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Review
Consensus regarding diagnosis and management of atypical hemolytic uremic syndrome
Hajeong Lee, Eunjeong Kang, Hee Gyung Kang, Young Hoon Kim, Jin Seok Kim, Hee-Jin Kim, Kyung Chul Moon, Tae Hyun Ban, Se Won Oh, Sang Kyung Jo, Heeyeon Cho, Bum Soon Choi, Junshik Hong, Hae Il Cheong, Doyeun Oh
Korean J Intern Med. 2020;35(1):25-40. Published online January 2, 2020
Thrombotic microangiopathy (TMA) is defined by specific clinical characteristics, including microangiopathic hemolytic anemia, thrombocytopenia, and pathologic evidence of endothelial cell damage, as well as the resulting ischemic end-organ injuries. A variety of clinical scenarios have features of ..
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Gastroenterology / Original Article
Quality of information on the Internet for Korean patients with inflammatory bowel disease
Jun Sik Yoon, Sang Jik Lee, Eun Soo Kim, Sung Kook Kim, Min Kyu Jung, Hyun Seok Lee, Yong Hwan Kwon, Su Youn Nam, Seong Woo Jeon, Sun Jin, Joon Seop Lee, Seong Jae Yeo
Korean J Intern Med. 2019;34(6):1215-1222. Published online October 1, 2018
Background/Aims: The Internet is the main resource for health-related information. The incidence of inflammatory bowel disease (IBD) is rapidly increasing in Asian countries. However, the quality of websites for IBD available in this region has not been evaluated. We aimed to evaluate the quality of the..
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Rheumatology / Original Article
Impact of sleep quality on clinical features of primary Sjögren's syndrome
Sang Wan Chung, Jaehyung Hur, You-Jung Ha, Eun Ha Kang, Joon Young Hyon, Hyo-Jung Lee, Yeong Wook Song, Yun Jong Lee
Korean J Intern Med. 2019;34(5):1154-1164. Published online February 20, 2018
Background/Aims: This study aimed to investigate the inf luence of poor sleep quality on clinical features of primary Sjögren’s syndrome (pSS).
Methods: Sleep quality was cross-sectionally assessed using the Pittsburgh Sleep Quality Index (PSQI), and demographic, clinical, and laboratory data we..
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Hemato-oncology / Original Article
Clinical activity of fulvestrant in metastatic breast cancer previously treated with endocrine therapy and/or chemotherapy
Mi Hwa Heo, Hee Kyung Kim, Hansang Lee, Ji-Yeon Kim, Jin-Seok Ahn, Young-Hyuck Im, Yeon Hee Park
Korean J Intern Med. 2019;34(5):1100-1106. Published online March 16, 2018
Background/Aims: We conducted a retrospective analysis of the clinical activity of fulvestrant in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) previously treated with endocrine therapy and/or chemotherapy..
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Gastroenterology / Original Article
Age at menarche and risk of colorectal adenoma
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Korean J Intern Med. 2019;34(5):998-1007. Published online May 31, 2018
Background/Aims: Limited data are available regarding the association between age at menarche and the risk of colorectal adenoma. Therefore, we aimed to evaluate the relationship between reproductive factors including age at menarche and the risk of colorectal adenoma.
Methods: A cross-sectional st..
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Infectious diseases / Original Article
MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts
[retracted-article]
Chun Zhang, Jinhua Dai, Youfen Fan, Xianghui He, Renxiong Wei
Korean J Intern Med. 2019;34(3):634-642. Published online January 5, 2018
Background/Aims: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts.
Methods: Primary human dermal fibroblasts were separated from normal human skin samples. Under heat stress, the levels of miR-16 and heat shock protein 7..
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Hemato-oncology / Original Article
Comparison of the morphologic criteria (RECIST) and metabolic criteria (EORTC and PERCIST) in tumor response assessments: a pooled analysis
Hong Deok Kim, Bum Jun Kim, Hyeong Su Kim, Jung Han Kim
Korean J Intern Med. 2019;34(3):608-617. Published online January 17, 2018
Background/Aims: The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) or European Organization for Research and Treatment of Cancer (EORTC) criteria are used to assess metabolic tumor responses. However, tumor responses have shown considerable discrepancies between the morpho..
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Pulmonology / Original Article
Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough
Ji Young Hong, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung, Seung Hun Jang
Korean J Intern Med. 2019;34(3):559-568. Published online December 13, 2018
Background/Aims: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial.
Methods: We conducted a prospective observational study to determine the ICS efficacy and clinical predictors of response t..
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Cardiology / Original Article
Gender difference in the association between brachial-ankle pulse wave velocity and cardiovascular risk scores
Tae-Min Rhee, Hack-Lyoung Kim, Sohee Oh, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
Korean J Intern Med. 2019;34(3):539-548. Published online March 16, 2018
Background/Aims: Although brachial-ankle pulse wave velocity (baPWV) has been validated as a novel method to predict the cardiovascular risk in general population, the relevance of baPWV to the traditional risk scores has not been clearly revealed. This study investigated the relationship between b..
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Gastroenterology / Original Article
Performance of disposable endoscopic forceps according to the manufacturing techniques
Chang-Il Kwon, Gwangil Kim, Jong Pil Moon, Ho Yun, Weon Jin Ko, Joo Young Cho, Sung Pyo Hong
Korean J Intern Med. 2019;34(3):530-538. Published online March 5, 2018
Background/Aims: Recently, to lower the production costs and risk of infection, new disposable biopsy forceps made using simple manufacturing techniques have been introduced. However, the effects of the manufacturing techniques are unclear. The aim of this study was to evaluate which types of biopsy..
