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Cardiology / Original Article
Update on association between exposure to renin-angiotensin-aldosterone system inhibitors and coronavirus disease 2019 in South Korea
Jeongkuk Seo, Minkook Son
Korean J Intern Med. 2021;36(Suppl 1):S114-S122. Published online February 25, 2021
Background/Aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angiotensin-aldosterone system (RAAS) inhibitors and the risk and severity of COVID-19.
Methods: We performed a case-control study that util..
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Cardiology / Original Article
Fimasartan, an angiotensin II receptor antagonist, ameliorates an in vivo zebrafish model of heart failure
Hailian Quan, Gyu Chul Oh, Seung Hyeok Seok, Hae-Young Lee
Korean J Intern Med. 2020;35(6):1400-1410. Published online March 13, 2020
Background/Aims: Angiotensin II in the failing heart initially helps to maintain cardiac output and blood pressure, but ultimately accelerates its deterioration. In this study, we established a model of arrhythmia-induced heart failure (HF) in zebrafish and investigated the role of renin-angiotensi..
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Gastroenterology / Review
Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension
Kwang Yong Shim, Young Woo Eom, Moon Young Kim, Seong Hee Kang, Soon Koo Baik
Korean J Intern Med. 2018;33(3):453-461. Published online February 21, 2018
The renin-angiotensin system (RAS) is an important regulator of cirrhosis and portal hypertension. As hepatic fibrosis progresses, levels of the RAS components angiotensin (Ang) II, Ang-(1–7), angiotensin-converting enzyme (ACE), and Ang II type 1 receptor (AT1R) are increased. The primary effector ..
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Nephrology / Original Article
Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal
injury in unilateral ureteral obstructed mice
Sarah Chung, Jin Young Jeong, Yoon Kyung Chang, Dae Eun Choi, Ki Ryang Na, Beom Jin Lim, Kang Wook Lee
Korean J Intern Med. 2016;31(2):323-334. Published online February 26, 2016
Background/Aims: There has been controversy about the role of Toll-like receptor 2 (TLR2) in renal injury following ureteric obstruction. Although inhibition of the renin angiotensin system (RAS) reduces TLR2 expression in mice, the exact relationship between TLR2 and RAS is not known. The aim of th..
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Nephrology / Review
The renin-angiotensin system and aging in the kidney
Hye Eun Yoon, Bum Soon Choi
Korean J Intern Med. 2014;29(3):291-295. Published online April 29, 2014
Aging is associated with progressive functional deterioration and structural changes in the kidney. Changes in the activity or responsiveness of the renin-angiotensin system (RAS) occur with aging. RAS changes predispose the elderly to various fluid and electrolyte imbalances as well as acute kidney..
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Cardiology / Original Article
Effect of renin-angiotensin-system blockers on contrast-medium-induced acute kidney injury after coronary angiography
Ja-Jun Goo, Jae-Joon Kim, Ji-Hoon Kang, Kyoung-Nyoun Kim, Ki-Sup Byun, Mi-kyung Kim, Tae-Ik Kim
Korean J Intern Med. 2014;29(2):203-209. Published online February 27, 2014
Background/Aims: With the increasing incidence of cardiovascular disease, angiocardiography using contrast-enhancing media has become an essential diagnostic and therapeutic tool, despite the risk of contrast-medium-induced acute kidney injury (CIAKI). CIAKI may be exacerbated by renin-angiotensin-s..
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