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Geriatrics
Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model
Heayon Lee, In Kyoung Kim, Jeonghyeon Im, Bae Suk Jin, Hwan Hee Kim, Sei Won Kim, Chang Dong Yeo, Sang Haak Lee
Korean J Intern Med. 2023;38(6):934-944. Published online October 5, 2023
Background/Aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we evaluated the effects of IH in an older mouse model of..
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Rheumatology
Atorvastatin inhibits osteoclast differentiation by suppressing NF-κB and MAPK signaling during IL-1β-induced osteoclastogenesis
Won-Seok Lee, Eun-Gyeong Lee, Myung-Soon Sung, Yun-Jung Choi, Wan-Hee Yoo
Korean J Intern Med. 2018;33(2):397-406. Published online March 28, 2017
Background/Aims: To define the effect of statins on interleukin 1β (IL-1β)-induced osteoclastogenesis and elucidate the underlying mechanisms.
Methods: Bone marrow cells were obtained from 5-week-old male ICR (Institute for Cancer Research) mice, and they were cultured to differentiate them into ..
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Hemato-oncology
Analgesic effect of quetiapine in a mouse model of cancer-induced bone pain
Mi Hwa Heo, Jin Young Kim, Ilseon Hwang, Eunyoung Ha, Keon Uk Park
Korean J Intern Med. 2017;32(6):1069-1074. Published online January 20, 2017
Background/Aims: Cancer-induced bone pain (CIBP) is one of the most common pains in patients with advanced neoplasms. Because of treatment-associated side effects, more than half of cancer patients are reported to have inadequate and undermanaged pain control. New mechanism-based therapies must be d..
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Comparison of Asthma Phenotypes Using Different Sensitizing Protocols in Mice
Yoon-Seok Chang, Yoon-Keun Kim, Joon-Woo Bahn, Sang-Heon Kim, Heung-Woo Park, Tae-Bum Kim, Sang-Heon Cho, Kyung-Up Min, You-Young Kim
Korean J Intern Med. 2005;20(2):152-158. Published online June 30, 2005
BackgroundSeveral methods have been reported to induce asthmatic reactions in mice but few studies have compared their efficiency. We evaluated the efficiency of the protocols frequently used in the literature. MethodsBALB/c mice were sensitized..
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