| Reviews |
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Cardiology
Recent technological updates and clinical applications of induced pluripotent stem cells
Sebastian Diecke, Seung Min Jung, Jaecheol Lee, Ji Hyeon Ju
Korean J Intern Med. 2014;29(5):547-557. Published online August 28, 2014
Induced pluripotent stem cells (iPSCs) were first described in 2006 and have since emerged as a promising cell source for clinical applications. The rapid progression in iPSC technology is still ongoing and directed toward increasing the efficacy of iPSC production and reducing the immunogenic and t..
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Gastroenterology
Crohn’s disease in Korea: past, present, and future
Kang-Moon Lee, Ji Min Lee
Korean J Intern Med. 2014;29(5):558-570. Published online August 28, 2014
The epidemiology, genetics, and clinical manifestations of Crohn’s disease (CD) vary considerably among geographic areas and ethnic groups. Thus, identifying the characteristics of Korean CD is important for establishing management strategies appropriate for Korean patients. Since the mid-2000s, m..
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| Editorials |
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Adverse effects of long-term amiodarone therapy
Hyoung-Seob Park, Yoon-Nyun Kim
Korean J Intern Med. 2014;29(5):571-573. Published online August 28, 2014
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Is vitamin D supplementation really effective in patients with type 2 diabetes?
Kyung-Jin Yun, Ki-Hyun Baek
Korean J Intern Med. 2014;29(5):574-576. Published online August 28, 2014
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| Original Articles |
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Gastroenterology
A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase
Su Jong Yu, Jae-Kyung Won, Han Suk Ryu, Won-Mook Choi, Hyeki Cho, Eun-Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Kyung-Suk Suh, Ja-June Jang, Chung Yong Kim, Hyo-Suk Lee, Jung-Hwan Yoon, Kwang-Hyun Cho
Korean J Intern Med. 2014;29(5):580-587. Published online August 28, 2014
Background/Aims: Protein disulfide isomerase (PDI) has been implicated in the survival and progression of some cancer cells, by compensating for endoplasmic reticulum stress by upregulating the protein-folding capacity. However, its prognostic role in patients with hepatocellular carcinoma (HCC) has..
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Cardiology
The incidence and predictors of overall adverse effects caused by low dose amiodarone in real-world clinical practice
Hack-Lyoung Kim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
Korean J Intern Med. 2014;29(5):588-596. Published online August 28, 2014
Background/Aims: Most current knowledge regarding amiodarone toxicity derives from clinical trials. This study was performed to investigate the incidence and risk factors of overall adverse effects of amiodarone in real-world practice using a large sample size.
Methods: Between January 1, 2000 and ..
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Long-term outcomes of simple crossover stenting from the left main to the left anterior descending coronary artery
Ho-Myung Lee, Chang-Wook Nam, Yun-Kyeong Cho, Hyuck-Jun Yoon, Hyoung-Seob Park, Hyungseop Kim, In-Sung Chung, Yun-Seok Heo, Seung-Ho Hur, Yoon-Nyun Kim, Kwon-Bae Kim
Korean J Intern Med. 2014;29(5):597-602. Published online August 28, 2014
Background/Aims: Although complex bifurcation stenting in patients with nonleft main (LM) bifurcation lesions has not yielded better clinical outcomes than simpler procedures, the utility of complex bifurcation stenting to treat LM bifurcation lesions has not yet been adequately explored.
Methods: ..
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Pulmonology
Factors predictive of the failure of medical treatment in patients with pleural infection
Sung-Kyoung Kim, Chul Ung Kang, So Hyang Song, Deog Gon Cho, Kyu Do Cho, Chi Hong Kim
Korean J Intern Med. 2014;29(5):603-612. Published online August 28, 2014
Background/Aims: The clinical outcomes of some patients with pleural infection may be favorable with medical treatment alone, but in others, the disease progresses and requires additional surgical treatment. However, little is known about the factors affecting this difference. The aim of this study ..
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The effects of secondhand smoke on chronic obstructive pulmonary disease in nonsmoking Korean adults
Woong Jun Kim, June Seok Song, Dong Won Park, Hyun Jung Kwak, Ji-Yong Moon, Sang-Heon Kim, Jang Won Sohn, Ho Joo Yoon, Dong Ho Shin, Sung Soo Park, Tae-Hyung Kim
Korean J Intern Med. 2014;29(5):613-619. Published online August 28, 2014
Background/Aims: Smoking is widely acknowledged as the single most important risk factor for chronic obstructive pulmonary disease (COPD). However, the risk of COPD in nonsmokers exposed to secondhand smoke remains controversial. In this study, we investigated the association of secondhand smoke exp..
