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Gastroenterology / Original Article
Correlation of the grade of hepatic steatosis between controlled attenuation parameter and ultrasound in patients with fatty liver: a multi-center retrospective cohort study
Jeong-Ju Yoo, Yang Jae Yoo, Woo Ram Moon, Seung Up Kim, Soung Won Jeong, Ha Na Park, Min Gyu Park, Jae Young Jang, Su Yeon Park, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Sang Gyune Kim, Young Seok Kim, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun
Korean J Intern Med. 2020;35(6):1346-1353. Published online November 8, 2019
Background/Aims: The controlled attenuation parameter (CAP), based on transient elastography, is widely used for noninvasive assessment of the degree of hepatic steatosis (HS). We investigated the correlation of the degree HS between CAP and ultrasound (US) in patients with HS.
Methods: In total, 9..
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Gastroenterology / Original Article
The quick sepsis-related organ failure score has limited value for predicting adverse outcomes in sepsis patients with liver cirrhosis
Jeongsuk Son, Sunhui Choi, Jin Won Huh, Chae-Man Lim, Younsuck Koh, Kang Mo Kim, Ju Hyun Shim, Young-Suk Lim, Sang-Bum Hong
Korean J Intern Med. 2020;35(4):861-872. Published online October 28, 2019
Background/Aims: The quick Sepsis-related Organ Failure Assessment (qSOFA) is a newly developed risk stratification tool, which has been presented along with a new sepsis definition, to classify infected patients outside of the intensive care unit (ICU). We evaluated the clinical usefulness of qSOFA..
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Review
Alcohol use disorder and liver transplant: new perspectives and critical issues
Stefano Gitto, Silvia Aspite, Lucia Golfieri, Fabio Caputo, Francesco Vizzutti, Silvana Grandi, Valentino Patussi, Fabio Marra
Korean J Intern Med. 2020;35(4):797-810. Published online April 3, 2020
Alcoholic liver disease is a consolidated indication for liver transplantation, but many unsolved issues can be highlighted. Patients with alcohol use disorder develop peculiar comorbidities that can become contraindications for transplantation. Moreover, a number of social and psychological pattern..
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Infectious diseases / Original Article
Clinical impact of healthcare-associated acquisition in cirrhotic patients with community-onset spontaneous bacterial peritonitis
Jungok Kim, Cheol-In Kang, Geum-Youn Gwak, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song
Korean J Intern Med. 2020;35(1):215-221. Published online March 5, 2018
Background/Aims: Healthcare-associated (HCA) infection is a recently suggested new category of community-onset infections. The implications of HCA infections in terms of diagnosis, treatment, and outcomes of spontaneous bacterial peritonitis (SBP) are not well understood. We sought to delineate the ..
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Gastroenterology / Original Article
Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
Jae Gon Lee, Joo Hyun Sohn, Jae Yoon Jeong, Tae Yeob Kim, Sun Min Kim, Young Seo Cho, Yongsoo Kim
Korean J Intern Med. 2020;35(1):88-98. Published online February 25, 2019
Background/Aims: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis.
Methods: We retrospectively collected da..
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Gastroenterology / Original Article
Potential etiology, prevalence of cirrhosis, and mode of detection among patients with non-B non-C hepatocellular carcinoma in Korea
Jihye Kim, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Korean J Intern Med. 2020;35(1):65-78. Published online June 17, 2019
Background/Aims: We systematically evaluated the clinical characteristics, prevalence of cirrhosis, and mode of detection in virus-unrelated (non-B non-C, NBNC) hepatocellular carcinoma (HCC) patients in Korea.
Methods: A total of 447 consecutive treatment-naïve NBNC-HCC adult patients who were r..
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Gastroenterology / Original Article
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease
Sang Bong Ahn, Dae Won Jun, Kiseok Jang, Byung Hoon Lee, Kye Jung Shin
Korean J Intern Med. 2019;34(4):777-784. Published online February 23, 2018
Background/Aims: Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD). We investigated the expression of NPC1L1 and its correlation with liver X receptor (LXR) expression in peripheral mon..
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Gastroenterology / Original Article
Time-dependent reversal of significant intrapulmonary shunt after liver transplantation
Xin Jin, Byung Joo Sun, Jae-Kwan Song, Jae-Hyung Roh, Jeong Yoon Jang, Dae-Hee Kim, Young-Suk Lim, Jong-Min Song, Duk-Hyun Kang, Sung Gyu Lee
Korean J Intern Med. 2019;34(3):510-518. Published online March 5, 2018
Background/Aims: Although the association between intrapulmonary shunt (IPS) and liver cirrhosis is clear, data of repeated contrast echocardiography (CE) before and after liver transplantation (LT) to evaluate factors associated with IPS are limited.
Methods: Hand-agitated saline was used for CE a..
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Gastroenterology / Original Article
Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis
Hyo Young Lee, Dae Won Jun, Hyun Jung Kim, Hyunwoo Oh, Waqar Khalid Saeed, Hyeongsik Ahn, Ramsey C. Cheung, Mindie H. Nguyen
Korean J Intern Med. 2019;34(2):296-304. Published online March 20, 2018
Background/Aims: A number of clinical trials reported varying effects of cholesterol lowering agents in nonalcoholic fatty liver disease (NAFLD) patients. We, therefore, assessed the changes in hepatic steatosis and NAFLD activity score (NAS) after treatment with cholesterol lowering agents in NAFLD..
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Gastroenterology / Review
Endoscopic management of anastomotic stricture after living-donor liver transplantation
Dong Wook Lee, Jimin Han
Korean J Intern Med. 2019;34(2):261-268. Published online February 25, 2019
The most effective and fundamental treatment for end-stage liver disease is liver transplantation. Deceased-donor liver transplantation has been performed for many of these cases. However, living-donor liver transplantation (LDLT) has emerged as an alternative because it enables timely procurement o..