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Rheumatology / Review
Molecular targeted therapies for microscopic polyangiitis and granulomatosis with polyangiitis
Masayoshi Harigai, Michi Tsutsumino, Hideto Takada, Kenji Nagasaka
Korean J Intern Med. 2019;34(3):492-503. Published online January 9, 2019
Clinical trials and observational studies have established cyclophosphamide (CY) or rituximab plus glucocorticoid (GC) as standard remission induction therapies in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). However, because these regimens are associated ..
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Hemato-oncology / Original Article
Factors associated with treatment interruption in elderly patients with cancer
Hye Sung Won, Der Sheng Sun, Ji Young Choi, Ho Jung An, Yoon Ho Ko
Korean J Intern Med. 2019;34(1):156-164. Published online February 23, 2018
Background/Aims: This study was conducted to identify risk factors that predict vulnerability to cancer therapy on the basis of the clinical, geriatric, and quality of life assessment before starting treatment in elderly patients.
Methods: Seventy-five patients aged 65 years and over with newly dia..
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Endocrinology-metabolism / Original Article
Analysis of diabetes quality assessment findings and future directions for the appropriate management of diabetes in Korea
Yu Jin Kim, Suk Chon, Seungjoon Oh, Jeong-taek Woo, Sung Woon Kim, Sang Youl Rhee
Korean J Intern Med. 2019;34(1):125-136. Published online March 15, 2017
Background/Aims: Due to recent increases in the disease burden of diabetes mellitus, the Health Insurance Review and Assessment Service (HIRA) of Korea implemented a quality assessment of the treatment of diabetes to improve patient care. The present study was conducted to identify any changes after..
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Cardiology / Review
Management plans for populations with normal-to-hypertensive blood pressures:
risks and benefits of antihypertensive drug treatment in populations previously defined as
having high-normal blood pressure
Sungha Park
Korean J Intern Med. 2019;34(1):44-49. Published online December 28, 2018
Recent changes in American and European guidelines on the management of arterial hypertension have caused a considerable shift in the landscape of hypertension management. The 2017 American College of Cardiology/American Heart Association/American Society of Hypertension guideline recommends an offi..
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Cardiology / Review
Update on heart failure management and future directions
[corrected-article]
Hong-Mi Choi, Myung-Soo Park, Jong-Chan Youn
Korean J Intern Med. 2019;34(1):11-43. Published online December 28, 2018
Heart failure (HF) is an important cardiovascular disease because of its increasing prevalence, significant morbidity, high mortality, and rapidly expanding health care cost. The number of HF patients is increasing worldwide, and Korea is no exception. There have been marked advances in definition, ..
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Gastroenterology / Original Article
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy?
Nam Hee Kim, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
Korean J Intern Med. 2018;33(6):1084-1092. Published online January 5, 2018
Background/Aims: There has been no evidence for the necessity of endoscopy in asymptomatic young men with iron deficiency anemia (IDA). To determine whether endoscopy should be recommended in asymptomatic young men with IDA, we compared the prevalence of gastrointestinal (GI) lesions between young m..
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Allergy / Original Article
Management and educational status of adult anaphylaxis patients at emergency department
Mi-Yeong Kim, Chan Sun Park, Jae-won Jeong
Korean J Intern Med. 2018;33(5):1008-1015. Published online December 28, 2017
Background/Aims: We evaluated the management and educational status of adult anaphylaxis patients at emergency departments (EDs).
Methods: Anaphylaxis patients who visited ED from 2011 to 2013 were enrolled from three hospitals. We analyzed clinical features, prior history of anaphylaxis, managemen..
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Pulmonology / Original Article
Clinical and molecular characteristics of pulmonary sarcomatoid carcinoma
Jae Kyeom Sim, Sang Mi Chung, Jong Hyun Choi, Jee Youn Oh, Seung Heon Lee, Je Hyeong Kim, Kyung Hoon Min, Gyu Young Hur, Jae Jeong Shim, Kyung Ho Kang, Bong Kyung Shin, Ju Han Lee, Sung Yong Lee
Korean J Intern Med. 2018;33(4):737-744. Published online February 20, 2018
Background/Aims: Pulmonary sarcomatoid carcinoma (PSC) is a poorly differentiated non-small cell lung cancer (NSCLC) that contains components of spindle or giant cells. Owing to its low prevalence, there are insufficient data regarding its clinical features, therapeutic strategies and prognosis.
Me..
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Rheumatology / Original Article
Grape seed proanthocyanidin extract ameliorates murine autoimmune arthritis through regulation of TLR4/MyD88/NF-κB signaling pathway
Sang-Hyon Kim, Jihye Bang, Chang-Nam Son, Won-Ki Baek, Ji-Min Kim
Korean J Intern Med. 2018;33(3):612-621. Published online June 3, 2016
Background/Aims: Grape seed proanthocyanidin extract (GSPE) has been reported to have a beneficial effect on regulating inf lammation. However, the anti-inflammatory mechanism of GSPE remains unclear. The aim of this study was to verify the influence of GSPE on the Toll-like receptor 4 (TLR4)-mediat..
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Gastroenterology / Original Article
Efficacy of preoperative percutaneous cholecystostomy in the management of acute cholecystitis according to severity grades
Seong Yeol Kim, Kyo-Sang Yoo
Korean J Intern Med. 2018;33(3):497-505. Published online January 6, 2017
Background/Aims: The aim of this retrospective study was to assess the efficacy of percutaneous cholecystostomy (PC) for patients with acute cholecystitis (AC) according to severity.
Methods: A total of 325 patients who underwent cholecystectomy between January 2008 and October 2010 were enrolled. ..
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