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Hemato-oncology / Original Article
The impact of primary tumor location in patients with metastatic colorectal cancer: a Korean Cancer Study Group CO12-04 study
Jae Ho Byun, Joong Bae Ahn, Sun Young Kim, Jung Hun Kang, Dae Young Zang, Seok Yun Kang, Myoung Joo Kang, Byoung Yong Shim, Sun Kyung Baek, Bong-Seog Kim, Kyung Hee Lee, Soon Il Lee, Sang-Hee Cho, Byeong Seok Sohn, Samyong Kim, In Gyu Hwang, Eun Mi Nam, Bong-Gun Seo, Sang Cheul Oh, Myung-Ah Lee, Sang-Cheol Lee, Ji Hyung Hong, Young Suk Park
Korean J Intern Med. 2019;34(1):165-177. Published online November 28, 2017
Background/Aims: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC).
Methods: Demographic data and clinical information were collected from 1..
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Nephrology / Original Article
Paricalcitol attenuates indoxyl sulfate-induced apoptosis through the inhibition of MAPK, Akt, and NF-kB activation in HK-2 cells
Jung Sun Park, Hoon In Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Korean J Intern Med. 2019;34(1):146-155. Published online October 10, 2017
Background/Aims: Indoxyl sulfate (IS) is a uremic toxin and an important causative factor in the progression of chronic kidney disease. Recently, paricalcitol (19-nor-1,25-dihydroxyvitamin D2) was shown to exhibit protective effects in kidney injury. Here, we investigated the effects of paricalcitol..
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Pulmonology / Original Article
Nonpulmonary risk factors of acute respiratory distress syndrome in patients with septic bacteraemia
Hyunseung Nam, Seung Hun Jang, Yong Il Hwang, Joo-Hee Kim, Ji Young Park, Sunghoon Park
Korean J Intern Med. 2019;34(1):116-124. Published online June 14, 2018
Background/Aims: The relationship between nonpulmonary organ failure and the development of acute respiratory distress syndrome (ARDS) in patients with sepsis has not been well studied.
Methods: We retrospectively reviewed the medical records of patients with septic bacteremia admitted to the medic..
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Pulmonology / Original Article
Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease
Sulhattin Arslan, Gürsel Yildiz, Levent Özdemir, Erdal Kaysoydu, Bülent Özdemir
Korean J Intern Med. 2019;34(1):108-115. Published online November 16, 2018
Background/Aims: Many systems including the cardiovascular system (ischemic heart diseases, heart failure, and hypertension) may act as comorbidities that can be seen during the course of chronic obstructive pulmonary disease (COPD). Comorbidities affect the severity and prognosis of COPD negatively..
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Cardiology / Original Article
Olmesartan is not associated with the risk of enteropathy: a Korean nationwide observational
cohort study
Seng Chan You, Hojun Park, Dukyong Yoon, Sooyoung Park, Boyoung Joung, Rae Woong Park
Korean J Intern Med. 2019;34(1):90-98. Published online November 27, 2017
Background/Aims: Olmesartan, a widely used angiotensin II receptor blocker (ARB), has been linked to sprue-like enteropathy. No cases of olmesartan-associated enteropathy have been reported in Northeast Asia. We investigated the associations between olmesartan and other ARBs and the incidence of ent..
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Gastroenterology / Original Article
The usefulness of fecal calprotectin in assessing inflammatory bowel disease activity
Yang Woon Lee, Kang-Moon Lee, Ji Min Lee, Yoon Yung Chung, Dae Bum Kim, Yeon Ji Kim, Woo Chul Chung, Chang-Nyol Paik
Korean J Intern Med. 2019;34(1):72-80. Published online January 20, 2018
Background/Aims: Fecal calprotectin (FC) is known to correlate with disease activity and can be used as a predictor for relapse or treatment response in inflammatory bowel disease (IBD). We evaluated the usefulness of FC as a biomarker for disease activity in patients with IBD using both enzyme-link..
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Cardiology / Review
Current status of acute myocardial infarction in Korea
Yongcheol Kim, Youngkeun Ahn, Myeong Chan Cho, Chong Jin Kim, Young Jo Kim, Myung Ho Jeong
Korean J Intern Med. 2019;34(1):1-10. Published online December 28, 2018
Coronary artery disease, especially acute myocardial infarction (AMI), is a leading cause of death in the Asia-Pacific region. The Korea Acute Myocardial Infarction Registry (KAMIR) is the first nationwide, prospective, multicenter registry of Korean patients with AMI. Since the KAMIR first began in..