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Gastroenterology / Original Article
Clinical significance of radiation-induced liver disease after stereotactic body radiation therapy for hepatocellular carcinoma
Baek Gyu Jun, Young Don Kim, Gab Jin Cheon, Eun Seog Kim, Eunjin Jwa, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Hong Soo Kim
Korean J Intern Med. 2018;33(6):1093-1102. Published online August 28, 2017
Background/Aims: The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and to identify the clinical significance of RILD.
Methods: We retrospectively rev..
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Infectious diseases / Original Article
Predictors of postoperative infectious complications in liver transplant recipients: experience of 185 consecutive cases
Seungjin Lim, Eun Jung Kim, Tae Beom Lee, Byung Hyun Choi, Young Mok Park, Kwangho Yang, Je Ho Ryu, Chong Woo Chu, Su Jin Lee
Korean J Intern Med. 2018;33(4):798-806. Published online February 23, 2018
Background/Aims: Infections following liver transplant (LT) remain a major cause of mortality. This study was conducted to evaluate risk factors for infection and to review clinical characteristics.
Methods: Medical records of patients who underwent LT from 2010 to 2014 were retrospectively analyze..
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Gastroenterology / Original Article
Outcome of donor biliary complications following living donor liver transplantation
Hyun Young Woo, In Seok Lee, Jae Hyuck Chang, Seung Bae Youn, Si Hyun Bae, Jong Young Choi, Ho Jong Chun, Young Kyoung You, Dong Goo Kim, Seung Kew Yoon
Korean J Intern Med. 2018;33(4):705-715. Published online March 14, 2018
Background/Aims: Biliary complications are the most common donor complication following living donor liver transplantation (LDLT). The aim of this study is to investigate the long-term outcomes of biliary complications in right lobe adult-to-adult LDLT donors, and to evaluate the efficacy of endosco..
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Endocrinology-metabolism / Original Article
Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats
Yoo-Cheol Hwang, Da-Hee Oh, Moon Chan Choi, Sang Yeoul Lee, Kyu-Jeong Ahn, Ho-Yeon Chung, Sung-Jig Lim, Sung Hyun Chung, In-Kyung Jeong
Korean J Intern Med. 2018;33(2):347-355. Published online February 1, 2017
Background/Aims: Non-alcoholic fatty liver disease is associated with insulin resistance. Compound K (CK) is the final metabolite of panaxadiol ginsenosides that have been shown to exert antidiabetic effects. However, the molecular mechanism of the antidiabetic effects in the liver have not been elu..
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Letter to the editor
Ascites reinfusion dialysis of refractory ascites as a bridge to kidney and liver transplantation in a patient on hemodialysis
Kyung Yoon Chang, Hyung Wook Kim, Dong Chan Jin, Young Soo Kim
Korean J Intern Med. 2017;32(2):363-364. Published online January 19, 2016
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Gastroenterology / Original Article
Decreased S100B expression in chronic liver diseases
Su Jung Baik, Tae Hun Kim, Kwon Yoo, Il Hwan Moon, Ju Young Choi, Kyu Won Chung, Dong Eun Song
Korean J Intern Med. 2017;32(2):269-276. Published online June 3, 2016
Background/Aims: Hepatic innervation in liver diseases is not fully understood. We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and semi-quantitatively.
Methods: Liver specimens were obtained from 70 subjects (three c..
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Gastroenterology / Original Article
Ultrasound-guided percutaneous portal transplantation of peripheral blood monocytes in patients with liver cirrhosis
Su Jong Yu, Jung-Hwan Yoon, Won Kim, Jeong Min Lee, Yun Bin Lee, Yuri Cho, Dong Hyeon Lee, Minjong Lee, Jeong-Ju Yoo, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Chung Yong Kim
Korean J Intern Med. 2017;32(2):261-268. Published online April 5, 2016
Background/Aims: Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. Stem cell therapy is attractive in this setting. In this study, we aimed to explore the safety and efficacy of ultrasound-guided percutaneous portal transplantation of peripheral blood m..
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Gastroenterology / Review
Reversal of liver cirrhosis: current evidence and expectations
Young Kul Jung, Hyung Joon Yim
Korean J Intern Med. 2017;32(2):213-228. Published online February 8, 2017
In the past, liver cirrhosis was considered an irreversible phenomenon. However, many experimental data have provided evidence of the reversibility of liver fibrosis. Moreover, multiple clinical studies have also shown regression of fibrosis and reversal of cirrhosis on repeated biopsy samples. As v..
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Letter to the editor
Recurrent pyogenic liver abscess as a presenting manifestation of colorectal cancer
Hee Yeon Kim, Chang Wook Kim, Dong Ryul Kim, Young Wook Cho, Jae-Young Cho, Woo Jung Kim, Hyung Gyu Choi
Korean J Intern Med. 2017;32(1):174-177. Published online February 3, 2016
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Nephrology / Original Article
Liver cirrhosis leads to poorer survival in patients with end-stage renal disease
Ae Jin Kim, Hye Jin Lim, Han Ro, Ji Yong Jung, Hyun Hee Lee, Wookyung Chung, Jae Hyun Chang
Korean J Intern Med. 2016;31(4):730-738. Published online March 26, 2016
Background/Aims: Liver cirrhosis (LC) is an important problem in patients withend-stage renal disease (ESRD). Few studies have investigated the inf luence ofLC on mortality in patients with ESRD. This study investigated the associationbetween LC and mortality among patients with ESRD and compare mor..
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