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Review
Glomerular filtration rate as a kidney outcome of diabetic kidney disease: a focus on new antidiabetic drugs
Hyo Jin Kim, Sang Soo Kim, Sang Heon Song
Korean J Intern Med. 2022;37(3):502-519. Published online April 4, 2022
Diabetes has reached epidemic proportions, both in Korea and worldwide and is associated with an increased risk of chronic kidney disease and kidney failure (KF). The natural course of kidney function among people with diabetes (especially type 2 diabetes) may be complex in real-world situations. St..
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Review
Emotional and cognitive changes in chronic kidney disease
Duk-Soo Kim, Seong-Wook Kim, Hyo-Wook Gil
Korean J Intern Med. 2022;37(3):489-501. Published online March 8, 2022
Chronic kidney disease (CKD) leads to cognitive impairment and emotional changes. However, the precise mechanism underlying the crosstalk between the kidneys and the nervous system is not fully understood. Inflammation and cerebrovascular disease can influence the development of depression in CKD. C..
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Image of interest
Histological similarity between tubulointerstitial nephritis and salivary gland biopsy in primary Sjögren’s syndrome
Yoon Ji Tak, Jong Sun Kim, Kyung-Ann Lee, Hyun-Sook Kim, So-Young Jin
Korean J Intern Med. 2022;37(2):486-487. Published online October 22, 2021
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Image of interest
Diabetic ketoacidosis and acute pancreatitis in a patient with agenesis of the dorsal pancreas
Chaiho Jeong, Ye Seul Yang, Hyun-Shik Son, Tae-Seo Sohn
Korean J Intern Med. 2022;37(2):484-485. Published online February 16, 2022
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Image of interest
Paradoxical reaction of tuberculosis masquerading as a gastric subepithelial tumor
Jinmo Kim, Kwangwoo Nam, Jooyeop Lee, Jun-Ho Choi, Won-Ae Lee
Korean J Intern Med. 2022;37(2):482-483. Published online November 16, 2021
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Image of interest
Hypervascular hepatic masses in a patient who underwent the Fontan procedure
Min Kyu Kang, Sung Bum Kim, Joon Hyuk Choi
Korean J Intern Med. 2022;37(2):480-481. Published online January 8, 2021
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Correspondence
Cancer risk in Korean patients with gout
Shih-Wei Lai, Chiu-Shong Liu, Bing-Fang Hwang
Korean J Intern Med. 2022;37(2):478-479. Published online October 21, 2021
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Geriatrics / Original Article
Factors associated with anticholinergic burden among older patients in long-term care hospitals in Korea
Jung-Yeon Choi, Hongsoo Kim, Young-il Jung, Seungyeon Chun, Sooyoung Yoo, Jae-Young Lim, Jin Young Ko, Kayoung Park, Kwang-il Kim
Korean J Intern Med. 2022;37(2):468-477. Published online February 18, 2022
Background/Aims: Drugs with anticholinergic properties (DAPs) are associated with adverse health outcomes in older patients. The objective of this study was to evaluate the factors that determine the prescribing of more DAPs in long-term care hospitals (LTCHs) in Korea. In addition, the current patt..
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Rheumatology / Original Article
Cancer risk in Korean patients with gout
Yoon-Jeong Oh, Yun Jong Lee, Eunyoung Lee, Bumhee Park, Jae-Woo Kwon, Jeongwon Heo, Ki Won Moon
Korean J Intern Med. 2022;37(2):460-467. Published online March 23, 2021
Background/Aims: Using a nationwide cohort, we investigated the cancer risk in Korean patients with gout.
Methods: Data were obtained from the Korean National Health Insurance Service Database. Patients with gout were defined as those aged ≥ 20 years who were diagnosed with gout and received anti..
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Infectious diseases / Original Article
Comparison of antibody responses after the 1st and 2nd doses of COVID-19 vaccine with those of patients with mild or severe COVID-19
Hye Hee Cha, So Yun Lim, Ji-Soo Kwon, Ji Yeun Kim, Seongman Bae, Jiwon Jung, Sung-Han Kim
Korean J Intern Med. 2022;37(2):455-459. Published online February 28, 2022
Background/Aims: Data comparing the antibody responses of different coronavirus disease 2019 (COVID-19) vaccine platforms according to dose with natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-induced antibody responses are limited.
Methods: Blood samples from adult p..
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Hemato-oncology / Original Article
How myeloproliferative neoplasms patients’ experience and expectations differ from physicians’: the international MPN Landmark survey
Ja Min Byun, Soo-Mee Bang, Eun-Ji Choi, Ki-Seong Eom, Chul Won Jung, Hye-seon Kim, Jiwon Park, Chul Won Choi
Korean J Intern Med. 2022;37(2):444-454. Published online February 28, 2022
Background/Aims: Recent advances in the understanding of the pathophysiology of myeloproliferative neoplasms (MPN) were not paralleled with advances in treatment options; thus many questions regarding optimal MPN management remain unanswered. Here, we report the results of descriptive survey study o..
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Hemato-oncology / Original Article
The efficacy of EGFR-tyrosine kinase inhibitor in non-small cell lung cancer patients with synchronous brain metastasis: a real-world study
Jin-Hyuk Choi, Yong Won Choi, Hyun Woo Lee, Seok Yun Kang, Geum Sook Jeong, Mi Sun Ahn, Young-Taek Oh, O kyu Noh, Se-Hyuk Kim, Tae Hoon Roh, Seung Soo Sheen
Korean J Intern Med. 2022;37(2):434-443. Published online February 16, 2022
Background/Aims: The optimal treatment (Tx) for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) remains to be determined.
