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Gut microbiota dysbiosis and its impact on asthma and other lung diseases: potential therapeutic approaches
Young-Chan Kim, Kyoung-Hee Sohn, Hye-Ryun Kang
Korean J Intern Med. 2024;39(5):746-758. Published online August 30, 2024
The emerging field of gut-lung axis research has revealed a complex interplay between the gut microbiota and respiratory health, particularly in asthma. This review comprehensively explored the intricate relationship between these two systems, focusing on their influence on immune responses, inflamm..
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Gastroenterology
Clinical course of asymptomatic duodenal subepithelial lesions
Seokin Kang, Kwangbeom Park, Do Hoon Kim, Yuri Kim, Hee Kyong Na, Jeong Hoon Lee, Ji Yong Ahn, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Korean J Intern Med. 2024;39(4):603-611. Published online June 13, 2024
Background/Aims: There is limited knowledge regarding the management of duodenal subepithelial lesions (SELs) owing to a lack of understanding of their natural course. This study aimed to assess the natural course of asymptomatic duodenal SELs and provide management recommendations.
Methods: Patien..
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Reduced risk of gastrointestinal bleeding associated with eupatilin in aspirin plus acid suppressant users: nationwide population-based study
Hyun Seok Lee, Ji Hyung Nam, Dong Jun Oh, Yeo Rae Moon, Yun Jeong Lim
Korean J Intern Med. 2024;39(2):261-271. Published online December 14, 2023
Background/Aims: Mucoprotective agents, such as eupatilin, are often prescribed to prevent gastrointestinal (GI) bleeding in addition to an acid suppressant despite the absence of a large-scale study. We evaluated the additional effect of eupatilin on the prevention of GI bleeding in both the upper ..
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Risk factors for anticoagulant-associated gastrointestinal hemorrhage: a systematic review and meta-analysis
Fuxin Ma, Shuyi Wu, Shiqi Li, Zhiwei Zeng, Jinhua Zhang
Korean J Intern Med. 2024;39(1):77-85. Published online December 8, 2023
Background/Aims: There may be many predictors of anticoagulation-related gastrointestinal bleeding (GIB), but until now, systematic reviews and assessments of the certainty of the evidence have not been published. We conducted a systematic review to identify all risk factors for anticoagulant-associ..
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Comparative study of the efficacy and safety of Abexol (suspension versus tablets) in patients with gastrointestinal symptoms
Alfredo Hierro González, Julio César Fernández Travieso, Yoandy Hernández Casas, Susana Borges González, María de los Angeles Camacho Morales, Elena Ferrer Batallie, Anaisa Roja Carralera, Yenney Reyes Nuñez, Sarahi Mendoza Castaño, Maytee Robaina García, Diana Margarita Rey Kaba
Korean J Intern Med. 2024;39(1):57-67. Published online November 30, 2023
Background/Aims: Abexol is a mixture of primary aliphatic alcohols purified from beeswax (Apis mellifera), that produces anti-inflammatory, antioxidant and gastroprotective effects, as well as it is safe and well tolerated. To investigate and compare the efficacy and safety of Abexol (suspens..
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Pulmonology
Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
Ji Yeon Choi, Bora Shim, Youngmok Park, Young Ae Kang
Korean J Intern Med. 2023;38(6):879-892. Published online October 23, 2023
Background/Aims: Although the incidence of nontuberculous mycobacteria pulmonary disease (NTM-PD), a chronic infectious disease, is increasing, lung and gut microbiota dysbiosis in NTM patients has rarely been studied and was therefore the focus of this study.
Methods: We analyzed the microbiota di..
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Gastroenterology
Association between eupatilin and reduction in small bowel bleeding in aspirin users and aspirin plus acid suppressant users
Hyun Seok Lee, Ji Hyung Nam, Dong Jun Oh, Hyun Jung Ahn, Yun Jeong Lim
Korean J Intern Med. 2023;38(4):484-492. Published online May 19, 2023
Background/Aims: Capsule endoscopy (CE) has shown that low-dose aspirin occasionally causes small bowel (SB) bleeding. We herein evaluated the protective effects of mucoprotective agents (MPAs) on SB bleeding in aspirin users using the nationwide database of claims data from the National Health Insu..
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Clinical outcomes of acute upper gastrointestinal bleeding according to the risk indicated by Glasgow-Blatchford risk score-computed tomography score in the emergency room
Hyun Ae Lee, Hye-Kyung Jung, Tae Oh Kim, Ju-Ran Byeon, Eui-Sun Jeong, Hyun-Ji Cho, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Ki-Nam Shim, Sung-Ae Jung
Korean J Intern Med. 2022;37(6):1176-1185. Published online November 1, 2022
Background/Aims: Acute upper gastrointestinal (UGI) bleeding is a significant emergency situation with a mortality rate of 2% to 10%. Therefore, initial risk stratification is important for proper management. We aimed to evaluate the role of contrast-enhanced multidetector computed tomography (MDCT)..
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The effect of rebamipide on non-steroidal anti-inflammatory drug-induced gastro-enteropathy: a multi-center, randomized pilot study
Dong Jun Oh, Hyuk Yoon, Hyun Soo Kim, Yoon Jin Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, You-Jung Ha, Eun Ha Kang, Yun Jong Lee, Nayoung Kim, Ki-Jeoung Kim, Fei Liu
Korean J Intern Med. 2022;37(6):1153-1166. Published online November 1, 2022
Background/Aims: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly-used medications, and ailments such as arthritis or heart disease, require long-term use of these drugs, which can induce gastroenteropathy with bleeding and ulcers. This study investigated the associations between efficacy..
