| Reviews |
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Gastroenterology
Immunoglobulin G4-related sclerosing cholangitis
George Goodchild, Stephen P. Pereira, George Webster
Korean J Intern Med. 2018;33(5):841-850. Published online July 27, 2018
Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition of which IgG4-related sclerosing cholangitis (IgG4-SC) is the biliary manifestation. In this review, we provide an overview of IgG4-RD, with a focus on the biliary manifestations. In particular, we describe the imp..
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Cardiology
Percutaneous coronary intervention in patients with multi-vessel coronary artery disease: a focus on physiology
Yun-Kyeong Cho, Chang-Wook Nam
Korean J Intern Med. 2018;33(5):851-859. Published online March 21, 2018
Multi-vessel coronary artery disease (MVD) frequently features ambiguous or intermediate lesions that may be both serial and complex, suggesting that multiple regions require revascularization. Percutaneous coronary intervention (PCI) is associated with various challenges such as appropriate identif..
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Nephrology
Clinical significance of Th17 cells in kidney transplantation
Byung Ha Chung, Chul Woo Yang, Mi-La Cho
Korean J Intern Med. 2018;33(5):860-866. Published online May 31, 2018
Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and..
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Allergy
Genetic markers of severe cutaneous adverse reactions
Jae-Woo Jung, Jae-Yeol Kim, In-Won Park, Byoung-Whui Choi, Hye-Ryun Kang
Korean J Intern Med. 2018;33(5):867-875. Published online June 22, 2018
Adverse drug reactions can cause considerable discomfort. They can be life-threatening in severe cases, requiring or prolonging hospitalization, impeding proper treatment, and increasing treatment costs considerably. Although the incidence of severe cutaneous adverse reactions (SCARs) is low, they c..
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| Editorials |
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The euphoria, the warnings and the downfall of the current bioresorbale stents: could the journey be restarted?
Nicholas G. Kounis, Ioanna Koniari, Emmanouil Chourdakis, Dimitrios Velissaris, George Hahalis
Korean J Intern Med. 2018;33(5):879-882. Published online August 30, 2018
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| Original Articles |
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Gastroenterology
Comparison of liquid-based cytology (CellPrepPlus) and conventional smears in pancreaticobiliary disease
Myeong Ho Yeon, Hee Seok Jeong, Hee Seung Lee, Jong Soon Jang, Seungho Lee, Soon Man Yoon, Hee Bok Chae, Seon Mee Park, Sei Jin Youn, Joung-Ho Han, Hye-Suk Han, Ho Chang Lee
Korean J Intern Med. 2018;33(5):883-892. Published online September 13, 2017
Background/Aims: Endoscopic ultrasound-guided fine needle aspiration (EUSFNA) and brushing cytology are used worldwide to diagnose pancreatic and biliary malignant tumors. Liquid-based cytology (LBC) has been developed and it is currently used to overcome the limitations of conventional smears (CS)...
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Characteristics of Helicobacter pylori-seropositive subjects according to the stool antigen test findings: a prospective study
Hee-Won Moon, Sun-Young Lee, Mina Hur, Yeo-Min Yun
Korean J Intern Med. 2018;33(5):893-901. Published online October 24, 2017
Background/Aims: In countries with a higher risk of gastric atrophic gastritis, noninvasive tests are helpful for a more reliable diagnosis of Helicobacter pylori infection. The aim of this study was to evaluate the characteristics of seropositive subjects according to their stool H. pylori a..
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Disparity in Crohn’s disease activity between home and clinics is associated with unscheduled hospital visits due to disease flares
Eun Soo Kim, Yoo Jin Lee, Byung Ik Jang, Kyeong Ok Kim, Eun Young Kim, Hyun Seok Lee, Seong Woo Jeon, Sang Gyu Kwak; on behalf of Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Korean J Intern Med. 2018;33(5):902-910. Published online January 17, 2018
Background/Aims: E-health technologies have been implemented for the management of Crohn’s disease (CD). We aimed to identify differences between patient activities at home and at routine clinic visits using a web-based self-reporting CD symptom diary (CDSD) and to determine the impact of this dis..
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Cardiology
Body fluid status assessment by bio-impedance analysis in patients presenting to the emergency department with dyspnea
Chan Soon Park, Sang-Eun Lee, Hyun-Jai Cho, Yong-Jin Kim, Hyun-Jae Kang, Byung-Hee Oh, Hae-Young Lee
Korean J Intern Med. 2018;33(5):911-921. Published online December 18, 2017
Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea.
