|
Endocrinology-metabolism / Review
Treatment of diabetic kidney disease: current and future targets
Mi-Kyung Kim
Korean J Intern Med. 2017;32(4):622-630. Published online June 30, 2017
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease in Korea and worldwide, and is a risk factor for the development of cardiovascular complications. The conventional treatments for DKD are control of blood glucose and blood pressure levels by inhibiting the renin-angiotensin..
|
|
|
Pulmonology / Review
The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation
Chang Dong Yeo, Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chan Kwon Park, Jin Woo Kim, Young Kyoon Kim, Seung Joon Kim
Korean J Intern Med. 2017;32(4):589-599. Published online June 30, 2017
A hypoxic microenvironment leads to cancer progression and increases the metastatic potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. The hypoxic response pathway can occur under oxygen tensions of < 40 mmHg through hypoxia-inducible..
|
|
|
Cardiology / Review
Three-dimensional echocardiography in adult congenital heart disease
Hyun Suk Yang
Korean J Intern Med. 2017;32(4):577-588. Published online June 30, 2017
Congenital heart disease (CHD) is now more common in adults than in children due to improvements in fetal echo, neonatal and pediatric care, and surgical techniques leading to dramatically increased survivability into adulthood. Adult patients with CHD, regardless of prior cardiac surgery, experienc..
|
|
|
Letter to the editor
A first case of high-flow nasal cannula oxygen therapy in patients with pulmonary tumor thrombotic microangiopathy
Hyonsoo Joo, Do-hyun Na, Jaeho Seung, Tong Yoon Kim, Gi June Min, Chin Kook Rhee
Korean J Intern Med. 2017;32(3):555-558. Published online April 18, 2017
|
|
|
Infectious diseases / Original Article
The seroprevalence of Bartonella henselae in healthy adults in Korea
Hea Yoon Kwon, Jae Hyoung Im, Sun Myoung Lee, Ji Hyeon Baek, Areum Durey, Shin-Goo Park, Jae-Seung Kang, Jin-Soo Lee
Korean J Intern Med. 2017;32(3):530-535. Published online April 20, 2017
Background/Aims: Cat-scratch disease (CSD), caused by Bartonella henselae is one of the most common zoonosis. However, only several cases of B. henselae infection have been reported in Korea. This study investigated the seroprevalence of B. henselae in healthy adults and related..
|
|
|
Hemato-oncology / Original Article
KRAS G12C mutation as a poor prognostic marker of pemetrexed treatment in non-small cell lung cancer
Sehhoon Park, Ji-Yeon Kim, Se-Hoon Lee, Beomseok Suh, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo
Korean J Intern Med. 2017;32(3):514-522. Published online April 14, 2017
Background/Aims: The predictive and prognostic value of KRAS mutation and its type of mutations in non-small cell lung cancer (NSCLC) are controversial. This clinical study was designed to investigate the predictive value of KRAS mutations and its mutation types to pemetrexed and gemcitabine based t..
|
|
|
Nephrology / Original Article
Vitamin D deficiency is associated with increased risk of bacterial infections after kidney transplantation
Young-Jae Park, Sang-Un Kim, Kyung-Hee Lee, Jong-Hak Lee, Eugene Kwon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Chan-Duck Kim
Korean J Intern Med. 2017;32(3):505-513. Published online March 25, 2016
Background/Aims: There may be an association between vitamin D levels and allograft outcomes in kidney transplant recipients (KTRs). However, few studies have been conducted to determine the association between vitamin D levels and post-transplant infections. This study investigated the impact of vi..
|
|
|
Pulmonology / Original Article
Clinical significance of positive Pneumocystis jirovecii polymerase chain reaction in non-human immunodeficiency virus immunocompromised patients in a real practice
Hea Yon Lee, Hye Seon Kang, Hwa Young Lee, Chin Kook Rhee, Sook Young Lee, Seok Chan Kim, Seung Joon Kim, Yeon Joon Park, Young Kyoon Kim, Ji Young Kang
Korean J Intern Med. 2017;32(3):478-485. Published online December 13, 2016
Background/Aims: Pneumocystis jirovecii polymerase chain reaction (PCR) can be helpful in diagnosing Pneumocystis pneumonia (PCP); however it has limitations. We evaluated the prevalence of positive P. jirovecii PCR from non-human immunodeficiency virus (HIV) immunocompromised p..
|
|
|
Cardiology / Original Article
Fragmented QRS and abnormal creatine kinase-MB are predictors of coronary artery disease in patients with angina and normal electrocardiographys
Jung Joo Lee, Jae Hoon Lee, Jin Woo Jeong, Jun Young Chung
Korean J Intern Med. 2017;32(3):469-477. Published online April 17, 2017
Background/Aims: Patients with symptoms of coronary artery disease (CAD) often display normal tracings or only nonspecific changes on electrocardiography (ECG). The aim of this study was to explore strategic elements of the ECG and other potential factors that are predictive of CAD in this scenario...
|
|
|
Cardiology / Original Article
Association between left ventricular function and paraprotein type in patients with multiple
myeloma
Jeong-Eun Yi, Sung-Eun Lee, Hae-Ok Jung, Chang-Ki Min, Ho-Joong Youn
Korean J Intern Med. 2017;32(3):459-468. Published online April 6, 2016
Background/Aims: Multiple myeloma (MM)–associated cardiac damage, particularly according to the type of monoclonal (M) protein has not been elucidated. We sought to investigate relationship between elevated serum M protein levels and echocardiographic indices of cardiac structure and function in pa..
