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Review
Current laboratory diagnosis of coronavirus disease 2019
Jihyang Lim, Jehoon Lee
Korean J Intern Med. 2020;35(4):741-748. Published online July 1, 2020
Coronavirus disease 2019 (COVID-19) emerged in December 2019 in Wuhan, China; it has since caused a pandemic, with more than 10,000 confirmed cases (> 800,000 tests) in Korea as of May 2020. Real-time reverse transcription polymerase chain reaction (RT-PCR) is currently the most commonly used method..
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Rheumatology
Liver enzyme elevation in patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors: a single-center historical cohort study
Su Jin Choi, Ji Seon Oh, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
Korean J Intern Med. 2020;35(3):723-731. Published online December 26, 2019
Background/Aims: Tumor necrosis factor inhibitors (TNFi) have been known to induce liver enzyme elevation, sometimes associated with viral reactivation or toxic hepatitis. We evaluated the incidence and risk factors of TNFi-associated liver enzyme elevation in Korean ankylosing spondylitis (AS) pati..
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Allergy
Incidence of teicoplanin adverse drug reactions among patients with vancomycin-associated adverse drug reactions and its risk factors
Byung-Keun Kim, Jung-Hyun Kim, Kyoung-Hee Sohn, Ju-Young Kim, Yoon-Seok Chang, Sae-Hoon Kim
Korean J Intern Med. 2020;35(3):714-722. Published online November 15, 2019
Background/Aims: Teicoplanin can be used as an alternative to vancomycin when treating beta-lactam-resistant gram-positive bacterial infections. Both vancomycin and teicoplanin are associated with relatively high rates of adverse drug reactions (ADRs), including hypersensitivity reactions. There is ..
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Infectious diseases
Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013
Bongyoung Kim, Hyeonjun Hwang, Jieun Kim, Myoung-jae Lee, Hyunjoo Pai
Korean J Intern Med. 2020;35(3):703-713. Published online September 27, 2018
Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea.
Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each ..
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Hemato-oncology
Risk factors for primary lung cancer among never-smoking women in South Korea: a retrospective nationwide population-based cohort study
Yoon Ho Ko, Seung Joon Kim, Wan-Seop Kim, Chan Kwon Park, Cheol-Kyu Park, Yang-Gun Suh, Jung Seop Eom, Sukki Cho, Jae Young Hur, Sung Ho Hwang, Jun-Pyo Myong
Korean J Intern Med. 2020;35(3):692-702. Published online February 19, 2020
Background/Aims: We performed a large-scale, retrospective, nationwide, cohort study to investigate the risk factors for lung cancer among never-smoking Korean females.
Methods: The study data were collected from a general health examination and questionnaire survey of eligible populations conducte..
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Nephrology
Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 as biomarkers of patients with established acute kidney injury
Won Yong Cho, Sung Yoon Lim, Ji Hyun Yang, Se Won Oh, Myung-Gyu Kim, Sang-Kyung Jo
Korean J Intern Med. 2020;35(3):662-671. Published online December 23, 2019
Background/Aims: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been recently discovered and validated as sensitive biomarkers that can predict stage 2 or 3 acute kidney injury (AKI) development in high-risk patients. We aimed ..
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Cardiology
Prevention of medical malpractice and disputes through analysis of lawsuits related to coronary angiography and intervention
Cheol Won Hyeon, Won Lee, So Yoon Kim, Ji Yong Park, Su Hwan Shin
Korean J Intern Med. 2020;35(3):605-618. Published online June 14, 2019
Background/Aims: Possible fatal complications arising from coronary angiography (CAG), percutaneous coronary intervention (PCI), and coronary artery disease itself, are likely to cause medical disputes. Presenting the current status and reasons for judgments given in lawsuits related to CAG/PCI, thi..