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Rheumatology / Original Article
Systemic review: agreement between the latent tuberculosis screening tests among patients with rheumatic diseases
Junhee Pyo, Soo-Kyung Cho, Dam Kim, Yoon-Kyoung Sung
Korean J Intern Med. 2018;33(6):1241-1251. Published online December 28, 2017
Background/Aims: To estimate the level of agreement and positivity rates of latent tuberculosis infection (LTBI) tests prior to the use of tumor necrosis factor (TNF) inhibitors in relation to underlying rheumatic diseases and endemic tuberculosis levels.
Methods: The Ovid-Medline, Embase, and Coch..
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Rheumatology / Original Article
Rapid onset of efficacy predicts response to therapy with certolizumab plus methotrexate in patients with active rheumatoid arthritis
Young Mo Kang, Young-Eun Park, Won Park, Jung-Yoon Choe, Chul-Soo Cho, Seung-Cheol Shim, Sang Cheol Bae, Chang-Hee Suh, Hoon-Suk Cha, Eun Mi Koh, Yeong-Wook Song, Bin Yoo, Shin-Seok Lee, Min-Chan Park, Sang-Heon Lee, Catherine Arendt, Willem Koetse, Soo-Kon Lee
Korean J Intern Med. 2018;33(6):1224-1233. Published online January 5, 2018
Background/Aims: The objective of this study was to determine the efficacy and safety of add-on therapy with certolizumab pegol (CZP) in active rheumatoid arthritis (RA) patients of a single ethnicity.
Methods: In this 24-week, phase 3, randomized, double-blind, placebo-controlled trial, eligible p..
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Infectious diseases / Original Article
Adverse drug reaction monitoring during antimicrobial therapy for septicemia patients at a university hospital in New Delhi
Muhammad Shamshir Alam, Krishna Kolappa Pillai, Syed Aliul Hasan Abdi, Prem Kapur, Paru Kutty Pillai, Kandasamy Nagarajan
Korean J Intern Med. 2018;33(6):1203-1209. Published online September 6, 2017
Background/Aims: Adverse drug reaction (ADR) is an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product. The present study was conducted in order to monitor the frequency and severity of ADR during antimicrobial therapy of septicemia.
..
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Hemato-oncology / Original Article
Clinical characteristics and treatment propensity in elderly patients aged over 80 years with colorectal cancer
Yun Hwa Jung, Jae Young Kim, Yu Na Jang, Sang Hoon Yoo, Gyo Hui Kim, Kang Min Lee, In Kyu Lee, Su Mi Chung, In Sook Woo
Korean J Intern Med. 2018;33(6):1182-1193. Published online November 24, 2017
Background/Aims: Elderly patients (≥ 80 years) with colorectal cancer (CRC) tend to avoid active treatment at the time of diagnosis despite of recent advances in treatment. The aim of this study was to determine treatment propensity of elderly patients aged ≥ 80 years with CRC in clinical practice ..
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Nephrology / Original Article
Number of existing permanent teeth is associated with chronic kidney disease in the elderly Korean population
Hye-Sun Shin
Korean J Intern Med. 2018;33(6):1150-1159. Published online April 14, 2017
Background/Aims: The aim of this study was to assess the association between the number of existing permanent teeth and chronic kidney disease (CKD) in a representative sample of the elderly Korean population.
Methods: A total of 2,519 subjects who participated in the Korean National Health and Nut..
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Cardiology / Original Article
Prognostic significance of non-chest pain symptoms in patients with non-ST-segment elevation myocardial infarction
Inna Kim, Min Chul Kim, Keun Ho Park, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Myeong Chan Cho, Jong Jin Kim, Young Jo Kim, Youngkeun Ahn; the Korea Acute Myocardial Infarction Registry Investigators
Korean J Intern Med. 2018;33(6):1111-1118. Published online November 10, 2017
Background/Aims: Chest pain is an essential symptom in the diagnosis of acute coronary syndrome (ACS). One-third of patients with ACS present atypically, which can influence their receiving timely lifesaving therapy.
Methods: A total of 617 NSTEMI patients from the Korea Acute MI Registry (KAMIR) ..
