|
Gastroenterology / Original Article
Association of age-adjusted skeletal muscle index and modest alcohol intake with hepatic steatosis and fibrosis in males
Janghan Jung, Jin Lee, Dong Hee Koh, Jung Hee Kim
Korean J Intern Med. 2026;41(6):1065-1076. Published online November 1, 2026
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern linked to obesity, insulin resistance, and metabolic syndrome. Although body composition and alcohol intake influence disease progression, their specific associations with hepatic ste..
|
|
|
Pulmonology / Review
Gastroesophageal reflux disease as a comorbidity in chronic lung diseases: mechanism, clinical impacts and therapeutic uncertainty
Jin-Young Huh, Jin Woo Song
Korean J Intern Med. 2026;41(6):995-1009. Published online November 1, 2026
Chronic lung diseases, particularly chronic obstructive pulmonary disease and interstitial lung disease, are major contributors to global morbidity and mortality. Gastroesophageal reflux disease (GERD) is highly prevalent in these populations and has been implicated in exacerbations and disease prog..
|
|
|
Pulmonology / Review
Epidemiology and clinical characteristics of progressive pulmonary fibrosis in Asia
Ju Hyun Oh, Felicia S. W. Teo, Hee-Young Yoon, Jin Woo Song
Korean J Intern Med. 2026;41(6):982-994. Published online November 1, 2026
Progressive pulmonary fibrosis (PPF) represents a progressive phenotype across various fibrosing interstitial lung diseases (ILDs). The epidemiology of PPF is confounded by differences in the defining criteria for PPF, data capture sources, as well as the heterogeneity of ILD subtype diagnoses. In As..
|
|
|
Pulmonology / Review
Epidemiology of interstitial lung diseases in Asia
Hee-Young Yoon, Felicia S. W. Teo, Ju Hyun Oh, Jin Woo Song
Korean J Intern Med. 2026;41(6):969-981. Published online November 1, 2026
The epidemiology of interstitial lung diseases (ILDs) in Asia has gained increasing attention with the emergence of new population- based datasets and national registries. Current evidence demonstrates that the burden and subtype distribution of ILDs vary considerably across regions, reflecting diff..
|
|
|
Allergy / Original Article
Clinical and immunologic features of adult primary antibody deficiency according to IVIGRT exposure
Jung-Eun Han, Hyun young Lee, Haeng Jun Kim, Yoo Seob Shin, Yeong-Min Ye, Hae-Sim Park
Korean J Intern Med. 2026;41(5):940-951. Published online September 1, 2026
Background/Aims: Primary antibody deficiency (PAD) in adults is increasingly recognized, but remains underdiagnosed and undertreated. We described the clinical and immunologic features of adult patients with PAD according to real-world exposure to intravenous immunoglobulin replacement therapy (IVIGR..
|
|
|
Endocrinology-metabolism / Original Article
Diabetes progression and severe hypoglycemia: a nationwide cohort study of 2,475,605 adults with type 2 diabetes mellitus
Kyu-Na Lee, Bongseong Kim, Mee Kyoung Kim, Sukil Kim
Korean J Intern Med. 2026;41(5):916-926. Published online September 1, 2026
Background/Aims: Severe hypoglycemia (SH) is a major concern in type 2 diabetes mellitus (T2DM). We evaluated whether a composite diabetes progression score could predict incident SH.
Methods: Using the Korean National Health Insurance Service database, we identified 2,475,605 adults with T2DM who und..
|
|
|
Cardiology / Original Article
Prognostic implications of functional significance, high-risk plaque and vessel characteristics in patients with diabetes mellitus
Jin-Eun Song, Seokhun Yang, Masahiro Hoshino, Taishi Yonetsu, Jinlong Zhang, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, Bon-Kwon Koo
Korean J Intern Med. 2026;41(5):873-883. Published online September 1, 2026
Background/Aims: We investigated the prognostic value of high-risk plaque (HRP) and high-risk vessel (HRV) characteristics on coronary computed tomography angiography (CCTA) alongside fractional flow reserve (FFR) in patients with diabetes mellitus (DM).