|
|
|
Gastroenterology / Original Article
Clinical implications of endoscopic ultrasonography non-traversability in patients with locoregional esophageal cancer receiving multimodality therapy
Charles J. Cho, Ho June Song, Gin Hyug Lee, Kee Don Choi, Yong-Hee Kim, Jin-Sook Ryu, Sung-Bae Kim, Jong Hoon Kim, Seung-Il Park, Hwoon-Yong Jung
Korean J Intern Med. 2017;32(3):443-451. Published online March 14, 2016
Background/Aims: Approximately 30% of esophageal cancer (EC) patients cannot complete endoscopic ultrasonography (EUS) due to malignant stricture (EUS non-traversability). This study examines clinical implications of EUS non-traversability in patients with advanced locoregional squamous EC receiving..
|
|
|
Gastroenterology / Review
Approach to cytomegalovirus infections in patients with ulcerative colitis
[corrected-article]
Sung Chul Park, Yoon Mi Jeen, Yoon Tae Jeen
Korean J Intern Med. 2017;32(3):383-392. Published online April 20, 2017
Cytomegalovirus (CMV) reactivation is common in patients with severe ulcerative colitis (UC), and may ref lect exacerbation of mucosal inf lammation and/or administration of immunosuppressants. The question of whether CMV is an active pathogen or ‘an innocent bystander’ in the exacerbation of UC ..
|
|
|
Letter to the editor
Ankylosing spondylitis associated with primary aldosteronism in a middle-aged woman
Young Sun Suh, Hyun-Ok Kim, Yun-Hong Cheon, Wonyong Jo, Jeongmin Hong, Sang-Il Lee
Korean J Intern Med. 2017;32(2):374-377. Published online February 3, 2016
|
|
|
Nephrology / Original Article
Sleep duration and chronic kidney disease: The Korean Genome and Epidemiology Study (KoGES)-Kangwha study
Hansol Choi, Hyeon Chang Kim, Joo Young Lee, Ju-Mi Lee, Dong Phil Choi, Il Suh
Korean J Intern Med. 2017;32(2):323-334. Published online February 15, 2017
Background/Aims: Sleep duration affects health in various ways. The objective of this study was to investigate the associations of sleep duration with chronic kidney disease (CKD) in a Korean adult population.
Methods: This cross-sectional analysis was conducted for total of 1,360 participants who ..
|
|
|
Nephrology / Original Article
Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats
Jian Jin, Sun Woo Lim, Long Jin, Ji Hyun Yu, Hyun Seon Kim, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2017;32(2):314-322. Published online September 30, 2016
Background/Aims: Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset diabetes after transplantation caused by immunosuppressant therapy is unclear. We compared the effects of MET on DM caused by tacrolimus (TAC) or sirolimus (SRL).
Methods: DM was induced..
|
|
|
Pulmonology / Original Article
Qualitative and quantitative results of interferon-γ release assays for monitoring the response to anti-tuberculosis treatment
I-Nae Park, Tae Sun Shim
Korean J Intern Med. 2017;32(2):302-308. Published online December 13, 2016
Background/Aims: The usefulness of interferon-γ release assays (IGRAs) in monitoring to responses to anti-tuberculosis (TB) treatment is controversial. We compared the results of two IGRAs before and after anti-TB treatment in same patients with active TB.
Methods: From a retrospective review, we..
|
|
|
Cardiology / Original Article
Features of electrocardiogram in patients with stenosis of the proximal right coronary artery
Moo Seong Koh, Jae Hoon Lee, Jin Woo Jeong, Jun Young Chung
Korean J Intern Med. 2017;32(2):277-285. Published online February 14, 2017
Background/Aims: Prediction of lesions of the proximal right coronary artery (pRCA) through electrocardiogram (ECG) is very important because pRCA occlusion has many complications and a high mortality rate, which has frequently been related with right ventricular infarction. The purpose of this stud..
|
|
|
Gastroenterology / Original Article
Ultrasound-guided percutaneous portal transplantation of peripheral blood monocytes in patients with liver cirrhosis
Su Jong Yu, Jung-Hwan Yoon, Won Kim, Jeong Min Lee, Yun Bin Lee, Yuri Cho, Dong Hyeon Lee, Minjong Lee, Jeong-Ju Yoo, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Chung Yong Kim
Korean J Intern Med. 2017;32(2):261-268. Published online April 5, 2016
Background/Aims: Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. Stem cell therapy is attractive in this setting. In this study, we aimed to explore the safety and efficacy of ultrasound-guided percutaneous portal transplantation of peripheral blood m..
|
|
|
Gastroenterology / Review
Reversal of liver cirrhosis: current evidence and expectations
Young Kul Jung, Hyung Joon Yim
Korean J Intern Med. 2017;32(2):213-228. Published online February 8, 2017
In the past, liver cirrhosis was considered an irreversible phenomenon. However, many experimental data have provided evidence of the reversibility of liver fibrosis. Moreover, multiple clinical studies have also shown regression of fibrosis and reversal of cirrhosis on repeated biopsy samples. As v..
|
|
|
Rheumatology / Original Article
Autonomic dysfunction in primary Sjogren’s syndrome: a prospective cohort analysis of 154 Korean patients
Jung Hee Koh, Seung-Ki Kwok, Jennifer Lee, Sung-Hwan Park
Korean J Intern Med. 2017;32(1):165-173. Published online March 25, 2016
Background/Aims: To determine the prevalence of autonomic dysfunction among Korean patients with primary Sjogren’s syndrome (pSS) and its associations with the clinical features of pSS. Methods: We analyzed 154 participants from the Korean Initiative of primary Sjogren’s Syndrome (KISS) as a pros..
|
|
|