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Gastroenterology / Original Article
Association of a genetic polymorphism of IL1RN with risk of acute pancreatitis in a Korean ethnic group
Jin Woo Park, Ja Sung Choi, Ki Joon Han, Sang Heun Lee, Eui Joo Kim, Jae Hee Cho
Korean J Intern Med. 2018;33(6):1103-1110. Published online November 10, 2017
Background/Aims: Several epidemiological studies have validated the association of interleukin gene polymorphisms with acute pancreatitis (AP) in different populations. However, there have been few studies in Asian ethnic groups. We aimed to investigate the relationships between inflammatory cytoki..
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Gastroenterology / Original Article
Clinical significance of radiation-induced liver disease after stereotactic body radiation therapy for hepatocellular carcinoma
Baek Gyu Jun, Young Don Kim, Gab Jin Cheon, Eun Seog Kim, Eunjin Jwa, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Hong Soo Kim
Korean J Intern Med. 2018;33(6):1093-1102. Published online August 28, 2017
Background/Aims: The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and to identify the clinical significance of RILD.
Methods: We retrospectively rev..
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Rheumatology / Original Article
Isoniazid treatment for latent tuberculosis infection is tolerable for rheumatoid arthritis patients receiving tumor necrosis factor inhibitor therapy
Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Soyoung Won, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Dae-Hyun Yoo, Sang-Cheol Bae
Korean J Intern Med. 2018;33(5):1016-1024. Published online March 13, 2017
Background/Aims: To evaluate the impact of isoniazid (INH) treatment for latent tuberculosis infection (LTBI) on the development of liver function test (LFT) abnormality and the persistence of tumor necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA) patients.
Methods: We retrospectively ..
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Infectious diseases / Original Article
Management of carbapenem-resistant Acinetobacter baumannii epidemic in an intensive care unit using multifaceted intervention strategy
Jeongmin Hong, Ok Jeom Jang, Mi Hui Bak, Eun Hwa Baek, Ki-Ho Park, Sun In Hong, Oh-Hyun Cho, In-Gyu Bae
Korean J Intern Med. 2018;33(5):1000-1007. Published online November 27, 2017
Background/Aims: We evaluated the effects of a multifaceted intervention for controlling a carbapenem-resistant Acinetobacter baumannii (CRAB) epidemic in an intensive care unit (ICU) with no restrictions on carbapenem use.
Methods: This study was conducted in a medical ICU between April 201..
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Pulmonology / Original Article
Use of serology and polymerase chain reaction to detect atypical respiratory pathogens during acute exacerbation of chronic obstructive pulmonary disease
Chi Young Jung, Yeoung Hun Choe, Sang Yeub Lee, Woo Jin Kim, Jong Deog Lee, Seung Won Ra, Eu Gene Choi, Jae Seung Lee, Myung Jae Park, Ju Ock Na
Korean J Intern Med. 2018;33(5):941-951. Published online June 25, 2018
Background/Aims: To use serological and multiplex polymerase chain reaction (PCR) assays to examine sputum samples from patients experiencing acute exacerbation of chronic obstructive pulmonary disease (AECOPD) for the presence of atypical pathogens, including Mycoplasma pneumoniae, Chlamydia pneumo..
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Cardiology / Original Article
Body fluid status assessment by bio-impedance analysis in patients presenting to the emergency department with dyspnea
Chan Soon Park, Sang-Eun Lee, Hyun-Jai Cho, Yong-Jin Kim, Hyun-Jae Kang, Byung-Hee Oh, Hae-Young Lee
Korean J Intern Med. 2018;33(5):911-921. Published online December 18, 2017
Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea.
Methods: A total of 100 ..
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Gastroenterology / Original Article
Disparity in Crohn’s disease activity between home and clinics is associated with unscheduled hospital visits due to disease flares
Eun Soo Kim, Yoo Jin Lee, Byung Ik Jang, Kyeong Ok Kim, Eun Young Kim, Hyun Seok Lee, Seong Woo Jeon, Sang Gyu Kwak; on behalf of Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Korean J Intern Med. 2018;33(5):902-910. Published online January 17, 2018
Background/Aims: E-health technologies have been implemented for the management of Crohn’s disease (CD). We aimed to identify differences between patient activities at home and at routine clinic visits using a web-based self-reporting CD symptom diary (CDSD) and to determine the impact of this dis..
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