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Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs
Hyo Jin Kim, Sang Soo Kim, Sang Heon Song
Korean J Intern Med. 2022;37(3):502-519. Published online April 4, 2022
Diabetes has reached epidemic proportions, both in Korea and worldwide and is associated with an increased risk of chronic kidney disease and kidney failure (KF). The natural course of kidney function among people with diabetes (especially type 2 diabetes) may be complex in real-world situations. St..
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The role of inflammation in diabetic kidney disease
Su Woong Jung, Ju-Young Moon
Korean J Intern Med. 2021;36(4):753-766. Published online July 1, 2021
Diabetic kidney disease (DKD) has been the leading cause of chronic kidney disease for over 20 years. Yet, over these two decades, the clinical approach to this condition has not much improved beyond the administration of glucose-lowering agents, renin-angiotensin-aldosterone system blockers for blo..
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Nephrology
Current findings of kidney biopsy including nephropathy associated with hypertension and diabetes mellitus in Korea
Kipyo Kim, Sang Ho Lee, Sung Woo Lee, Jung Pyo Lee, Ho Jun Chin; on behalf of the Korean GlomeruloNEphritis sTudy (KoGNET) Group
Korean J Intern Med. 2020;35(5):1173-1187. Published online August 14, 2020
Background/Aims: This study aimed to investigate long-term temporal trends and outcomes of biopsy-proven kidney diseases in a multicenter kidney biopsy cohort, focusing on hypertension and diabetes, the leading causes of end-stage kidney disease (ESKD).
Methods: The study included a total of 21,426..
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Cardiology
Adiponectin for the treatment of diabetic nephropathy
Jun Young Lee, Jae Won Yang, Byoung Geun Han, Seung Ok Choi, Jae Seok Kim
Korean J Intern Med. 2019;34(3):480-491. Published online April 30, 2019
The metabolic burden caused by hyperglycemia can result in direct and immediate metabolic injuries, such as oxidative stress and tissue inflammation, in the kidney. Furthermore, chronic hyperglycemia can lead to substantial structural changes such as formation of advanced glycation end-products, glo..
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Endocrinology-metabolism
Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus
Kang Hee Ahn, Sang Soo Kim, Won Jin Kim, Jong Ho Kim, Yun Jeong Nam, Su Bin Park, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim
Korean J Intern Med. 2017;32(5):875-882. Published online May 31, 2017
Background/Aims: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM).
Methods: This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospi..
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Nephrology
New therapeutic agents in diabetic nephropathy
Yaeni Kim, Cheol Whee Park
Korean J Intern Med. 2017;32(1):11-25. Published online January 1, 2017
Studies investigating diabetic nephropathy (DN) have mostly focused on interpreting the pathologic molecular mechanisms of DN, which may provide valuable tools for early diagnosis and prevention of disease onset and progression. Currently, there are few therapeutic drugs for DN, which mainly consist..
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The association between an abnormal post-voiding urine volume and a lower estimated glomerular filtration rate in patients with type 2 diabetes with no voiding symptoms
A Jin Cho, Sung Tae Cho, Young-Ki Lee, Jieun Oh, Sung Gyun Kim, Jang Won Seo, Jong-Woo Yoon, Ja-Ryong Koo, Hyung Jik Kim, Yong Seong Lee, Young-Goo Lee, Jung Woo Noh
Korean J Intern Med. 2015;30(1):82-87. Published online December 30, 2014
Background/Aims: Diabetic cystopathy is a frequent complication of diabetes mellitus. This study assessed the association between the post-voiding residual (PVR) urine volume and diabetic nephropathy in type 2 diabetics with no voiding symptoms.
Methods: This study investigated 42 patients with typ..
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Renal outcomes and clinical course of nondiabetic renal diseases in patients with type 2 diabetes
Ja Min Byun, Cheol Hyun Lee, Sul Ra Lee, Ju Young Moon, Sang Ho Lee, Tae Won Lee, Chun Gyoo Ihm, Kyung Hwan Jeong
Korean J Intern Med. 2013;28(5):565-572. Published online August 14, 2013
Background/AimsIn several recent studies, renal biopsies in patients with type 2 diabetes and renal disease have revealed a heterogeneous group of disease entities. Our aim was to study the prognosis and clinical course of nondiabetic renal disease (NDRD) and to determine risk..