Methods: We analyzed 307 vessels from 184 dia..
|
|
|
Gastroenterology / Original Article
Population-specific rare variants influence age at diagnosis in Korean inflammatory bowel disease
Mina Cho, DongHwan Shin, Jongwook Yu, Jae Hee Cheon, Ju Han Kim
Korean J Intern Med. 2026;41(5):847-857. Published online September 1, 2026
Background/Aims: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is increasing in East Asia. Most known susceptibility loci, identified primarily in Europeans, remain insufficient to explain clinical heterogeneity in Asians. We performed whole-exome..
|
|
|
Pulmonology / Review
Health effects of air pollution on chronic respiratory diseases
Yong Suk Jo, Jin Woo Song
Korean J Intern Med. 2026;41(5):831-846. Published online September 1, 2026
Exposure to both outdoor and indoor air pollution poses significant global public health challenges at all life stages. As the respiratory system serves as the primary entry route for inhaled pollutants, extensive evidence has demonstrated the detrimental effects of various air pollutants on respira..
|
|
|
Rheumatology / Original Article
Association of hyperuricemia with valvular heart disease and the modifying effect of obesity
Seung Min Jung, Sang-Hyuk Jung, Su-Nam Lee, Jin A Choi, Dokyoon Kim, Hong-Hee Won, Jae-Seung Yun
Korean J Intern Med. 2026;41(4):748-762. Published online July 1, 2026
Background/Aims: Hyperuricemia has been widely associated with cardiovascular health, but its relationship with incident valvular heart disease (VHD) remains uncertain. This study investigated the association between hyperuricemia and VHD, and further explored the role of weight management within thi..
|
|
|
Gastroenterology / Original Article
The 2020 disease burden and economic implications of digestive diseases in Korea: a nation-wide comprehensive study
Eui Sun Jeong, Hye-Kyung Jung, Younhee Kim, Hyung Seok Lim
Korean J Intern Med. 2026;41(4):649-662. Published online July 1, 2026
Background/Aims: Digestive diseases are highly prevalent and contribute substantially to healthcare utilization and costs. However, national-level data on digestive diseases burden in Korea are limited. This study aimed to estimate the healthcare burden of digestive diseases in Korea via a national ..
|
|
|
Rheumatology / Review
Autoimmune diseases in the era of COVID-19: emerging mechanisms, clinical implications, vaccine considerations, and future directions
Jaehyun Kong, Seohyun Hong, Jiyeon Oh, Sooji Lee, Lee Smith, Francesco Branda, Hanseul Cho, Jiyoung Hwang, Dong Keon Yon
Korean J Intern Med. 2026;41(4):597-619. Published online July 1, 2026
The coronavirus disease 2019 (COVID-19) pandemic has highlighted a complex, bidirectional relationship between SARSCoV-2 infection and autoimmune diseases. This review examines how SARS-CoV-2 infection influences the incidence, progression, and outcomes of five major autoimmune conditions: systemic ..
|
|
|
Gastroenterology / Review
Recent advances in the management of small bowel Crohn’s disease
Kwangwoo Nam, Hee Seok Moon
Korean J Intern Med. 2026;41(4):563-571. Published online July 1, 2026
Crohn’s disease (CD) is a chronic inflammatory disorder of the bowel characterized by alternating periods of remission and relapse. Although CD can affect any part of the gastrointestinal tract, small bowel involvement is particularly common and generally considered a more challenging subtype than..
|
|
|
Endocrinology-metabolism / Original Article
Does physical activity reduce cardiovascular risk associated with knee osteoarthritis in type 2 diabetes? A nationwide cohort study
Dojoon Park, Kyuho Kim, Hae-Seok Koh, Kyungdo Han, Youn-Ho Choi
Korean J Intern Med. 2026;41(3):485-500. Published online May 1, 2026
Background/Aims: Knee osteoarthritis (OA), type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) share overlapping mechanisms but are often managed independently. We evaluated whether knee OA increases CVD risk in Korean T2DM patients and whether physical activity (PA) modifies this risk..
