|
Endocrinology-metabolism / Original Article
Dexamethasone synergizes with high-fat diet to increase lipid deposition in adipocytes
Mingli Su, Ying Wang, Zheng Yan, Jia Luo, Jie Yang, Hua Ye, Aiming Liu, Julin Yang
Korean J Intern Med. 2025;40(1):92-102. Published online January 1, 2025
Background/Aims: Dexamethasone (DEX) is a widely used exogenous therapeutic glucocorticoid in clinical settings. Its long-term use leads to many side effects. However, its effect on metabolic disorders in individuals on a high-fat diet (HFD) remains poorly understood.
Methods: In this study, HFD-fe..
|
|
|
Gastroenterology / Original Article
Evolving epidemiology of non-alcoholic fatty liver disease in South Korea: incidence, prevalence, progression, and healthcare implications from 2010 to 2022
Jae Woo Park, Jeong-Ju Yoo, Dong Hyeon Lee, Young Chang, Hoongil Jo, Young Youn Cho, Sangheun Lee, Log Young Kim, Jae Young Jang; the Korean Association for the Study of the Liver
Korean J Intern Med. 2024;39(6):931-944. Published online October 24, 2024
Background/Aims: Non-alcoholic fatty liver disease (NAFLD), now the most common chronic liver worldwide, has become a significant public health concern. This study aims to analyze the evolving epidemiology of NAFLD in South Korea.
Methods: We utilized claim data from the Korean National Health Insu..
|
|
|
Gastroenterology / Original Article
Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Korean J Intern Med. 2021;36(3):557-567. Published online July 7, 2020
Background/Aims: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rar..
|
|
|
Gastroenterology / Original Article
The quality of non-alcoholic fatty liver disease information resources for patients on the internet in Korea
In Tae So, Yoo Jin Lee, Hye In Jung, Jae Seok Hwang, Byoung Kuk Jang
Korean J Intern Med. 2021;36(1):86-96. Published online July 31, 2019
Background/Aims: Many patients uses the internet to obtain information about their diseases. However, there is increasing concern regarding the quality of internet information. Thus, we aimed to systematically evaluate the quality of websites containing educational information about non-alcoholic fat..
|
|
|
Rheumatology / Original Article
Pilot study: asymptomatic hyperuricemia patients with obesity and nonalcoholic fatty liver disease have increased risk of double contour sign
Hong Ki Min, Hyonjoung Cho, Sung-Hwan Park
Korean J Intern Med. 2020;35(6):1517-1523. Published online June 13, 2019
Background/Aims: Double contour sign (DCS) is a representative ultrasonographic finding in gout. DCS is evidence of monosodium urate deposit in gouty arthritis and has been identified in some patients with asymptomatic hyperuricemia. However, the specific characteristics of asymptomatic hyperuricemi..
|
|
|
Gastroenterology / Original Article
Association between high fatty liver index and development of colorectal cancer: a nationwide cohort study with 21,592,374 Korean
Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han
Korean J Intern Med. 2020;35(6):1354-1363. Published online April 10, 2020
Background/Aims: In Korea, the incidence of colorectal cancer (CRC) and nonalcoholic fatty liver disease (NAFLD) has increased due to a westernized lifestyle. This study investigated whether a high fatty liver index that reflects NAFLD correlates with CRC.
Methods: Data from the National Health Ins..
|
|
|
Cardiology / Original Article
The effect of alcohol dose on the development of hypertension in Asian and Western men: systematic review and meta-analysis
Mi-Hyang Jung, Ein-Soon Shin, Sang-Hyun Ihm, Jin-Gyu Jung, Hae-Young Lee, Cheol-Ho Kim
Korean J Intern Med. 2020;35(4):906-916. Published online December 6, 2019
Background/Aims: There are inconsistencies in the effects of low to moderate dose alcohol consumption on the development of hypertension in adult men. We hypothesized that a region-specific effect might participate in this heterogeneity.