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Phosphodiesterase Inhibitor Improves Renal Tubulointerstitial Hypoxia of the Diabetic Rat Kidney
Hui-Kyoung Sun, Yun Mi Lee, Kum Hyun Han, Han-Seong Kim, Seon-Ho Ahn, Sang-Youb Han
Korean J Intern Med. 2012;27(2):163-170. Published online May 31, 2012
Background/AimsRenal hypoxia is involved in the pathogenesis of diabetic nephropathy. Pentoxifyllin (PTX), a nonselective phosphodiesterase inhibitor, is used to attenuate peripheral vascular diseases. To determine whether PTX can improve renal hypoxia, we investigated its eff..
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Long-Term Effects of Rosiglitazone on the Progressive Decline in Renal Function in Patients With Type 2 Diabetes
Mee Kyoung Kim, Seung-Hyun Ko, Ki-Hyun Baek, Yu-Bae Ahn, Kun-Ho Yoon, Moo-Il Kang, Kwang-Woo Lee, Ki-Ho Song
Korean J Intern Med. 2009;24(3):227-232. Published online August 26, 2009
Background/AimsThiazolidinediones reduce urinary albumin excretion and may prevent the development of renal injury. We evaluated the long-term effects of rosiglitazone on the progression of renal dysfunction in patients with type 2 diabetes mellitus. Metho.. </div>
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<div id="main_image_wrap"><table style="margin: auto;"><tr>
<td onclick="mImage_sliding('prev')" valign="middle" style="cursor: pointer;"><img src="/image/b_prev.png" alt="prev" border="0" /></td>
<td valign="middle" style="width: 800px;height:448px;"><img id="main_image" src="" width="800" height="448" /></td>
<td onclick="mImage_sliding('next')" valign="middle" style="cursor: pointer;"><img src="/image/b_next.png" alt="next" border="0" /></td>
</tr></table></div>
</div>
</div>
<script>
/* Image Slide */
var thumb_array = new Array();
var thumb_index = 0;
// $(window).scroll(function () {
// var y = $(this).scrollTop();
// $("#overlay").css("margin-top", y+100);
// });
function mImage_sliding(dir) {
if(dir == 'next') {
thumb_index++;
if(thumb_index >= thumb_array.length) {
thumb_index--;
return false;
}
} else {
thumb_index--;
if(thumb_index < 0) {
thumb_index++;
return false;
}
}
changeMainImage(thumb_array[thumb_index]);
}
function openPhotoView(obj) {
var y = $(this).scrollTop();
$("#overlay").css("margin-top", y+100);
$("#overlay").show();
thumb_array = new Array();
$(obj).parent().parent().find('img.thumb').each(function (index) {
thumb_array.push($(this).attr("src"));
if($(obj).attr("src") == $(this).attr("src")) {
thumb_index = index;
changeMainImage($(this).attr("src"));
}
});
}
function openPhotoView2() {
var y = $(this).scrollTop();
$("#overlay").css("margin-top", y+100);
$("#overlay").show();
thumb_array = new Array();
var src_data = $("#ss_516").html();
console.log(src_data);
}
/*
function openPhotoView2() {
var y = $(this).scrollTop();
$("#overlay").css("margin-top", y+100);
$("#overlay").show();
thumb_array = new Array();
$("#ss_516").find('img.thumb').each(function (index) {
if(index != 0) {
thumb_array.push($("#ss_516").attr("src"));
if($("#ss_516").attr("src") == $(this).attr("src")) {
thumb_index = index;
changeMainImage($(this).attr("src"));
}
}
});
console.log(thumb_array);
}
*/
function closePhotoView() {
$('#overlay').hide();
thumb_array = new Array();
}
function changeMainImage(src) {
$("<img />").attr("src", src).load(function() {
var ratio = 800 / this.width;
var width = this.width * ratio;
var height = this.height * ratio;
if(height > 448) {
ratio = 448 / this.height;
width = this.width * ratio;
height = this.height * ratio;
}
$("#overlay #main_image_wrap #main_image").attr('src', this.src);
$("#overlay #main_image_wrap #main_image").attr('width', width);
$("#overlay #main_image_wrap #main_image").attr('height', height);
});
}
/* Image Slide End */
</script>
</body>
</html> | | |