Methods: A total of 100 ..
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Early experience and favorable clinical outcomes of everolimus-eluting bioresorbable scaffolds for coronary artery disease in Korea
Osung Kwon, Jung-Min Ahn, Do-Yoon Kang, Se Hun Kang, Pil Hyung Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Duk-Woo Park, Seung-Jung Park
Korean J Intern Med. 2018;33(5):922-932. Published online November 7, 2017
Background/Aims: Compared with metallic drug-eluting stents (DES), bioresorbable vascular scaffolds (BVS) may further improve long-term outcomes of percutaneous coronary intervention (PCI) in patients with coronary artery disease. We report our early experience with BVS in Korea.
Methods: We evalu..
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Pulmonology
The effect of metformin on culture conversion in tuberculosis patients with diabetes mellitus
Ye-Jin Lee, Sung Koo Han, Ju Hee Park, Jung Kyu Lee, Deog Keom Kim, Hee Soon Chung, Eun Young Heo
Korean J Intern Med. 2018;33(5):933-940. Published online March 16, 2018
Background/Aims: Patients with diabetes mellitus (DM) and tuberculosis (TB) have increased morbidity and a high risk of treatment failure or recurrence. It is important to manage both diseases simultaneously. Among anti-diabetic drugs, metformin inhibits intracellular growth of mycobacteria. Therefo..
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Use of serology and polymerase chain reaction to detect atypical respiratory pathogens during acute exacerbation of chronic obstructive pulmonary disease
Chi Young Jung, Yeoung Hun Choe, Sang Yeub Lee, Woo Jin Kim, Jong Deog Lee, Seung Won Ra, Eu Gene Choi, Jae Seung Lee, Myung Jae Park, Ju Ock Na
Korean J Intern Med. 2018;33(5):941-951. Published online June 25, 2018
Background/Aims: To use serological and multiplex polymerase chain reaction (PCR) assays to examine sputum samples from patients experiencing acute exacerbation of chronic obstructive pulmonary disease (AECOPD) for the presence of atypical pathogens, including Mycoplasma pneumoniae, Chlamydia pneumo..
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Endocrinology-metabolism
Depth and combined infection is important predictor of lower extremity amputations in hospitalized diabetic foot ulcer patients
Eun-Gyo Jeong, Sung Shim Cho, Sang-Hoon Lee, Kang-Min Lee, Seo-Kyung Woo, Yoongoo Kang, Jae-Seung Yun, Seon-Ah Cha, Yoon-Jung Kim, Yu-Bae Ahn, Seung-Hyun Ko, Jung-Min Lee
Korean J Intern Med. 2018;33(5):952-960. Published online June 7, 2017
Background/Aims: As the prevalence of diabetes mellitus and its complications increase rapidly, diabetic foot ulcers (DFUs), which are a major diabetic complication, are expected to increase. For prevention and effective treatment, it is important to understand the clinical course of DFUs. The aim o..
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Nephrology
Update of aristolochic acid nephropathy in Korea
Tae Hyun Ban, Ji-Won Min, Changhwan Seo, Da Rae Kim, Yu Ho Lee, Byung Ha Chung, Kyung-Hwan Jeong, Jae Wook Lee, Beom Seok Kim, Sang-Ho Lee, Bum Soon Choi, Jin Suk Han, Chul Woo Yang
Korean J Intern Med. 2018;33(5):961-969. Published online March 20, 2018
Background/Aims: The true incidence of aristolochic acid nephropathy (AAN) is thought to be underestimated because numerous ingredients known or suspected to contain aristolochic acid (AA) are used in traditional medicine in Korea.
Methods: We collected data on cases of AAN since 1996 via a databas..
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Predialysis hyponatremia and mortality in elderly patients beginning to undergo hemodialysis
Seon Ha Baek, Sejoong Kim, Ki Young Na, Suhnggwon Kim, Ho Jun Chin
Korean J Intern Med. 2018;33(5):970-979. Published online October 19, 2017
Background/Aims: Predialysis hyponatremia has been recently reported to be associated with mortality in incident hemodialysis patients. However, whether hyponatremia is associated with unfavorable outcomes in elderly patients remains unknown. We hypothesized that nephrology referral inf luences hypo..