Methods: A retrospective review was conducted on 77 NSCLC patients with synchronous BM who underwent first-..
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Nephrology / Original Article
The presence of simple renal cysts is associated with an increased risk of albuminuria in young adults
Hyo Jin Boo, Jung Eun Lee, Son Mi Chung, Hye Ryoun Jang, Wooseong Huh, Dae Joong Kim, Yoon-Goo Kim
Korean J Intern Med. 2022;37(2):425-433. Published online December 7, 2021
Background/Aims: The prevalence of simple renal cysts increases with age; however, they are occasionally found in adults aged < 40 years. This cross-sectional study evaluated the clinical significance of simple cysts in young adults, focusing on their associations with hematuria and albuminuria.
Me..
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Nephrology / Original Article
Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells
Sun Woo Lim, Kyung Woon Kim, Bo Mi Kim, Yoo Jin Shin, Kang Luo, Yi Quan, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang
Korean J Intern Med. 2022;37(2):411-424. Published online September 16, 2021
Background/Aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) exert powerful therapeutic..
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Endocrinology-metabolism / Original Article
Clinical features and signaling effects of RET D631Y variant multiple endocrine neoplasia type 2 (MEN2)
Ji-young Lee, Su Yeon Kim, Kwan Hoon Jo, Eun Yeong Mo, Eun Sook Kim, Hye Soo Kim, Je Ho Han, Sung-dae Moon
Korean J Intern Med. 2022;37(2):398-410. Published online December 15, 2021
Background/Aims: Germline mutations of the rearranged during transfection (RET) gene cause multiple endocrine neoplasia type 2 (MEN2). About 85% of RET mutations in MEN2 occur in codon Cys634. The RET D631Y mutation has recently been discovered, and we have studied its molecular expres..
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Pulmonology / Original Article
Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis
Heemoon Park, Jaeyoung Cho, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Sun Mi Choi
Korean J Intern Med. 2022;37(2):387-397. Published online December 7, 2021
Background/Aims: The prevalence and effects of airway diseases, including asthma, eosinophilic bronchitis (EB), chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) have not been thoroughly studied in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to evalu..
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Pulmonology / Original Article
Diagnostic index for acute eosinophilic pneumonia without bronchoscopy in military smokers
Sunmin Park, Deokjae Han, Ji Eun Lee, Duck Hyun Ryu, Hyung-Jun Kim
Korean J Intern Med. 2022;37(2):377-386. Published online December 16, 2021
Background/Aims: Acute eosinophilic pneumonia (AEP) is common among military smokers; however, bronchoscopy is required for the diagnosis. We aimed to derive and validate a scoring system to diagnose AEP without bronchoscopy.
Methods: We conducted a retrospective study including patients diagnosed ..
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Pulmonology / Original Article
Efficacy of lower dose pirfenidone for idiopathic pulmonary fibrosis in real practice: a retrospective cohort study
Hyeontaek Hwang, Jung-Kyu Lee, Sun Mi Choi, Yeon Joo Lee, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Young Whan Kim, Jong Sun Park
Korean J Intern Med. 2022;37(2):366-376. Published online July 27, 2021
Background/Aims: Pirfenidone slows the progression of idiopathic pulmonary fibrosis (IPF). We investigated its efficacy and safety in terms of dose and disease severity in real-world patients with IPF.
Methods: This multicenter retrospective cohort study investigated 338 patients treated with pirfe..
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Cardiology / Original Article
The current status and outcomes of in-hospital P2Y12 receptor inhibitor switching in Korean patients with acute myocardial infarction
Keun-Ho Park, Myung Ho Jeong, Hyun Kuk Kim, Young-Jae Ki, Sung Soo Kim, Youngkeun Ahn, Hyun Yi Kook, Hyo-Soo Kim, Hyeon Cheol Gwon, Ki Bae Seung, Seung Woon Rha, Shung Chull Chae, Chong Jin Kim, Kwang Soo Cha, Jong Seon Park, Jung Han Yoon, Jei Keon Chae, Seung Jae Joo, Dong-Joo Choi, Seung Ho Hur, In Whan Seong, Myeong Chan Cho, Doo Il Kim, Seok Kyu Oh, Tae Hoon Ahn, Jin Yong Hwang; on behalf of the KAMIR-NIH registry investigators
Korean J Intern Med. 2022;37(2):350-365. Published online January 12, 2022
Background/Aims: While switching strategies of P2Y12 receptor inhibitors (RIs) have sometimes been used in acute myocardial infarction (AMI) patients, the current status of in-hospital P2Y12RI switching remains unknown.
Methods: Overall, 8,476 AMI patients who underwent successful revascularization..
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Cardiology / Original Article
Clinical outcome in patients with end-stage heart failure who underwent continuous-flow left ventricular assist devices in a single center
Yoonjee Park, Darae Kim, Jeong Hoon Yang, Yang Hyun Cho, Jin-Oh Choi, Eun-Seok Jeon
Korean J Intern Med. 2022;37(2):340-349. Published online December 7, 2021
Background/Aims: The continuous flow left ventricular assist device (cf-LVAD) has improved the survival of chronic end-stage heart failure (HF) patients. Here we describe our clinical experience of the initial 50 LVAD patients from a single center.
Methods: A total of 50 patients underwent LVAD imp..
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