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Endocrinology-metabolism
The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes
Ohk-Hyun Ryu, Wankyo Chung, Sungwha Lee, Kyung-Soon Hong, Moon-Gi Choi, Hyung Joon Yoo
Korean J Intern Med. 2014;29(5):620-629. Published online August 28, 2014
Background/Aims: Recent epidemiological studies revealed a striking inverse relationship between vitamin D levels, glucose intolerance/insulin resistance (IR), and cardiovascular disease. However, few interventional studies have evaluated the effect of vitamin D supplementation on cardiovascular ris..
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Hemato-oncology
Etanercept for steroid-refractory acute graft versus host disease following allogeneic hematopoietic stem cell transplantation
Joo Han Park, Hyo Jung Lee, Sei Rhan Kim, Ga Won Song, Seung Kyong Lee, Sun Young Park, Ki Chan Kim, Sun Hyuk Hwang, Joon Seong Park
Korean J Intern Med. 2014;29(5):630-636. Published online August 28, 2014
Background/Aims: The treatment for steroid-refractory acute graft versus host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) needs to be standardized. We report our clinical experience with etanercept for steroid-refractory acute GVHD.
Methods: Eighteen patients who underwent ..
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Infectious diseases
Prevalence and impact of extended-spectrum β-lactamase production on clinical outcomes in cancer patients with Enterobacter species bacteremia
Sun Jong Kim, Ki-Ho Park, Jin-Won Chung, Heungsup Sung, Seong-Ho Choi, Sang-Ho Choi
Korean J Intern Med. 2014;29(5):637-646. Published online August 28, 2014
Background/Aims: We examined the prevalence of extended-spectrum β-lactamase (ESBL) production and the impact of ESBL on clinical outcomes in cancer patients with Enterobacter spp. bacteremia. Methods: Using prospective cohort data on Enterobacter bacteremia obtai..
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Rheumatology
SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes
Choong Hyeok Choi, Tae-Hwan Kim, Yoon-Kyoung Sung, Chan-Bum Choi, Young-In Na, Hunseung Yoo, Jae-Bum Jun
Korean J Intern Med. 2014;29(5):647-655. Published online August 28, 2014
Background/Aims: SKI306X, a mixed extract of three herbs, Clematis mandshurica (CM), Prunella vulgaris (PV), and Trichosanthes kirilowii (TK), is chondroprotective in animal models of osteoarthritis (OA). The objectives of this study were to invest..
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Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials
Gwan Gyu Song, Sang-Cheol Bae, Young Ho Lee
Korean J Intern Med. 2014;29(5):656-663. Published online August 28, 2014
Background/Aims: The aim of this study was to assess the efficacy and safety of tofacitinib (5 and 10 mg twice daily) in patients with active rheumatoid arthritis (RA).
Methods: A systematic review of randomized controlled trials (RCTs) that examined the efficacy and safety of tofacitinib in patien..
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| Letters to the editor |
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Unexpected development of acute abdominal aortic thrombosis during percutaneous coronary intervention
Sang Jin Ha, Joo Hyeong Oh, Soo-Joong Kim
Korean J Intern Med. 2014;29(5):664-666. Published online August 28, 2014
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Adrenocorticotropic hormone-independent macronodular adrenal hyperplasia with abnormal cortisol secretion mediated by catecholamines
Harin Rhee, Yun Kyung Jeon, Sang Soo Kim, Yang Ho Kang, Seok Man Son, Yong Ki Kim, In Joo Kim
Korean J Intern Med. 2014;29(5):667-670. Published online August 28, 2014
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Immune thrombocytopenic purpura in a patient with renal cell carcinoma
Eun Ju Cho, Ha Jung Lee, Kyung Un Park, Uk-Yeon Kim, Hak Jong Lee, Soo Mee Bang
Korean J Intern Med. 2014;29(5):671-674. Published online August 28, 2014
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Cytomegalovirus appendicitis with concurrent bacteremia after chemotherapy for acute leukemia
Min Jung Cho, Jongmin Lee, Joo-Yeun Hu, Jung Woo Lee, Sung-Yeon Cho, Dong-Gun Lee, Seok Lee
Korean J Intern Med. 2014;29(5):675-678. Published online August 28, 2014
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Aldosterone- and cortisol-co-producing adrenal adenoma without clinical features of Cushing syndrome
Kyung Yoon Chang, Seongyul Ryu, Jae Young Cho, Hyung Wook Kim
Korean J Intern Med. 2014;29(5):679-682. Published online August 28, 2014
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| Image of interest |
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Seropositive rheumatoid arthritis in a female patient with sensory neuropathy
Ki-Jo Kim
Korean J Intern Med. 2014;29(5):683-684. Published online August 28, 2014
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