| Reviews |
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Recent advances in the management of difficult bile-duct stones: a focus on single-operator cholangioscopy-guided lithotripsy
Chi Hyuk Oh, Seok Ho Dong
Korean J Intern Med. 2021;36(2):235-246. Published online December 1, 2020
The most effective and the standard treatment for bile duct stones (BDSs) is endoscopic retrograde cholangiopancreatography (ERCP). However, in 10% to 15% of patients with BDSs, the stones cannot be removed by conventional ERCP, which involves endoscopic sphincterotomy followed by balloon or basket ..
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Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019
Sang Heon Suh, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
Korean J Intern Med. 2021;36(2):247-262. Published online October 16, 2020
In the decades since the discovery of angiotensin-converting enzyme 2 (ACE2), its protective role in terms of antagonizing activation of the classical renin-angiotensin system (RAS) axis has been recognized in clinical and experimental studies on kidney and cardiovascular diseases. The effects of AC..
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Severe hypoglycemia as a preventable risk factor for cardiovascular disease in patients with type 2 diabetes mellitus
Soo-Yeon Choi, Seung-Hyun Ko
Korean J Intern Med. 2021;36(2):263-270. Published online January 8, 2021
Glucose-lowering medication and lifestyle modification are essential for optimal glycemic control in patients with type 2 diabetes mellitus (T2DM). However, glucose-lowering agents, particularly insulin and insulin secretagogues, may cause hypoglycemia, which has multiple negative effects on the car..
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How lessons learned from the 2015 Middle East respiratory syndrome outbreak affected the response to coronavirus disease 2019 in the Republic of Korea
Tae Un Yang, Ji Yun Noh, Joon-Young Song, Hee Jin Cheong, Woo Joo Kim
Korean J Intern Med. 2021;36(2):271-285. Published online February 5, 2021
The Republic of Korea (ROK) experienced a public health crisis due to Middle East respiratory syndrome (MERS) in 2015 and is currently going through the coronavirus disease 2019 (COVID-19) pandemic. Lessons learned from the disastrous MERS outbreak were ref lected in the preparedness system, and the..
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| Editorials |
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| Original Articles |
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Gastroenterology
Comparison of the efficacy and safety of direct-acting antiviral therapy with or without hepatitis C-related hepatocellular carcinoma
Byung Soo Kwan, Jeong Han Kim, Seong Jun Park, Won Hyeok Choe, So Young Kwon, Byung-Chul Yoo
Korean J Intern Med. 2021;36(2):292-304. Published online April 3, 2020
Background/Aims: Chronic hepatitis C (CHC) treatment has dramatically improved since direct-acting antiviral (DAA) therapy was introduced. However, the use of DAA therapy in CHC patients with hepatocellular carcinoma (HCC) remains controversial. We investigated the DAA treatment response in CHC pati..
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Risk factors of advanced metachronous neoplasms in surveillance after colon cancer resection
Kwangwoo Nam, Jeong Eun Shin
Korean J Intern Med. 2021;36(2):305-312. Published online April 21, 2020
Background/Aims: Regular surveillance colonoscopy after colon cancer resection is recommended for detecting metachronous adenoma and cancer. However, risk factors for metachronous neoplasms have not been fully evaluated. We aimed to assess risk factors for advanced metachronous neoplasms during surv..
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Environmental risk factors and comorbidities of primary biliary cholangitis in Korea: a case-control study
Kyung-Ah Kim, Young Seok Kim, Sang Hoon Park, Woo Jin Chung, Dae Hee Choi, Eun Sun Jang, Sook-Hyang Jeong
Korean J Intern Med. 2021;36(2):313-321. Published online March 26, 2020
Background/Aims: The risk factors for the development of primary biliary cholangitis (PBC) is unclear. This study aimed to investigate the risk factors associated with PBC in Korea through a questionnaire survey.
Methods: Consecutively enrolled 103 PBC patients from six referral hospitals and 100 a..
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Sex difference in bowel preparation quality and colonoscopy time
Young-Jae Hwang, Dong Woo Shin, Nayoung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
Korean J Intern Med. 2021;36(2):322-331. Published online June 22, 2020
Background/Aims: The length of colon is known to be longer in females than in males. In addition, the morphology of colon cancer is different between males and females. The aim of this study was to investigate sex differences in Boston bowel preparation score (BBPS) and colonoscopy insertion time.
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Cardiology
Progression of ascending aortopathy may not occur after transcatheter aortic valve replacement in severe bicuspid aortic stenosis
Ji-Hyun Jung, Hyung-Kwan Kim, Jun-Bean Park, Seung-Pyo Lee, Bon-Kwon Koo, Yong-Jin Kim, Hyo-Soo Kim, Dae-Won Sohn
Korean J Intern Med. 2021;36(2):332-341. Published online August 14, 2019
Background/Aims: We evaluated changes in the ascending aorta dimension post-transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve (BiAV) and tricuspid aortic valve (TAV) patients.
