Hand-Foot Syndrome with Scleroderma-like Change Induced by the Oral Capecitabine: A Case Report
Sehe-Dong Lee, Hye-Jeong Kim, Seung-Jae Hwang, Yoon-Jung Kim, Seung-Hyun Nam, Bong-Seog Kim
Korean J Intern Med. 2007;22(2):109-112. Published online June 30, 2007
Hand-foot syndrome (HFS) is a well-known adverse event associated with capecitabine, a prodrug of 5-Fluorouracil (5-FU). HFS manifests as acral erythema, with swelling and dysesthesia of the palms and plantar aspects of the feet, which in the absence of dosage reduction or drug cessation, progres..
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