Hemato-oncology
Recent advances in the diagnosis and management of primary myelofibrosis
Katsuto Takenaka, Kazuya Shimoda, Koichi Akashi
Korean J Intern Med. 2018;33(4):679-690. Published online April 20, 2018
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) in which dysregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathways is the major pathogenic mechanism. Most patients with PMF carry a driver mutation in the JAK2, MPL (my..
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