Methods: Patients with severe aortic stenosis undergoing TAVR at Seoul National University Hospital we..
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Impact of carotid atherosclerosis in CHA2DS2-VASc-based risk score on predicting ischemic stroke in patients with atrial fibrillation
Dong-Hyuk Cho, Jong-Il Choi, Jimi Choi, Yun Gi Kim, Suk-Kyu Oh, Hyungdon Kook, Kwang No Lee, Jaemin Shim, Seong-Mi Park, Wan Joo Shim, Young-Hoon Kim
Korean J Intern Med. 2021;36(2):342-351. Published online February 27, 2020
Background/Aims: Vascular disease is an established risk factor for stroke in patients with atrial fibrillation (AF), which is included in CHA2DS2-VASc score. However, the role of carotid atherosclerosis remains to be determined.
Methods: Three hundred-ten patients with AF who..
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The effect of antiplatelet drug on coronary endothelial and microvascular function: comparison with ticagrelor and clopidogrel
Woong Gil Choi, Gi Chang Kim, Cheol Ho Lee, Hye Young Kim, Dong Woon Kim
Korean J Intern Med. 2021;36(2):352-361. Published online June 23, 2020
Background/Aims: Coronary endothelial and microvascular function play important roles in cardiovascular disease. We aimed to evaluate the effect of ticagrelor on coronary artery function and tested the antiplatelet effect of low dose ticagrelor in East-Asian patients.
Methods: Sixty-one consecutive..
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Pulmonology
Efficacy and safety of mepolizumab in Korean patients with severe eosinophilic asthma from the DREAM and MENSA studies
Mi-Kyeong Kim, Hae-Sim Park, Choon-Sik Park, Soung-Jun Min, Frank C. Albers, Steven W. Yancey, Bhabita Mayer, Namhee Kwon
Korean J Intern Med. 2021;36(2):362-370. Published online May 26, 2020
Background/Aims: The efficacy and safety of mepolizumab in patients with severe eosinophilic asthma has been evaluated in a global clinical trial programme. This post hoc analysis assesses the efficacy and safety of mepolizumab in Korean patients.
Methods: Data from Korean patients in the Ph..
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Effect of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker on the patients with sepsis
Hyun Woo Lee, Jae Kyung Suh, Eunjin Jang, Sang-Min Lee
Korean J Intern Med. 2021;36(2):371-381. Published online April 9, 2020
Background/Aims: Inhibitors of the renin-angiotensin system, angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), reportedly have anti-inflammatory effects. This study assessed the association of prior use of ACE inhibitors and ARBs with sepsis-related clinical..
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Endocrinology-metabolism
Impaired fasting glucose levels in overweight or obese subjects for screening of type 2 diabetes in Korea
Jin-Hee Lee, Suk Chon, Seon-Ah Cha, Sun-Young Lim, Kook-Rye Kim, Jae-Seung Yun, Sang Youl Rhee, Kun-Ho Yoon, Yu-Bae Ahn, Jeong-Taek Woo, Seung-Hyun Ko; Korean Diabetes Prevention Study Investigators
Korean J Intern Med. 2021;36(2):382-391. Published online March 5, 2020
Background/Aims: We examined the concordance rate among fasting plasma glucose (FPG), 2-hour post-challenge glucose (2hr PG), and hemoglobin A1c (HbA1c) in the diagnosis of diabetes in a population with a high-risk for type 2 diabetes mellitus (T2DM) in Korea.
Methods: Among the participants from th..
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Nephrology
Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy
Yohan Park, Tae Hyun Ban, Hyung Duk Kim, Eun Jeong Ko, Jongmin Lee, Seok Chan Kim, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
Korean J Intern Med. 2021;36(2):392-400. Published online July 7, 2020
Background/Aims: We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
Methods: This study enrolled 169 patients who underwent serum NGAL testing at CRRT..
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Hemato-oncology
Leukemic stem cell phenotype is associated with mutational profile in acute myeloid leukemia
Heejoo Han, Ja Min Byun, Dong-Yeop Shin, Sung-Soo Yoon, Youngil Koh, Junshik Hong, Inho Kim, Chansup Lee, Hyeonjoo Yoo, Hongseok Yun, Man Jin Kim, Sung Im Cho, Moon-Woo Seong, Sung Sup Park
Korean J Intern Med. 2021;36(2):401-412. Published online August 20, 2020
Background/Aims: Understanding leukemic stem cell (LSC) is important for acute myeloid leukemia (AML) treatment. However, association of LSC with patient prognosis and genetic information in AML patients is unclear.
