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Pulmonology
Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma
Hea Yon Lee, Hwa Young Lee, Jung Hur, Hye Seon Kang, Joon Young Choi, Chin Kook Rhee, Ji Young Kang, Young Kyoon Kim, Sook Young Lee
Korean J Intern Med. 2020;35(3):619-629. Published online March 19, 2020
Background/Aims: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays a key role in Th2-mediated inflammation, both directly by promoting the proliferation of naïve CD4 Th2 cells, and indirectly by activating dendritic cells (DCs). TSLP-activated DCs induce the exp..
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Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer
Hea Yon Lee, In Kyoung Kim, Hye In Lee, Hwa Young Lee, Hye Seon Kang, Chang Dong Yeo, Hyun Hui Kang, Hwa Sik Moon, Sang Haak Lee
Korean J Intern Med. 2018;33(3):541-551. Published online December 15, 2017
Background/Aims: We explored the effects of intermittent normobaric hyperoxia alone or combined with chemotherapy on the growth, general morphology, oxidative stress, and apoptosis of benzo[a]pyrene (B[a]P)-induced lung tumors in mice.
Methods: Female A/J mice were given a single dose of B[a]P and ..
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Clinical significance of positive Pneumocystis jirovecii polymerase chain reaction in non-human immunodeficiency virus immunocompromised patients in a real practice
Hea Yon Lee, Hye Seon Kang, Hwa Young Lee, Chin Kook Rhee, Sook Young Lee, Seok Chan Kim, Seung Joon Kim, Yeon Joon Park, Young Kyoon Kim, Ji Young Kang
Korean J Intern Med. 2017;32(3):478-485. Published online December 13, 2016
Background/Aims: Pneumocystis jirovecii polymerase chain reaction (PCR) can be helpful in diagnosing Pneumocystis pneumonia (PCP); however it has limitations. We evaluated the prevalence of positive P. jirovecii PCR from non-human immunodeficiency virus (HIV) immunocompromised p..
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Clinical significance of serum vascular endothelial growth factor in young male asthma patients
Hea Yon Lee, Kyung Hoon Min, Sang Min Lee, Ji Eun Lee, Chin Kook Rhee
Korean J Intern Med. 2017;32(2):295-301. Published online March 21, 2016
Background/Aims: Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and t..
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Allergy
Different anti-remodeling effect of nilotinib and fluticasone in a chronic asthma model
Hye Seon Kang, Chin Kook Rhee, Hea Yon Lee, Hyoung Kyu Yoon, Soon Seok Kwon, Sook Young Lee
Korean J Intern Med. 2016;31(6):1150-1158. Published online October 20, 2016
Background/Aims: Inhaled corticosteroids are the most effective treatment currently available for asthma, but their beneficial effect against airway remodeling is limited. The tyrosine kinase inhibitor nilotinib has inhibitory activity against c-kit and the platelet-derived growth factor receptor. W..
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Pulmonology
Clinical outcomes of extracorporeal membrane oxygenation support in patients with hematologic malignancies
Hye Seon Kang, Chin Kook Rhee, Hea Yon Lee, Young Kyoon Kim, Soon Seog Kwon, Seok Chan Kim, Jong Wook Lee
Korean J Intern Med. 2015;30(4):478-488. Published online June 29, 2015
Background/Aims: The clinical outcomes of patients with hematologic malignancies who were treated with extracorporeal membrane oxygenation (ECMO) after the failu re of optimal conventional therapy were determined.
Methods: The medical records of all patients administered ECMO during their stay in a..
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