| Reviews |
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Gastroenterology
Diagnosis and management of gastric dysplasia
Jae Kyu Sung
Korean J Intern Med. 2016;31(2):201-209. Published online February 26, 2016
Gastric dysplasia is a neoplastic lesion and a precursor of gastric cancer. The Padova, Vienna, and World Health Organization classifications were developed to overcome the discrepancies between Western and Japanese pathologic diagnoses and to provide a universally accepted classification of gastric..
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Rheumatology
Current concepts in the management of rheumatoid arthritis
Yoshiya Tanaka
Korean J Intern Med. 2016;31(2):210-218. Published online February 26, 2016
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction that causes significant morbidity and mortality. However, the combined use of methotrexate, a synthetic disease-modifying antirheumatic drug (DMARD), and biologic DMARD has revolutionized t..
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The specialist physician’s approach to rheumatoid arthritis in South Africa
Frederik C. J. Bester, Fredricka J. Bosch, Barend J. Jansen van Rensburg
Korean J Intern Med. 2016;31(2):219-236. Published online February 26, 2016
Rheumatoid arthritis (RA) is expected to increase in Africa and South Africa. Due to the low numbers of rheumatologists in South Africa, specialist physicians also have to care for patients with RA. Furthermore several new developments have taken place in recent years which improved the management a..
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| Editorial |
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Angiotensin converting enzyme inhibitors remain the first treatment of choice
Pyung Chun Oh, Ichiro Sakuma, Toshio Hayashi, Kwang Kon Koh
Korean J Intern Med. 2016;31(2):237-241. Published online February 26, 2016
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| Original Articles |
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Gastroenterology
Combination transarterial chemoembolization and radiofrequency ablation therapy for early hepatocellular carcinoma
Myeong Jun Song, Si Hyun Bae, June Sung Lee, Sung Won Lee, Do Seon Song, Chan Ran You, Jong Young Choi, Seung Kew Yoon
Korean J Intern Med. 2016;31(2):242-252. Published online February 15, 2016
Background/Aims: We compared the recurrence of hepatocellular carcinoma (HCC) and the survival of patients who received radiofrequency ablation (RFA) after transarterial chemoembolization (TACE) with patients treated with TACE or RFA alone.
Methods: This study included 201 patients with HCC, who were..
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Synchronous second primary cancers in patients with squamous esophageal cancer: clinical features and survival outcome
Jin Seo Lee, Ji Yong Ahn, Kee Don Choi, Ho June Song, Yong Hee Kim, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Sook Ryu, Sung-Bae Kim, Jong Hoon Kim, Seung-Il Park, Kyung-Ja Cho, Jin-Ho Kim
Korean J Intern Med. 2016;31(2):253-259. Published online February 11, 2016
Background/Aims: Unexpected diagnosis of synchronous second primary cancers (SPC) complicates physicians’ decision-making because clinical details of squamous esophageal cancer (EC) patients with SPC have been limited. We evaluated clinical features and treatment outcomes of patients with synchron..
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Effects of bispectral index monitoring as an adjunct to nurse-administered propofol combined sedation during colonoscopy: a randomized clinical trial
Jun Heo, Min Kyu Jung, Hyun Seok Lee, Chang Min Cho, Seong Woo Jeon, Sung Kook Kim, Young Hoon Jeon
Korean J Intern Med. 2016;31(2):260-266. Published online February 26, 2016
Background/Aims: The efficacy of bispectral index (BIS) monitoring during colonoscopic sedation is debated. We aimed to determine whether BIS monitoring was useful for propofol dose titration, and to evaluate differences in sedative administration between expert and inexperienced medical personnel d..
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Cardiology
Angiotensin II type 1 receptor blockers as a first choice in patients with acute myocardial infarction
Jang Hoon Lee, Myung Hwan Bae, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Won Kee Lee, Myung Ho Jeong, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim, Shung Chull Chae, Korea Acute Myocardial Infarction Registry Investigators
Korean J Intern Med. 2016;31(2):267-276. Published online December 23, 2015
Background/Aims: Angiotensin II type 1 receptor blockers (ARBs) have not been adequately evaluated in patients without left ventricular (LV) dysfunction or heart failure after acute myocardial infarction (AMI).
Methods: Between November 2005 and January 2008, 6,781 patients who were not receiving a..
