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Machine learning approaches toward an understanding of acute kidney injury: current trends and future directions
Inyong Jeong, Nam-Jun Cho, Se-Jin Ahn, Hwamin Lee, Hyo-Wook Gil
Korean J Intern Med. 2024;39(6):882-897. Published online October 29, 2024
Acute kidney injury (AKI) is a significant health challenge associated with adverse patient outcomes and substantial economic burdens. Many authors have sought to prevent and predict AKI. Here, we comprehensively review recent advances in the use of artificial intelligence (AI) to predict AKI, and t..
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Role of T cells in ischemic acute kidney injury and repair
Kyungho Lee, Hye Ryoun Jang
Korean J Intern Med. 2022;37(3):534-550. Published online April 28, 2022
Ischemic acute kidney injury (AKI) is a common medical problem with significant mortality and morbidity, affecting a large number of patients globally. Ischemic AKI is associated with intrarenal inflammation as well as systemic inflammation; thus, the innate and adaptive immune systems are implicate..
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Nephrology
Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells
Sun Woo Lim, Kyung Woon Kim, Bo Mi Kim, Yoo Jin Shin, Kang Luo, Yi Quan, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2022;37(2):411-424. Published online September 16, 2021
Background/Aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) exert powerful therapeutic..
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Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease
Il Young Kim, Yeon Kyeong Park, Sang Heon Song, Eun Young Seong, Dong Won Lee, Sun Sik Bae, Soo Bong Lee
Korean J Intern Med. 2021;36(4):962-974. Published online December 16, 2020
Background/Aims: Acute kidney injury (AKI) is an underestimated yet important risk factor for the development of chronic kidney disease (CKD), characterized by tubulointerstitial fibrosis and tubular dedifferentiation. Tubular dedifferentiation, which is associated with the loss of epithelial marker..
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Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy
Yohan Park, Tae Hyun Ban, Hyung Duk Kim, Eun Jeong Ko, Jongmin Lee, Seok Chan Kim, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2021;36(2):392-400. Published online July 7, 2020
Background/Aims: We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
Methods: This study enrolled 169 patients who underwent serum NGAL testing at CRRT..
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Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 as biomarkers of patients with established acute kidney injury
Won Yong Cho, Sung Yoon Lim, Ji Hyun Yang, Se Won Oh, Myung-Gyu Kim, Sang-Kyung Jo
Korean J Intern Med. 2020;35(3):662-671. Published online December 23, 2019
Background/Aims: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been recently discovered and validated as sensitive biomarkers that can predict stage 2 or 3 acute kidney injury (AKI) development in high-risk patients. We aimed ..
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Continuous renal replacement therapy in elderly with acute kidney injury
[corrected-article]
Kristianne Rachel P. Medina-Liabres, Sejoong Kim
Korean J Intern Med. 2020;35(2):284-294. Published online February 28, 2020
The objective of this article is to raise awareness among physicians of the increasing incidence of acute kidney injury in the elderly population and the utility of continuous renal replacement therapy (CRRT) in its management. While CRRT is frequently applied in younger patients, its use in elderly..
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Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury
Sun Chul Kim, Yoon Sook Ko, Hee Young Lee, Myung-Gyu Kim, Sang-Kyung Jo, Won-Yong Cho
Korean J Intern Med. 2017;32(6):1053-1061. Published online February 15, 2017
Background/Aims: Recent findings have demonstrated the occurrence of neutrophil transendothelial migration in the reverse direction (reverse TEM) and that endothelial junctional adhesion molecule C (JAM-C) is a negative regulator of reverse TEM. In this study, we tested the effects of a JAM-C blocki..
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Duration of anuria predicts recovery of renal function after acute kidney injury requiring continuous renal replacement therapy
Hee-Yeon Jung, Jong-Hak Lee, Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jang-Hee Cho
Korean J Intern Med. 2016;31(5):930-937. Published online February 12, 2016
Background/Aims: Little is known regarding the incidence rate of and factors associated with developing chronic kidney disease after continuous renal replacement therapy (CRRT) in acute kidney injury (AKI) patients. We investigated renal outcomes and the factors associated with incomplete renal reco..
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Renal Klotho expression in patients with acute kidney injury is associated with the severity of the injury
Min Young Seo, Jihyun Yang, Jun Yong Lee, Kitae Kim, Sun Chul Kim, Hyojeong Chang, Nam Hee Won, Myung-Gyu Kim, Sang-Kyung Jo, Wonyong Cho, Hyoung Kyu Kim
Korean J Intern Med. 2015;30(4):489-495. Published online June 29, 2015
Background/Aims: The potential physiologic roles of Klotho in acute kidney injury (AKI) have recently been demonstrated in animal models. However, to date, there have been no human studies investigating the expression of renal Klotho in AKI.
