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Cardiology / Original Article
Predictive value of CHADS2 score for cardiovascular events in patients with acute coronary syndrome and documented coronary artery disease
In Sook Kang, Wook Bum Pyun, Gil Ja Shin
Korean J Intern Med. 2016;31(1):73-81. Published online December 28, 2015
Background/Aims: The CHADS2 score, used to predict the risk of ischemic stroke in atrial fibrillation (AF) patients, has been reported recently to predict ischemic stroke in patients with coronary heart disease, regardless of the presence of AF. However, little data are available regardin..
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Gastroenterology / Original Article
New monoclonal antibody-based test for Helicobacter pylori urease in gastric tissue
Do Hyun Kim, Ho Dong Kim, Hyeuk Park, Seung Choi, Jae Won Beom, Woo Jong Kim, Chang Kook Park, Young Jik Lee, Ju Young Park, Hyung Rag Kim, Chul Park, Young Eun Joo, Young Do Jung
Korean J Intern Med. 2016;31(1):40-45. Published online December 28, 2015
Background/Aims: To evaluate a new monoclonal antibody for Helicobacter pylori urease in gastric tissue.
Methods: A total of 107 volunteers were enrolled. All subjects underwent a 13C-urea breath test and esophagogastroduodenoscopy. Gastric aspirates were analyzed for pH and ammon..
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Gastroenterology / Review
The antibacterial effect of fatty acids on Helicobacter pylori infection
Sung Woo Jung, Sang Woo Lee
Korean J Intern Med. 2016;31(1):30-35. Published online December 28, 2015
Eradication of Helicobacter pylori is recommended for the management of various gastric diseases, including peptic ulcers and mucosa-associated lymphoid tissue lymphoma. Because of the increasing prevalence of antibiotic resistance, the eradication rates of antibiotic-based therapies have dec..
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Cardiology / Review
Breakthrough in heart failure with preserved ejection fraction: are we there yet?
Shir Lynn Lim, Carolyn Su Ping Lam
Korean J Intern Med. 2016;31(1):1-14. Published online December 28, 2015
Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective therapies underscores our incomplete understanding of this complex heterogeneous syndrome. A no..
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Letter to the editor
Fabry disease previously diagnosed as Henoch-Schonlein purpura
Ji Hyeong Kim, Dong Hoon Han, Moo Yong Park, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, So Young Jin
Korean J Intern Med. 2015;30(6):925-927. Published online October 30, 2015
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Letter to the editor
Acute myocardial infarction caused by a floating thrombus in the proximal ascending aorta
Woong Jeon, Seung-Jin Lee, Sang-Ho Park, Se-Whan Lee, Won-Yong Shin, Dong-Kyu Jin
Korean J Intern Med. 2015;30(6):921-924. Published online October 30, 2015
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Infectious diseases / Original Article
Serum galactomannan levels in the diagnosis of invasive aspergillosis
Yildiz Okuturlar, Fahir Ozkalemkas, Beyza Ener, Sibel Ocak Serin, Esra Kazak, Tulay Ozcelik, Vildan Ozkocaman, Hasan Atilla Ozkan, Halis Akalin, Meral Gunaldi, Ridvan Ali
Korean J Intern Med. 2015;30(6):899-905. Published online October 30, 2015
Background/Aims: In this study, the sensitivity-specificity of galactomannan-enzyme immunoassay (GM-EIA) with a cut-off value of 0.5 for a single, two, or three consecutive positivity in the diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients with hematological malignancy was inves..
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Hemato-oncology / Original Article
Clinical efficacy of erlotinib, a salvage treatment for non-small cell lung cancer patients following gefitinib failure
Kyoung Min Cho, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae Seog Heo
Korean J Intern Med. 2015;30(6):891-898. Published online October 30, 2015
Background/Aims: The purpose of this study was to identify predictive factors for erlotinib treatment in non-small cell lung cancer (NSCLC) patients following gefitinib failure.
Methods: Forty-five patients with NSCLC who were treated with erlotinib following gefitinib failure at Seoul National Uni..
