|
Rheumatology
Predictors of renal relapse in Koreans with lupus nephritis after achieving complete response: a 35-years of experience at a single center
Howook Jeon, Jennifer Lee, Su-Jin Moon, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2024;39(2):347-359. Published online January 22, 2024
Background/Aims: Renal relapse has known to be a poor prognostic factor in patients with lupus nephritis (LN), but there were few studies that identified the risk factors of renal relapse in real world. We conducted this study based on 35-years of experience at a single center to find out predictors..
|
|
|
Characteristics of patients with psoriatic arthritis in Korea: focusing on axial involvement
Hanna Park, Ji Hyun Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park, Jennifer Jooha Lee
Korean J Intern Med. 2024;39(1):184-193. Published online December 8, 2023
Background/Aims: We aimed to clarify the clinical characteristics of psoriatic arthritis (PsA) in Korean patients focusing on PsA with axial involvement.
Methods: A retrospective medical chart review was performed to identify PsA patients at a single tertiary center. Cases of AS patients with psori..
|
|
|
Two-year clinical outcomes after discontinuation of long-term golimumab therapy in Korean patients with rheumatoid arthritis
Kichul Shin, Hyun Mi Kwon, Min Jung Kim, Myung Jae Yoon, Hyun Gyung Chai, Seong-Wook Kang, Won Park, Sung-Hwan Park, Chang Hee Suh, Hyun Ah Kim, Seung-Geun Lee, Choong Ki Lee, Sang-Cheol Bae, Yong-Beom Park, Yeong Wook Song
Korean J Intern Med. 2022;37(5):1061-1069. Published online December 13, 2021
Background/Aims: The aim of this study was to investigate long-term post-discontinuation outcomes in patients with rheumatoid arthritis (RA) who had been treated with tumor necrosis factor-α inhibitors (TNF-αi) which was then discontinued.
Methods: Sixty Korean patients with RA who participated i..
|
|
|
Metformin and its therapeutic applications in autoimmune inflammatory rheumatic disease
Ji-Won Kim, Jung-Yoon Choe, Sung-Hwan Park
Korean J Intern Med. 2022;37(1):13-26. Published online December 10, 2021
Metformin is a first-line therapeutic agent for type 2 diabetes. Apart from its glucose- lowering effect, metformin is attracting interest regarding possible therapeutic benefits in various other conditions. As metformin regulates cell metabolism, proliferation, growth, and autophagy, it may also mo..
|
|
|
Rheumatology
Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort
Youngjae Park, Jennifer Lee, Jung Hee Koh, Jung Yoon Choe, Yoon-Kyoung Sung, Shin-Seok Lee, Ji-Min Kim, Sung-Hwan Park, Seung-Ki Kwok
Korean J Intern Med. 2021;36(6):1492-1503. Published online August 24, 2020
Background/Aims: This study was performed to clarify inf luences of anticentromere antibody (ACA) on clinical phenotypes of primary Sjögren’s syndrome (pSS) patients in Korea. Methods: We assessed 318 patients who met the 2016 American College of Rheumatology/ European League Against Rheumatism cla..
|
|
|
Pilot study: asymptomatic hyperuricemia patients with obesity and nonalcoholic fatty liver disease have increased risk of double contour sign
Hong Ki Min, Hyonjoung Cho, Sung-Hwan Park
Korean J Intern Med. 2020;35(6):1517-1523. Published online June 13, 2019
Background/Aims: Double contour sign (DCS) is a representative ultrasonographic finding in gout. DCS is evidence of monosodium urate deposit in gouty arthritis and has been identified in some patients with asymptomatic hyperuricemia. However, the specific characteristics of asymptomatic hyperuricemi..
|
|
|
Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
Kichul Shin, Sung Soo Kim, Sang-Heon Lee, Seung-Jae Hong, Sung Jae Choi, Jung-Yoon Choe, Seung-Geun Lee, Hoon-Suk Cha, Eun Young Lee, Sung-Hwan Park, Jin-Wuk Hur, Sung Soo Na, Chang-Hee Suh, Min Wook So, Seung Won Choi, Dong-Hyuk Sheen, Won Park, Shin-Seok Lee, Wan Hee Ryu, Jin Seok Kim, Jung Soo Song, Hye Soon Lee, Seong Ho Kim, Dae-Hyun Yoo
Korean J Intern Med. 2020;35(1):231-239. Published online January 28, 2019
Background/Aims: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. Methods: This was ..
|
|
|
Rheumatoid arthritis is associated with early tooth loss: results from Korea National Health and Nutrition Examination Survey V to VI
Ji-Won Kim, Jun-Beom Park, Hyeon Woo Yim, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2019;34(6):1381-1391. Published online September 1, 2018
Background/aims: To examine the association between rheumatoid arthritis (RA) and periodontitis or tooth loss.
Methods: The study used data from the fifth and sixth Korea National Health and Nutrition Examination Surveys conducted from 2010 to 2015. RA was defined as participant-reported physician-..
|
|
|
Risk of malignancy in patients with rheumatoid arthritis after anti-tumor necrosis factor therapy: results from Korean National Health Insurance claims data
Seung Min Jung, Seung-Ki Kwok, Ji Hyeon Ju, Yong-Beom Park, Sung-Hwan Park
Korean J Intern Med. 2019;34(3):669-677. Published online November 29, 2017
Background/Aims: Inhibition of tumor necrosis factor (TNF) is an effective treatment for rheumatoid arthritis (RA), but safety concerns about malignancy remain. The aim of this study was to evaluate cancer risk in RA patients treated with TNF inhibitors (TNFi), based on Korean Nationwide Health Insu..
|
|
|
Clinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor
Hong Ki Min, Youn Soo Lee, Suk-Woo Yang, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2019;34(1):220-226. Published online October 19, 2017
Background/Aims: This study investigated the clinical and pathological features of immunoglobulin G4 (IgG4)-related ophthalmic disease. To clarify the features, we compared IgG4-related ophthalmic disease and orbital inflammatory pseudotumor.
