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Allergy
N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression
Pureun-Haneul Lee, Jisu Hong, An-Soo Jang
Korean J Intern Med. 2020;35(5):1229-1237. Published online February 28, 2020
Background/Aims: N-acetylcysteine (NAC) affects signaling pathways involved in apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, and the inflammatory response. However, it is not known how the signal mechanism for tight junctional protein claudin (CLDN) 18 is regulate..
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Methacholine bronchial provocation test in patients with asthma: serial measurements and clinical significance
Hyun-Jung Seo, Pureun-Haneul Lee, Byeong-Gon Kim, Sun-Hye Lee, Jong-Sook Park, Junehyuck Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang
Korean J Intern Med. 2018;33(4):807-814. Published online January 17, 2018
Background/Aims: The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since improvements in the severity of asthma are associated with improvements in AHR, clinical studies of asthma therapies routinely use the change of airway responsi..
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Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey
Jun-Ho Myung, Hyun-Jeong Seo, Soo-Jeong Park, Bo-Young Kim, Il-Sang Shin, Jun-Hak Jang, Yun-Kyung Kim, An-Soo Jang
Korean J Intern Med. 2015;30(2):226-231. Published online February 27, 2015
Background/Aims: We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness.
Methods: We co..
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The role of rhinosinusitis in severe asthma
An-Soo Jang
Korean J Intern Med. 2013;28(6):646-651. Published online October 29, 2013
The prevalence of asthma is approximately 5% to 10% in the general population. Of these, approximately 5% to 10% are severe asthmatics who respond poorly to asthmatic drugs, including high-dose inhaled steroids. Severe asthmatics have persistent symptoms, frequent symptom exacerbation, and sever..
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The effects of pycnogenol on antioxidant enzymes in a mouse model of ozone exposure
Min-Sung Lee, Kuk-Young Moon, Da-Jeong Bae, Moo-Kyun Park, An-Soo Jang
Korean J Intern Med. 2013;28(2):216-223. Published online February 27, 2013
Background/AimsOzone is an environmentally reactive oxidant, and pycnogenol is a mixture of flavonoid compounds extracted from pine tree bark that have antioxidant activity. We investigated the effects of pycnogenol on reactive nitrogen species, antioxidant responses, and airw..
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A Case of Combined Cholinergic and Cold Urticaria
Hong-Woo Cheon, Su-Jung Han, So-Jeong Yeo, Sun-Hyo Lee, Min-Jin Kim, Shin-Hee Kim, An-Soo Jang
Korean J Intern Med. 2012;27(4):478-479. Published online November 27, 2012
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Ozone Exposure Suppresses Proliferative Response in Mice Skin
Su-Jung Han, Mi-Kyung Kwak, Dong-Hoon Han, Shin-Hee Kim, An-Soo Jang
Korean J Intern Med. 2012;27(3):360-362. Published online September 1, 2012
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Steroid Response in Refractory Asthmatics
An-Soo Jang
Korean J Intern Med. 2012;27(2):143-148. Published online May 31, 2012
Inhaled glucocorticosteroids are currently the most effective anti-inflammatory controller medications for treating persistent asthma. The efficacies of glucocorticoids include reducing asthma symptoms, reducing exacerbation frequency, improving quality of life, improving lung function, decreasin..
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Volatile Organic Compounds Contribute to Airway Hyperresponsiveness
An-Soo Jang, Inseon-S Choi, Young-Il Koh, Choon-Sik Park
Korean J Intern Med. 2007;22(1):8-12. Published online March 31, 2007
BackgroundVolatile organic compounds (VOCs) in concentrations found in both the work and home environments may influence lung function. We investigated the prevalence of airway responsiveness in workers exposed to VOCs. Methods
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Severe Airway Hyperresponsiveness in School-aged Boys with a High Body Mass Index
An-Soo Jang, June Huk Lee, Sung Woo Park, Mee Yong Shin, Do Jin Kim, Choon-Sik Park
Korean J Intern Med. 2006;21(1):10-14. Published online March 30, 2006
BackgroundAn association between obesity and asthma has been reported. The prevalence of airway hyperresponsiveness (AHR), results of skin prick tests, body mass index (BMI), and asthma symptoms were examined in schoolchildren. MethodsThe result..
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Asthmatic Airway Inflammation is More Closely Related to Airway Hyperresponsiveness to Hypertonic Saline than to Methacholine
Inseon S. Choi, Seo-Na Hong, Yeon-Kyung Lee, Youngil I. Koh, An-Soo Jang, Hyeon-Cheo Lee
Korean J Intern Med. 2003;18(2):83-88. Published online June 1, 2003
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