Methods: We retrospectively collected biopsy specimens a..
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Relationship between duration of hospital-acquired acute kidney injury and mortality: a prospective observational study
Jinyoung Yoo, Ji Sung Lee, Jiyeon Lee, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Soon Hyo Kwon
Korean J Intern Med. 2015;30(2):205-211. Published online February 27, 2015
Background/Aims: New definitions of acute kidney injury (AKI) have recently emerged. Some studies have suggested that duration of AKI is an additional predictive parameter for mortality. Here, we evaluated whether AKI duration was predictive of long-term mortality in patients with hospital-acquired ..
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Subcutaneous sarcoidosis presenting as a suprapubic mass, acute kidney injury, and hypercalcemia
Jeong Min Kim, Yoon Kyeong Song, Seon Jin Park, Young-Hwan Hwang, Su Ah Sung, So Young Lee, Jong Eun Joo, Se Won Oh
Korean J Intern Med. 2014;29(4):535-538. Published online June 27, 2014
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Cardiology
Effect of renin-angiotensin-system blockers on contrast-medium-induced acute kidney injury after coronary angiography
Ja-Jun Goo, Jae-Joon Kim, Ji-Hoon Kang, Kyoung-Nyoun Kim, Ki-Sup Byun, Mi-kyung Kim, Tae-Ik Kim
Korean J Intern Med. 2014;29(2):203-209. Published online February 27, 2014
Background/Aims: With the increasing incidence of cardiovascular disease, angiocardiography using contrast-enhancing media has become an essential diagnostic and therapeutic tool, despite the risk of contrast-medium-induced acute kidney injury (CIAKI). CIAKI may be exacerbated by renin-angiotensin-s..
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Hypothermia-induced acute kidney injury in an
elderly patient
Hyun Ju Yoon, Mun Chul Kim, Jae Woo Park, Min A Yang, Cheon Beom Lee, In O Sun, Kwang Young Lee
Korean J Intern Med. 2014;29(1):111-115. Published online January 2, 2014
Hypothermia, defined as an unintentional decline in the core body temperature
to below 35°C, is a life-threatening condition. Patients with malnutrition and
diabetes mellitus as well as those of advanced age are at high risk for accidental
hypothermia. Due to the high mortality rates of acciden..
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Nephrology
Renal adverse effects of sunitinib and its clinical significance: a single-center experience in Korea
Seon Ha Baek, Hyunsuk Kim, Jeonghwan Lee, Dong Ki Kim, Kook-Hwan Oh, Yon Su Kim, Jin Suk Han, Tae Min Kim, Se-Hoon Lee, Kwon-Wook Joo
Korean J Intern Med. 2014;29(1):40-48. Published online January 2, 2014
Background/Aims: Sunitinib is an oral multitargeted tyrosine kinase inhibitor
used mainly for the treatment of metastatic renal cell carcinoma. The renal adverse
effects (RAEs) of sunitinib have not been investigated. The aim of this study
was to determine the incidence and risk factors of RAEs (..
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Acute Kidney Injury due to Sodium Bromate Intoxication: A Report of Two Cases
Dong Hwan Ryu, Kyung Ae Jang, Seok Min Kim, Jong Won Park, Jun Young Do, Kyung Woo Yoon
Korean J Intern Med. 2011;26(4):463-465. Published online November 28, 2011
Sodium bromate is a strong oxidant used as a neutralizing solution in hair permanents, as well as an auxiliary agent in printing and dyeing. Accidental or deliberate ingestion of bromate solution has rarely been reported in Korea. The clinical manifestations of bromate intoxication are vomiting, ..
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Role of IL-1α in Cisplatin-Induced Acute Renal Failure in Mice
Jay-Wook Lee, Woo-Jin Nam, Min-Jee Han, Jung-Ho Shin, Jin-Gun Kim, Su-Hyun Kim, Hye-Ryoun Kim, Dong-Jin Oh
Korean J Intern Med. 2011;26(2):187-194. Published online June 1, 2011
Background/AimsFor unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1α. We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mic..
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Continuous renal replacement therapy for the treatment of acute kidney injury
Woo Kyun Bae, Dae Hun Lim, Ji Min Jeong, Hae Young Jung, Seong Ku Kim, Jeong Woo Park, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim, Nam Ho Kim, Ki Chul Choi
Korean J Intern Med. 2008;23(2):58-63. Published online June 20, 2008
Backgraound/AimsContinuous renal replacement therapy (CRRT) has been widely used for treating critically ill patients with acute kidney injury (AKI). Whether CRRT is better than intermittent hemodialysis for the treatment of AKI remains controversial. We sought to identify the..
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