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Pulmonology / Original Article
Clinical efficacy of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in patients with multidrug-resistant bacteremia: a single-center study in Korea
Jeongha Mok, Eun-Jung Jo, Jung Seop Eom, Mi-Hyun Kim, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Kwangha Lee
Korean J Intern Med. 2019;34(5):1058-1067. Published online May 13, 2019
Background/Aims: Matrix-assisted laser desorption/ionization time-of-f light mass spectrometry (MALDI-TOF MS) is a new diagnostic tool for microorganism identification. The clinical usefulness of this approach has not been widely examined in Korea. This retrospective pre–post-intervention quasi-ex..
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Pulmonology / Original Article
Cutaneous adverse drug reactions in patients with peripheral blood eosinophilia during antituberculosis treatment
Tae-Ok Kim, Hong-Joon Shin, Yu-Il Kim, Sung-Chul Lim, Young-Il Koh, Yong-Soo Kwon
Korean J Intern Med. 2019;34(5):1050-1057. Published online March 19, 2019
Background/Aims: Peripheral eosinophilia during tuberculosis (TB) treatment is common, but has not been fully evaluated. The aim of this study was to determine the prevalence and clinical significance of peripheral blood eosinophilia in patients undergoing anti-TB treatment.
Methods: We retrospecti..
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Cardiology / Original Article
Clinical characteristics and outcomes in acute myocardial infarction patients with versus without any cardiovascular risk factors
Ah-Ra Choi, Myung Ho Jeong, Young Joon Hong, Seok-Joon Sohn, Hyun Yi Kook, Doo Sun Sim, Young Keun Ahn, Ki Hong Lee, Jae Yeong Cho, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim; other Korea Acute Myocardial Infarction Registry Investigators
Korean J Intern Med. 2019;34(5):1040-1049. Published online September 1, 2018
Background/Aims: Although cardiovascular (CV) risk factors are well established, some patients experience acute myocardial infarction (AMI) even without any risk factors.
Methods: We analyzed total 11,390 patients (63.6 ± 12.6 years old, 8,401 males) with AMI enrolled in Korea Acute Myocardial In..
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Cardiology / Original Article
The mortality benefit of carvedilol versus bisoprolol in patients with heart failure with reduced ejection fraction
Ki Hong Choi, Ga Yeon Lee, Jin-Oh Choi, Eun-Seok Jeon, Hae-Young Lee, Sang Eun Lee, Jae-Joong Kim, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Hyun-Young Park, Byung-Hee Oh
Korean J Intern Med. 2019;34(5):1030-1039. Published online October 16, 2018
Background/Aims: It is unknown whether different β-blockers (BBs) have variable effects on long-term survival of patients with heart failure with reduced ejection fraction (HFrEF). This study compares the effects of two BBs, carvedilol and bisoprolol, on survival in patients with HFrEF.
Methods: ..
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Gastroenterology / Original Article
Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis
Young Woon Chang, Weon Jin Ko, Chi Hyuk Oh, Yoo Min Park, Shin Ju Oh, Jung Rock Moon, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang
Korean J Intern Med. 2019;34(5):1022-1029. Published online June 14, 2018
Background/Aims: The eradication rate of the first-line triple therapy (a proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has gradually decreased in Korea. We evaluated whether clinical parameters, clarithromycin resistance, and CYP2C19 genotype can affect t..
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Gastroenterology / Original Article
The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis
Ki-Nam Shim, Jin Il Kim, Nayoung Kim, Sang Gyun Kim, Yun Ju Jo, Su Jin Hong, Jeong Eun Shin, Gwang Ha Kim, Kyung Sik Park, Suck Chei Choi, Joong Goo Kwon, Jie-Hyun Kim, Hyun Jin Kim, Ji Won Kim
Korean J Intern Med. 2019;34(5):1008-1021. Published online June 1, 2018
Background/Aims: Irsogladine maleate, an enhancer of gastric mucosal protective factors, has demonstrated its efficacy for various gastric mucosal injuries. The aim of this study was to evaluate the efficacy and safety of irsogladine for prevention of nonsteroidal anti-inflammatory drugs (NSAIDs) or..
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Gastroenterology / Original Article
Age at menarche and risk of colorectal adenoma
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Korean J Intern Med. 2019;34(5):998-1007. Published online May 31, 2018
Background/Aims: Limited data are available regarding the association between age at menarche and the risk of colorectal adenoma. Therefore, we aimed to evaluate the relationship between reproductive factors including age at menarche and the risk of colorectal adenoma.
Methods: A cross-sectional st..
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Gastroenterology / Original Article
Platelet count is associated with sustained virological response rates in treatments for chronic hepatitis C
Baek Gyu Jun, Eui Ju Park, Woong Cheul Lee, Jae Young Jang, Soung Won Jeong, Young Don Kim, Gab Jin Cheon, Young Sin Cho, Sae Hwan Lee, Hong Soo Kim, Yun Nah Lee, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim
Korean J Intern Med. 2019;34(5):989-997. Published online March 14, 2018
Background/Aims: This study was conducted to clarify the sustained virological response (SVR) prediction ability of baseline and treatment-related factors in patients with chronic hepatitis C virus (HCV) infection.
