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Cardiology / Original Article
Clinical significance of changes in the corrected QT interval in stress-induced cardiomyopathy
Jung-Hee Lee, Jae-Sun Uhm, Dong Geum Shin, Boyoung Joung, Hui-Nam Pak, Young-Guk Ko, Geu-Ru Hong, Moon-Hyoung Lee
Korean J Intern Med. 2016;31(3):507-516. Published online April 7, 2016
Background/Aims: Although transient changes in the electrocardiogram (ECG) of patients with stress-induced cardiomyopathy (SCMP) are common, there are little data about ECG changes in patients with SCMP and the clinical implications of these variations.
Methods: We investigated a total of 128 pati..
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Gastroenterology / Original Article
Diagnostic value of alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index combined with γ-glutamyl transferase in differentiating ALD and NAFLD
Junling Wang, Ping Li, Zhilong Jiang, Qiuhui Yang, Yuqiang Mi, Yonggang Liu, Ruifang Shi, Yonghe Zhou, Jinsheng Wang, Wei Lu, Si Li, Dan Liu
Korean J Intern Med. 2016;31(3):479-487. Published online March 30, 2016
Background/Aims: This study aimed to verify the reliability of the alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index (ANI) for distinguishing ALD in patients with hepatic steatosis from NAFLD, and to investigate whether ANI combined with γ-glutamyl transferase (GGT) woul..
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Gastroenterology / Original Article
Comparison of enhancement and image quality: different iodine concentrations for liver on 128-slice multidetector computed tomography in the same chronic liver disease patients
Byoung Goo Jo, Yun Gyu Song, Sang Goon Shim, Young Wook Kim
Korean J Intern Med. 2016;31(3):461-469. Published online December 23, 2015
Background/Aims: The objective of this study was to compare the degree of hepatic enhancement and image quality using contrast media of different iodine concentrations with the same iodine dose.
Methods: From July 2011 to June 2013, 50 patients with chronic liver disease who underwent baseline and ..
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Rheumatology / Original Article
The role of neutrophil lymphocyte ratio to leverage the differential diagnosis of familial Mediterranean fever attack and acute appendicitis
Adem Kucuk, Mehmet Fatih Erol, Soner Senel, Emir Eroler, Havvanur Alparslan Yumun, Ali Ugur Uslu, Asiye Mukaddes Erol, Deniz Tihan, Ugur Duman, Tevfik Kucukkartallar, Yalcin Solak
Korean J Intern Med. 2016;31(2):386-391. Published online February 11, 2016
Background/Aims: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and diffuse abdominal pain. The primary concern with this presentation is to distinguish it from acute appendicitis promptly. Thus, we aimed to evaluate the role of neutrophil lym..
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Hemato-oncology / Original Article
Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
Dae Sik Kim, Yoo Jin Na, Myoung Hee Kang, Soo-Young Yoon, Chul Won Choi
Korean J Intern Med. 2016;31(2):357-366. Published online February 15, 2016
Background/Aims: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed, and a substantial number of patients need alternative treatment ..
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Nephrology / Original Article
Validation of the Korean coefficient for the modification of diet in renal disease study equation
Yun Jung Oh, Ran-hui Cha, Seung Hwan Lee, Kyung Sang Yu, Satbyul Estella Kim, Ho Kim, Yon Su Kim
Korean J Intern Med. 2016;31(2):344-356. Published online January 13, 2016
Background/Aims: Race and ethnicity are important determinants when estimating
glomerular filtration rate (GFR). The Korean coefficients for the isotope dilution mass spectrometry (IDMS) Modification of Diet in Renal Disease (MDRD) Study equations were developed in 2010. However, the coefficients h..
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Nephrology / Original Article
Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal
injury in unilateral ureteral obstructed mice
Sarah Chung, Jin Young Jeong, Yoon Kyung Chang, Dae Eun Choi, Ki Ryang Na, Beom Jin Lim, Kang Wook Lee
Korean J Intern Med. 2016;31(2):323-334. Published online February 26, 2016
Background/Aims: There has been controversy about the role of Toll-like receptor 2 (TLR2) in renal injury following ureteric obstruction. Although inhibition of the renin angiotensin system (RAS) reduces TLR2 expression in mice, the exact relationship between TLR2 and RAS is not known. The aim of th..
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Endocrinology-metabolism / Original Article
Comparison of two- and three-dimensional sonography for the prediction of the extrathyroidal extension of papillary thyroid carcinomas
Yang Seon Yi, Sang Soo Kim, Won Jin Kim, Min Jung Bae, Ji Hyun Kang, Bo Gwang Choi, Yun Kyung Jeon, Bo Hyun Kim, Byung Joo Lee, Soo Geun Wang, In Joo Kim, Yong Ki Kim
Korean J Intern Med. 2016;31(2):313-322. Published online December 23, 2015
Background/Aims: The purpose of this study was to compare the diagnostic validity of two-dimensional (2D) and three-dimensional (3D) ultrasonography (US) when predicting the extrathyroidal extension of papillary thyroid cancer.
Methods: All 2D data were interpreted in real time and 3D data were sto..
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Pulmonology / Original Article
Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
So Young Park, Sang Min Lee, Jong Wook Shin, Byoung Whui Choi, Hojoong Kim, Jae Seung Lee, Sang Do Lee, Sung Soo Park, Hwa Sik Moon, Yong Bum Park
Korean J Intern Med. 2016;31(2):305-312. Published online January 29, 2016
Background/Aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and o..