Methods: Here we investigated the associations between genetic information and the ..
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Mutations in genes affecting DNA methylation enhances responses to decitabine in patients with myelodysplastic syndrome
Hyun Ae Jung, Chul Won Jung, Jun Ho Jang
Korean J Intern Med. 2021;36(2):413-423. Published online October 23, 2020
Background/Aims: In this study, we tested whether mutations in the methylation pathway genes ten-eleven-translocation 2 (TET2) and DNA methyltransferase gene 3A (DNMT3A) improve the responses of patients with myelodysplastic syndrome (MDS) to decitabine.
Methods: We retrospectively se..
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The clinical, laboratory, and radiologic improvement due to siltuximab treatment in idiopathic multicentric Castleman’s disease
Gi-June Min, Young-Woo Jeon, Sung-Soo Park, Silvia Park, Seung-Hawn Shin, Seung-Ah Yahng, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Dong-Wook Kim, Jong-Wook Lee, Seok-Goo Cho
Korean J Intern Med. 2021;36(2):424-432. Published online February 24, 2020
Background/Aims: Idiopathic multicentric Castleman disease (iMCD) comprises approximately 30% of all cases of Castleman disease. It is characterized by constitutional symptoms, enlarged lymph nodes at multiple anatomical sites, and laboratory test abnormalities, which are primarily related to the o..
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Infectious diseases
Comparison of antimicrobial resistances and clinical features in community-onset Escherichia coli and Klebsiella pneumoniae bacteremia
Hwa Seok Sung, Je Won Lee, Sohyun Bae, Ki Tae Kwon
Korean J Intern Med. 2021;36(2):433-440. Published online March 31, 2020
Background/Aims: The aim of this study was to compare antimicrobial resistance, clinical features, and outcomes of community-onset Escherichia coli (COEC) and Klebsiella pneumoniae (COKP) bacteremia.
Methods: The medical records of patients diagnosed with E. coli or K. pneum..
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Rheumatology
Reclassification of Korean patients with polymyositis and dermatomyositis based on the Bohan and Peter criteria by the 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies
Juyoung Yoo, Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Korean J Intern Med. 2021;36(2):441-446. Published online December 30, 2019
Background/Aims: We investigated the concordance rate of the classification of polymyositis (PM) and dermatomyositis (DM) between the Bohan and Peter criteria and the 2017 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for idiopathic inflamm..
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Allergy
Retinol-binding protein-4 was associated with sensitization to inhalant allergens in the elderly population
Byung-Keun Kim, Woo-Jung Song, Bomi Seo, Ju-Young Kim, Sae-Hoon Kim, Hak C. Jang, Ki-Woong Kim, Yoon-Seok Chang
Korean J Intern Med. 2021;36(2):447-455. Published online October 13, 2020
Background/Aims: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin s..
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Geriatrics
Validation of the Korean Frailty Index in community-dwelling older adults in a nationwide Korean Frailty and Aging Cohort study
Hee-Won Jung, Sunyoung Kim, Chang Won Won
Korean J Intern Med. 2021;36(2):456-466. Published online April 17, 2020
Background/Aims: We aimed to assess validity of the Korean Frailty Index (KFI) and the modified KFI (mKFI) in nationwide Korean population as screening measures for frailty status in older adults.
Methods: Analysis was performed in the records of baseline assessments of 2,886 participants in the Ko..
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| Correspondence |
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Airborne transmission of coronavirus disease 2019: a clinician’s perspective
Myoung-don Oh
Korean J Intern Med. 2021;36(2):467-470. Published online February 5, 2021
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| Images of interest |
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Floating teeth in systemic sclerosis
Jae-Bum Jun, Seunghun Lee, Jiyoon Bae
Korean J Intern Med. 2021;36(2):471-472. Published online April 29, 2020
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Hepatic hemangioma presenting as a large cystic tumor
Jin-Seon Park, Gi-Ae Kim, Jae-Jun Shim, Bum-Soo Kim, Seong Jin Park, Youn Wha Kim
Korean J Intern Med. 2021;36(2):473-474. Published online June 17, 2020
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Endoscopic removal of swallowed acupuncture needle infiltrated into the kidney from the duodenum
Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim, Dae Hwan Kang, Hyung Wook Kim
Korean J Intern Med. 2021;36(2):475-476. Published online July 2, 2020
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Primary hyperaldosteronism: a rare cause of acute aortic dissection
Heung Yong Jin, Kyung Ae Lee
Korean J Intern Med. 2021;36(2):477-478. Published online September 18, 2020
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