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Endocrinology-metabolism
Weight change and microvascular outcomes in patients with new-onset diabetes: a nationwide cohort study
Eun Sil Koh, Kyung Do Han, Mee Kyoung Kim, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
Korean J Intern Med. 2021;36(4):932-941. Published online May 13, 2021
Background/Aims: Because weight control is important in treatment of type 2 diabetes, it is essential to understand the associations between weight change and the risk of microvascular complications among patients with type 2 diabetes. We examined whether weight changes early after new-onset diabete..
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Pulmonology
Pulse pressure during the initial resuscitative period in patients with septic shock treated with a protocol-driven resuscitation bundle therapy
Sang-Hun Lee, Youn-Jung Kim, Gi Na Yu, Jae Cheon Jeon, Won Young Kim
Korean J Intern Med. 2021;36(4):924-931. Published online August 20, 2020
Background/Aims: Maintaining a mean arterial pressure (MAP) ≥ 65 mmHg during septic shock should be based on individual circumstances, but specific target is poorly understood. We investigated associations between time-weighted average (TWA) hemodynamic parameters during the initial resuscitative ..
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Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis
Ji-Hye Son, Jong-Uk Lee, Susie Chin, Eun-Suk Go, Jai-Seong Park, Hwa-Kyun Shin, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park
Korean J Intern Med. 2021;36(4):914-923. Published online September 21, 2020
Background/Aims: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a major regulator of Wnt signaling, which is involved in fibroblast dysfunction. Because its role has not been evaluated in idiopathic pulmonary fibrosis (IPF), we examined the clinical implications of ROR2 expression.
Metho..
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Cardiology
A prospective, observational study of rivaroxaban for stroke prevention in atrial fibrillation: the XANAP Korea
Jaemin Shim, Young Keun On, Sun U. Kwon, Gi-Byoung Nam, Moon-Hyoung Lee, Hyung-Wook Park, Keun-Sik Hong, Nam-Ho Kim, Pierre Amarenco, Seung-Woon Rha, Dong-Gu Shin, Joung-Ho Rha, Young-Hoon Kim
Korean J Intern Med. 2021;36(4):906-913. Published online June 11, 2021
Background/Aims: Atrial fibrillation (AF)-related stroke accounts for 20% of ischemic strokes. Rivaroxaban use in AF patients for preventing stroke and systemic embolism was approved in 2013 in Korea. This study was to investigate the safety and effectiveness of rivaroxaban use in Korean patients wi..
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The effect of beta-blockers in acute heart failure according to heart rate
Hyun-Jin Kim, Sang-Ho Jo, Min-Ho Lee, Won-Woo Seo, Jin-Oh Choi, Kyu-Hyung Ryu
Korean J Intern Med. 2021;36(4):898-905. Published online September 21, 2020
Background/Aims: Beta-blockers (BBs) have been shown to improve clinical outcomes in heart failure (HF) patients. We evaluated the prescribing status of BBs in patients with HF with reduced ejection fraction (HFrEF) at discharge according to the presence or not of bradycardia, and its effect on prog..
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Apparent treatment-resistant hypertension among ambulatory hypertensive patients: a cross-sectional study from 13 general hospitals
Sehun Kim, Jin Joo Park, Mi-Seung Shin, Choong Hwan Kwak, Bong-Ryeol Lee, Sung-Ji Park, Hae-Young Lee, Sang-Hyun Kim, Seok-Min Kang, Byung-Su Yoo, Joong-Wha Chung, Si Wan Choi, Sang-Ho Jo, Jinho Shin, Dong-Ju Choi
Korean J Intern Med. 2021;36(4):888-897. Published online June 7, 2021
Background/Aims: To examine the prevalence and clinical characteristics of apparent treatment-resistant hypertension among ambulatory hypertensive patients.
Methods: We enrolled adult ambulatory hypertensive patients at 13 well-qualified general hospitals in Korea from January to June 2012. Apparen..
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Gastroenterology
Clinical risk factors and pattern of initial fungal contamination in endoscopic biopsy-derived gastrointestinal cancer organoid culture
Su Youn Nam, Seung Jin Lee, Hee Jung Lim, Ji Young Park, Seong Woo Jeon
Korean J Intern Med. 2021;36(4):878-887. Published online April 8, 2021
Background/Aims: Because gastrointestinal tract is not sterile, primary culture has contamination risk despite of massive washing with antimicrobial media. Microbial contamination can play a key role in initial failure during biopsy-derived primary tumor culture.
Methods: Tumor tissue was acquired ..
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Subclinical sacroiliitis detected by abdominopelvic computed tomography in Korean patients with Crohn’s disease
You-Jung Ha, Hyo Jin Kim, Eugene Lee, Ji Hye Park, Young Soo Park, Yun Jong Lee, Yusuhn Kang, Hyuk Yoon
Korean J Intern Med. 2021;36(4):868-877. Published online March 22, 2021
Background/Aims: Sacroiliitis is a frequent extraintestinal manifestation of inflammatory bowel diseases (IBDs). This study aimed to assess the prevalence of sacroiliitis using a validated screening tool based on abdominopelvic computed tomography (APCT) in Korean patients with Crohn’s disease (CD..