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Hemato-oncology
Third-party regulatory T cells prevent murine acute graft-versus-host disease
Jung-Yeon Lim, Keon-Il Im, Yunejin Song, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho
Korean J Intern Med. 2018;33(5):980-989. Published online October 19, 2017
Background/Aims: Adoptive therapy with regulatory T (Treg) cells to prevent graft-versus-host disease (GVHD) would benefit from a strategy to improve homing to the sites of inflammation following hematopoietic stem cell transplantation (HSCT). Although donor-derived Treg cells have mainly been used ..
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The neutrophil-to-lymphocyte ratio prechemotherapy and postchemotherapy as a prognostic marker in metastatic gastric cancer
Hyunho Kim, Sang Mi Ro, Ji Hyun Yang, Joon Won Jeong, Ji Eun Lee, Sang Young Roh, In-Ho Kim
Korean J Intern Med. 2018;33(5):990-999. Published online May 4, 2018
Background/Aims: Markers of inflammation have been associated with outcomes in various cancers. The purpose of this study was to evaluate whether systemic inf lammatory markers and their f luctuations can predict survival and chemotherapy response in patients with metastatic gastric cancer (mGC).
M..
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Infectious diseases
Management of carbapenem-resistant Acinetobacter baumannii epidemic in an intensive care unit using multifaceted intervention strategy
Jeongmin Hong, Ok Jeom Jang, Mi Hui Bak, Eun Hwa Baek, Ki-Ho Park, Sun In Hong, Oh-Hyun Cho, In-Gyu Bae
Korean J Intern Med. 2018;33(5):1000-1007. Published online November 27, 2017
Background/Aims: We evaluated the effects of a multifaceted intervention for controlling a carbapenem-resistant Acinetobacter baumannii (CRAB) epidemic in an intensive care unit (ICU) with no restrictions on carbapenem use.
Methods: This study was conducted in a medical ICU between April 201..
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Allergy
Management and educational status of adult anaphylaxis patients at emergency department
Mi-Yeong Kim, Chan Sun Park, Jae-won Jeong
Korean J Intern Med. 2018;33(5):1008-1015. Published online December 28, 2017
Background/Aims: We evaluated the management and educational status of adult anaphylaxis patients at emergency departments (EDs).
Methods: Anaphylaxis patients who visited ED from 2011 to 2013 were enrolled from three hospitals. We analyzed clinical features, prior history of anaphylaxis, managemen..
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Rheumatology
Isoniazid treatment for latent tuberculosis infection is tolerable for rheumatoid arthritis patients receiving tumor necrosis factor inhibitor therapy
Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Soyoung Won, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Dae-Hyun Yoo, Sang-Cheol Bae
Korean J Intern Med. 2018;33(5):1016-1024. Published online March 13, 2017
Background/Aims: To evaluate the impact of isoniazid (INH) treatment for latent tuberculosis infection (LTBI) on the development of liver function test (LFT) abnormality and the persistence of tumor necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA) patients.
Methods: We retrospectively ..
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Clinical phenotypes of Korean patients with Behcet disease according to gender, age at onset,
and HLA-B51
Hee Jung Ryu, Mi Ryoung Seo, Hyo Jin Choi, Han Joo Baek
Korean J Intern Med. 2018;33(5):1025-1031. Published online January 12, 2017
Background/Aims: The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B51 have also been known as the factors that influence the clinical features of BD. The aim of this study is t..
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| Images of interest |
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Epidermoid splenic cyst with elevated serum level of CA19-9
Natalia Buda, Anna Wszołek, Maciej Śledziński, Anton Żawrocki, Krzysztof Sworczak
Korean J Intern Med. 2018;33(5):1032-1033. Published online October 19, 2017
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Painful erythematous nodules in the left finger pads
Jeong Rae Yoo, Sang Taek Heo, Suhyun Oh, Seung-Jae Joo, Ki Yung Boo
Korean J Intern Med. 2018;33(5):1034-1035. Published online May 23, 2018
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Coexistence of metastatic thyroid cancer and tuberculosis in a single neck lymph node: a rare association
Kyueng-Whan Min, Dong-Hoon Kim, Seoung Wan Chae, Jin Hee Sohn, Kyoung Min Moon
Korean J Intern Med. 2018;33(5):1036-1037. Published online November 15, 2017
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