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Nephrology / Original Article
The effects of nonyl phenoxypolyethoxyl ethanol on cell damage pathway gene expression in SK-NSH cells
Samel Park, Il-woong Hwang, Jin-sheon Kim, Hyo-chul Kang, Su-Yeon Park, Hyo-wook Gil, Ho-yeon Song, Sae-yong Hong
Korean J Intern Med. 2015;30(6):873-883. Published online October 30, 2015
Background/Aims: Most pesticide formulations contain both chief and additive ingredients. But, the additives may not have been tested as thoroughly as the chief ingredients. The surfactant, nonyl phenoxypolyethoxylethanol (NP40), is an additive frequently present in pesticide formulations. We invest..
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Nephrology / Original Article
Predicting postoperative total calcium requirements after parathyroidectomy in secondary hyperparathyroidism
Byung Heon Kang, Soon Young Hwang, Jeong Yeop Kim, Yu Ah Hong, Mi Yeon Jung, Eun Ah Lee, Ji Eun Lee, Jae Bok Lee, Gang Jee Ko, Heui Jung Pyo, Young Joo Kwon
Korean J Intern Med. 2015;30(6):856-864. Published online October 30, 2015
Background/Aims: To prevent hypocalcemia after parathyroidectomy (PTX), parenteral calcium is required in addition to oral calcitriol and calcium. After switching to oral calcium, patients can be discharged from the hospital. The aim of this study was to analyze the clinical characteristics and outc..
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Endocrinology-metabolism / Original Article
Obstructive sleep apnea with excessive daytime sleepiness is associated with non-alcoholic fatty liver disease regardless of visceral fat
Ji Hee Yu, Jae Hee Ahn, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Chol Shin, Nan Hee Kim
Korean J Intern Med. 2015;30(6):846-855. Published online October 30, 2015
Background/Aims: Obstructive sleep apnea (OSA) is associated with an increased risk of obesity and non-alcoholic fatty liver disease (NAFLD), but it remains unclear whether the risk of NAFLD is independently related to OSA regardless of visceral obesity. Thus, the aim of the present study was to exa..
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Cardiology / Original Article
Temporal trends and in-hospital outcomes of primary percutaneous coronary intervention in nonagenarians with ST-segment elevation myocardial infarction
Joon Young Kim, Myung Ho Jeong, Yong Woo Choi, Yong Keun Ahn, Shung Chull Chae, Seung Ho Hur, Taek Jong Hong, Young Jo Kim, In Whan Seong, In Ho Chae, Myeong Chan Cho, Jung Han Yoon, Ki Bae Seung, Other Korea Acute Myocardial Infarction Registry Investigators
Korean J Intern Med. 2015;30(6):821-828. Published online October 30, 2015
Background/Aims: Data regarding the outcomes of primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in nonagenarians are very limited. The aim of the present study was to evaluate the temporal trends and in-hospital outcomes of primary PCI in nonag..
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Gastroenterology / Original Article
Trends in Helicobacter pylori eradication rates by first-line triple therapy and related factors in eradication therapy
Sung Eun Kim, Moo In Park, Seun Ja Park, Won Moon, Youn Jung Choi, Ji Hyun Cheon, Hye Jung Kwon, Ki Hwan Ku, Chang Hun Yoo, Jae Hyun Kim, Gyu Won Lee, Sung Eun Song
Korean J Intern Med. 2015;30(6):801-807. Published online October 30, 2015
Background/Aims: Trends in successful eradication of Helicobacter pylori using first-line triple therapy, consisting of a proton pump inhibitor, amoxicillin, and clarithromycin, have been understudied. We evaluated H. pylori eradication rates at a single center over the last 10 years a..
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Gastroenterology / Original Article
Incidence of and risk factors for thyroid dysfunction during peginterferon α and ribavirin treatment in patients with chronic hepatitis C
Yong Hwang, Won Kim, So Young Kwon, Hyung Min Yu, Jeong Han Kim, Won Hyeok Choe
Korean J Intern Med. 2015;30(6):792-800. Published online October 30, 2015
Background/Aims: Thyroid dysfunction (TD) is more likely to occur in patients with chronic hepatitis C (CHC) and is particularly associated with interferon (IFN) treatment. The purpose of this study was to investigate the incidence, outcomes, and risk factors for TD during pegylated interferon (PEG-..
