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Review
Systemic treatment for advanced urothelial cancer: an update on recent clinical trials and current treatment options
Inkeun Park, Jae Lyun Lee
Korean J Intern Med. 2020;35(4):834-853. Published online July 1, 2020
After cisplatin-based chemotherapy became the standard treatment for metastatic urothelial cancer (mUC), very little progress has been made in the treatment landscape of this condition until recently. With increased knowledge about the molecular biology of mUC and advances in the field of cancer imm..
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Review
Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications
Youngwoo Choi, Soyoon Sim, Hae-Sim Park
Korean J Intern Med. 2020;35(4):823-833. Published online May 29, 2020
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncon..
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Review
Recent progress in the management of chronic cough
Woo-Jung Song, Jin An, Lorcan McGarvey
Korean J Intern Med. 2020;35(4):811-822. Published online May 20, 2020
Chronic cough is a common clinical condition with significant impact on quality of life and for which effective therapy remains an unmet clinical need. Over the past decade, there has been a major shift in how we approach this problem, driven by better appreciation of the clinical manifestation of ch..
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Review
Alcohol use disorder and liver transplant: new perspectives and critical issues
Stefano Gitto, Silvia Aspite, Lucia Golfieri, Fabio Caputo, Francesco Vizzutti, Silvana Grandi, Valentino Patussi, Fabio Marra
Korean J Intern Med. 2020;35(4):797-810. Published online April 3, 2020
Alcoholic liver disease is a consolidated indication for liver transplantation, but many unsolved issues can be highlighted. Patients with alcohol use disorder develop peculiar comorbidities that can become contraindications for transplantation. Moreover, a number of social and psychological pattern..
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Rapid Communication / Brief Communication
Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs
Se Yoon Park, Soon Gyu Yun, Jeong Won Shin, Bo Young Lee, Hyo-Ju Son, Seungjae Lee, Eunjung Lee, Tae Hyong Kim
Korean J Intern Med. 2020;35(4):793-796. Published online June 19, 2020
There are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after rem..
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Rapid Communication / Brief Communication
Four cases of coronavirus disease 2019 in the early stage of pandemic of South Korea: a single public hospital experience
Mi Young Ahn, Dong Hyun Oh, Suhyun Kim, Jae-Phil Choi, Ji Hyeon Lee, Young Kyung Lee, Ki Ho Hong
Korean J Intern Med. 2020;35(4):788-792. Published online July 1, 2020
In view of this pandemic, as of February 2020, South Korea has the second highest number of confirmed cases in the world. Herein, we report four confirmed coronavirus disease 2019 (COVID-19) cases in the early stage of the pandemic in South Korea and describe the identification, diagnosis, clinical ..
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Original Article / Brief Communication
In vitro activity of lopinavir/ritonavir and hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 at concentrations achievable by usual doses
Chang Kyung Kang, Moon-Woo Seong, Su-Jin Choi, Taek Soo Kim, Pyoeng Gyun Choe, Sang Hoon Song, Nam-Joong Kim, Wan Beom Park, Myoung-don Oh
Korean J Intern Med. 2020;35(4):782-787. Published online May 29, 2020
Background/Aims: As the coronavirus disease-2019 global pandemic progresses, screening of antiviral agents effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed. In addition, considering the viral load kinetics of SARS-CoV-2, which peaks early in the illne..
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Original Article / Brief Communication
Lung ultrasound for early diagnosis and severity assessment of pneumonia in patients with coronavirus disease 2019
[corrected-article]
Young-Jae Cho, Kyoung-Ho Song, Yunghee Lee, Joo Heung Yoon, Ji Young Park, Jongtak Jung, Sung Yoon Lim, Hyunju Lee, Ho Il Yoon, Kyoung Un Park, Hong Bin Kim, Eu Suk Kim
Korean J Intern Med. 2020;35(4):771-781. Published online July 1, 2020
Background/Aims: Current evidence supports lung ultrasound as a point-ofcare alternative diagnostic tool for various respiratory diseases. We sought to determine the utility of lung ultrasound for early detection of pneumonia and for assessment of respiratory failure among patients with coronavirus ..
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Original Article / Brief Communication
Selecting coronavirus disease 2019 patients with negligible risk of progression: early experience from non-hospital isolation facility in Korea
Pyoeng Gyun Choe, Eun Kyo Kang, Sun Young Lee, Boram Oh, Dahae Im, Hyo Yeon Lee, Hyemin Jung, Chang Kyung Kang, Min Sun Kim, Wan Beom Park, Eun Hwa Choi, BeLong Cho, Myoung-don Oh, Nam Joong Kim
Korean J Intern Med. 2020;35(4):765-770. Published online May 29, 2020
Background/Aims: As the novel coronavirus (coronavirus disease 2019 [COVID-19]) outbreak progresses rapidly, staying home is recommended for suspected patients; however, the safety of this recommendation is uncertain. In Korea, non-hospital facilities called “living and treatment centers (LTCs)” ..
