Hong-Mi Choi, Mi-Seung Shin
Korean J Intern Med. 2020;35(3):498-513. Published online April 29, 2020
Heart failure (HF) is a growing health concern in aging societies worldwide. Sacubitril/valsartan is changing the real-world treatment in the whole spectrum of HF. The beginning was the PARADIGM-HF trial published in 2014, which demonstrated the beneficial effects of inhibiting natriuretic peptide b..
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Current status of heart failure: global and Korea
Jin Joo Park, Dong-Ju Choi
Korean J Intern Med. 2020;35(3):487-497. Published online April 29, 2020
Heart failure (HF) is a condition in which the heart is unable to pump enough blood to meet the body’s needs for blood and oxygen. Thus, HF is a grave disease with high morbidity and mortality. Because the prevalence of and exposure to the risk factors for HF increase with age, the prevalence of H..
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Cardiology
Attitudes toward advance directives and prognosis in patients with heart failure: a pilot study
JinShil Kim, Minjeong An, Seongkum Heo, Mi-Seung Shin
Korean J Intern Med. 2020;35(1):109-118. Published online February 15, 2019
Background/Aims: Advance directives (ADs) in Korean patients with heart failure (HF) and the associations of attitude towards ADs and HF prognosis with ADs were initially assessed using the model of the Korean-Advance Directive (K-AD).
Methods: Twenty-four patients with HF (age, 67.1 years; men, 58..
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The mortality benefit of carvedilol versus bisoprolol in patients with heart failure with reduced ejection fraction
Ki Hong Choi, Ga Yeon Lee, Jin-Oh Choi, Eun-Seok Jeon, Hae-Young Lee, Sang Eun Lee, Jae-Joong Kim, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Hyun-Young Park, Byung-Hee Oh
Korean J Intern Med. 2019;34(5):1030-1039. Published online October 16, 2018
Background/Aims: It is unknown whether different β-blockers (BBs) have variable effects on long-term survival of patients with heart failure with reduced ejection fraction (HFrEF). This study compares the effects of two BBs, carvedilol and bisoprolol, on survival in patients with HFrEF.
Methods: ..
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