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Gender differences in the presentation of chest pain in obstructive coronary artery disease: results from the Korean Women’s Chest Pain Registry
Dong-Hyuk Cho, Jimi Choi, Mi-Na Kim, Hack-Lyoung Kim, Yong Hyun Kim, Jin Oh Na, Jin-Ok Jeong, Hyun Ju Yoon, Mi-Seung Shin, Myung-A Kim, Kyung-Soon Hong, Gil Ja Shin, Seong-Mi Park, Wan Joo Shim
Korean J Intern Med. 2020;35(3):582-592. Published online March 19, 2019
Background/Aims: Chest pain in patients with obstructive coronary artery disease (OCAD) is affected by several social factors. The gender-based differences in chest pain among Koreans have yet to be investigated.
Methods: The study consecutively enrolled 1,549 patients (male/female, 514/1,035; 61 ..
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Gastroenterology
Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy
Young Woon Chang, Yoo Min Park, Chi Hyuk Oh, Shin Ju Oh, Jun-Hyung Cho, Jung-Wook Kim, Jae-Young Jang
Korean J Intern Med. 2020;35(3):574-581. Published online December 12, 2019
Background/Aims: The eradication failure rate of standard triple therapy (proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has increased owing to antibiotic resistance in Korea. We assessed whether Saccharomyces boulardii probiotic or broccoli s..
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Heart failure with preserved ejection fraction: insights from recent clinical researches
[corrected-article]
Mi-Na Kim, Seong-Mi Park
Korean J Intern Med. 2020;35(3):514-534. Published online April 29, 2020
Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for nearly half of the cases of HF and its incidence might be increasing with the aging society. Patients with HFpEF present with significant symptoms, including exercise intolerance, impaired quality of life, and have a poor progn..
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Cardiology
Early efficacy and safety of statin therapy in Korean patients with hypercholesterolemia: Daegu and Gyeongbuk Statin Registry
Han Joon Bae, Yun-Kyeong Cho, Hyoung-Seob Park, Hyuck-Jun Yoon, Hyungseop Kim, Seongwook Han, Seung-Ho Hur, Yoon-Nyun Kim, Kwon-Bae Kim, Jae-Kean Ryu, Deug Young Nah, Chang-Wook Nam
Korean J Intern Med. 2020;35(2):342-350. Published online August 19, 2019
Background/Aims: To date, prospective data are limited on efficacy and safety profiles of statin therapy in Korean hypercholesterolemic patients. Hence, the aim of this study was to evaluate the practice patterns of statin therapy and its efficacy and safety through the prospective Daegu and Gyeong..
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Gastroenterology
Comparison of procedural sequence in same-day bidirectional endoscopy: a systematic review and meta-analysis
Geun Joo Choi, Hyoung-Chul Oh, Hee-Kyeong Seong, Jeong Wook Kim, Jin Soo Ko, Hyun Kang
Korean J Intern Med. 2020;35(2):331-341. Published online December 27, 2019
Background/Aims: To compare the efficacy and safety of procedural sequence in same-day bidirectional endoscopy.
Methods: We searched OVID-MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Google Scholar to identify randomized controlled trials that compared the procedural sequenc..
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Outcomes and clinical relevance of stool multiplex bacterial polymerase chain reaction in patients with acute diarrhea: single center experience
Won Gun Kwack, Yun Jeong Lim, Ki Hwan Kwon, Jae Woo Chung, Jin Young Oh
Korean J Intern Med. 2020;35(2):300-309. Published online January 29, 2019
Background/Aims: Diagnostic stool multiplex polymerase chain reaction (PCR) testing has attracted considerable interest, because of its high sensitivity, short turnaround time, and ability to detect multiple organisms simultaneously. This study investigates the clinical usefulness of a stool multipl..
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Pulmonology
Role of phosphodiesterase-4 inhibitors in chronic obstructive pulmonary disease
Chin Kook Rhee, Deog Kyeom Kim
Korean J Intern Med. 2020;35(2):276-283. Published online February 28, 2020
Phosphodiesterase-4 inhibitors (PDE4Is) are potent anti-inf lammatory agents and roflumilast has been used to prevent acute exacerbation of chronic obstructive pulmonary disease (COPD). Roflumilast decreases neutrophil migration, restores cystic fibrosis transmembrane conductance regulator activity,..