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Hemato-oncology / Review
Guidelines for the management of myeloproliferative neoplasms
Chul Won Choi, Soo-Mee Bang, Seongsoo Jang, Chul Won Jung, Hee-Jin Kim, Ho Young Kim, Soo-Jeong Kim, Yeo-Kyeoung Kim, Jinny Park, Jong-Ho Won
Korean J Intern Med. 2015;30(6):771-788. Published online October 30, 2015
Polycythemia vera, essential thrombocythemia, and primary myelofibrosis are collectively known as ‘Philadelphia-negative classical myeloproliferative neoplasms (MPNs).’ The discovery of new genetic aberrations such as Janus kinase 2 (JAK2) have enhanced our understanding of the pathophysio..
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Rheumatology / Original Article
Cross-cultural adaptation and validation of the Behcet’s Disease Current Activity Form in Korea
Hyo Jin Choi, Mi Ryoung Seo, Hee Jung Ryu, Han Joo Baek
Korean J Intern Med. 2015;30(5):714-718. Published online August 27, 2015
Background/Aims: This study was undertaken to perform a cross-cultural adaptation of the Behcet’s Disease Current Activity Form (BDCAF, version 2006) questionnaire to the Korean language and to evaluate its reliability and validity in a population of Korean patients with Behcet’s disease (BD).
..
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Hemato-oncology / Original Article
Clinical characteristics and outcomes in diffuse large B cell lymphoma patients aged 70 years and older: a single-center experience with a literature review
Yun Hwa Jung, In Sook Woo, Chi Wha Han
Korean J Intern Med. 2015;30(5):684-693. Published online August 27, 2015
Background/Aims: Among diffuse large B cell lymphoma (DLBCL) patients, determining the appropriate dose and chemotherapy schedule to balance toxicity and efficacy is harder in elderly than in younger patients. Moreover, there are no currently available clinical factors that consistently identify pat..
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Endocrinology-metabolism / Original Article
Blood electrolyte disturbances during severe hypoglycemia in Korean patients with type 2 diabetes
Mi Yeon Kang
Korean J Intern Med. 2015;30(5):648-656. Published online August 27, 2015
Background/Aims: To investigate abnormalities in blood electrolyte levels during severe hypoglycemia in Korean patients with type 2 diabetes mellitus (T2DM) in a clinical setting.
Methods: Blood electrolyte levels in adult T2DM patients during severe hypoglycemia were collected from January 1, 200..
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Pulmonology / Original Article
Chronic obstructive pulmonary disease (COPD) assessment test scores corresponding to modified Medical Research Council grades among COPD patients
Chang-Hoon Lee, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Jae-Joon Yim, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo
Korean J Intern Med. 2015;30(5):629-637. Published online August 27, 2015
Background/Aims: In assigning patients with chronic obstructive pulmonary disease (COPD) to subgroups according to the updated guidelines of the Global Initiative for Chronic Obstructive Lung Disease, discrepancies have been noted between the COPD assessment test (CAT) criteria and modified Medical ..
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Cardiology / Original Article
A pharmacodynamic study of the optimal P2Y12 inhibitor regimen for East Asian patients with acute coronary syndrome
Ji Hyun Lee, Sung Gyun Ahn, Bonil Park, Sang Wook Park, Yong Seok Kang, Jun-Won Lee, Young Jin Youn, Min-Soo Ahn, Jang-Young Kim, Byung-Su Yoo, Seung-Hwan Lee, Junghan Yoon
Korean J Intern Med. 2015;30(5):620-628. Published online August 27, 2015
Background/Aims: Newer P2Y12 inhibitors, such as prasugrel and ticagrelor, have greater antiplatelet efficacy but may increase the risk of bleeding. In this study, we compared the pharmacodynamic efficacy of prasugrel and ticagrelor in East Asian patients with acute coronary syndrome (ACS..
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