Methods: This retrospective study collected data at four tertiary referral hospitals..
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Editorial
Recommended and real-world treatment of knee osteoarthritis in Korea: differences and compromises
Hyun-Sook Kim
Korean J Intern Med. 2019;34(5):985-988. Published online August 28, 2019
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Editorial
Female hormones and the risk of colorectal neoplasm
Yunho Jung
Korean J Intern Med. 2019;34(5):982-984. Published online August 28, 2019
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Review
A paradigm shift in studies based on rheumatoid arthritis clinical registries
Soo-Kyung Cho, Yoon-Kyoung Sung
Korean J Intern Med. 2019;34(5):974-981. Published online February 18, 2019
Clinical research is the study of aspects of patient health or illness that are closely related to clinical practice. In the late 20th and early 21th century, outcomes for patients with rheumatoid arthritis (RA) improved dramatically due to breakthroughs in new drugs. Patient-reported outcome measur..
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Review
Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis
Mikala C. Osani, Raveendhara R. Bannuru
Korean J Intern Med. 2019;34(5):966-973. Published online March 15, 2019
About 21% of adults with osteoarthritis (OA) are diagnosed with concomitant depression in addition to chronic pain. Duloxetine, an anti-depressant medication, has been recently approved for managing Knee OA. We performed a systematic review to ascertain the efficacy and safety of duloxetine for OA. ..
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Review
Cellular immunotherapy in multiple myeloma
Manh-Cuong Vo, Thangaraj Jaya Lakshmi, Sung-Hoon Jung, Duck Cho, Hye-Seong Park, Tan-Huy Chu, Hyun-Ju Lee, Hyeoung-Joon Kim, Sang-Ki Kim, Je-Jung Lee
Korean J Intern Med. 2019;34(5):954-965. Published online February 15, 2019
In multiple myeloma (MM), the impaired function of several types of immune cells favors the tumor’s escape from immune surveillance and, therefore, its growth and survival. Tremendous improvements have been made in the treatment of MM over the past decade but cellular immunotherapy using dendritic..
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Review
The epidemiology of hepatitis B virus infection in Korea
Sun Young Yim, Ji Hoon Kim
Korean J Intern Med. 2019;34(5):945-953. Published online March 29, 2019
The global burden of hepatitis B virus (HBV) infection is profound, and represents a public health threat as chronic infection can lead to liver cirrhosis, hepatocellular carcinoma, and death. The risk factors for chronic hepatitis B-related liver disease differ according to HBV endemicity, hepatiti..
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Corrigendum
Update on heart failure management and future directions
Hong-Mi Choi, Myung-Soo Park, Jong-Chan Youn
Korean J Intern Med. 2019;34(4):944-944. Published online July 1, 2019
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Image of interest
Massive ventilator-associated pleural empyema
Philipp Jud, Nicole Fink-Neuboeck, Joerg Lindenmann
Korean J Intern Med. 2019;34(4):942-943. Published online March 8, 2019
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Image of interest
Direct cholangioscopy with argon plasma coagulation of an intraductal papillary mucinous neoplasm of the bile duct
Boram Cha, Jin-Seok Park, Seok Jeong, Don Haeng Lee, Joon Mee Kim
Korean J Intern Med. 2019;34(4):940-941. Published online May 16, 2018
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Image of interest
Transarterial embolization for incorrectable abdominal wall hematoma after abdominal paracentesis
Seong Nam Moon
Korean J Intern Med. 2019;34(4):938-939. Published online January 5, 2018
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Rheumatology / Original Article
The evaluation of cellular immune function in elderly patients with systemic lupus erythematosus
Kun Men, Yu Chen, Jingwei Zhang, Dianjun Wei
Korean J Intern Med. 2019;34(4):932-937. Published online November 29, 2017
Background/Aims: To evaluate cellular immune function in systemic lupus erythematosus (SLE) patients over 60 years old, the association between antinuclear antibody (ANA) titers and the ratio of CD4+ /CD8+ was analyzed in this study. The distribution of ANAs and extractable nu..
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Rheumatology / Original Article
Efficacy and safety of tocilizumab in Korean patients with active rheumatoid arthritis
Han Joo Baek, Mie Jin Lim, Won Park, Sung Hwan Park, Seung-Cheol Shim, Dae-Hyun Yoo, Hyun Ah Kim, Soo Kon Lee, Yun Jong Lee, Young Eun Park, Hoon-Suk Cha, Yeong-Wook Song
Korean J Intern Med. 2019;34(4):917-931. Published online January 17, 2018
Background/Aims: To investigate the efficacy and safety of tocilizumab (TCZ) humanized anti-interleukin-6 receptor monoclonal antibody, in Korean patients with active rheumatoid arthritis (RA) refractory to conventional disease modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX)
Me..
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