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Gastric Coccidioidomycosis Presenting As Gastric Outlet Obstruction
Taher Jamali, Kati Choi, Syed Tasleem, Neda Zarrin-Khameh, Robert J. Sealock
Korean J Intern Med. 2022;37(1):241-242. Published online March 17, 2021
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Rheumatology
Reliability and validity of the Korean version of the University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract instrument in patients with systemic sclerosis
Tae Hee Lee, Joon Seong Lee, Suyeon Park, Kyung-Ann Lee, Hyun-Sook Kim
Korean J Intern Med. 2021;36(6):1504-1514. Published online February 10, 2021
Background/Aims: Systemic sclerosis (SSc) is associated with a wide range of gastrointestinal (GI) changes. The University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract (UCLA SCTC GIT 2.0) instrument is a self-administered GI assessment instrument for patie..
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Gastroenterology
Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals
Weitao Shen, Jiayu Sun, Zhiyang Li, Fen Yao, Kaihuang Lin, Xiaoyang Jiao
Korean J Intern Med. 2021;36(3):568-583. Published online November 10, 2020
Background/Aim: It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types of intestinal flora remains to be clarified. We aimed to analyze the associations between food intake and intestinal flora ..
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The clinical impact of gut microbiota in chronic kidney disease
So Mi Kim, Il han Song
Korean J Intern Med. 2020;35(6):1305-1316. Published online September 29, 2020
Gut microorganisms play critical roles in both maintaining host homeostasis and the development of diverse diseases. Gut dysbiosis, an alteration of the composition and function of gut microorganisms, is commonly seen in patients with chronic kidney disease (CKD). CKD itself contributes to a disrupt..
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Gastroenterology
Predictors for the need for endoscopic therapy in patients with presumed acute upper gastrointestinal bleeding
Su Sun Kim, Kyung Up Kim, Sung Jun Kim, Seung In Seo, Hyoung Su Kim, Myoung Kuk Jang, Hak Yang Kim, Woon Geon Shin
Korean J Intern Med. 2019;34(2):288-295. Published online December 15, 2017
Background/Aims: Selecting patients with an urgent need for endoscopic hemostasis is difficult based only on simple parameters of presumed acute upper gastrointestinal bleeding. This study assessed easily applicable factors to predict cases in need of urgent endoscopic hemostasis due to acute upper ..
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Hemato-oncology
Prevalence of and factors associated with anxiety and depression in Korean patients with newly diagnosed advanced gastrointestinal cancer
Junghwa Chung, Gawon Ju, Jiyoul Yang, Jiwon Jeong, Yusook Jeong, Moon Ki Choi, Jihyun Kwon, Ki Hyeong Lee, Seung Taik Kim, Hye Sook Han
Korean J Intern Med. 2018;33(3):585-594. Published online February 14, 2017
Background/Aims: The purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer.
Methods: One hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer ..
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Synchronous diffuse large B-cell lymphoma of the small intestine and adenocarcinoma of the colon
Ji Hyun Yang, Jain Lee, Shin Bum Kim, Seon Hoo Kim, Guk Jin Lee
Korean J Intern Med. 2018;33(2):438-441. Published online November 10, 2017
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Two different KIT mutations may lead to different responses to imatinib in metastatic gastrointestinal stromal tumor
Eunjung Yim, Ho Jung An, Uiju Cho, Youngwoo Kim, Seung Hoon Kim, Yeon-Geun Choi, Byoung Yong Shim
Korean J Intern Med. 2018;33(2):432-434. Published online July 7, 2016
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Gastroenterology
Early versus late bedside endoscopy for gastrointestinal bleeding in critically ill patients
Jee Hyun Kim, Ji Hye Kim, Jaeyoung Chun, Changhyun Lee, Jong Pil Im, Joo Sung Kim
Korean J Intern Med. 2018;33(2):304-312. Published online March 15, 2017
Background/Aims: Gastrointestinal (GI) bleeding is a life-threatening complication in critically ill patients. The aim of this study was to determine the efficacy of bedside endoscopy in an intensive care unit (ICU) setting, and to compare the outcomes of early endoscopy (within 24 hours of detectin..
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Erythromycin infusion prior to endoscopy for acute nonvariceal upper gastrointestinal bleeding: a pilot randomized controlled trial
Hee Kyong Na, Hwoon-Yong Jung, Dong Woo Seo, Hyun Lim, Ji Yong Ahn, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Jin-Ho Kim
Korean J Intern Med. 2017;32(6):1002-1009. Published online March 28, 2017
Background/Aims: The aim of this study was to compare the effects of erythromycin infusion and gastric lavage in order to improve the quality of visualization during emergency upper endoscopy.
Methods: We performed a prospective randomized pilot study. Patients presented with hematemesis or melena..
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Rheumatology
Ileocolonoscopic findings in patients with ankylosing spondylitis: a single center retrospective
study
Soo Min Ahn, Yong-Gil Kim, Seung-Hyeon Bae, Doo-Ho Lim, Seokchan Hong, Sang Hyoung Park, Chang-Keun Lee, Bin Yoo
Korean J Intern Med. 2017;32(5):916-922. Published online August 11, 2017
Background/Aims: In some Western countries, up to 50% of patients with ankylosing spondylitis (AS) have subclinical gut inflammation. This study was conducted to evaluate the prevalence and severity of gut inflammation and to determine clinical factors associated with colonic inflammation in Korean ..
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