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Nephrology
Renal Klotho expression in patients with acute kidney injury is associated with the severity of the injury
Min Young Seo, Jihyun Yang, Jun Yong Lee, Kitae Kim, Sun Chul Kim, Hyojeong Chang, Nam Hee Won, Myung-Gyu Kim, Sang-Kyung Jo, Wonyong Cho, Hyoung Kyu Kim
Korean J Intern Med. 2015;30(4):489-495. Published online June 29, 2015
Background/Aims: The potential physiologic roles of Klotho in acute kidney injury (AKI) have recently been demonstrated in animal models. However, to date, there have been no human studies investigating the expression of renal Klotho in AKI.
Methods: We retrospectively collected biopsy specimens a..
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Klotho and the Aging Process
Makoto Kuro-o
Korean J Intern Med. 2011;26(2):113-122. Published online June 1, 2011
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the th..
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Polymorphism in the promoter region of the klotho gene (G-395A) is associated with early dysfunction in vascular access in hemodialysis patients
Youngsu Kim, Sun Joo Jeong, Hyung Suk Lee, Eun Jung Kim, Young Rim Song, Sung Gyun Kim, Ji Eun Oh, Young Ki Lee, Jang Won Seo, Jong Woo Yoon, Ja-Ryong Koo, Hyung Jik Kim, Jung Woo Noh, Seung Ho Park
Korean J Intern Med. 2008;23(4):201-207. Published online December 30, 2008
Background/AimsVascular access dysfunction is an important cause of morbidity and mortality in hemodialysis (HD) patients. Recent studies have shown that a klotho gene mutation is related to endothelial dysfunction, thrombosis, and arteriosclerosis, which are ..
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