Methods: We conducted a systematic review and meta-analysis t..
|
|
|
Review
Alcohol use disorder and liver transplant: new perspectives and critical issues
Stefano Gitto, Silvia Aspite, Lucia Golfieri, Fabio Caputo, Francesco Vizzutti, Silvana Grandi, Valentino Patussi, Fabio Marra
Korean J Intern Med. 2020;35(4):797-810. Published online April 3, 2020
Alcoholic liver disease is a consolidated indication for liver transplantation, but many unsolved issues can be highlighted. Patients with alcohol use disorder develop peculiar comorbidities that can become contraindications for transplantation. Moreover, a number of social and psychological pattern..
|
|
|
Gastroenterology / Original Article
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease
Sang Bong Ahn, Dae Won Jun, Kiseok Jang, Byung Hoon Lee, Kye Jung Shin
Korean J Intern Med. 2019;34(4):777-784. Published online February 23, 2018
Background/Aims: Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD). We investigated the expression of NPC1L1 and its correlation with liver X receptor (LXR) expression in peripheral mon..
|
|
|
Gastroenterology / Original Article
Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis
Hyo Young Lee, Dae Won Jun, Hyun Jung Kim, Hyunwoo Oh, Waqar Khalid Saeed, Hyeongsik Ahn, Ramsey C. Cheung, Mindie H. Nguyen
Korean J Intern Med. 2019;34(2):296-304. Published online March 20, 2018
Background/Aims: A number of clinical trials reported varying effects of cholesterol lowering agents in nonalcoholic fatty liver disease (NAFLD) patients. We, therefore, assessed the changes in hepatic steatosis and NAFLD activity score (NAS) after treatment with cholesterol lowering agents in NAFLD..
|
|
|
Endocrinology-metabolism / Original Article
Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats
Yoo-Cheol Hwang, Da-Hee Oh, Moon Chan Choi, Sang Yeoul Lee, Kyu-Jeong Ahn, Ho-Yeon Chung, Sung-Jig Lim, Sung Hyun Chung, In-Kyung Jeong
Korean J Intern Med. 2018;33(2):347-355. Published online February 1, 2017
Background/Aims: Non-alcoholic fatty liver disease is associated with insulin resistance. Compound K (CK) is the final metabolite of panaxadiol ginsenosides that have been shown to exert antidiabetic effects. However, the molecular mechanism of the antidiabetic effects in the liver have not been elu..
|
|
|
Gastroenterology / Original Article
Diagnostic value of alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index combined with γ-glutamyl transferase in differentiating ALD and NAFLD
Junling Wang, Ping Li, Zhilong Jiang, Qiuhui Yang, Yuqiang Mi, Yonggang Liu, Ruifang Shi, Yonghe Zhou, Jinsheng Wang, Wei Lu, Si Li, Dan Liu
Korean J Intern Med. 2016;31(3):479-487. Published online March 30, 2016
Background/Aims: This study aimed to verify the reliability of the alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index (ANI) for distinguishing ALD in patients with hepatic steatosis from NAFLD, and to investigate whether ANI combined with γ-glutamyl transferase (GGT) woul..
|
|
|
Etc. - Orthopedic / Original Article
Evaluation of the effect of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms
Roberto Puente, José Illnait, Rosa Mas, Daisy Carbajal, Sarahí Mendoza, Julio César Fernández, Meilis Mesa, Rafael Gámez, Pablo Reyes
Korean J Intern Med. 2014;29(2):191-202. Published online February 27, 2014
Background/Aims: Nonsteroidal anti-inflammatory drugs relieve osteoarthritis (OA) symptoms but cause adverse effects. D-002, a mixture of beeswax alcohols, is effective against experimental OA. A pilot study found that D-002 (50 mg/day) for 8 weeks improves OA symptoms. The aim of this study was to ..
|
|
|
Gastroenterology / Original Article
Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease
José Illnait, Iván Rodríguez, Sarahí Mendoza, Yolanda Fernández, Rosa Mas, Mirtha Miranda, Jesús Piñera, Julio César Fernández, Meilis Mesa, Lilia Fernández, Daisy Carbajal, Rafael Gámez
Korean J Intern Med. 2013;28(4):439-448. Published online July 1, 2013
Background/AimsNonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis. NAFLD management mainly involves dietary modification and weight loss. Although no fully successful pharmacologi..
|
|
|
