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Review
Proprotein convertase subtilisin/kexin type 9 inhibition in cardiovascular disease: current status and future perspectives
Kyung Hoon Cho, Young Joon Hong
Korean J Intern Med. 2020;35(5):1045-1058. Published online August 28, 2020
Proprotein convertase subtilisin/kexin type 9 (PCSK9) targets the degradation of low-density lipoprotein (LDL) receptors; it has been proved that its inhibition improves cardiovascular outcomes in patients with established atherosclerotic cardiovascular disease (ASCVD). Herein, we review the current..
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Hemato-oncology / Original Article
Is immunological recovery clinically relevant at 100 days after allogeneic transplantation?
Jin Park, Sung Hee Lim, Se Hyung Kim, Jina Yun, Chan Kyu Kim, Sang Cheol Lee, Jong Ho Won, Dae Sik Hong, Seong Kyu Park
Korean J Intern Med. 2020;35(4):957-969. Published online April 21, 2020
Background/Aims: Immune reconstitution following allogeneic hematopoietic stem cell transplantation (HSCT) is affected by multiple variables during the transplantation.
Methods: We assessed the clinical factors contributing to immune function reconstitution at 100 days post-allogeneic HSCT in 114 p..
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Review
Alcohol use disorder and liver transplant: new perspectives and critical issues
Stefano Gitto, Silvia Aspite, Lucia Golfieri, Fabio Caputo, Francesco Vizzutti, Silvana Grandi, Valentino Patussi, Fabio Marra
Korean J Intern Med. 2020;35(4):797-810. Published online April 3, 2020
Alcoholic liver disease is a consolidated indication for liver transplantation, but many unsolved issues can be highlighted. Patients with alcohol use disorder develop peculiar comorbidities that can become contraindications for transplantation. Moreover, a number of social and psychological pattern..
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Guideline / Brief Communication
Consensus statement on coronary intervention during the coronavirus disease 19 pandemic: from the Korean Society of Interventional Cardiology
Kwan Yong Lee, Bong-Ki Lee, Won-Jang Kim, Se Hun Kang, Taek Kyu Park, Song-Yi Kim, Jung-Won Suh, Chang-Hwan Yoon, Dong Heon Yang, Sung Kee Ryu, Sang-Hyun Kim, Sung Yun Lee, In-Ho Chae; The Korean Society of Interventional Cardiology COVID-19 Task Force Team
Korean J Intern Med. 2020;35(4):749-757. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the novel virus severe acute respiratory syndrome coronavirus 2. The first case developed in December, 2019 in Wuhan, China; several months later, COVID-19 has become pandemic, and there is no end in sight. This disaster is..
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Cardiology / Original Article
Contemporary use of lipid-lowering therapy for secondary prevention in Korean patients with atherosclerotic cardiovascular diseases
Su-Yeon Choi, Bo Ram Yang, Hyun-Jae Kang, Kyong Soo Park, Hyo-Soo Kim
Korean J Intern Med. 2020;35(3):593-604. Published online November 25, 2019
Background/Aims: We evaluated the contemporary use of lipid-lowering therapy (LLT) in Korean patients with atherosclerotic cardiovascular disease (ASCVD), and identified factors associated with statin non-prescription.
Methods: Using the Korean Health Insurance Review and Assessment data, we identi..
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Cardiology / Original Article
Gender differences in the presentation of chest pain in obstructive coronary artery disease: results from the Korean Women’s Chest Pain Registry
Dong-Hyuk Cho, Jimi Choi, Mi-Na Kim, Hack-Lyoung Kim, Yong Hyun Kim, Jin Oh Na, Jin-Ok Jeong, Hyun Ju Yoon, Mi-Seung Shin, Myung-A Kim, Kyung-Soon Hong, Gil Ja Shin, Seong-Mi Park, Wan Joo Shim
Korean J Intern Med. 2020;35(3):582-592. Published online March 19, 2019
Background/Aims: Chest pain in patients with obstructive coronary artery disease (OCAD) is affected by several social factors. The gender-based differences in chest pain among Koreans have yet to be investigated.
Methods: The study consecutively enrolled 1,549 patients (male/female, 514/1,035; 61 ..