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Gastroenterology / Original Article
Synchronous second primary cancers in patients with squamous esophageal cancer: clinical features and survival outcome
Jin Seo Lee, Ji Yong Ahn, Kee Don Choi, Ho June Song, Yong Hee Kim, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Sook Ryu, Sung-Bae Kim, Jong Hoon Kim, Seung-Il Park, Kyung-Ja Cho, Jin-Ho Kim
Korean J Intern Med. 2016;31(2):253-259. Published online February 11, 2016
Background/Aims: Unexpected diagnosis of synchronous second primary cancers (SPC) complicates physicians’ decision-making because clinical details of squamous esophageal cancer (EC) patients with SPC have been limited. We evaluated clinical features and treatment outcomes of patients with synchron..
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Gastroenterology / Original Article
Combination transarterial chemoembolization and radiofrequency ablation therapy for early hepatocellular carcinoma
Myeong Jun Song, Si Hyun Bae, June Sung Lee, Sung Won Lee, Do Seon Song, Chan Ran You, Jong Young Choi, Seung Kew Yoon
Korean J Intern Med. 2016;31(2):242-252. Published online February 15, 2016
Background/Aims: We compared the recurrence of hepatocellular carcinoma (HCC) and the survival of patients who received radiofrequency ablation (RFA) after transarterial chemoembolization (TACE) with patients treated with TACE or RFA alone.
Methods: This study included 201 patients with HCC, who were..
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Gastroenterology / Review
Diagnosis and management of gastric dysplasia
Jae Kyu Sung
Korean J Intern Med. 2016;31(2):201-209. Published online February 26, 2016
Gastric dysplasia is a neoplastic lesion and a precursor of gastric cancer. The Padova, Vienna, and World Health Organization classifications were developed to overcome the discrepancies between Western and Japanese pathologic diagnoses and to provide a universally accepted classification of gastric..
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Letter to the editor
Epithelioid sarcoma with spontaneous pneumothorax and massive pleural effusion
So-Yeon Jeon, Ho-Young Yhim, Na-Ri Lee
Korean J Intern Med. 2016;31(1):191-193. Published online December 28, 2015
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Letter to the editor
Diagnosis of cyclic Cushing syndrome using the morning urine free cortisol to creatinine ratio
Yi Sun Jang, Ihn Suk Lee, Jong Min Lee, Soo A Choi, Gi Jun Kim, Hye Soo Kim
Korean J Intern Med. 2016;31(1):184-187. Published online December 28, 2015
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Letter to the editor
Churg-Strauss syndrome that presented with mediastinal lymphadenopathy and calculous cholecystitis
Jung Yoon Choi, Ji Eun Kim, In Young Choi, Ju Han Lee, Je Hyeong Kim, Chol Shin, Seung Heon Lee
Korean J Intern Med. 2016;31(1):179-183. Published online December 28, 2015
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Infectious diseases / Original Article
Amikacin therapy for urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli
Sung-Yeon Cho, Su-Mi Choi, Sun Hee Park, Dong-Gun Lee, Jung-Hyun Choi, Jin-Hong Yoo
Korean J Intern Med. 2016;31(1):156-161. Published online December 28, 2015
Background/Aims: The number of urinary tract infections (UTIs) caused by extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) is increasing. In an outpatient setting, there are limited therapeutic options to treat ESBL-producing pathogens. We evaluated the outcomes of amikacin..
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Hemato-oncology / Original Article
Evaluation of treatment response and tissue necrosis as prognostic indicators following neoadjuvant chemoradiotherapy in rectal cancer patients
Ji-Han Jung, Ho Jung An, Hyung-Jin Kim, Jonghoon Lee, Kang-Moon Lee, Sung Hwan Kim, Hyeon-Min Cho, Byoung Yong Shim
Korean J Intern Med. 2016;31(1):134-144. Published online December 28, 2015
Background/Aims: The objective of this study was to assess the prognostic roles of treatment response and tissue necrosis after chemoradiotherapy (CRT) in locally advanced rectal cancer.
Methods: A total of 243 patients with locally advanced rectal cancer who underwent neoadjuvant CRT were included..
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Nephrology / Original Article
Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
Hyung Wook Kim, Young Ok Kim, Sun Ae Yoon, Jeong-Sun Han, Hyun-Bae Chun, Young Soo Kim
Korean J Intern Med. 2016;31(1):116-124. Published online December 28, 2015
Background/Aims: We investigated whether angiotensin III (Ang III) is involved in monocyte recruitment through regulation of the chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured human proximal tubular epithelial cells (HK-2 cells).
Methods: We measured MCP-1 levels in HK-2 cells tha..
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Pulmonology / Original Article
Clinical efficacy of high-flow nasal cannula compared to noninvasive ventilation in patients with post-extubation respiratory failure
Jung-Wan Yoo, Ara Synn, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim
Korean J Intern Med. 2016;31(1):82-88. Published online December 28, 2015
Background/Aims: Post-extubation respiratory failure (PERF) is associated with poor clinica l outcomes. High-f low nasa l cannula (HF NC) ox ygen therapy has been used in patients with respiratory failure, but the clinical benefit in patients with PERF remains unclear. The aim of this study was to e..
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Infectious diseases / Review
Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?
Wing Wai Yew, Won-Jung Koh
Korean J Intern Med. 2016;31(1):15-29. Published online December 28, 2015
A worsening scenario of drug-resistant tuberculosis has increased the need for new treatment strategies to tackle this worldwide emergency. There is a pressing need to simplify and shorten the current 6-month treatment regimen for drug-susceptible tuberculosis. Rifamycins and fluoroquinolones, as we..
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