|
|
|
Gastroenterology / Original Article
Incidence and risk factors of rebleeding in Crohn’s disease patients with acute lower gastrointestinal bleeding
Gabin Moon, Kyeong Ok Kim, Sung Noh Hong, Seong Joon Koh, Sung Hoon Jung, Chang Hwan Choi, Eun Mi Song, Hong Sub Lee, Yoo Jin Lee, Ki Bae Bang; On behalf of the IBD Research Group of the Korean Association for the Study of Intestinal Diseases
Korean J Intern Med. 2026;41(3):454-461. Published online May 1, 2026
Background/Aims: Acute lower gastrointestinal bleeding (LGIB) in Crohn’s disease (CD) is a rare but potentially life-threatening complication. This study aimed to investigate the incidence and risk factors of rebleeding in CD patients with LGIB.
Methods: We retrospectively analyzed 137 CD patient..
|
|
|
Hospital medicine / Original Article
Global burden of adverse effects of medical treatment from 1990 to 2021: a Global Burden of Disease Study 2021
GBD 2021 AEMT Collaborators, Yi Deun Jeong, Seoyoung Park, Wonwoo Jang, Min Seo Kim, A Bhoomadevi et al.
Korean J Intern Med. 2026;41(2):350-366. Published online March 1, 2026
Background/Aims: This study aims to evaluate the global burden of adverse effects of medical treatment (AEMT) using data from the Global Burden of Disease Study (GBD) 2021.
Methods: Data were extracted from the GBD 2021, covering 204 countries/territories from 1990 to 2021. AEMT was defined using I..
|
|
|
Rheumatology / Original Article
Cross-cultural adaptation and preliminary validation of the Korean version of the Psoriatic Arthritis Impact of Disease-12 questionnaire
Bon San Koo, Jung Gon Kim, Bo Young Yoon, Ji-Hyoun Kang, Sung-Eun Choi, Sooin Jung, Seyeong Kim, Tae-Jong Kim
Korean J Intern Med. 2026;41(2):341-349. Published online March 1, 2026
Background/Aims: The Psoriatic Arthritis Impact of Disease (PsAID-12) questionnaire was developed to measure quality of life and disease impact in patients with psoriatic arthritis (PsA). We aimed to translate the English PsAID-12 into Korean and to evaluate its reliability and validity.
Methods: T..
|
|
|
Gastroenterology / Review
The epidemiology of inflammatory bowel disease: exploring the impacts of environmental factors
Jihye Park, Jae Hee Cheon
Korean J Intern Med. 2026;41(2):186-196. Published online December 4, 2025
Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are distinct chronic immune-mediated intestinal inflammatory disorders. The pathogenesis of IBD is complex and involves a combination of genetic and environmental factors, the gut microbiome, and the host immune syste..
|
|
|
Cardiology / Original Article
Comparative efficacy and safety of warfarin and direct oral anticoagulants in patients with end-stage kidney disease and atrial fibrillation
[corrected-article]
Yujin Yang, Sun Hwa Lee, Wonmook Hwang, Ji Hoon Jung, Jae-Hyeong Park
Korean J Intern Med. 2026;41(1):107-117. Published online January 1, 2026
Background/Aims: Patients with atrial fibrillation (AF) and end-stage kidney disease (ESKD) require careful anticoagulation because thrombotic and bleeding risks are both elevated. We evaluated the efficacy and safety of warfarin, direct oral anticoagulants (DOACs), and no anticoagulation in Korean ..
|
|
|
Gastroenterology / Original Article
Prevalence of viral hepatitis A and C in patients with inflammatory bowel disease: a nationwide population-based study in South Korea
Jin Hwa Park, Sang Hyoung Park, Sang Pyo Lee, Kang Nyeong Lee, Hang Lak Lee, Oh Young Lee, Soorack Ryu, Junwon Go
Korean J Intern Med. 2026;41(1):95-106. Published online January 1, 2026
Background/Aims: We investigated whether patients with inflammatory bowel disease (IBD) in Korea have an increased risk of hepatitis A virus (HAV) and hepatitis C virus (HCV) infections and sought to identify the risk factors for these infections.
Methods: We performed a nationwide population-based..
|
|
|