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Rheumatology / Original Article
Mutation of ten-eleven translocation-2 is associated with increased risk of autoimmune disease in patients with myelodysplastic syndrome
Yoon-Jeong Oh, Dong-Yeop Shin, Sang Mee Hwang, Sung-Min Kim, Kyongok Im, Hee Sue Park, Jung-Ah Kim, Yeong Wook Song, Ana Márquez, Javier Martín, Dong-Soon Lee, Jin Kyun Park
Korean J Intern Med. 2020;35(2):457-464. Published online October 25, 2019
Background/Aims: Myelodysplastic syndrome (MDS) is caused by genetic and epigenetic alteration of hematopoietic precursors and immune dysregulation. Approximately 20% of patients with MDS develop an autoimmune disease (AID). Here, we investigated whether particular genetic mutations are associated w..
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Hemato-oncology / Original Article
Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation
Taeyun Kim, Yunsuk Choi, Je-Hwan Lee, Silvia Park, Jae-Sook Ahn, Joon-Ho Moon, Ho-Jin Shin, Won Sik Lee, Dajung Kim, Ho Sup Lee
Korean J Intern Med. 2020;35(2):429-437. Published online January 10, 2019
Background/Aims: Rabbit anti-thymocyte globulin (ATG) is usually incorporated in hematopoietic stem cell transplantation (HSCT) to reduce the incidence of graft-versus-host disease (GVHD). This study aimed to find optimal ATG doses in patients undergoing human leukocyte antigen (HLA)-mismatched allo..
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Pulmonology / Review
Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease
Chin Kook Rhee, Deog Kyeom Kim
Korean J Intern Med. 2020;35(2):276-283. Published online February 28, 2020
Phosphodiesterase-4 inhibitors (PDE4Is) are potent anti-inf lammatory agents and roflumilast has been used to prevent acute exacerbation of chronic obstructive pulmonary disease (COPD). Roflumilast decreases neutrophil migration, restores cystic fibrosis transmembrane conductance regulator activity,..
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Guideline
The use of biological disease-modifying antirheumatic drugs for inflammatory arthritis in Korea: results of a Korean Expert Consensus
Eun-Jung Park, Hyungjin Kim, Seung Min Jung, Yoon-Kyoung Sung, Han Joo Baek, Jisoo Lee
Korean J Intern Med. 2020;35(1):41-59. Published online January 2, 2020
Biological disease-modifying antirheumatic drugs (bDMARDs) are highly effective agents for the treatment of inf lammatory arthritis; however, they also possess a potential risk for serious infection. Recently, with the rapid expansion of the bDMARDs market in Korea, reports of serious adverse events ..
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Rheumatology / Original Article
Rheumatoid arthritis is associated with early tooth loss: results from Korea National Health and Nutrition Examination Survey V to VI
Ji-Won Kim, Jun-Beom Park, Hyeon Woo Yim, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Wan-Uk Kim, Sung-Hwan Park
Korean J Intern Med. 2019;34(6):1381-1391. Published online September 1, 2018
Background/aims: To examine the association between rheumatoid arthritis (RA) and periodontitis or tooth loss.
Methods: The study used data from the fifth and sixth Korea National Health and Nutrition Examination Surveys conducted from 2010 to 2015. RA was defined as participant-reported physician-..
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Pulmonology / Original Article
Mortality of patients with chronic obstructive pulmonary disease: a nationwide populationbased cohort study
Seon Cheol Park, Dong Wook Kim, Eun Cheol Park, Cheung Soo Shin, Chin Kook Rhee, Young Ae Kang, Young Sam Kim
Korean J Intern Med. 2019;34(6):1272-1278. Published online October 16, 2019
Background/Aims: Chronic obstructive pulmonary disease (COPD) is a major cause of mortality in the world. There are no population-based studies on longterm mortality in COPD patients in Korea.
Methods: Using the large, population-based, National Health Insurance Service- National Sample Cohort (NHI..