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Helicobacter pylori-derived outer membrane vesicles stimulate interleukin 8 secretion through nuclear factor kappa B activation
Mun Sun Choi, Eun Young Ze, Jae Yong Park, Tae-Seop Shin, Jae Gyu Kim
Korean J Intern Med. 2021;36(4):854-867. Published online November 27, 2020
Background/Aims: Bacteria-derived outer membrane vesicles (OMVs) are commonly associated with various biological activities and functions. Helicobacter pylori-derived OMVs are thought to contribute to pathogenesis. This study aimed to investigate the effects of H. pylori-derived OMVs.
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Application of deep learning to predict advanced neoplasia using big clinical data in colorectal cancer screening of asymptomatic adults
Hyo-Joon Yang, Chang Woo Cho, Jongha Jang, Sang Soo Kim, Kwang-Sung Ahn, Soo-Kyung Park, Dong Il Park
Korean J Intern Med. 2021;36(4):845-856. Published online October 23, 2020
Background/Aims: We aimed to develop a deep learning model for the prediction of the risk of advanced colorectal neoplasia (ACRN) in asymptomatic adults, based on which colorectal cancer screening could be customized.
Methods: We collected data on 26 clinical and laboratory parameters, including ag..
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Rivaroxaban: striking two birds with one stone
Yae Min Park
Korean J Intern Med. 2021;36(4):842-844. Published online July 1, 2021
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Risk-stratified colorectal cancer screening for optimal use of colonoscopy resources
Dong-Hoon Yang
Korean J Intern Med. 2021;36(4):839-841. Published online July 1, 2021
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Evidence based guidelines for the treatment of Helicobacter pylori infection in Korea 2020
Hye-Kyung Jung, Seung Joo Kang, Yong Chan Lee, Hyo-Joon Yang, Seon-Young Park, Cheol Min Shin, Sung Eun Kim, Hyun Chul Lim, Jie-Hyun Kim, Su Youn Nam, Woon Geon Shin, Jae Myung Park, Il Ju Choi, Jae Gyu Kim, Miyoung Choi; Korean College of Helicobacter and Upper Gastrointesinal Research
Korean J Intern Med. 2021;36(4):807-838. Published online June 8, 2021
Helicobacter pylori infection is one of the most common infectious diseases worldwide. H. pylori is responsible for substantial gastrointestinal morbidity with a high disease burden. Since the revision of the H. pylori Clinical Practice Guidelines in 2013 in Korea, the eradicati..
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How important is dietary management in chronic kidney disease progression? A role for low protein diets
Gang-Jee Ko, Kamyar Kalantar-Zadeh
Korean J Intern Med. 2021;36(4):795-806. Published online June 22, 2021
High dietary protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration, which in the long-term can lead to de novo or aggravating preexisting chronic kidney disease (CKD). Hence, a low protein diet (LPD, 0.6 to 0.8 g/kg/day) is recommended for the management of CKD..
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Blood pressure control in patients with chronic kidney disease
Jee Young Lee, Seung Hyeok Han
Korean J Intern Med. 2021;36(4):780-794. Published online June 22, 2021
Uncontrolled blood pressure (BP) in patients with chronic kidney disease (CKD) can lead to serious adverse outcomes. To prevent the occurrence of cardiovascular events (CVEs), and end-stage kidney disease, achieving an optimal BP level is important. Recently, there has been a paradigm shift in the m..
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Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients
Yun Kyu Oh, Hayne Cho Park, Hyunjin Ryu, Yong-Chul Kim, Kook-Hwan Oh
Korean J Intern Med. 2021;36(4):767-779. Published online July 1, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by cyst growth in the kidneys, resulting in kidney enlargement and end-stage kidney disease. The polycystic kidney disease 1 (PKD1) and PKD2 have been identified as ge..
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The role of inflammation in diabetic kidney disease
Su Woong Jung, Ju-Young Moon
Korean J Intern Med. 2021;36(4):753-766. Published online July 1, 2021
Diabetic kidney disease (DKD) has been the leading cause of chronic kidney disease for over 20 years. Yet, over these two decades, the clinical approach to this condition has not much improved beyond the administration of glucose-lowering agents, renin-angiotensin-aldosterone system blockers for blo..
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Approach to cytomegalovirus infections in patients with ulcerative colitis
Sung Chul Park, Yoon Mi Jeen, Yoon Tae Jeen
Korean J Intern Med. 2021;36(3):751-751. Published online April 30, 2021
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18F-fluorodeoxyglucose positron emission tomography/computed tomography of bilateral primary ureter lymphoma
Liang Yin, Yusheng Zhen, Zhichun Lin, Weilong Li, Zhaowei Meng
Korean J Intern Med. 2021;36(3):748-750. Published online March 22, 2021
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Endoscopic ultrasound-guided fine-needle aspiration of parathyroid adenoma in a patient with hypercalcemia and ureter stone
Kwangwoo Nam, Sungwook Jang, Sung Hyeok Ryou, Kyungjun Kim, Yong-Moon Lee
Korean J Intern Med. 2021;36(3):746-747. Published online August 10, 2020
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