Methods: We retrospectively reviewed the medical records..
|
|
|
Insulin resistance is an independent predictor of erectile dysfunction in patients with gout
Ji Hun Kim, Min Kyung Chung, Jin Young Kang, Jung Hee Koh, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Sung-Hwan Park
Korean J Intern Med. 2019;34(1):202-209. Published online October 12, 2017
Background/Aims: Gout is associated with metabolic disorders that are important risk factors for cardiovascular disease and erectile dysfunction (ED). We aimed to identify independent predictors of ED in patients with gout.
Methods: From August 2014 to August 2015, male outpatients who were being t..
|
|
|
Autonomic dysfunction in primary Sjogren’s syndrome: a prospective cohort analysis of 154 Korean patients
Jung Hee Koh, Seung-Ki Kwok, Jennifer Lee, Sung-Hwan Park
Korean J Intern Med. 2017;32(1):165-173. Published online March 25, 2016
Background/Aims: To determine the prevalence of autonomic dysfunction among Korean patients with primary Sjogren’s syndrome (pSS) and its associations with the clinical features of pSS. Methods: We analyzed 154 participants from the Korean Initiative of primary Sjogren’s Syndrome (KISS) as a pros..
|
|
|
Allopurinol hypersensitivity syndrome in patients with hematological malignancies: characteristics and clinical outcomes
Hong Ki Min, Boin Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Young Min Park, Sung-Hwan Park
Korean J Intern Med. 2015;30(4):521-530. Published online June 29, 2015
Background/Aims: Allopurinol is a urate-lowering agent that is commonly used to prevent chemotherapy-related hyperuricemia. Allopurinol hypersensitivity syndrome (AHS) is a disorder involving multiple organs, which may be accompanied by cutaneous adverse reactions. We identified the characteristics ..
|
|
|
Pulmonary hypertension in systemic lupus erythematosus: an independent predictor of patient survival
Hong Ki Min, Jae Ho Lee, Seung Min Jung, Jennifer Lee, Kwi Young Kang, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Sung-Hwan Park
Korean J Intern Med. 2015;30(2):232-241. Published online February 27, 2015
Background/Aims: We investigated whether transthoracic echocardiography-suspected pulmonary hypertension (PH) affects survival in systemic lupus erythematosus (SLE) patients and examined factors associated with PH occurrence and survival.
Methods: This retrospective single-center study included 154..
|
|
|
Unusual metatarsophalangeal joint deformity in an advanced rheumatoid foot
Seung-Min Jung, Jae Hoon Ahn, Sung-Hwan Park, Kyung-Su Park
Korean J Intern Med. 2014;29(3):402-403. Published online April 29, 2014
|
|
|
Cervical spine fracture in advanced ankylosing
spondylitis
Jennifer Lee, Sung-Hwan Park, Kyung-Su Park
Korean J Intern Med. 2014;29(1):131-131. Published online January 2, 2014
|
|
|
Rheumatology
S100A8/A9 as a biomarker for synovial inflammation
and joint damage in patients with rheumatoid
arthritis
Kwi Young Kang, Jung-Won Woo, Sung-Hwan Park
Korean J Intern Med. 2014;29(1):12-19. Published online January 2, 2014
S100A8 and S100A9 are major leukocyte proteins, known as damage-associated
molecular patterns, found at high concentrations in the synovial fluid of patients
with rheumatoid arthritis (RA). A heterodimeric complex of S100A8/A9 is secreted
by activated leukocytes and binds to Toll-like receptor 4,..
|
|
|
Engagement of Toll-Like Receptor 3 Induces Vascular Endothelial Growth Factor and Interleukin-8 in Human Rheumatoid Synovial Fibroblasts
Su-Jin Moon, Mi-Kyung Park, Hye-Jwa Oh, Seon-Yeong Lee, Seung-Ki Kwok, Mi-La Cho, Ji Hyeon Ju, Kyung-Su Park, Ho-Youn Kim, Sung-Hwan Park
Korean J Intern Med. 2010;25(4):429-435. Published online November 27, 2010
Background/AimsAngiogenesis, which is a critical step in the initiation and progression of rheumatoid arthritis (RA), involves pro-angiogenic factors, including interleukin (IL)-8 and vascular endothelial growth factor (VEGF). We investigated the role of Toll-like receptor 3 (..
|
|
|
Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway
Hae-Rim Kim, Mi-Kyung Park, Mi-La Cho, Kyoung-Woon Kim, Hye-Joa Oh, Jin-Sil Park, Yang-Mi Heo, Sang-Heon Lee, Ho-Youn Kim, Sung-Hwan Park
Korean J Intern Med. 2010;25(3):317-326. Published online August 31, 2010
Background/AimsThis study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. MethodsHuman RA synovial fibr..
|
|
|
Long-term outcome of interstitial lung disease in patients with primary Sjögren's syndrome: a retrospective observational study
Jung Hee Koh, Youngjae Park, Jennifer Lee, Howook Jeon, Su-Jin Moon, Yong Hyun Kim, Jun-Ki Min, Sung-Hwan Park, Seung-Ki Kwok
Received September 22, 2023 Accepted June 10, 2024 Published online October 25, 2024
Background/Aims: Interstitial lung disease (ILD) is a potentially serious but underdiagnosed manifestation of primary Sjögren's syndrome (pSS). This observational study investigated the prevalence and clinical course of ILD in pSS, together with prognostic factors.
Methods: A multicenter, retrosp..
|
|
|