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Gastroenterology / Original Article
Quality of information on the Internet for Korean patients with inflammatory bowel disease
Jun Sik Yoon, Sang Jik Lee, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Hyun Seok Lee, Yong Hwan Kwon, Su Youn Nam, Seong Woo Jeon, Sun Jin, Joon Seop Lee, Seong Jae Yeo
Korean J Intern Med. 2019;34(6):1215-1222. Published online October 1, 2018
Background/Aims: The Internet is the main resource for health-related information. The incidence of inflammatory bowel disease (IBD) is rapidly increasing in Asian countries. However, the quality of websites for IBD available in this region has not been evaluated. We aimed to evaluate the quality of the..
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Review
Optimal blood pressure target and measurement in patients with chronic kidney disease
Chang Seong Kim, Hong Sang Choi, Eun Hui Bae, Soo Wan Kim, Seong Kwon Ma
Korean J Intern Med. 2019;34(6):1181-1187. Published online June 17, 2019
The prevalence rates of hypertension and chronic kidney disease (CKD) are increasing with the aging of the population. Hypertension and CKD are closely related, and hypertension with accompanying CKD is difficult to control. This difficulty controlling blood pressure (BP) can be explained by changes..
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Hemato-oncology / Original Article
Clinical factors affecting progression-free survival with crizotinib in ALK-positive non-small cell lung cancer
Chan-Young Ock, Shin-Hye Yoo, Bhumsuk Keam, Miso Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Dae Seog Heo
Korean J Intern Med. 2019;34(5):1116-1124. Published online June 29, 2018
Background/Aims: Although crizotinib is standard chemotherapy for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), clinical factors affecting progression-free survival (PFS) have not been reported. The purpose of this study was to identify clinical factor..
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Nephrology / Original Article
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease
Seon Ha Baek, Ran-hui Cha, Shin Wook Kang, Cheol Whee Park, Dae Ryong Cha, Sung Gyun Kim, Sun Ae Yoon, Sejoong Kim, Sang-Youb Han, Jung Hwan Park, Jae Hyun Chang, Chun Soo Lim, Yon Su Kim, Ki Young Na
Korean J Intern Med. 2019;34(4):858-866. Published online November 29, 2017
Background/Aims: Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical ou..
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Gastroenterology / Original Article
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease
Sang Bong Ahn, Dae Won Jun, Kiseok Jang, Byung Hoon Lee, Kye Jung Shin
Korean J Intern Med. 2019;34(4):777-784. Published online February 23, 2018
Background/Aims: Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD). We investigated the expression of NPC1L1 and its correlation with liver X receptor (LXR) expression in peripheral mon..
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Nephrology / Original Article
Impact of sarcopenia on long-term mortality and cardiovascular events in patients undergoing hemodialysis
Jwa-Kyung Kim, Sung Gyun Kim, Ji-Eun Oh, Young-Ki Lee, Jung-Woo Noh, Hyung Jik Kim, Young Rim Song
Korean J Intern Med. 2019;34(3):599-607. Published online November 23, 2017
Background/Aims: A high body mass index (BMI) is known to correlate with better survival in patients on hemodialysis (HD). However, the impacts of body composition and sarcopenia on survival have not been well studied in this population.
Methods: One hundred and forty-two prevalent HD patients were..
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Endocrinology-metabolism / Original Article
Aromatase inhibitor use is a risk factor of carotid plaque presence in endocrine-responsive breast cancer patients
Da Hea Seo, Yongin Cho, Sujin Lee, Seho Park, Seung-Il Kim, Byeong Woo Park, Yumie Rhee
Korean J Intern Med. 2019;34(3):579-587. Published online August 25, 2017
Background/Aims: The aromatase inhibitors (AIs) are well known anti-hormonal therapy in endocrine-responsive breast cancer patients. It can lead to dyslipidemia and be the risk factor of cardiovascular disease due to low estrogen level. However, some recent studies comparing AIs with placebo have sh..
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Pulmonology / Original Article
Left ventricular dysfunction in relation with systemic inflammation in chronic obstructive pulmonary disease patients
Sule Tas Gulen, Ufuk Eryilmaz, Mustafa Yilmaz, Fisun Karadag
Korean J Intern Med. 2019;34(3):569-578. Published online October 29, 2018
Background/Aims: Most important cause of mortality in chronic obstructive pulmonary disease (COPD) patients is known to be cardiovascular disease (CVD). The objective of the present study was to evaluate the echocardiographic parameters in COPD patients with or without pre-diagnosed CVD and to inves..
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