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Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study
Hae-Young Lee, Wook-Jin Chung, Hui-Kyung Jeon, Hong-Seog Seo, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Joon Han Shin, Seok-Min Kang, Sung Cil Lim, Sang-Hong Baek
Korean J Intern Med. 2016;31(2):277-287. Published online February 16, 2016
Background/Aims: We evaluated the association between coding region variants of adrenergic receptor genes and therapeutic effect in patients with congestive heart failure (CHF).
Methods: One hundred patients with stable CHF (left ventricular ejection fraction [LVEF] < 45%) were enrolled. Enrolled ..
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Pulmonology
Bleeding complications in critically ill patients with liver cirrhosis
Jaeyoung Cho, Sun Mi Choi, Su Jong Yu, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Jinwoo Lee
Korean J Intern Med. 2016;31(2):288-295. Published online January 25, 2016
Background/Aims: Patients with liver cirrhosis (LC) are at risk for critical events leading to Intensive Care Unit (ICU) admission. Coagulopathy in cirrhotic patients is complex and can lead to bleeding as well as thrombosis. The aim of this study was to investigate bleeding complications in critica..
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Facility characteristics as independent prognostic factors of nursing home-acquired pneumonia
Che Wan Lim, Younghoon Choi, Chang Hyeok An, Sang Joon Park, Hee-Jin Hwang, Jae Ho Chung, Joo-Won Min
Korean J Intern Med. 2016;31(2):296-304. Published online February 2, 2016
Background/Aims: Recently, the incidence of nursing home-acquired pneumonia (NHAP) has been increasing and is now the leading cause of death among nursing home residents. This study was performed to identify risk factors associated with NHAP mortality, focusing on facility characteristics.
Methods:..
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Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
So Young Park, Sang Min Lee, Jong Wook Shin, Byoung Whui Choi, Hojoong Kim, Jae Seung Lee, Sang Do Lee, Sung Soo Park, Hwa Sik Moon, Yong Bum Park
Korean J Intern Med. 2016;31(2):305-312. Published online January 29, 2016
Background/Aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and o..
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Endocrinology-metabolism
Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas
Yang Seon Yi, Sang Soo Kim, Won Jin Kim, Min Jung Bae, Ji Hyun Kang, Bo Gwang Choi, Yun Kyung Jeon, Bo Hyun Kim, Byung Joo Lee, Soo Geun Wang, In Joo Kim, Yong Ki Kim
Korean J Intern Med. 2016;31(2):313-322. Published online December 23, 2015
Background/Aims: The purpose of this study was to compare the diagnostic validity of two-dimensional (2D) and three-dimensional (3D) ultrasonography (US) when predicting the extrathyroidal extension of papillary thyroid cancer.
Methods: All 2D data were interpreted in real time and 3D data were sto..
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Nephrology
Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal
injury in unilateral ureteral obstructed mice
Sarah Chung, Jin Young Jeong, Yoon Kyung Chang, Dae Eun Choi, Ki Ryang Na, Beom Jin Lim, Kang Wook Lee
Korean J Intern Med. 2016;31(2):323-334. Published online February 26, 2016
Background/Aims: There has been controversy about the role of Toll-like receptor 2 (TLR2) in renal injury following ureteric obstruction. Although inhibition of the renin angiotensin system (RAS) reduces TLR2 expression in mice, the exact relationship between TLR2 and RAS is not known. The aim of th..
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Effect of low-dose valsartan on proteinuria in normotensive immunoglobulin A nephropathy with minimal proteinuria: a randomized trial
Young-Il Jo, Ha-Young Na, Ju-Young Moon, Sang-Woong Han, Dong-Ho Yang, Sang-Ho Lee, Hyeong-Cheon Park, Hoon-Young Choi, So-Dug Lim, Jeong-Hae Kie, Yong-Kyu Lee, Sug-Kyun Shin
Korean J Intern Med. 2016;31(2):335-343. Published online February 15, 2016
Background/Aims: Immunoglobulin A nephropathy (IgAN) is a generally progressive disease, even in patients with favorable prognostic features. In this study, we aimed to investigate the antiproteinuric effect and tolerability of low-dose valsartan (an angiotensin II receptor blocker) therapy in normo..