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Infectious diseases
Clinical impact of healthcare-associated acquisition in cirrhotic patients with community-onset spontaneous bacterial peritonitis
Jungok Kim, Cheol-In Kang, Geum-Youn Gwak, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song
Korean J Intern Med. 2020;35(1):215-221. Published online March 5, 2018
Background/Aims: Healthcare-associated (HCA) infection is a recently suggested new category of community-onset infections. The implications of HCA infections in terms of diagnosis, treatment, and outcomes of spontaneous bacterial peritonitis (SBP) are not well understood. We sought to delineate the ..
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Hemato-oncology
Practice patterns of multidisciplinary team meetings in Korean cancer care and patient satisfaction with this approach
Chi Hoon Maeng, Hee Kyung Ahn, Sung Yong Oh, Seungtaek Lim, Bong-Seog Kim, Do Yeun Kim
Korean J Intern Med. 2020;35(1):205-214. Published online December 6, 2019
Background/Aims: The multidisciplinary team (MDT) approach is a cornerstone of clinical oncology. This study investigated the current state of MDT care, including patient satisfaction, in Korea.
Methods: We obtained the annual number of cancer patients who have received MDT care since 2014 from the..
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Nephrology
Low parathyroid hormone level predicts infection-related mortality in incident dialysis patients: a prospective cohort study
Yu Ah Hong, Jeong Ho Kim, Yong Kyun Kim, Yoon Kyung Chang, Cheol Whee Park, Suk Young Kim, Yon Su Kim, Shin-Wook Kang, Nam-Ho Kim, Yong-Lim Kim, Chul Woo Yang
Korean J Intern Med. 2020;35(1):160-170. Published online October 28, 2019
Background/Aims: Parathyroid hormone (PTH) is an important factor influencing immunologic dysfunction, but the effect of PTH level on infection-related outcomes remains unclear in incident dialysis.
Methods: We evaluated a multicenter prospective cohort study of 1,771 incident dialysis patients (1,..
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Pulmonology
Analysis of high predicted pulmonary function: possibility of overestimation in small elderly examinees
Youjin Chang, Ho Cheol Kim, Kyung-Wook Jo, Jae Seung Lee, Yeon-Mok Oh, Sang Do Lee, Sei Won Lee
Korean J Intern Med. 2020;35(1):142-149. Published online October 17, 2019
Background/Aims: Few studies have attempted to interpret unusually high predicted pulmonary function test results. This study aimed to investigate the demographic features of patients with an unusually high predicted pulmonary function.
Methods: The demographic data of subjects who underwent pulmon..
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Cardiology
Pre-hospital delay and emergency medical services in acute myocardial infarction
Seung Hun Lee, Hyun Kuk Kim, Myung Ho Jeong, Joo Myung Lee, Hyeon-Cheol Gwon, Shung Chull Chae, In-Whan Seong, Jong-Seon Park, Jei Keon Chae, Seung-Ho Hur, Kwang Soo Cha, Hyo-Soo Kim, Ki-Bae Seung, Seung-Woon Rha, Tae Hoon Ahn, Chong-Jin Kim, Jin-Yong Hwang, Dong-Ju Choi, Junghan Yoon, Seung-Jae Joo, Kyung-Kuk Hwang, Doo-Il Kim, Seok Kyu Oh; for the KAMIR Investigators
Korean J Intern Med. 2020;35(1):119-132. Published online November 28, 2019
Background/Aims: Minimising total ischemic time (TIT) is important for improving clinical outcomes in patients with ST-segment elevation myocardial infarction who have undergone percutaneous coronary intervention (PCI). TIT has not shown a significant improvement due to persistent pre-hospital delay..
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Attitudes toward advance directives and prognosis in patients with heart failure: a pilot study
JinShil Kim, Minjeong An, Seongkum Heo, Mi-Seung Shin
Korean J Intern Med. 2020;35(1):109-118. Published online February 15, 2019
Background/Aims: Advance directives (ADs) in Korean patients with heart failure (HF) and the associations of attitude towards ADs and HF prognosis with ADs were initially assessed using the model of the Korean-Advance Directive (K-AD).
Methods: Twenty-four patients with HF (age, 67.1 years; men, 58..
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