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Original Article / Brief Communication
A cluster of tertiary transmissions of 2019 novel coronavirus (SARS-CoV-2) in the community from infectors with common cold symptoms
Nam Joong Kim, Pyoeng Gyun Choe, Sang-Joon Park, Jaegyun Lim, Wang Jun Lee, Chang Kyung Kang, Wan Beom Park, Moon-Woo Seong, Myoung-don Oh
Korean J Intern Med. 2020;35(4):758-764. Published online June 11, 2020
Background/Aims: As the global impact of the novel coronavirus disease 2019 (COVID-19) has been severe, many countries have intensified containment activities to eliminate virus transmission, through early detection and isolation strategies. To establish a proper quarantine strategy, it is essential..
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Guideline / Brief Communication
Consensus statement on coronary intervention during the coronavirus disease 19 pandemic: from the Korean Society of Interventional Cardiology
Kwan Yong Lee, Bong-Ki Lee, Won-Jang Kim, Se Hun Kang, Taek Kyu Park, Song-Yi Kim, Jung-Won Suh, Chang-Hwan Yoon, Dong Heon Yang, Sung Kee Ryu, Sang-Hyun Kim, Sung Yun Lee, In-Ho Chae; The Korean Society of Interventional Cardiology COVID-19 Task Force Team
Korean J Intern Med. 2020;35(4):749-757. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the novel virus severe acute respiratory syndrome coronavirus 2. The first case developed in December, 2019 in Wuhan, China; several months later, COVID-19 has become pandemic, and there is no end in sight. This disaster is..
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Review / Brief Communication
Current laboratory diagnosis of coronavirus disease 2019
Jihyang Lim, Jehoon Lee
Korean J Intern Med. 2020;35(4):741-748. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) emerged in December 2019 in Wuhan, China; it has since caused a pandemic, with more than 10,000 confirmed cases (> 800,000 tests) in Korea as of May 2020. Real-time reverse transcription polymerase chain reaction (RT-PCR) is currently the most commonly used method..
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Erratum
Continuous renal replacement therapy in elderly with acute kidney injury
Kristianne Rachel P. Medina-Liabres, Sejoong Kim
Korean J Intern Med. 2020;35(3):740-740. Published online April 29, 2020
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Image of interest
Retinal artery occlusion after herpes zoster mandibularis in a patient with systemic lupus erythematosus
Gae-Eil Jang, Hyun-Sook Kim
Korean J Intern Med. 2020;35(3):738-739. Published online December 28, 2018
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Image of interest
Unusual milia-type intradermal tophi in a patient with gout
Mingyo Kim, Sang-Il Lee, Yun-Hong Cheon
Korean J Intern Med. 2020;35(3):736-737. Published online December 31, 2018
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Image of interest
Solitary fibrous tumor of the liver mimicking malignancy
Hee Chul Nam, Pil Soo Sung, Eun Sun Jung, Seung Kew Yoon
Korean J Intern Med. 2020;35(3):734-735. Published online March 8, 2019
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Image of interest
A rare collision tumor comprising intracystic papillary neoplasm associated with adenocarcinoma and angiosarcoma in the gallbladder
Geon Park, Won Suk Park, Sang Kuon Lee, Jong Ok Kim
Korean J Intern Med. 2020;35(3):732-733. Published online July 31, 2019
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Rheumatology / Original Article
Liver enzyme elevation in patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors: a single-center historical cohort study
Su Jin Choi, Ji Seon Oh, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
Korean J Intern Med. 2020;35(3):723-731. Published online December 26, 2019
Background/Aims: Tumor necrosis factor inhibitors (TNFi) have been known to induce liver enzyme elevation, sometimes associated with viral reactivation or toxic hepatitis. We evaluated the incidence and risk factors of TNFi-associated liver enzyme elevation in Korean ankylosing spondylitis (AS) pati..
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Allergy / Original Article
Incidence of teicoplanin adverse drug reactions among patients with vancomycin-associated adverse drug reactions and its risk factors
Byung-Keun Kim, Jung-Hyun Kim, Kyoung-Hee Sohn, Ju-Young Kim, Yoon-Seok Chang, Sae-Hoon Kim
Korean J Intern Med. 2020;35(3):714-722. Published online November 15, 2019
Background/Aims: Teicoplanin can be used as an alternative to vancomycin when treating beta-lactam-resistant gram-positive bacterial infections. Both vancomycin and teicoplanin are associated with relatively high rates of adverse drug reactions (ADRs), including hypersensitivity reactions. There is ..
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Infectious diseases / Original Article
Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013
Bongyoung Kim, Hyeonjun Hwang, Jieun Kim, Myoung-jae Lee, Hyunjoo Pai
Korean J Intern Med. 2020;35(3):703-713. Published online September 27, 2018
Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea.
Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each ..
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