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Validation of the Korean coefficient for the modification of diet in renal disease study equation
Yun Jung Oh, Ran-hui Cha, Seung Hwan Lee, Kyung Sang Yu, Satbyul Estella Kim, Ho Kim, Yon Su Kim
Korean J Intern Med. 2016;31(2):344-356. Published online January 13, 2016
Background/Aims: Race and ethnicity are important determinants when estimating
glomerular filtration rate (GFR). The Korean coefficients for the isotope dilution mass spectrometry (IDMS) Modification of Diet in Renal Disease (MDRD) Study equations were developed in 2010. However, the coefficients h..
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Hemato-oncology
Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
Dae Sik Kim, Yoo Jin Na, Myoung Hee Kang, Soo-Young Yoon, Chul Won Choi
Korean J Intern Med. 2016;31(2):357-366. Published online February 15, 2016
Background/Aims: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed, and a substantial number of patients need alternative treatment ..
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Infectious diseases
Controlling endemic multidrug-resistant Acinetobacter baumannii in Intensive Care Units using antimicrobial stewardship and infection control
Shinhye Cheon, Mi-Ja Kim, Seon-Jin Yun, Jae Young Moon, Yeon-Sook Kim
Korean J Intern Med. 2016;31(2):367-374. Published online February 15, 2016
Background/Aims: Nosocomial infections caused by multidrug-resistant (MDR) Acinetobacter baumannii have become public-health problem. However, few studies have evaluated the control of endemic MDR A. baumannii in Intensive Care Units (ICUs). Therefore, we investigated the effectiveness..
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Allergy
Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma
Duy Le Pham, Seung-Hyun Kim, Purevsuren Losol, Eun-Mi Yang, Yoo Seob Shin, Young-Min Ye, Hae-Sim Park
Korean J Intern Med. 2016;31(2):375-385. Published online December 23, 2015
Background/Aims: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic association of ATG5 and ATG7 polymorphisms with asthma risk, s..
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Rheumatology
The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis
Adem Kucuk, Mehmet Fatih Erol, Soner Senel, Emir Eroler, Havvanur Alparslan Yumun, Ali Ugur Uslu, Asiye Mukaddes Erol, Deniz Tihan, Ugur Duman, Tevfik Kucukkartallar, Yalcin Solak
Korean J Intern Med. 2016;31(2):386-391. Published online February 11, 2016
Background/Aims: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and diffuse abdominal pain. The primary concern with this presentation is to distinguish it from acute appendicitis promptly. Thus, we aimed to evaluate the role of neutrophil lym..
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| Letters to the editor |
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Large Brunner’s gland hamartoma with annular stricture causing gastric outlet obstruction
In Tae Hwang, Young Bum Cho, Dong Eun Park, Keum Ha Choi, Tae Hyeon Kim
Korean J Intern Med. 2016;31(2):392-395. Published online January 25, 2016
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Series with complete resolution of left atrial appendage thrombi with apixaban in elderly patients
Sang Hoon Lee, Seongwook Han
Korean J Intern Med. 2016;31(2):396-398. Published online February 12, 2016
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Painful immunoglobulin G4-related thyroiditis treated by total thyroidectomy
Ihn Suk Lee, Jung Uee Lee, Kwan-Ju Lee, Yi Sun Jang, Jong Min Lee, Hye Soo Kim
Korean J Intern Med. 2016;31(2):399-402. Published online February 26, 2016
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Microscopic polyangiitis with crescentic glomerulonephritis initially presenting as acute pancreatitis
A Young Cho, Byeong Gwan Kim, Sang Sun Kim, Seong Hee Lee, Hong Shik Shin, Yeong Jin Choi, In O Sun
Korean J Intern Med. 2016;31(2):403-405. Published online February 11, 2016
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Mixed-phenotype acute leukemia treated with decitabine
Ji-Young Lee, Sang-min Lee, Ja-Young Lee, Ki-Hyang Kim, Moon-Young Choi, Won-Sik Lee
Korean J Intern Med. 2016;31(2):406-408. Published online February 15, 2016
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| Images of interest |
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Widespread intracranial calcifications in a patient with hypoparathyroidism
Jeong Young Seo, Ju Hyun Seo, Younghee Choe, Hannah Seok, Tae-Seo Sohn
Korean J Intern Med. 2016;31(2):409-410. Published online January 29, 2016
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| Letter to the editor |
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Paraneoplastic dermatomyositis presenting myopathy combined with synchronous cervical and sigmoid colon cancer
Jae Heun Chung, Min Wook So, Seong-Geun Kim
Korean J Intern Med. 2016;31(2):413-416. Published online January 29, 2016
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